MEDIC-AD: Towards Medical Vision-Language Model's Clinical Intelligence

Lesion detection, symptom tracking, and visual explainability are central to real-world medical image analysis, yet current medical Vision-Language Models (VLMs) still lack mechanisms that translate their broad knowledge into clinically actionable outputs. To bridge this gap, we present MEDIC-AD, a clinically oriented VLM that strengthens these three capabilities through a stage-wise framework. First, learnable anomaly-aware tokens (<Ano>) encourage the model to focus on abnormal regions and build more discriminative lesion centered representations. Second, inter image difference tokens (<Diff>) explicitly encode temporal changes between studies, allowing the model to distinguish worsening, improvement, and stability in disease burden. Finally, a dedicated explainability stage trains the model to generate heatmaps that highlight lesion-related regions, offering clear visual evidence that is consistent with the model's reasoning. Through our staged design, MEDIC-AD steadily boosts performance across anomaly detection, symptom tracking, and anomaly segmentation, achieving state-of-the-art results compared with both closed source and medical-specialized baselines. Evaluations on real longitudinal clinical data collected from real hospital workflows further show that MEDIC-AD delivers stable predictions and clinically faithful explanations in practical patient-monitoring and decision-support workflows

ViBA: Implicit Bundle Adjustment with Geometric and Temporal Consistency for Robust Visual Matching

Most existing image keypoint detection and description methods rely on datasets with accurate pose and depth annotations, limiting scalability and generalization, and often degrading navigation and localization performance. We propose ViBA, a sustainable learning framework that integrates geometric optimization with feature learning for continuous online training on unconstrained video streams. Embedded in a standard visual odometry pipeline, it consists of an implicitly differentiable geometric residual framework: (i) an initial tracking network for inter-frame correspondences, (ii) depth-based outlier filtering, and (iii) differentiable global bundle adjustment that jointly refines camera poses and feature positions by minimizing reprojection errors. By combining geometric consistency from BA with long-term temporal consistency across frames, ViBA enforces stable and accurate feature representations. We evaluate ViBA on EuRoC and UMA datasets. Compared with state-of-the-art methods such as SuperPoint+SuperGlue, ALIKED, and LightGlue, ViBA reduces mean absolute translation error (ATE) by 12-18% and absolute rotation error (ARE) by 5-10% across sequences, while maintaining real-time inference speeds (FPS 36-91). When evaluated on unseen sequences, it retains over 90% localization accuracy, demonstrating robust generalization. These results show that ViBA supports continuous online learning with geometric and temporal consistency, consistently improving navigation and localization in real-world scenarios.

Big2Small: A Unifying Neural Network Framework for Model Compression

With the development of foundational models, model compression has become a critical requirement. Various model compression approaches have been proposed such as low-rank decomposition, pruning, quantization, ergodic dynamic systems, and knowledge distillation, which are based on different heuristics. To elevate the field from fragmentation to a principled discipline, we construct a unifying mathematical framework for model compression grounded in measure theory. We further demonstrate that each model compression technique is mathematically equivalent to a neural network subject to a regularization. Building upon this mathematical and structural equivalence, we propose an experimentally-verified data-free model compression framework, termed \textit{Big2Small}, which translates Implicit Neural Representations (INRs) from data domain to the domain of network parameters. \textit{Big2Small} trains compact INRs to encode the weights of larger models and reconstruct the weights during inference. To enhance reconstruction fidelity, we introduce Outlier-Aware Preprocessing to handle extreme weight values and a Frequency-Aware Loss function to preserve high-frequency details. Experiments on image classification and segmentation demonstrate that \textit{Big2Small} achieves competitive accuracy and compression ratios compared to state-of-the-art baselines.

TuLaBM: Tumor-Biased Latent Bridge Matching for Contrast-Enhanced MRI Synthesis

Contrast-enhanced magnetic resonance imaging (CE-MRI) plays a crucial role in brain tumor assessment; however, its acquisition requires gadolinium-based contrast agents (GBCAs), which increase costs and raise safety concerns. Consequently, synthesizing CE-MRI from non-contrast MRI (NC-MRI) has emerged as a promising alternative. Early Generative Adversarial Network (GAN)-based approaches suffered from instability and mode collapse, while diffusion models, despite impressive synthesis quality, remain computationally expensive and often fail to faithfully reproduce critical tumor contrast patterns. To address these limitations, we propose Tumor-Biased Latent Bridge Matching (TuLaBM), which formulates NC-to-CE MRI translation as Brownian bridge transport between source and target distributions in a learned latent space, enabling efficient training and inference. To enhance tumor-region fidelity, we introduce a Tumor-Biased Attention Mechanism (TuBAM) that amplifies tumor-relevant latent features during bridge evolution, along with a boundary-aware loss that constrains tumor interfaces to improve margin sharpness. While bridge matching has been explored for medical image translation in pixel space, our latent formulation substantially reduces computational cost and inference time. Experiments on BraTS2023-GLI (BraSyn) and Cleveland Clinic (in-house) liver MRI dataset show that TuLaBM consistently outperforms state-of-the-art baselines on both whole-image and tumor-region metrics, generalizes effectively to unseen liver MRI data in zero-shot and fine-tuned settings, and achieves inference times under 0.097 seconds per image.

