Auxiliary Input in Training: Incorporating Catheter Features into Deep Learning Models for ECG-Free Dynamic Coronary Roadmapping

Dynamic coronary roadmapping is a technology that overlays the vessel maps (the "roadmap") extracted from an offline image sequence of X-ray angiography onto a live stream of X-ray fluoroscopy in real-time. It aims to offer navigational guidance for interventional surgeries without the need for repeated contrast agent injections, thereby reducing the risks associated with radiation exposure and kidney failure. The precision of the roadmaps is contingent upon the accurate alignment of angiographic and fluoroscopic images based on their cardiac phases, as well as precise catheter tip tracking. The former ensures the selection of a roadmap that closely matches the vessel shape in the current frame, while the latter uses catheter tips as reference points to adjust for translational motion between the roadmap and the present vessel tree. Training deep learning models for both tasks is challenging and underexplored. However, incorporating catheter features into the models could offer substantial benefits, given humans heavily rely on catheters to complete the tasks. To this end, we introduce a simple but effective method, auxiliary input in training (AIT), and demonstrate that it enhances model performance across both tasks, outperforming baseline methods in knowledge incorporation and transfer learning.

Retrieval-augmented Few-shot Medical Image Segmentation with Foundation Models

Medical image segmentation is crucial for clinical decision-making, but the scarcity of annotated data presents significant challenges. Few-shot segmentation (FSS) methods show promise but often require retraining on the target domain and struggle to generalize across different modalities. Similarly, adapting foundation models like the Segment Anything Model (SAM) for medical imaging has limitations, including the need for finetuning and domain-specific adaptation. To address these issues, we propose a novel method that adapts DINOv2 and Segment Anything Model 2 (SAM 2) for retrieval-augmented few-shot medical image segmentation. Our approach uses DINOv2's feature as query to retrieve similar samples from limited annotated data, which are then encoded as memories and stored in memory bank. With the memory attention mechanism of SAM 2, the model leverages these memories as conditions to generate accurate segmentation of the target image. We evaluated our framework on three medical image segmentation tasks, demonstrating superior performance and generalizability across various modalities without the need for any retraining or finetuning. Overall, this method offers a practical and effective solution for few-shot medical image segmentation and holds significant potential as a valuable annotation tool in clinical applications.

ESALE: Enhancing Code-Summary Alignment Learning for Source Code Summarization

(Source) code summarization aims to automatically generate succinct natural language summaries for given code snippets. Such summaries play a significant role in promoting developers to understand and maintain code. Inspired by neural machine translation, deep learning-based code summarization techniques widely adopt an encoder-decoder framework, where the encoder transforms given code snippets into context vectors, and the decoder decodes context vectors into summaries. Recently, large-scale pre-trained models for source code are equipped with encoders capable of producing general context vectors and have achieved substantial improvements on code summarization. However, although they are usually trained mainly on code-focused tasks and can capture general code features, they still fall short in capturing specific features that need to be summarized. This paper proposes a novel approach to improve code summarization based on summary-focused tasks. Specifically, we exploit a multi-task learning paradigm to train the encoder on three summary-focused tasks to enhance its ability to learn code-summary alignment, including unidirectional language modeling (ULM), masked language modeling (MLM), and action word prediction (AWP). Unlike pre-trained models that mainly predict masked tokens in code snippets, we design ULM and MLM to predict masked words in summaries. Intuitively, predicting words based on given code snippets would help learn the code-summary alignment. Additionally, we introduce the domain-specific task AWP to enhance the ability of the encoder to learn the alignment between action words and code snippets. The extensive experiments on four datasets demonstrate that our approach, called ESALE significantly outperforms baselines in all three widely used metrics, including BLEU, METEOR, and ROUGE-L.

ToneUnit: A Speech Discretization Approach for Tonal Language Speech Synthesis

Representing speech as discretized units has numerous benefits in supporting downstream spoken language processing tasks. However, the approach has been less explored in speech synthesis of tonal languages like Mandarin Chinese. Our preliminary experiments on Chinese speech synthesis reveal the issue of "tone shift", where a synthesized speech utterance contains correct base syllables but incorrect tones. To address the issue, we propose the ToneUnit framework, which leverages annotated data with tone labels as CTC supervision to learn tone-aware discrete speech units for Mandarin Chinese speech. Our findings indicate that the discrete units acquired through the TonUnit resolve the "tone shift" issue in synthesized Chinese speech and yield favorable results in English synthesis. Moreover, the experimental results suggest that finite scalar quantization enhances the effectiveness of ToneUnit. Notably, ToneUnit can work effectively even with minimal annotated data.

DDGS-CT: Direction-Disentangled Gaussian Splatting for Realistic Volume Rendering

Digitally reconstructed radiographs (DRRs) are simulated 2D X-ray images generated from 3D CT volumes, widely used in preoperative settings but limited in intraoperative applications due to computational bottlenecks, especially for accurate but heavy physics-based Monte Carlo methods. While analytical DRR renderers offer greater efficiency, they overlook anisotropic X-ray image formation phenomena, such as Compton scattering. We present a novel approach that marries realistic physics-inspired X-ray simulation with efficient, differentiable DRR generation using 3D Gaussian splatting (3DGS). Our direction-disentangled 3DGS (DDGS) method separates the radiosity contribution into isotropic and direction-dependent components, approximating complex anisotropic interactions without intricate runtime simulations. Additionally, we adapt the 3DGS initialization to account for tomography data properties, enhancing accuracy and efficiency. Our method outperforms state-of-the-art techniques in image accuracy. Furthermore, our DDGS shows promise for intraoperative applications and inverse problems such as pose registration, delivering superior registration accuracy and runtime performance compared to analytical DRR methods.

