Revisiting Markovian Generative Architectures for Efficient Task-Oriented Dialog Systems

Recently, Transformer based pretrained language models (PLMs), such as GPT2 and T5, have been leveraged to build generative task-oriented dialog (TOD) systems. A drawback of existing PLM-based models is their non-Markovian architectures across turns, i.e., the whole history is used as the conditioning input at each turn, which brings inefficiencies in memory, computation and learning. In this paper, we propose to revisit Markovian Generative Architectures (MGA), which have been used in previous LSTM-based TOD systems, but not studied for PLM-based systems. Experiments on MultiWOZ2.1 show the efficiency advantages of the proposed Markovian PLM-based systems over their non-Markovian counterparts, in both supervised and semi-supervised settings.

Breast Cancer Molecular Subtypes Prediction on Pathological Images with Discriminative Patch Selecting and Multi-Instance Learning

Molecular subtypes of breast cancer are important references to personalized clinical treatment. For cost and labor savings, only one of the patient's paraffin blocks is usually selected for subsequent immunohistochemistry (IHC) to obtain molecular subtypes. Inevitable sampling error is risky due to tumor heterogeneity and could result in a delay in treatment. Molecular subtype prediction from conventional H&E pathological whole slide images (WSI) using AI method is useful and critical to assist pathologists pre-screen proper paraffin block for IHC. It's a challenging task since only WSI level labels of molecular subtypes can be obtained from IHC. Gigapixel WSIs are divided into a huge number of patches to be computationally feasible for deep learning. While with coarse slide-level labels, patch-based methods may suffer from abundant noise patches, such as folds, overstained regions, or non-tumor tissues. A weakly supervised learning framework based on discriminative patch selecting and multi-instance learning was proposed for breast cancer molecular subtype prediction from H&E WSIs. Firstly, co-teaching strategy was adopted to learn molecular subtype representations and filter out noise patches. Then, a balanced sampling strategy was used to handle the imbalance in subtypes in the dataset. In addition, a noise patch filtering algorithm that used local outlier factor based on cluster centers was proposed to further select discriminative patches. Finally, a loss function integrating patch with slide constraint information was used to finetune MIL framework on obtained discriminative patches and further improve the performance of molecular subtyping. The experimental results confirmed the effectiveness of the proposed method and our models outperformed even senior pathologists, with potential to assist pathologists to pre-screen paraffin blocks for IHC in clinic.

Simultaneous Alignment and Surface Regression Using Hybrid 2D-3D Networks for 3D Coherent Layer Segmentation of Retina OCT Images

Automated surface segmentation of retinal layer is important and challenging in analyzing optical coherence tomography (OCT). Recently, many deep learning based methods have been developed for this task and yield remarkable performance. However, due to large spatial gap and potential mismatch between the B-scans of OCT data, all of them are based on 2D segmentation of individual B-scans, which may loss the continuity information across the B-scans. In addition, 3D surface of the retina layers can provide more diagnostic information, which is crucial in quantitative image analysis. In this study, a novel framework based on hybrid 2D-3D convolutional neural networks (CNNs) is proposed to obtain continuous 3D retinal layer surfaces from OCT. The 2D features of individual B-scans are extracted by an encoder consisting of 2D convolutions. These 2D features are then used to produce the alignment displacement field and layer segmentation by two 3D decoders, which are coupled via a spatial transformer module. The entire framework is trained end-to-end. To the best of our knowledge, this is the first study that attempts 3D retinal layer segmentation in volumetric OCT images based on CNNs. Experiments on a publicly available dataset show that our framework achieves superior results to state-of-the-art 2D methods in terms of both layer segmentation accuracy and cross-B-scan 3D continuity, thus offering more clinical values than previous works.

SRP-DNN: Learning Direct-Path Phase Difference for Multiple Moving Sound Source Localization

Multiple moving sound source localization in real-world scenarios remains a challenging issue due to interaction between sources, time-varying trajectories, distorted spatial cues, etc. In this work, we propose to use deep learning techniques to learn competing and time-varying direct-path phase differences for localizing multiple moving sound sources. A causal convolutional recurrent neural network is designed to extract the direct-path phase difference sequence from signals of each microphone pair. To avoid the assignment ambiguity and the problem of uncertain output-dimension encountered when simultaneously predicting multiple targets, the learning target is designed in a weighted sum format, which encodes source activity in the weight and direct-path phase differences in the summed value. The learned direct-path phase differences for all microphone pairs can be directly used to construct the spatial spectrum according to the formulation of steered response power (SRP). This deep neural network (DNN) based SRP method is referred to as SRP-DNN. The locations of sources are estimated by iteratively detecting and removing the dominant source from the spatial spectrum, in which way the interaction between sources is reduced. Experimental results on both simulated and real-world data show the superiority of the proposed method in the presence of noise and reverberation.

Learning Deep Direct-Path Relative Transfer Function for Binaural Sound Source Localization

Direct-path relative transfer function (DP-RTF) refers to the ratio between the direct-path acoustic transfer functions of two microphone channels. Though DP-RTF fully encodes the sound spatial cues and serves as a reliable localization feature, it is often erroneously estimated in the presence of noise and reverberation. This paper proposes to learn DP-RTF with deep neural networks for robust binaural sound source localization. A DP-RTF learning network is designed to regress the binaural sensor signals to a real-valued representation of DP-RTF. It consists of a branched convolutional neural network module to separately extract the inter-channel magnitude and phase patterns, and a convolutional recurrent neural network module for joint feature learning. To better explore the speech spectra to aid the DP-RTF estimation, a monaural speech enhancement network is used to recover the direct-path spectrograms from the noisy ones. The enhanced spectrograms are stacked onto the noisy spectrograms to act as the input of the DP-RTF learning network. We train one unique DP-RTF learning network using many different binaural arrays to enable the generalization of DP-RTF learning across arrays. This way avoids time-consuming training data collection and network retraining for a new array, which is very useful in practical application. Experimental results on both simulated and real-world data show the effectiveness of the proposed method for direction of arrival (DOA) estimation in the noisy and reverberant environment, and a good generalization ability to unseen binaural arrays.