Designing Any Imaging System from Natural Language: Agent-Constrained Composition over a Finite Primitive Basis

Designing a computational imaging system -- selecting operators, setting parameters, validating consistency -- requires weeks of specialist effort per modality, creating an expertise bottleneck that excludes the broader scientific community from prototyping imaging instruments. We introduce spec.md, a structured specification format, and three autonomous agents -- Plan, Judge, and Execute -- that translate a one-sentence natural-language description into a validated forward model with bounded reconstruction error. A design-to-real error theorem decomposes total reconstruction error into five independently bounded terms, each linked to a corrective action. On 6 real-data modalities spanning all 5 carrier families, the automated pipeline matches expert-library quality (98.1 +/- 4.2%). Ten novel designs -- composing primitives into chains from 3D to 5D -- demonstrate compositional reach beyond any single-modality tool.

Why not to use Cosine Similarity between Label Representations

Cosine similarity is often used to measure the similarity of vectors. These vectors might be the representations of neural network models. However, it is not guaranteed that cosine similarity of model representations will tell us anything about model behaviour. In this paper we show that when using a softmax classifier, be it an image classifier or an autoregressive language model, measuring the cosine similarity between label representations (called unembeddings in the paper) does not give any information on the probabilities assigned by the model. Specifically, we prove that for any softmax classifier model, given two label representations, it is possible to make another model which gives the same probabilities for all labels and inputs, but where the cosine similarity between the representations is now either 1 or -1. We give specific examples of models with very high or low cosine simlarity between representations and show how to we can make equivalent models where the cosine similarity is now -1 or 1. This translation ambiguity can be fixed by centering the label representations, however, labels with representations with low cosine similarity can still have high probability for the same inputs. Fixing the length of the representations still does not give a guarantee that high(or low) cosine similarity will give high(or low) probability to the labels for the same inputs. This means that when working with softmax classifiers, cosine similarity values between label representations should not be used to explain model probabilities.

SciVisAgentBench: A Benchmark for Evaluating Scientific Data Analysis and Visualization Agents

Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.

IMTBench: A Multi-Scenario Cross-Modal Collaborative Evaluation Benchmark for In-Image Machine Translation

End-to-end In-Image Machine Translation (IIMT) aims to convert text embedded within an image into a target language while preserving the original visual context, layout, and rendering style. However, existing IIMT benchmarks are largely synthetic and thus fail to reflect real-world complexity, while current evaluation protocols focus on single-modality metrics and overlook cross-modal faithfulness between rendered text and model outputs. To address these shortcomings, we present In-image Machine Translation Benchmark (IMTBench), a new benchmark of 2,500 image translation samples covering four practical scenarios and nine languages. IMTBench supports multi-aspect evaluation, including translation quality, background preservation, overall image quality, and a cross-modal alignment score that measures consistency between the translated text produced by the model and the text rendered in the translated image. We benchmark strong commercial cascade systems, and both closed- and open-source unified multi-modal models, and observe large performance gaps across scenarios and languages, especially on natural scenes and resource-limited languages, highlighting substantial headroom for end-to-end image text translation. We hope IMTBench establishes a standardized benchmark to accelerate progress in this emerging task.

HyPER-GAN: Hybrid Patch-Based Image-to-Image Translation for Real-Time Photorealism Enhancement

Generative models are widely employed to enhance the photorealism of synthetic data for training computer vision algorithms. However, they often introduce visual artifacts that degrade the accuracy of these algorithms and require high computational resources, limiting their applicability in real-time training or evaluation scenarios. In this paper, we propose Hybrid Patch Enhanced Realism Generative Adversarial Network (HyPER-GAN), a lightweight image-to-image translation method based on a U-Net-style generator designed for real-time inference. The model is trained using paired synthetic and photorealism-enhanced images, complemented by a hybrid training strategy that incorporates matched patches from real-world data to improve visual realism and semantic consistency. Experimental results demonstrate that HyPER-GAN outperforms state-of-the-art paired image-to-image translation methods in terms of inference latency, visual realism, and semantic robustness. Moreover, it is illustrated that the proposed hybrid training strategy indeed improves visual quality and semantic consistency compared to training the model solely with paired synthetic and photorealism-enhanced images. Code and pretrained models are publicly available for download at: https://github.com/stefanos50/HyPER-GAN

6D Robotic OCT Scanning of Curved Tissue Surfaces

Optical coherence tomography (OCT) is a non-invasive volumetric imaging modality with high spatial and temporal resolution. For imaging larger tissue structures, OCT probes need to be moved to scan the respective area. For handheld scanning, stitching of the acquired OCT volumes requires overlap to register the images. For robotic scanning and stitching, a typical approach is to restrict the motion to translations, as this avoids a full hand-eye calibration, which is complicated by the small field of view of most OCT probes. However, stitching by registration or by translational scanning are limited when curved tissue surfaces need to be scanned. We propose a marker for full six-dimensional hand-eye calibration of a robot mounted OCT probe. We show that the calibration results in highly repeatable estimates of the transformation. Moreover, we evaluate robotic scanning of two phantom surfaces to demonstrate that the proposed calibration allows for consistent scanning of large, curved tissue surfaces. As the proposed approach is not relying on image registration, it does not suffer from a potential accumulation of errors along a scan path. We also illustrate the improvement compared to conventional 3D-translational robotic scanning.