Building a Human-Verified Clinical Reasoning Dataset via a Human LLM Hybrid Pipeline for Trustworthy Medical AI

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the predominant reliance of current medical LLMs on corpora from scientific literature or synthetic data, which often lack the granular expert validation and high clinical relevance essential for advancing their specialized medical capabilities. To address these critical gaps, we introduce a highly clinically relevant dataset with 31,247 medical question-answer pairs, each accompanied by expert-validated chain-of-thought (CoT) explanations. This resource, spanning multiple clinical domains, was curated via a scalable human-LLM hybrid pipeline: LLM-generated rationales were iteratively reviewed, scored, and refined by medical experts against a structured rubric, with substandard outputs revised through human effort or guided LLM regeneration until expert consensus. This publicly available dataset provides a vital source for the development of medical LLMs that capable of transparent and verifiable reasoning, thereby advancing safer and more interpretable AI in medicine.

TCM-3CEval: A Triaxial Benchmark for Assessing Responses from Large Language Models in Traditional Chinese Medicine

Large language models (LLMs) excel in various NLP tasks and modern medicine, but their evaluation in traditional Chinese medicine (TCM) is underexplored. To address this, we introduce TCM3CEval, a benchmark assessing LLMs in TCM across three dimensions: core knowledge mastery, classical text understanding, and clinical decision-making. We evaluate diverse models, including international (e.g., GPT-4o), Chinese (e.g., InternLM), and medical-specific (e.g., PLUSE). Results show a performance hierarchy: all models have limitations in specialized subdomains like Meridian & Acupoint theory and Various TCM Schools, revealing gaps between current capabilities and clinical needs. Models with Chinese linguistic and cultural priors perform better in classical text interpretation and clinical reasoning. TCM-3CEval sets a standard for AI evaluation in TCM, offering insights for optimizing LLMs in culturally grounded medical domains. The benchmark is available on Medbench's TCM track, aiming to assess LLMs' TCM capabilities in basic knowledge, classic texts, and clinical decision-making through multidimensional questions and real cases.

Benchmarking Chinese Medical LLMs: A Medbench-based Analysis of Performance Gaps and Hierarchical Optimization Strategies

The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific error patterns or address cross-modal challenges. This study introduces a granular error taxonomy through systematic analysis of top 10 models on MedBench, categorizing incorrect responses into eight types: Omissions, Hallucination, Format Mismatch, Causal Reasoning Deficiency, Contextual Inconsistency, Unanswered, Output Error, and Deficiency in Medical Language Generation. Evaluation of 10 leading models reveals vulnerabilities: despite achieving 0.86 accuracy in medical knowledge recall, critical reasoning tasks show 96.3% omission, while safety ethics evaluations expose alarming inconsistency (robustness score: 0.79) under option shuffled. Our analysis uncovers systemic weaknesses in knowledge boundary enforcement and multi-step reasoning. To address these, we propose a tiered optimization strategy spanning four levels, from prompt engineering and knowledge-augmented retrieval to hybrid neuro-symbolic architectures and causal reasoning frameworks. This work establishes an actionable roadmap for developing clinically robust LLMs while redefining evaluation paradigms through error-driven insights, ultimately advancing the safety and trustworthiness of AI in high-stakes medical environments.

Predictive Modeling with Temporal Graphical Representation on Electronic Health Records

Deep learning-based predictive models, leveraging Electronic Health Records (EHR), are receiving increasing attention in healthcare. An effective representation of a patient's EHR should hierarchically encompass both the temporal relationships between historical visits and medical events, and the inherent structural information within these elements. Existing patient representation methods can be roughly categorized into sequential representation and graphical representation. The sequential representation methods focus only on the temporal relationships among longitudinal visits. On the other hand, the graphical representation approaches, while adept at extracting the graph-structured relationships between various medical events, fall short in effectively integrate temporal information. To capture both types of information, we model a patient's EHR as a novel temporal heterogeneous graph. This graph includes historical visits nodes and medical events nodes. It propagates structured information from medical event nodes to visit nodes and utilizes time-aware visit nodes to capture changes in the patient's health status. Furthermore, we introduce a novel temporal graph transformer (TRANS) that integrates temporal edge features, global positional encoding, and local structural encoding into heterogeneous graph convolution, capturing both temporal and structural information. We validate the effectiveness of TRANS through extensive experiments on three real-world datasets. The results show that our proposed approach achieves state-of-the-art performance.

