Solving the Inverse Problem of Electrocardiography for Cardiac Digital Twins: A Survey

Cardiac digital twins are personalized virtual representations used to understand complex heart mechanisms. Solving the ECG inverse problem is crucial for accurate virtual heart modelling, enabling the derivation of internal electrical activity information from recorded surface potentials. Despite challenges from cardiac complexity, noisy ECG data, and computational efficiency, recent advancements hold significant promise for enhancing virtual heart modelling, ultimately advancing precision medicine in cardiology. This paper aims to provide a comprehensive review of the methods of solving ECG inverse problem, the validation strategies, the clinical applications, and future perspectives. For the computing methodologies, we broadly classify state-of-the-art approaches into two categories: deterministic and probabilistic methods, including conventional and deep learning-based techniques. Integrating physics laws with deep learning models holds promise, but challenges such as capturing dynamic electrophysiology accurately, accessing accurate domain knowledge, and quantifying prediction uncertainty persist. Integrating models into clinical workflows while ensuring interpretability and usability for healthcare professionals is essential. Overcoming these challenges will drive further research in cardiac digital twins.

Robust Channel Learning for Large-Scale Radio Speaker Verification

Recent research in speaker verification has increasingly focused on achieving robust and reliable recognition under challenging channel conditions and noisy environments. Identifying speakers in radio communications is particularly difficult due to inherent limitations such as constrained bandwidth and pervasive noise interference. To address this issue, we present a Channel Robust Speaker Learning (CRSL) framework that enhances the robustness of the current speaker verification pipeline, considering data source, data augmentation, and the efficiency of model transfer processes. Our framework introduces an augmentation module that mitigates bandwidth variations in radio speech datasets by manipulating the bandwidth of training inputs. It also addresses unknown noise by introducing noise within the manifold space. Additionally, we propose an efficient fine-tuning method that reduces the need for extensive additional training time and large amounts of data. Moreover, we develop a toolkit for assembling a large-scale radio speech corpus and establish a benchmark specifically tailored for radio scenario speaker verification studies. Experimental results demonstrate that our proposed methodology effectively enhances performance and mitigates degradation caused by radio transmission in speaker verification tasks. The code will be available on Github.

Evaluating Durability: Benchmark Insights into Multimodal Watermarking

With the development of large models, watermarks are increasingly employed to assert copyright, verify authenticity, or monitor content distribution. As applications become more multimodal, the utility of watermarking techniques becomes even more critical. The effectiveness and reliability of these watermarks largely depend on their robustness to various disturbances. However, the robustness of these watermarks in real-world scenarios, particularly under perturbations and corruption, is not well understood. To highlight the significance of robustness in watermarking techniques, our study evaluated the robustness of watermarked content generated by image and text generation models against common real-world image corruptions and text perturbations. Our results could pave the way for the development of more robust watermarking techniques in the future. Our project website can be found at \url{https://mmwatermark-robustness.github.io/}.

Video-MME: The First-Ever Comprehensive Evaluation Benchmark of Multi-modal LLMs in Video Analysis

In the quest for artificial general intelligence, Multi-modal Large Language Models (MLLMs) have emerged as a focal point in recent advancements. However, the predominant focus remains on developing their capabilities in static image understanding. The potential of MLLMs in processing sequential visual data is still insufficiently explored, highlighting the absence of a comprehensive, high-quality assessment of their performance. In this paper, we introduce Video-MME, the first-ever full-spectrum, Multi-Modal Evaluation benchmark of MLLMs in Video analysis. Our work distinguishes from existing benchmarks through four key features: 1) Diversity in video types, spanning 6 primary visual domains with 30 subfields to ensure broad scenario generalizability; 2) Duration in temporal dimension, encompassing both short-, medium-, and long-term videos, ranging from 11 seconds to 1 hour, for robust contextual dynamics; 3) Breadth in data modalities, integrating multi-modal inputs besides video frames, including subtitles and audios, to unveil the all-round capabilities of MLLMs; 4) Quality in annotations, utilizing rigorous manual labeling by expert annotators to facilitate precise and reliable model assessment. 900 videos with a total of 256 hours are manually selected and annotated by repeatedly viewing all the video content, resulting in 2,700 question-answer pairs. With Video-MME, we extensively evaluate various state-of-the-art MLLMs, including GPT-4 series and Gemini 1.5 Pro, as well as open-source image models like InternVL-Chat-V1.5 and video models like LLaVA-NeXT-Video. Our experiments reveal that Gemini 1.5 Pro is the best-performing commercial model, significantly outperforming the open-source models. Our dataset along with these findings underscores the need for further improvements in handling longer sequences and multi-modal data. Project Page: https://video-mme.github.io

DeCo: Decoupling Token Compression from Semantic Abstraction in Multimodal Large Language Models

The visual projector, which bridges the vision and language modalities and facilitates cross-modal alignment, serves as a crucial component in MLLMs. However, measuring the effectiveness of projectors in vision-language alignment remains under-explored, which currently can only be inferred from the performance of MLLMs on downstream tasks. Motivated by the problem, this study examines the projector module by interpreting the vision-language semantic flow within MLLMs. Specifically, we trace back the semantic relevance flow from generated language tokens to raw visual encoder patches and the intermediate outputs produced by projectors. Our findings reveal that compressive projectors (e.g., QFormer), abstract visual patches into a limited set of semantic concepts, such as objects or attributes, resulting in a 'double abstraction' phenomenon. This involves a first visual semantic abstraction by the projector referring to pre-defined query tokens, and a second extraction by the LLM based on text instructions. The double abstraction is inefficient in training and will result in cumulative vision semantics deficiency. To mitigate this issue, we propose the key insight of 'Decouple Compression from Abstraction (DeCo), that is compressing the visual token number at the patch level by projectors and allowing the LLM to handle visual semantic abstraction entirely. Consequently, we adopt a simple compressor, i.e., 2D Adaptive Pooling, to downsample visual patches in a parameter-free manner. Empirical evaluation demonstrates that DeCo surpasses traditional compressive projectors regarding both performance and efficiency. It achieves performance gains of 0.9%, 7.1%, and 2.9% across the MLLM Benchmarks, Visual Localization, and Open-ended VQA tasks with fewer trainable parameters and faster convergence speed.