Towards Flexible Interactive Reflection Removal with Human Guidance

Single image reflection removal is inherently ambiguous, as both the reflection and transmission components requiring separation may follow natural image statistics. Existing methods attempt to address the issue by using various types of low-level and physics-based cues as sources of reflection signals. However, these cues are not universally applicable, since they are only observable in specific capture scenarios. This leads to a significant performance drop when test images do not align with their assumptions. In this paper, we aim to explore a novel flexible interactive reflection removal approach that leverages various forms of sparse human guidance, such as points and bounding boxes, as auxiliary high-level prior to achieve robust reflection removal. However, incorporating the raw user guidance naively into the existing reflection removal network does not result in performance gains. To this end, we innovatively transform raw user input into a unified form -- reflection masks using an Interactive Segmentation Foundation Model. Such a design absorbs the quintessence of the foundational segmentation model and flexible human guidance, thereby mitigating the challenges of reflection separations. Furthermore, to fully utilize user guidance and reduce user annotation costs, we design a mask-guided reflection removal network, comprising our proposed self-adaptive prompt block. This block adaptively incorporates user guidance as anchors and refines transmission features via cross-attention mechanisms. Extensive results on real-world images validate that our method demonstrates state-of-the-art performance on various datasets with the help of flexible and sparse user guidance. Our code and dataset will be publicly available here https://github.com/ShawnChenn/FlexibleReflectionRemoval.

Post-Semantic-Thinking: A Robust Strategy to Distill Reasoning Capacity from Large Language Models

Chain of thought finetuning aims to endow small student models with reasoning capacity to improve their performance towards a specific task by allowing them to imitate the reasoning procedure of large language models (LLMs) beyond simply predicting the answer to the question. However, the existing methods 1) generate rationale before the answer, making their answer correctness sensitive to the hallucination in the rationale;2) force the student model to repeat the exact LLMs rationale expression word-after-word, which could have the model biased towards learning the expression in rationale but count against the model from understanding the core logic behind it. Therefore, we propose a robust Post-Semantic-Thinking (PST) strategy to generate answers before rationale. Thanks to this answer-first setting, 1) the answering procedure can escape from the adverse effects caused by hallucinations in the rationale; 2) the complex reasoning procedure is tightly bound with the relatively concise answer, making the reasoning for questions easier with the prior information in the answer; 3) the efficiency of the method can also benefit from the setting since users can stop the generation right after answers are outputted when inference is conducted. Furthermore, the PST strategy loose the constraint against the generated rationale to be close to the LLMs gold standard in the hidden semantic space instead of the vocabulary space, thus making the small student model better comprehend the semantic reasoning logic in rationale. Extensive experiments conducted across 12 reasoning tasks demonstrate the effectiveness of PST.

Spatiotemporal Diffusion Model with Paired Sampling for Accelerated Cardiac Cine MRI

Current deep learning reconstruction for accelerated cardiac cine MRI suffers from spatial and temporal blurring. We aim to improve image sharpness and motion delineation for cine MRI under high undersampling rates. A spatiotemporal diffusion enhancement model conditional on an existing deep learning reconstruction along with a novel paired sampling strategy was developed. The diffusion model provided sharper tissue boundaries and clearer motion than the original reconstruction in experts evaluation on clinical data. The innovative paired sampling strategy substantially reduced artificial noises in the generative results.

Federated Data Model

In artificial intelligence (AI), especially deep learning, data diversity and volume play a pivotal role in model development. However, training a robust deep learning model often faces challenges due to data privacy, regulations, and the difficulty of sharing data between different locations, especially for medical applications. To address this, we developed a method called the Federated Data Model (FDM). This method uses diffusion models to learn the characteristics of data at one site and then creates synthetic data that can be used at another site without sharing the actual data. We tested this approach with a medical image segmentation task, focusing on cardiac magnetic resonance images from different hospitals. Our results show that models trained with this method perform well both on the data they were originally trained on and on data from other sites. This approach offers a promising way to train accurate and privacy-respecting AI models across different locations.

Clinically Feasible Diffusion Reconstruction for Highly-Accelerated Cardiac Cine MRI

The currently limited quality of accelerated cardiac cine reconstruction may potentially be improved by the emerging diffusion models, but the clinically unacceptable long processing time poses a challenge. We aim to develop a clinically feasible diffusion-model-based reconstruction pipeline to improve the image quality of cine MRI. A multi-in multi-out diffusion enhancement model together with fast inference strategies were developed to be used in conjunction with a reconstruction model. The diffusion reconstruction reduced spatial and temporal blurring in prospectively undersampled clinical data, as validated by experts inspection. The 1.5s per video processing time enabled the approach to be applied in clinical scenarios.