Large Language Models in Biomedical and Health Informatics: A Bibliometric Review

Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This bibliometric review aims to provide a panoramic view of how LLMs have been used in BHI by examining research articles and collaboration networks from 2022 to 2023. It further explores how LLMs can improve Natural Language Processing (NLP) applications in various BHI areas like medical diagnosis, patient engagement, electronic health record management, and personalized medicine. To do this, our bibliometric review identifies key trends, maps out research networks, and highlights major developments in this fast-moving field. Lastly, it discusses the ethical concerns and practical challenges of using LLMs in BHI, such as data privacy and reliable medical recommendations. Looking ahead, we consider how LLMs could further transform biomedical research as well as healthcare delivery and patient outcomes. This bibliometric review serves as a resource for stakeholders in healthcare, including researchers, clinicians, and policymakers, to understand the current state and future potential of LLMs in BHI.

NPHardEval4V: A Dynamic Reasoning Benchmark of Multimodal Large Language Models

Understanding the reasoning capabilities of Multimodal Large Language Models (MLLMs) is an important area of research. In this study, we introduce a dynamic benchmark, NPHardEval4V, aimed at addressing the existing gaps in evaluating the pure reasoning abilities of MLLMs. Our benchmark aims to provide a venue to disentangle the effect of various factors such as image recognition and instruction following, from the overall performance of the models, allowing us to focus solely on evaluating their reasoning abilities. It is built by converting textual description of questions from NPHardEval to image representations. Our findings reveal significant discrepancies in reasoning abilities across different models and highlight the relatively weak performance of MLLMs compared to LLMs in terms of reasoning. We also investigate the impact of different prompting styles, including visual, text, and combined visual and text prompts, on the reasoning abilities of MLLMs, demonstrating the different impacts of multimodal inputs in model performance. Unlike traditional benchmarks, which focus primarily on static evaluations, our benchmark will be updated monthly to prevent overfitting and ensure a more authentic and fine-grained evaluation of the models. We believe that this benchmark can aid in understanding and guide the further development of reasoning abilities in MLLMs. The benchmark dataset and code are available at https://github.com/lizhouf/NPHardEval4V

Deformable Object Manipulation With Constraints Using Path Set Planning and Tracking

In robotic deformable object manipulation (DOM) applications, constraints arise commonly from environments and task-specific requirements. Enabling DOM with constraints is therefore crucial for its deployment in practice. However, dealing with constraints turns out to be challenging due to many inherent factors such as inaccessible deformation models of deformable objects (DOs) and varying environmental setups. This article presents a systematic manipulation framework for DOM subject to constraints by proposing a novel path set planning and tracking scheme. First, constrained DOM tasks are formulated into a versatile optimization formalism which enables dynamic constraint imposition. Because of the lack of the local optimization objective and high state dimensionality, the formulated problem is not analytically solvable. To address this, planning of the path set, which collects paths of DO feedback points, is proposed subsequently to offer feasible path and motion references for DO in constrained setups. Both theoretical analyses and computationally efficient algorithmic implementation of path set planning are discussed. Lastly, a control architecture combining path set tracking and constraint handling is designed for task execution. The effectiveness of our methods is validated in a variety of DOM tasks with constrained experimental settings.

Latte: Latent Diffusion Transformer for Video Generation

We propose a novel Latent Diffusion Transformer, namely Latte, for video generation. Latte first extracts spatio-temporal tokens from input videos and then adopts a series of Transformer blocks to model video distribution in the latent space. In order to model a substantial number of tokens extracted from videos, four efficient variants are introduced from the perspective of decomposing the spatial and temporal dimensions of input videos. To improve the quality of generated videos, we determine the best practices of Latte through rigorous experimental analysis, including video clip patch embedding, model variants, timestep-class information injection, temporal positional embedding, and learning strategies. Our comprehensive evaluation demonstrates that Latte achieves state-of-the-art performance across four standard video generation datasets, i.e., FaceForensics, SkyTimelapse, UCF101, and Taichi-HD. In addition, we extend Latte to text-to-video generation (T2V) task, where Latte achieves comparable results compared to recent T2V models. We strongly believe that Latte provides valuable insights for future research on incorporating Transformers into diffusion models for video generation.

