Evaluate underdiagnosis and overdiagnosis bias of deep learning model on primary open-angle glaucoma diagnosis in under-served patient populations

In the United States, primary open-angle glaucoma (POAG) is the leading cause of blindness, especially among African American and Hispanic individuals. Deep learning has been widely used to detect POAG using fundus images as its performance is comparable to or even surpasses diagnosis by clinicians. However, human bias in clinical diagnosis may be reflected and amplified in the widely-used deep learning models, thus impacting their performance. Biases may cause (1) underdiagnosis, increasing the risks of delayed or inadequate treatment, and (2) overdiagnosis, which may increase individuals' stress, fear, well-being, and unnecessary/costly treatment. In this study, we examined the underdiagnosis and overdiagnosis when applying deep learning in POAG detection based on the Ocular Hypertension Treatment Study (OHTS) from 22 centers across 16 states in the United States. Our results show that the widely-used deep learning model can underdiagnose or overdiagnose underserved populations. The most underdiagnosed group is female younger (< 60 yrs) group, and the most overdiagnosed group is Black older (>=60 yrs) group. Biased diagnosis through traditional deep learning methods may delay disease detection, treatment and create burdens among under-served populations, thereby, raising ethical concerns about using deep learning models in ophthalmology clinics.

Towards NeuroAI: Introducing Neuronal Diversity into Artificial Neural Networks

Throughout history, the development of artificial intelligence, particularly artificial neural networks, has been open to and constantly inspired by the increasingly deepened understanding of the brain, such as the inspiration of neocognitron, which is the pioneering work of convolutional neural networks. Per the motives of the emerging field: NeuroAI, a great amount of neuroscience knowledge can help catalyze the next generation of AI by endowing a network with more powerful capabilities. As we know, the human brain has numerous morphologically and functionally different neurons, while artificial neural networks are almost exclusively built on a single neuron type. In the human brain, neuronal diversity is an enabling factor for all kinds of biological intelligent behaviors. Since an artificial network is a miniature of the human brain, introducing neuronal diversity should be valuable in terms of addressing those essential problems of artificial networks such as efficiency, interpretability, and memory. In this Primer, we first discuss the preliminaries of biological neuronal diversity and the characteristics of information transmission and processing in a biological neuron. Then, we review studies of designing new neurons for artificial networks. Next, we discuss what gains can neuronal diversity bring into artificial networks and exemplary applications in several important fields. Lastly, we discuss the challenges and future directions of neuronal diversity to explore the potential of NeuroAI.

CbwLoss: Constrained Bidirectional Weighted Loss for Self-supervised Learning of Depth and Pose

Photometric differences are widely used as supervision signals to train neural networks for estimating depth and camera pose from unlabeled monocular videos. However, this approach is detrimental for model optimization because occlusions and moving objects in a scene violate the underlying static scenario assumption. In addition, pixels in textureless regions or less discriminative pixels hinder model training. To solve these problems, in this paper, we deal with moving objects and occlusions utilizing the difference of the flow fields and depth structure generated by affine transformation and view synthesis, respectively. Secondly, we mitigate the effect of textureless regions on model optimization by measuring differences between features with more semantic and contextual information without adding networks. In addition, although the bidirectionality component is used in each sub-objective function, a pair of images are reasoned about only once, which helps reduce overhead. Extensive experiments and visual analysis demonstrate the effectiveness of the proposed method, which outperform existing state-of-the-art self-supervised methods under the same conditions and without introducing additional auxiliary information.

Denoising Self-attentive Sequential Recommendation

Transformer-based sequential recommenders are very powerful for capturing both short-term and long-term sequential item dependencies. This is mainly attributed to their unique self-attention networks to exploit pairwise item-item interactions within the sequence. However, real-world item sequences are often noisy, which is particularly true for implicit feedback. For example, a large portion of clicks do not align well with user preferences, and many products end up with negative reviews or being returned. As such, the current user action only depends on a subset of items, not on the entire sequences. Many existing Transformer-based models use full attention distributions, which inevitably assign certain credits to irrelevant items. This may lead to sub-optimal performance if Transformers are not regularized properly.

MIMO-DBnet: Multi-channel Input and Multiple Outputs DOA-aware Beamforming Network for Speech Separation

Recently, many deep learning based beamformers have been proposed for multi-channel speech separation. Nevertheless, most of them rely on extra cues known in advance, such as speaker feature, face image or directional information. In this paper, we propose an end-to-end beamforming network for direction guided speech separation given merely the mixture signal, namely MIMO-DBnet. Specifically, we design a multi-channel input and multiple outputs architecture to predict the direction-of-arrival based embeddings and beamforming weights for each source. The precisely estimated directional embedding provides quite effective spatial discrimination guidance for the neural beamformer to offset the effect of phase wrapping, thus allowing more accurate reconstruction of two sources' speech signals. Experiments show that our proposed MIMO-DBnet not only achieves a comprehensive decent improvement compared to baseline systems, but also maintain the performance on high frequency bands when phase wrapping occurs.