Edge Computing Enabled Real-Time Video Analysis via Adaptive Spatial-Temporal Semantic Filtering

This paper proposes a novel edge computing enabled real-time video analysis system for intelligent visual devices. The proposed system consists of a tracking-assisted object detection module (TAODM) and a region of interesting module (ROIM). TAODM adaptively determines the offloading decision to process each video frame locally with a tracking algorithm or to offload it to the edge server inferred by an object detection model. ROIM determines each offloading frame's resolution and detection model configuration to ensure that the analysis results can return in time. TAODM and ROIM interact jointly to filter the repetitive spatial-temporal semantic information to maximize the processing rate while ensuring high video analysis accuracy. Unlike most existing works, this paper investigates the real-time video analysis systems where the intelligent visual device connects to the edge server through a wireless network with fluctuating network conditions. We decompose the real-time video analysis problem into the offloading decision and configurations selection sub-problems. To solve these two sub-problems, we introduce a double deep Q network (DDQN) based offloading approach and a contextual multi-armed bandit (CMAB) based adaptive configurations selection approach, respectively. A DDQN-CMAB reinforcement learning (DCRL) training framework is further developed to integrate these two approaches to improve the overall video analyzing performance. Extensive simulations are conducted to evaluate the performance of the proposed solution, and demonstrate its superiority over counterparts.

Energy-Efficient UAV Swarm Assisted MEC with Dynamic Clustering and Scheduling

In this paper, the energy-efficient unmanned aerial vehicle (UAV) swarm assisted mobile edge computing (MEC) with dynamic clustering and scheduling is studied. In the considered system model, UAVs are divided into multiple swarms, with each swarm consisting of a leader UAV and several follower UAVs to provide computing services to end-users. Unlike existing work, we allow UAVs to dynamically cluster into different swarms, i.e., each follower UAV can change its leader based on the time-varying spatial positions, updated application placement, etc. in a dynamic manner. Meanwhile, UAVs are required to dynamically schedule their energy replenishment, application placement, trajectory planning and task delegation. With the aim of maximizing the long-term energy efficiency of the UAV swarm assisted MEC system, a joint optimization problem of dynamic clustering and scheduling is formulated. Taking into account the underlying cooperation and competition among intelligent UAVs, we further reformulate this optimization problem as a combination of a series of strongly coupled multi-agent stochastic games, and then propose a novel reinforcement learning-based UAV swarm dynamic coordination (RLDC) algorithm for obtaining the equilibrium. Simulations are conducted to evaluate the performance of the RLDC algorithm and demonstrate its superiority over counterparts.

Generative AI-Driven Human Digital Twin in IoT-Healthcare: A Comprehensive Survey

The Internet of things (IoT) can significantly enhance the quality of human life, specifically in healthcare, attracting extensive attentions to IoT-healthcare services. Meanwhile, the human digital twin (HDT) is proposed as an innovative paradigm that can comprehensively characterize the replication of the individual human body in the digital world and reflect its physical status in real time. Naturally, HDT is envisioned to empower IoT-healthcare beyond the application of healthcare monitoring by acting as a versatile and vivid human digital testbed, simulating the outcomes and guiding the practical treatments. However, successfully establishing HDT requires high-fidelity virtual modeling and strong information interactions but possibly with scarce, biased and noisy data. Fortunately, a recent popular technology called generative artificial intelligence (GAI) may be a promising solution because it can leverage advanced AI algorithms to automatically create, manipulate, and modify valuable while diverse data. This survey particularly focuses on the implementation of GAI-driven HDT in IoT-healthcare. We start by introducing the background of IoT-healthcare and the potential of GAI-driven HDT. Then, we delve into the fundamental techniques and present the overall framework of GAI-driven HDT. After that, we explore the realization of GAI-driven HDT in detail, including GAI-enabled data acquisition, communication, data management, digital modeling, and data analysis. Besides, we discuss typical IoT-healthcare applications that can be revolutionized by GAI-driven HDT, namely personalized health monitoring and diagnosis, personalized prescription, and personalized rehabilitation. Finally, we conclude this survey by highlighting some future research directions.