3D Neural Edge Reconstruction

Real-world objects and environments are predominantly composed of edge features, including straight lines and curves. Such edges are crucial elements for various applications, such as CAD modeling, surface meshing, lane mapping, etc. However, existing traditional methods only prioritize lines over curves for simplicity in geometric modeling. To this end, we introduce EMAP, a new method for learning 3D edge representations with a focus on both lines and curves. Our method implicitly encodes 3D edge distance and direction in Unsigned Distance Functions (UDF) from multi-view edge maps. On top of this neural representation, we propose an edge extraction algorithm that robustly abstracts parametric 3D edges from the inferred edge points and their directions. Comprehensive evaluations demonstrate that our method achieves better 3D edge reconstruction on multiple challenging datasets. We further show that our learned UDF field enhances neural surface reconstruction by capturing more details.

MindMerger: Efficient Boosting LLM Reasoning in non-English Languages

Reasoning capabilities are crucial for Large Language Models (LLMs), yet a notable gap exists between English and non-English languages. To bridge this disparity, some works fine-tune LLMs to relearn reasoning capabilities in non-English languages, while others replace non-English inputs with an external model's outputs such as English translation text to circumvent the challenge of LLM understanding non-English. Unfortunately, these methods often underutilize the built-in skilled reasoning and useful language understanding capabilities of LLMs. In order to better utilize the minds of reasoning and language understanding in LLMs, we propose a new method, namely MindMerger, which merges LLMs with the external language understanding capabilities from multilingual models to boost the multilingual reasoning performance. Furthermore, a two-step training scheme is introduced to first train to embeded the external capabilities into LLMs and then train the collaborative utilization of the external capabilities and the built-in capabilities in LLMs. Experiments on three multilingual reasoning datasets and a language understanding dataset demonstrate that MindMerger consistently outperforms all baselines, especially in low-resource languages. Without updating the parameters of LLMs, the average accuracy improved by 6.7% and 8.0% across all languages and low-resource languages on the MGSM dataset, respectively.

Scaling Law for Time Series Forecasting

Scaling law that rewards large datasets, complex models and enhanced data granularity has been observed in various fields of deep learning. Yet, studies on time series forecasting have cast doubt on scaling behaviors of deep learning methods for time series forecasting: while more training data improves performance, more capable models do not always outperform less capable models, and longer input horizons may hurt performance for some models. We propose a theory for scaling law for time series forecasting that can explain these seemingly abnormal behaviors. We take into account the impact of dataset size and model complexity, as well as time series data granularity, particularly focusing on the look-back horizon, an aspect that has been unexplored in previous theories. Furthermore, we empirically evaluate various models using a diverse set of time series forecasting datasets, which (1) verifies the validity of scaling law on dataset size and model complexity within the realm of time series forecasting, and (2) validates our theoretical framework, particularly regarding the influence of look back horizon. We hope our findings may inspire new models targeting time series forecasting datasets of limited size, as well as large foundational datasets and models for time series forecasting in future works.\footnote{Codes for our experiments will be made public at: \url{https://github.com/JingzheShi/ScalingLawForTimeSeriesForecasting}.

$T^2$ of Thoughts: Temperature Tree Elicits Reasoning in Large Language Models

Large Language Models (LLMs) have emerged as powerful tools in artificial intelligence, especially in complex decision-making scenarios, but their static problem-solving strategies often limit their adaptability to dynamic environments. We explore the enhancement of reasoning capabilities in LLMs through Temperature Tree ($T^2$) prompting via Particle Swarm Optimization, termed as $T^2$ of Thoughts ($T^2oT$). The primary focus is on enhancing decision-making processes by dynamically adjusting search parameters, especially temperature, to improve accuracy without increasing computational demands. We empirically validate that our hybrid $T^2oT$ approach yields enhancements in, single-solution accuracy, multi-solution generation and text generation quality. Our findings suggest that while dynamic search depth adjustments based on temperature can yield mixed results, a fixed search depth, when coupled with adaptive capabilities of $T^2oT$, provides a more reliable and versatile problem-solving strategy. This work highlights the potential for future explorations in optimizing algorithmic interactions with foundational language models, particularly illustrated by our development for the Game of 24 and Creative Writing tasks.

Generative Enzyme Design Guided by Functionally Important Sites and Small-Molecule Substrates

Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across all functional families. Our key idea is to generate an enzyme's amino acid sequence and their three-dimensional (3D) coordinates based on functionally important sites and substrates corresponding to a desired catalytic function. These sites are automatically mined from enzyme databases. EnzyGen consists of a novel interleaving network of attention and neighborhood equivariant layers, which captures both long-range correlation in an entire protein sequence and local influence from nearest amino acids in 3D space. To learn the generative model, we devise a joint training objective, including a sequence generation loss, a position prediction loss and an enzyme-substrate interaction loss. We further construct EnzyBench, a dataset with 3157 enzyme families, covering all available enzymes within the protein data bank (PDB). Experimental results show that our EnzyGen consistently achieves the best performance across all 323 testing families, surpassing the best baseline by 10.79% in terms of substrate binding affinity. These findings demonstrate EnzyGen's superior capability in designing well-folded and effective enzymes binding to specific substrates with high affinities.