Abstract:Verifiers are crucial components for enhancing modern LLMs' reasoning capability. Typicalverifiers require resource-intensive superviseddataset construction, which is costly and faceslimitations in data diversity. In this paper, wepropose LOVER, an unsupervised verifier regularized by logical rules. LOVER treats theverifier as a binary latent variable, utilizinginternal activations and enforcing three logical constraints on multiple reasoning paths:negation consistency, intra-group consistency,and inter-group consistency (grouped by thefinal answer). By incorporating logical rulesas priors, LOVER can leverage unlabeled examples and is directly compatible with any offthe-shelf LLMs. Experiments on 10 datasetsdemonstrate that LOVER significantly outperforms unsupervised baselines, achieving performance comparable to the supervised verifier(reaching its 95% level on average). The sourcecode is publicly available at https://github.com/wangxinyufighting/llm-lover.
Abstract:Post-training large language models (LLMs) often suffers from catastrophic forgetting, where improvements on a target objective degrade previously acquired capabilities. Recent evidence suggests that this phenomenon is primarily driven by excessive distributional drift during optimization. Motivated by this perspective, we propose Anchored Learning, a simple framework that explicitly controls distributional updates during offline fine-tuning via a dynamically evolving moving anchor. Instead of matching a fixed reference distribution, the anchor interpolates between the current model and a frozen reference to construct an intermediate target that the model distills toward, transforming global fine-tuning into a sequence of local trust-region updates in distribution space. Theoretically, we prove this anchor-based update admits a linear KL-divergence upper bound per iteration, ensuring a stable transition between model distributions. Extensive experiments on iGSM, MedCalc, and IFEval show that Anchored Learning consistently lies on the Pareto frontier of gain-stability trade-offs, achieving near-optimal performance improvements while substantially reducing degradation compared to strong baselines. For example, while standard SFT suffers from over 53% performance degradation on iGSM and MedCalc, Anchored Learning slashes this drop to under 5% while maintaining near-optimal gains (e.g., 75.2% on iGSM).
Abstract:External memory is a key component of modern large language model (LLM) systems, enabling long-term interaction and personalization. Despite its importance, memory management is still largely driven by hand-designed heuristics, offering little insight into the long-term and uncertain consequences of memory decisions. In practice, choices about what to read or write shape future retrieval and downstream behavior in ways that are difficult to anticipate. We argue that memory management should be viewed as a sequential decision-making problem under uncertainty, where the utility of memory is delayed and dependent on future interactions. To this end, we propose DAM (Decision-theoretic Agent Memory), a decision-theoretic framework that decomposes memory management into immediate information access and hierarchical storage maintenance. Within this architecture, candidate operations are evaluated via value functions and uncertainty estimators, enabling an aggregate policy to arbitrate decisions based on estimated long-term utility and risk. Our contribution is not a new algorithm, but a principled reframing that clarifies the limitations of heuristic approaches and provides a foundation for future research on uncertainty-aware memory systems.




Abstract:Protein design is a fundamental challenge in biotechnology, aiming to design novel sequences with specific functions within the vast space of possible proteins. Recent advances in deep generative models have enabled function-based protein design from textual descriptions, yet struggle with structural plausibility. Inspired by classical protein design methods that leverage natural protein structures, we explore whether incorporating fragments from natural proteins can enhance foldability in generative models. Our empirical results show that even random incorporation of fragments improves foldability. Building on this insight, we introduce ProDVa, a novel protein design approach that integrates a text encoder for functional descriptions, a protein language model for designing proteins, and a fragment encoder to dynamically retrieve protein fragments based on textual functional descriptions. Experimental results demonstrate that our approach effectively designs protein sequences that are both functionally aligned and structurally plausible. Compared to state-of-the-art models, ProDVa achieves comparable function alignment using less than 0.04% of the training data, while designing significantly more well-folded proteins, with the proportion of proteins having pLDDT above 70 increasing by 7.38% and those with PAE below 10 increasing by 9.6%.
Abstract:In recent years, while natural language processing and multimodal learning have seen rapid advancements, the field of de novo protein design has also experienced significant growth. However, most current methods rely on proprietary datasets and evaluation rubrics, making fair comparisons between different approaches challenging. Moreover, these methods often employ evaluation metrics that capture only a subset of the desired properties of designed proteins, lacking a comprehensive assessment framework. To address these, we introduce PDFBench, the first comprehensive benchmark for evaluating de novo protein design from function. PDFBench supports two tasks: description-guided design and keyword-guided design. To ensure fair and multifaceted evaluation, we compile 22 metrics covering sequence plausibility, structural fidelity, and language-protein alignment, along with measures of novelty and diversity. We evaluate five state-of-the-art baselines, revealing their respective strengths and weaknesses across tasks. Finally, we analyze inter-metric correlations, exploring the relationships between four categories of metrics, and offering guidelines for metric selection. PDFBench establishes a unified framework to drive future advances in function-driven de novo protein design.