SMARTQUERY: An Active Learning Framework for Graph Neural Networks through Hybrid Uncertainty Reduction

Graph neural networks have achieved significant success in representation learning. However, the performance gains come at a cost; acquiring comprehensive labeled data for training can be prohibitively expensive. Active learning mitigates this issue by searching the unexplored data space and prioritizing the selection of data to maximize model's performance gain. In this paper, we propose a novel method SMARTQUERY, a framework to learn a graph neural network with very few labeled nodes using a hybrid uncertainty reduction function. This is achieved using two key steps: (a) design a multi-stage active graph learning framework by exploiting diverse explicit graph information and (b) introduce label propagation to efficiently exploit known labels to assess the implicit embedding information. Using a comprehensive set of experiments on three network datasets, we demonstrate the competitive performance of our method against state-of-the-arts on very few labeled data (up to 5 labeled nodes per class).

Improving Training and Inference of Face Recognition Models via Random Temperature Scaling

Data uncertainty is commonly observed in the images for face recognition (FR). However, deep learning algorithms often make predictions with high confidence even for uncertain or irrelevant inputs. Intuitively, FR algorithms can benefit from both the estimation of uncertainty and the detection of out-of-distribution (OOD) samples. Taking a probabilistic view of the current classification model, the temperature scalar is exactly the scale of uncertainty noise implicitly added in the softmax function. Meanwhile, the uncertainty of images in a dataset should follow a prior distribution. Based on the observation, a unified framework for uncertainty modeling and FR, Random Temperature Scaling (RTS), is proposed to learn a reliable FR algorithm. The benefits of RTS are two-fold. (1) In the training phase, it can adjust the learning strength of clean and noisy samples for stability and accuracy. (2) In the test phase, it can provide a score of confidence to detect uncertain, low-quality and even OOD samples, without training on extra labels. Extensive experiments on FR benchmarks demonstrate that the magnitude of variance in RTS, which serves as an OOD detection metric, is closely related to the uncertainty of the input image. RTS can achieve top performance on both the FR and OOD detection tasks. Moreover, the model trained with RTS can perform robustly on datasets with noise. The proposed module is light-weight and only adds negligible computation cost to the model.

SadTalker: Learning Realistic 3D Motion Coefficients for Stylized Audio-Driven Single Image Talking Face Animation

Generating talking head videos through a face image and a piece of speech audio still contains many challenges. ie, unnatural head movement, distorted expression, and identity modification. We argue that these issues are mainly because of learning from the coupled 2D motion fields. On the other hand, explicitly using 3D information also suffers problems of stiff expression and incoherent video. We present SadTalker, which generates 3D motion coefficients (head pose, expression) of the 3DMM from audio and implicitly modulates a novel 3D-aware face render for talking head generation. To learn the realistic motion coefficients, we explicitly model the connections between audio and different types of motion coefficients individually. Precisely, we present ExpNet to learn the accurate facial expression from audio by distilling both coefficients and 3D-rendered faces. As for the head pose, we design PoseVAE via a conditional VAE to synthesize head motion in different styles. Finally, the generated 3D motion coefficients are mapped to the unsupervised 3D keypoints space of the proposed face render, and synthesize the final video. We conduct extensive experiments to show the superior of our method in terms of motion and video quality.

Local-to-Global Registration for Bundle-Adjusting Neural Radiance Fields

Neural Radiance Fields (NeRF) have achieved photorealistic novel views synthesis; however, the requirement of accurate camera poses limits its application. Despite analysis-by-synthesis extensions for jointly learning neural 3D representations and registering camera frames exist, they are susceptible to suboptimal solutions if poorly initialized. We propose L2G-NeRF, a Local-to-Global registration method for bundle-adjusting Neural Radiance Fields: first, a pixel-wise flexible alignment, followed by a frame-wise constrained parametric alignment. Pixel-wise local alignment is learned in an unsupervised way via a deep network which optimizes photometric reconstruction errors. Frame-wise global alignment is performed using differentiable parameter estimation solvers on the pixel-wise correspondences to find a global transformation. Experiments on synthetic and real-world data show that our method outperforms the current state-of-the-art in terms of high-fidelity reconstruction and resolving large camera pose misalignment. Our module is an easy-to-use plugin that can be applied to NeRF variants and other neural field applications. The Code and supplementary materials are available at https://rover-xingyu.github.io/L2G-NeRF/.

Combating Health Misinformation in Social Media: Characterization, Detection, Intervention, and Open Issues

Social media has been one of the main information consumption sources for the public, allowing people to seek and spread information more quickly and easily. However, the rise of various social media platforms also enables the proliferation of online misinformation. In particular, misinformation in the health domain has significant impacts on our society such as the COVID-19 infodemic. Therefore, health misinformation in social media has become an emerging research direction that attracts increasing attention from researchers of different disciplines. Compared to misinformation in other domains, the key differences of health misinformation include the potential of causing actual harm to humans' bodies and even lives, the hardness to identify for normal people, and the deep connection with medical science. In addition, health misinformation on social media has distinct characteristics from conventional channels such as television on multiple dimensions including the generation, dissemination, and consumption paradigms. Because of the uniqueness and importance of combating health misinformation in social media, we conduct this survey to further facilitate interdisciplinary research on this problem. In this survey, we present a comprehensive review of existing research about online health misinformation in different disciplines. Furthermore, we also systematically organize the related literature from three perspectives: characterization, detection, and intervention. Lastly, we conduct a deep discussion on the pressing open issues of combating health misinformation in social media and provide future directions for multidisciplinary researchers.