ReinPath: A Multimodal Reinforcement Learning Approach for Pathology

Interpretability is significant in computational pathology, leading to the development of multimodal information integration from histopathological image and corresponding text data.However, existing multimodal methods have limited interpretability due to the lack of high-quality dataset that support explicit reasoning and inference and simple reasoning process.To address the above problems, we introduce a novel multimodal pathology large language model with strong reasoning capabilities.To improve the generation of accurate and contextually relevant textual descriptions, we design a semantic reward strategy integrated with group relative policy optimization.We construct a high-quality pathology visual question answering (VQA) dataset, specifically designed to support complex reasoning tasks.Comprehensive experiments conducted on this dataset demonstrate that our method outperforms state-of-the-art methods, even when trained with only 20% of the data.Our method also achieves comparable performance on downstream zero-shot image classification task compared with CLIP.

AI Co-Scientist for Knowledge Synthesis in Medical Contexts: A Proof of Concept

Research waste in biomedical science is driven by redundant studies, incomplete reporting, and the limited scalability of traditional evidence synthesis workflows. We present an AI co-scientist for scalable and transparent knowledge synthesis based on explicit formalization of Population, Intervention, Comparator, Outcome, and Study design (PICOS). The platform integrates relational storage, vector-based semantic retrieval, and a Neo4j knowledge graph. Evaluation was conducted on dementia-sport and non-communicable disease corpora. Automated PICOS compliance and study design classification from titles and abstracts were performed using a Bidirectional Long Short-Term Memory baseline and a transformer-based multi-task classifier fine-tuned from PubMedBERT. Full-text synthesis employed retrieval-augmented generation with hybrid vector and graph retrieval, while BERTopic was used to identify thematic structure, redundancy, and evidence gaps. The transformer model achieved 95.7% accuracy for study design classification with strong agreement against expert annotations, while the Bi-LSTM achieved 87% accuracy for PICOS compliance detection. Retrieval-augmented generation outperformed non-retrieval generation for queries requiring structured constraints, cross-study integration, and graph-based reasoning, whereas non-retrieval approaches remained competitive for high-level summaries. Topic modeling revealed substantial thematic redundancy and identified underexplored research areas. These results demonstrate that PICOS-aware and explainable natural language processing can improve the scalability, transparency, and efficiency of evidence synthesis. The proposed architecture is domain-agnostic and offers a practical framework for reducing research waste across biomedical disciplines.

Explaining Generalization of AI-Generated Text Detectors Through Linguistic Analysis

AI-text detectors achieve high accuracy on in-domain benchmarks, but often struggle to generalize across different generation conditions such as unseen prompts, model families, or domains. While prior work has reported these generalization gaps, there are limited insights about the underlying causes. In this work, we present a systematic study aimed at explaining generalization behavior through linguistic analysis. We construct a comprehensive benchmark that spans 6 prompting strategies, 7 large language models (LLMs), and 4 domain datasets, resulting in a diverse set of human- and AI-generated texts. Using this dataset, we fine-tune classification-based detectors on various generation settings and evaluate their cross-prompt, cross-model, and cross-dataset generalization. To explain the performance variance, we compute correlations between generalization accuracies and feature shifts of 80 linguistic features between training and test conditions. Our analysis reveals that generalization performance for specific detectors and evaluation conditions is significantly associated with linguistic features such as tense usage and pronoun frequency.

Left, Right, or Center? Evaluating LLM Framing in News Classification and Generation

Large Language Model (LLM) based summarization and text generation are increasingly used for producing and rewriting text, raising concerns about political framing in journalism where subtle wording choices can shape interpretation. Across nine state-of-the-art LLMs, we study political framing by testing whether LLMs' classification-based bias signals align with framing behavior in their generated summaries. We first compare few-shot ideology predictions against LEFT/CENTER/RIGHT labels. We then generate "steered" summaries under FAITHFUL, CENTRIST, LEFT, and RIGHT prompts, and score all outputs using a single fixed ideology evaluator. We find pervasive ideological center-collapse in both article-level ratings and generated text, indicating a systematic tendency toward centrist framing. Among evaluated models, Grok 4 is by far the most ideologically expressive generator, while Claude Sonnet 4.5 and Llama 3.1 achieve the strongest bias-rating performance among commercial and open-weight models, respectively.

Predicting When to Trust Vision-Language Models for Spatial Reasoning

Vision-Language Models (VLMs) demonstrate impressive capabilities across multimodal tasks, yet exhibit systematic spatial reasoning failures, achieving only 49% (CLIP) to 54% (BLIP-2) accuracy on basic directional relationships. For safe deployment in robotics and autonomous systems, we need to predict when to trust VLM spatial predictions rather than accepting all outputs. We propose a vision-based confidence estimation framework that validates VLM predictions through independent geometric verification using object detection. Unlike text-based approaches relying on self-assessment, our method fuses four signals via gradient boosting: geometric alignment between VLM claims and coordinates, spatial ambiguity from overlap, detection quality, and VLM internal uncertainty. We achieve 0.674 AUROC on BLIP-2 (34.0% improvement over text-based baselines) and 0.583 AUROC on CLIP (16.1% improvement), generalizing across generative and classification architectures. Our framework enables selective prediction: at 60% target accuracy, we achieve 61.9% coverage versus 27.6% baseline (2.2x improvement) on BLIP-2. Feature analysis reveals vision-based signals contribute 87.4% of model importance versus 12.7% from VLM confidence, validating that external geometric verification outperforms self-assessment. We demonstrate reliable scene graph construction where confidence-based pruning improves precision from 52.1% to 78.3% while retaining 68.2% of edges.

