DPL: Decoupled Prompt Learning for Vision-Language Models

Prompt learning has emerged as an efficient and effective approach for transferring foundational Vision-Language Models (e.g., CLIP) to downstream tasks. However, current methods tend to overfit to seen categories, thereby limiting their generalization ability for unseen classes. In this paper, we propose a new method, Decoupled Prompt Learning (DPL), which reformulates the attention in prompt learning to alleviate this problem. Specifically, we theoretically investigate the collaborative process between prompts and instances (i.e., image patches/text tokens) by reformulating the original self-attention into four separate sub-processes. Through detailed analysis, we observe that certain sub-processes can be strengthened to bolster robustness and generalizability by some approximation techniques. Furthermore, we introduce language-conditioned textual prompting based on decoupled attention to naturally preserve the generalization of text input. Our approach is flexible for both visual and textual modalities, making it easily extendable to multi-modal prompt learning. By combining the proposed techniques, our approach achieves state-of-the-art performance on three representative benchmarks encompassing 15 image recognition datasets, while maintaining parameter-efficient. Moreover, our DPL does not rely on any auxiliary regularization task or extra training data, further demonstrating its remarkable generalization ability.

Progressive Visual Prompt Learning with Contrastive Feature Re-formation

Prompt learning has been designed as an alternative to fine-tuning for adapting Vision-language (V-L) models to the downstream tasks. Previous works mainly focus on text prompt while visual prompt works are limited for V-L models. The existing visual prompt methods endure either mediocre performance or unstable training process, indicating the difficulty of visual prompt learning. In this paper, we propose a new Progressive Visual Prompt (ProVP) structure to strengthen the interactions among prompts of different layers. More importantly, our ProVP could effectively propagate the image embeddings to deep layers and behave partially similar to an instance adaptive prompt method. To alleviate generalization deterioration, we further propose a new contrastive feature re-formation, which prevents the serious deviation of the prompted visual feature from the fixed CLIP visual feature distribution. Combining both, our method (ProVP-Ref) is evaluated on 11 image benchmark datasets and achieves 7/11 state-of-theart results on both few-shot and base-to-novel settings. To the best of our knowledge, we are the first to demonstrate the superior performance of visual prompts in V-L models to previous prompt-based methods in downstream tasks. Meanwhile, it implies that our ProVP-Ref shows the best capability to adapt and to generalize.

Microscope Based HER2 Scoring System

The overexpression of human epidermal growth factor receptor 2 (HER2) has been established as a therapeutic target in multiple types of cancers, such as breast and gastric cancers. Immunohistochemistry (IHC) is employed as a basic HER2 test to identify the HER2-positive, borderline, and HER2-negative patients. However, the reliability and accuracy of HER2 scoring are affected by many factors, such as pathologists' experience. Recently, artificial intelligence (AI) has been used in various disease diagnosis to improve diagnostic accuracy and reliability, but the interpretation of diagnosis results is still an open problem. In this paper, we propose a real-time HER2 scoring system, which follows the HER2 scoring guidelines to complete the diagnosis, and thus each step is explainable. Unlike the previous scoring systems based on whole-slide imaging, our HER2 scoring system is integrated into an augmented reality (AR) microscope that can feedback AI results to the pathologists while reading the slide. The pathologists can help select informative fields of view (FOVs), avoiding the confounding regions, such as DCIS. Importantly, we illustrate the intermediate results with membrane staining condition and cell classification results, making it possible to evaluate the reliability of the diagnostic results. Also, we support the interactive modification of selecting regions-of-interest, making our system more flexible in clinical practice. The collaboration of AI and pathologists can significantly improve the robustness of our system. We evaluate our system with 285 breast IHC HER2 slides, and the classification accuracy of 95\% shows the effectiveness of our HER2 scoring system.