Inter-object Discriminative Graph Modeling for Indoor Scene Recognition

Variable scene layouts and coexisting objects across scenes make indoor scene recognition still a challenging task. Leveraging object information within scenes to enhance the distinguishability of feature representations has emerged as a key approach in this domain. Currently, most object-assisted methods use a separate branch to process object information, combining object and scene features heuristically. However, few of them pay attention to interpretably handle the hidden discriminative knowledge within object information. In this paper, we propose to leverage discriminative object knowledge to enhance scene feature representations. Initially, we capture the object-scene discriminative relationships from a probabilistic perspective, which are transformed into an Inter-Object Discriminative Prototype (IODP). Given the abundant prior knowledge from IODP, we subsequently construct a Discriminative Graph Network (DGN), in which pixel-level scene features are defined as nodes and the discriminative relationships between node features are encoded as edges. DGN aims to incorporate inter-object discriminative knowledge into the image representation through graph convolution. With the proposed IODP and DGN, we obtain state-of-the-art results on several widely used scene datasets, demonstrating the effectiveness of the proposed approach.

SEINE: Short-to-Long Video Diffusion Model for Generative Transition and Prediction

Recently video generation has achieved substantial progress with realistic results. Nevertheless, existing AI-generated videos are usually very short clips ("shot-level") depicting a single scene. To deliver a coherent long video ("story-level"), it is desirable to have creative transition and prediction effects across different clips. This paper presents a short-to-long video diffusion model, SEINE, that focuses on generative transition and prediction. The goal is to generate high-quality long videos with smooth and creative transitions between scenes and varying lengths of shot-level videos. Specifically, we propose a random-mask video diffusion model to automatically generate transitions based on textual descriptions. By providing the images of different scenes as inputs, combined with text-based control, our model generates transition videos that ensure coherence and visual quality. Furthermore, the model can be readily extended to various tasks such as image-to-video animation and autoregressive video prediction. To conduct a comprehensive evaluation of this new generative task, we propose three assessing criteria for smooth and creative transition: temporal consistency, semantic similarity, and video-text semantic alignment. Extensive experiments validate the effectiveness of our approach over existing methods for generative transition and prediction, enabling the creation of story-level long videos. Project page: https://vchitect.github.io/SEINE-project/ .

A Neural Tangent Kernel View on Federated Averaging for Deep Linear Neural Network

Federated averaging (FedAvg) is a widely employed paradigm for collaboratively training models from distributed clients without sharing data. Nowadays, the neural network has achieved remarkable success due to its extraordinary performance, which makes it a preferred choice as the model in FedAvg. However, the optimization problem of the neural network is often non-convex even non-smooth. Furthermore, FedAvg always involves multiple clients and local updates, which results in an inaccurate updating direction. These properties bring difficulties in analyzing the convergence of FedAvg in training neural networks. Recently, neural tangent kernel (NTK) theory has been proposed towards understanding the convergence of first-order methods in tackling the non-convex problem of neural networks. The deep linear neural network is a classical model in theoretical subject due to its simple formulation. Nevertheless, there exists no theoretical result for the convergence of FedAvg in training the deep linear neural network. By applying NTK theory, we make a further step to provide the first theoretical guarantee for the global convergence of FedAvg in training deep linear neural networks. Specifically, we prove FedAvg converges to the global minimum at a linear rate $\mathcal{O}\big((1-\eta K /N)^t\big)$, where $t$ is the number of iterations, $\eta$ is the learning rate, $N$ is the number of clients and $K$ is the number of local updates. Finally, experimental evaluations on two benchmark datasets are conducted to empirically validate the correctness of our theoretical findings.

LAVIE: High-Quality Video Generation with Cascaded Latent Diffusion Models

This work aims to learn a high-quality text-to-video (T2V) generative model by leveraging a pre-trained text-to-image (T2I) model as a basis. It is a highly desirable yet challenging task to simultaneously a) accomplish the synthesis of visually realistic and temporally coherent videos while b) preserving the strong creative generation nature of the pre-trained T2I model. To this end, we propose LaVie, an integrated video generation framework that operates on cascaded video latent diffusion models, comprising a base T2V model, a temporal interpolation model, and a video super-resolution model. Our key insights are two-fold: 1) We reveal that the incorporation of simple temporal self-attentions, coupled with rotary positional encoding, adequately captures the temporal correlations inherent in video data. 2) Additionally, we validate that the process of joint image-video fine-tuning plays a pivotal role in producing high-quality and creative outcomes. To enhance the performance of LaVie, we contribute a comprehensive and diverse video dataset named Vimeo25M, consisting of 25 million text-video pairs that prioritize quality, diversity, and aesthetic appeal. Extensive experiments demonstrate that LaVie achieves state-of-the-art performance both quantitatively and qualitatively. Furthermore, we showcase the versatility of pre-trained LaVie models in various long video generation and personalized video synthesis applications.