Training-Free Adaptation of New-Generation LLMs using Legacy Clinical Models

Adapting language models to the clinical domain through continued pretraining and fine-tuning requires costly retraining for each new model generation. We propose Cross-Architecture Proxy Tuning (CAPT), a model-ensembling approach that enables training-free adaptation of state-of-the-art general-domain models using existing clinical models. CAPT supports models with disjoint vocabularies, leveraging contrastive decoding to selectively inject clinically relevant signals while preserving the general-domain model's reasoning and fluency. On six clinical classification and text-generation tasks, CAPT with a new-generation general-domain model and an older-generation clinical model consistently outperforms both models individually and state-of-the-art ensembling approaches (average +17.6% over UniTE, +41.4% over proxy tuning across tasks). Through token-level analysis and physician case studies, we demonstrate that CAPT amplifies clinically actionable language, reduces context errors, and increases clinical specificity.

PDFInspect: A Unified Feature Extraction Framework for Malicious Document Detection

The increasing prevalence of malicious Portable Document Format (PDF) files necessitates robust and comprehensive feature extraction techniques for effective detection and analysis. This work presents a unified framework that integrates graph-based, structural, and metadata-driven analysis to generate a rich feature representation for each PDF document. The system extracts text from PDF pages and constructs undirected graphs based on pairwise word relationships, enabling the computation of graph-theoretic features such as node count, edge density, and clustering coefficient. Simultaneously, the framework parses embedded metadata to quantify character distributions, entropy patterns, and inconsistencies across fields such as author, title, and producer. Temporal features are derived from creation and modification timestamps to capture behavioral signatures, while structural elements including, object streams, fonts, and embedded images, are quantified to reflect document complexity. Boolean flags for potentially malicious PDF constructs (e.g., JavaScript, launch actions) are also extracted. Together, these features form a high-dimensional vector representation (170 dimensions) that is well-suited for downstream tasks such as malware classification, anomaly detection, and forensic analysis. The proposed approach is scalable, extensible, and designed to support real-world PDF threat intelligence workflows.6

BYOL: Bring Your Own Language Into LLMs

Large Language Models (LLMs) exhibit strong multilingual capabilities, yet remain fundamentally constrained by the severe imbalance in global language resources. While over 7,000 languages are spoken worldwide, only a small subset (fewer than 100) has sufficient digital presence to meaningfully influence modern LLM training. This disparity leads to systematic underperformance, cultural misalignment, and limited accessibility for speakers of low-resource and extreme-low-resource languages. To address this gap, we introduce Bring Your Own Language (BYOL), a unified framework for scalable, language-aware LLM development tailored to each language's digital footprint. BYOL begins with a language resource classification that maps languages into four tiers (Extreme-Low, Low, Mid, High) using curated web-scale corpora, and uses this classification to select the appropriate integration pathway. For low-resource languages, we propose a full-stack data refinement and expansion pipeline that combines corpus cleaning, synthetic text generation, continual pretraining, and supervised finetuning. Applied to Chichewa and Maori, this pipeline yields language-specific LLMs that achieve approximately 12 percent average improvement over strong multilingual baselines across 12 benchmarks, while preserving English and multilingual capabilities via weight-space model merging. For extreme-low-resource languages, we introduce a translation-mediated inclusion pathway, and show on Inuktitut that a tailored machine translation system improves over a commercial baseline by 4 BLEU, enabling high-accuracy LLM access when direct language modeling is infeasible. Finally, we release human-translated versions of the Global MMLU-Lite benchmark in Chichewa, Maori, and Inuktitut, and make our codebase and models publicly available at https://github.com/microsoft/byol .

Loci Similes: A Benchmark for Extracting Intertextualities in Latin Literature

Tracing connections between historical texts is an important part of intertextual research, enabling scholars to reconstruct the virtual library of a writer and identify the sources influencing their creative process. These intertextual links manifest in diverse forms, ranging from direct verbatim quotations to subtle allusions and paraphrases disguised by morphological variation. Language models offer a promising path forward due to their capability of capturing semantic similarity beyond lexical overlap. However, the development of new methods for this task is held back by the scarcity of standardized benchmarks and easy-to-use datasets. We address this gap by introducing Loci Similes, a benchmark for Latin intertextuality detection comprising of a curated dataset of ~172k text segments containing 545 expert-verified parallels linking Late Antique authors to a corpus of classical authors. Using this data, we establish baselines for retrieval and classification of intertextualities with state-of-the-art LLMs.

CytoCLIP: Learning Cytoarchitectural Characteristics in Developing Human Brain Using Contrastive Language Image Pre-Training

The functions of different regions of the human brain are closely linked to their distinct cytoarchitecture, which is defined by the spatial arrangement and morphology of the cells. Identifying brain regions by their cytoarchitecture enables various scientific analyses of the brain. However, delineating these areas manually in brain histological sections is time-consuming and requires specialized knowledge. An automated approach is necessary to minimize the effort needed from human experts. To address this, we propose CytoCLIP, a suite of vision-language models derived from pre-trained Contrastive Language-Image Pre-Training (CLIP) frameworks to learn joint visual-text representations of brain cytoarchitecture. CytoCLIP comprises two model variants: one is trained using low-resolution whole-region images to understand the overall cytoarchitectural pattern of an area, and the other is trained on high-resolution image tiles for detailed cellular-level representation. The training dataset is created from NISSL-stained histological sections of developing fetal brains of different gestational weeks. It includes 86 distinct regions for low-resolution images and 384 brain regions for high-resolution tiles. We evaluate the model's understanding of the cytoarchitecture and generalization ability using region classification and cross-modal retrieval tasks. Multiple experiments are performed under various data setups, including data from samples of different ages and sectioning planes. Experimental results demonstrate that CytoCLIP outperforms existing methods. It achieves an F1 score of 0.87 for whole-region classification and 0.91 for high-resolution image tile classification.