Gene-SGAN: a method for discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially reflecting disease subtypes that can be captured using MRI and machine learning methods. However, biological interpretability and treatment relevance are limited if the derived subtypes are not associated with genetic drivers or susceptibility factors. Herein, we describe Gene-SGAN - a multi-view, weakly-supervised deep clustering method - which dissects disease heterogeneity by jointly considering phenotypic and genetic data, thereby conferring genetic correlations to the disease subtypes and associated endophenotypic signatures. We first validate the generalizability, interpretability, and robustness of Gene-SGAN in semi-synthetic experiments. We then demonstrate its application to real multi-site datasets from 28,858 individuals, deriving subtypes of Alzheimer's disease and brain endophenotypes associated with hypertension, from MRI and SNP data. Derived brain phenotypes displayed significant differences in neuroanatomical patterns, genetic determinants, biological and clinical biomarkers, indicating potentially distinct underlying neuropathologic processes, genetic drivers, and susceptibility factors. Overall, Gene-SGAN is broadly applicable to disease subtyping and endophenotype discovery, and is herein tested on disease-related, genetically-driven neuroimaging phenotypes.

ROSE: Real One-Stage Effort to Detect the Fingerprint Singular Point Based on Multi-scale Spatial Attention

Detecting the singular point accurately and efficiently is one of the most important tasks for fingerprint recognition. In recent years, deep learning has been gradually used in the fingerprint singular point detection. However, current deep learning-based singular point detection methods are either two-stage or multi-stage, which makes them time-consuming. More importantly, their detection accuracy is yet unsatisfactory, especially in the case of the low-quality fingerprint. In this paper, we make a Real One-Stage Effort to detect fingerprint singular points more accurately and efficiently, and therefore we name the proposed algorithm ROSE for short, in which the multi-scale spatial attention, the Gaussian heatmap and the variant of focal loss are applied together to achieve a higher detection rate. Experimental results on the datasets FVC2002 DB1 and NIST SD4 show that our ROSE outperforms the state-of-art algorithms in terms of detection rate, false alarm rate and detection speed.

Singular points detection with semantic segmentation networks

Singular points detection is one of the most classical and important problem in the field of fingerprint recognition. However, current detection rates of singular points are still unsatisfactory, especially for low-quality fingerprints. Compared with traditional image processing-based detection methods, methods based on deep learning only need the original fingerprint image but not the fingerprint orientation field. In this paper, different from other detection methods based on deep learning, we treat singular points detection as a semantic segmentation problem and just use few data for training. Furthermore, we propose a new convolutional neural network called SinNet to extract the singular regions of interest and then use a blob detection method called SimpleBlobDetector to locate the singular points. The experiments are carried out on the test dataset from SPD2010, and the proposed method has much better performance than the other advanced methods in most aspects. Compared with the state-of-art algorithms in SPD2010, our method achieves an increase of 11% in the percentage of correctly detected fingerprints and an increase of more than 18% in the core detection rate.