Virtual Adversarial Training for Semi-supervised Breast Mass Classification

This study aims to develop a novel computer-aided diagnosis (CAD) scheme for mammographic breast mass classification using semi-supervised learning. Although supervised deep learning has achieved huge success across various medical image analysis tasks, its success relies on large amounts of high-quality annotations, which can be challenging to acquire in practice. To overcome this limitation, we propose employing a semi-supervised method, i.e., virtual adversarial training (VAT), to leverage and learn useful information underlying in unlabeled data for better classification of breast masses. Accordingly, our VAT-based models have two types of losses, namely supervised and virtual adversarial losses. The former loss acts as in supervised classification, while the latter loss aims at enhancing model robustness against virtual adversarial perturbation, thus improving model generalizability. To evaluate the performance of our VAT-based CAD scheme, we retrospectively assembled a total of 1024 breast mass images, with equal number of benign and malignant masses. A large CNN and a small CNN were used in this investigation, and both were trained with and without the adversarial loss. When the labeled ratios were 40% and 80%, VAT-based CNNs delivered the highest classification accuracy of 0.740 and 0.760, respectively. The experimental results suggest that the VAT-based CAD scheme can effectively utilize meaningful knowledge from unlabeled data to better classify mammographic breast mass images.

Deep Facial Synthesis: A New Challenge

The goal of this paper is to conduct a comprehensive study on the facial sketch synthesis (FSS) problem. However, due to the high costs in obtaining hand-drawn sketch datasets, there lacks a complete benchmark for assessing the development of FSS algorithms over the last decade. As such, we first introduce a high-quality dataset for FSS, named FS2K, which consists of 2,104 image-sketch pairs spanning three types of sketch styles, image backgrounds, lighting conditions, skin colors, and facial attributes. FS2K differs from previous FSS datasets in difficulty, diversity, and scalability, and should thus facilitate the progress of FSS research. Second, we present the largest-scale FSS study by investigating 139 classical methods, including 24 handcrafted feature based facial sketch synthesis approaches, 37 general neural-style transfer methods, 43 deep image-to-image translation methods, and 35 image-to-sketch approaches. Besides, we elaborate comprehensive experiments for existing 19 cutting-edge models. Third, we present a simple baseline for FSS, named FSGAN. With only two straightforward components, i.e., facial-aware masking and style-vector expansion, FSGAN surpasses the performance of all previous state-of-the-art models on the proposed FS2K dataset, by a large margin. Finally, we conclude with lessons learned over the past years, and point out several unsolved challenges. Our open-source code is available at https://github.com/DengPingFan/FSGAN.

Multi-Modal Perception Attention Network with Self-Supervised Learning for Audio-Visual Speaker Tracking

Multi-modal fusion is proven to be an effective method to improve the accuracy and robustness of speaker tracking, especially in complex scenarios. However, how to combine the heterogeneous information and exploit the complementarity of multi-modal signals remains a challenging issue. In this paper, we propose a novel Multi-modal Perception Tracker (MPT) for speaker tracking using both audio and visual modalities. Specifically, a novel acoustic map based on spatial-temporal Global Coherence Field (stGCF) is first constructed for heterogeneous signal fusion, which employs a camera model to map audio cues to the localization space consistent with the visual cues. Then a multi-modal perception attention network is introduced to derive the perception weights that measure the reliability and effectiveness of intermittent audio and video streams disturbed by noise. Moreover, a unique cross-modal self-supervised learning method is presented to model the confidence of audio and visual observations by leveraging the complementarity and consistency between different modalities. Experimental results show that the proposed MPT achieves 98.6% and 78.3% tracking accuracy on the standard and occluded datasets, respectively, which demonstrates its robustness under adverse conditions and outperforms the current state-of-the-art methods.

Pose-guided Feature Disentangling for Occluded Person Re-identification Based on Transformer

Occluded person re-identification is a challenging task as human body parts could be occluded by some obstacles (e.g. trees, cars, and pedestrians) in certain scenes. Some existing pose-guided methods solve this problem by aligning body parts according to graph matching, but these graph-based methods are not intuitive and complicated. Therefore, we propose a transformer-based Pose-guided Feature Disentangling (PFD) method by utilizing pose information to clearly disentangle semantic components (e.g. human body or joint parts) and selectively match non-occluded parts correspondingly. First, Vision Transformer (ViT) is used to extract the patch features with its strong capability. Second, to preliminarily disentangle the pose information from patch information, the matching and distributing mechanism is leveraged in Pose-guided Feature Aggregation (PFA) module. Third, a set of learnable semantic views are introduced in transformer decoder to implicitly enhance the disentangled body part features. However, those semantic views are not guaranteed to be related to the body without additional supervision. Therefore, Pose-View Matching (PVM) module is proposed to explicitly match visible body parts and automatically separate occlusion features. Fourth, to better prevent the interference of occlusions, we design a Pose-guided Push Loss to emphasize the features of visible body parts. Extensive experiments over five challenging datasets for two tasks (occluded and holistic Re-ID) demonstrate that our proposed PFD is superior promising, which performs favorably against state-of-the-art methods. Code is available at https://github.com/WangTaoAs/PFD_Net