Abstract:Current Large Language Models (LLMs) for understanding proteins primarily treats amino acid sequences as a text modality. Meanwhile, Protein Language Models (PLMs), such as ESM-2, have learned massive sequential evolutionary knowledge from the universe of natural protein sequences. Furthermore, structure-based encoders like ProteinMPNN learn the structural information of proteins through Graph Neural Networks. However, whether the incorporation of protein encoders can enhance the protein understanding of LLMs has not been explored. To bridge this gap, we propose EvoLlama, a multimodal framework that connects a structure-based encoder, a sequence-based protein encoder and an LLM for protein understanding. EvoLlama consists of a ProteinMPNN structure encoder, an ESM-2 protein sequence encoder, a multimodal projector to align protein and text representations and a Llama-3 text decoder. To train EvoLlama, we fine-tune it on protein-oriented instructions and protein property prediction datasets verbalized via natural language instruction templates. Our experiments show that EvoLlama's protein understanding capabilities have been significantly enhanced, outperforming other fine-tuned protein-oriented LLMs in zero-shot settings by an average of 1%-8% and surpassing the state-of-the-art baseline with supervised fine-tuning by an average of 6%. On protein property prediction datasets, our approach achieves promising results that are competitive with state-of-the-art task-specific baselines. We will release our code in a future version.




Abstract:We introduce a new dynamic vocabulary for language models. It can involve arbitrary text spans during generation. These text spans act as basic generation bricks, akin to tokens in the traditional static vocabularies. We show that, the ability to generate multi-tokens atomically improve both generation quality and efficiency (compared to the standard language model, the MAUVE metric is increased by 25%, the latency is decreased by 20%). The dynamic vocabulary can be deployed in a plug-and-play way, thus is attractive for various downstream applications. For example, we demonstrate that dynamic vocabulary can be applied to different domains in a training-free manner. It also helps to generate reliable citations in question answering tasks (substantially enhancing citation results without compromising answer accuracy).




Abstract:Large Vision-Language Models (LVLMs) have achieved impressive performance, yet research has pointed out a serious issue with object hallucinations within these models. However, there is no clear conclusion as to which part of the model these hallucinations originate from. In this paper, we present an in-depth investigation into the object hallucination problem specifically within the CLIP model, which serves as the backbone for many state-of-the-art vision-language systems. We unveil that even in isolation, the CLIP model is prone to object hallucinations, suggesting that the hallucination problem is not solely due to the interaction between vision and language modalities. To address this, we propose a counterfactual data augmentation method by creating negative samples with a variety of hallucination issues. We demonstrate that our method can effectively mitigate object hallucinations for CLIP model, and we show the the enhanced model can be employed as a visual encoder, effectively alleviating the object hallucination issue in LVLMs.




Abstract:Existing rhetorical understanding and generation datasets or corpora primarily focus on single coarse-grained categories or fine-grained categories, neglecting the common interrelations between different rhetorical devices by treating them as independent sub-tasks. In this paper, we propose the Chinese Essay Rhetoric Dataset (CERD), consisting of 4 commonly used coarse-grained categories including metaphor, personification, hyperbole and parallelism and 23 fine-grained categories across both form and content levels. CERD is a manually annotated and comprehensive Chinese rhetoric dataset with five interrelated sub-tasks. Unlike previous work, our dataset aids in understanding various rhetorical devices, recognizing corresponding rhetorical components, and generating rhetorical sentences under given conditions, thereby improving the author's writing proficiency and language usage skills. Extensive experiments are conducted to demonstrate the interrelations between multiple tasks in CERD, as well as to establish a benchmark for future research on rhetoric. The experimental results indicate that Large Language Models achieve the best performance across most tasks, and jointly fine-tuning with multiple tasks further enhances performance.




Abstract:Large language models (LLMs) have performed remarkably well in various natural language processing tasks by benchmarking, including in the Western medical domain. However, the professional evaluation benchmarks for LLMs have yet to be covered in the traditional Chinese medicine(TCM) domain, which has a profound history and vast influence. To address this research gap, we introduce TCM-Bench, an comprehensive benchmark for evaluating LLM performance in TCM. It comprises the TCM-ED dataset, consisting of 5,473 questions sourced from the TCM Licensing Exam (TCMLE), including 1,300 questions with authoritative analysis. It covers the core components of TCMLE, including TCM basis and clinical practice. To evaluate LLMs beyond accuracy of question answering, we propose TCMScore, a metric tailored for evaluating the quality of answers generated by LLMs for TCM related questions. It comprehensively considers the consistency of TCM semantics and knowledge. After conducting comprehensive experimental analyses from diverse perspectives, we can obtain the following findings: (1) The unsatisfactory performance of LLMs on this benchmark underscores their significant room for improvement in TCM. (2) Introducing domain knowledge can enhance LLMs' performance. However, for in-domain models like ZhongJing-TCM, the quality of generated analysis text has decreased, and we hypothesize that their fine-tuning process affects the basic LLM capabilities. (3) Traditional metrics for text generation quality like Rouge and BertScore are susceptible to text length and surface semantic ambiguity, while domain-specific metrics such as TCMScore can further supplement and explain their evaluation results. These findings highlight the capabilities and limitations of LLMs in the TCM and aim to provide a more profound assistance to medical research.