Spatial Pathomics Toolkit for Quantitative Analysis of Podocyte Nuclei with Histology and Spatial Transcriptomics Data in Renal Pathology

Podocytes, specialized epithelial cells that envelop the glomerular capillaries, play a pivotal role in maintaining renal health. The current description and quantification of features on pathology slides are limited, prompting the need for innovative solutions to comprehensively assess diverse phenotypic attributes within Whole Slide Images (WSIs). In particular, understanding the morphological characteristics of podocytes, terminally differentiated glomerular epithelial cells, is crucial for studying glomerular injury. This paper introduces the Spatial Pathomics Toolkit (SPT) and applies it to podocyte pathomics. The SPT consists of three main components: (1) instance object segmentation, enabling precise identification of podocyte nuclei; (2) pathomics feature generation, extracting a comprehensive array of quantitative features from the identified nuclei; and (3) robust statistical analyses, facilitating a comprehensive exploration of spatial relationships between morphological and spatial transcriptomics features.The SPT successfully extracted and analyzed morphological and textural features from podocyte nuclei, revealing a multitude of podocyte morphomic features through statistical analysis. Additionally, we demonstrated the SPT's ability to unravel spatial information inherent to podocyte distribution, shedding light on spatial patterns associated with glomerular injury. By disseminating the SPT, our goal is to provide the research community with a powerful and user-friendly resource that advances cellular spatial pathomics in renal pathology. The implementation and its complete source code of the toolkit are made openly accessible at https://github.com/hrlblab/spatial_pathomics.

A Revolution of Personalized Healthcare: Enabling Human Digital Twin with Mobile AIGC

Mobile Artificial Intelligence-Generated Content (AIGC) technology refers to the adoption of AI algorithms deployed at mobile edge networks to automate the information creation process while fulfilling the requirements of end users. Mobile AIGC has recently attracted phenomenal attentions and can be a key enabling technology for an emerging application, called human digital twin (HDT). HDT empowered by the mobile AIGC is expected to revolutionize the personalized healthcare by generating rare disease data, modeling high-fidelity digital twin, building versatile testbeds, and providing 24/7 customized medical services. To promote the development of this new breed of paradigm, in this article, we propose a system architecture of mobile AIGC-driven HDT and highlight the corresponding design requirements and challenges. Moreover, we illustrate two use cases, i.e., mobile AIGC-driven HDT in customized surgery planning and personalized medication. In addition, we conduct an experimental study to prove the effectiveness of the proposed mobile AIGC-driven HDT solution, which shows a particular application in a virtual physical therapy teaching platform. Finally, we conclude this article by briefly discussing several open issues and future directions.

Understanding and Improving Deep Graph Neural Networks: A Probabilistic Graphical Model Perspective

Recently, graph-based models designed for downstream tasks have significantly advanced research on graph neural networks (GNNs). GNN baselines based on neural message-passing mechanisms such as GCN and GAT perform worse as the network deepens. Therefore, numerous GNN variants have been proposed to tackle this performance degradation problem, including many deep GNNs. However, a unified framework is still lacking to connect these existing models and interpret their effectiveness at a high level. In this work, we focus on deep GNNs and propose a novel view for understanding them. We establish a theoretical framework via inference on a probabilistic graphical model. Given the fixed point equation (FPE) derived from the variational inference on the Markov random fields, the deep GNNs, including JKNet, GCNII, DGCN, and the classical GNNs, such as GCN, GAT, and APPNP, can be regarded as different approximations of the FPE. Moreover, given this framework, more accurate approximations of FPE are brought, guiding us to design a more powerful GNN: coupling graph neural network (CoGNet). Extensive experiments are carried out on citation networks and natural language processing downstream tasks. The results demonstrate that the CoGNet outperforms the SOTA models.