Cluster-First Labelling: An Automated Pipeline for Segmentation and Morphological Clustering in Histology Whole Slide Images

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring manual boundary delineation and classification. We present a cloudnative, end-to-end pipeline that automates this process through a cluster-first paradigm. Our system tiles WSIs, filters out tiles deemed unlikely to contain valuable information, segments tissue components with Cellpose-SAM (including cells, nuclei, and other morphologically similar structures), extracts neural embeddings via a pretrained ResNet-50, reduces dimensionality with UMAP, and groups morphologically similar objects using DBSCAN clustering. Under this paradigm, a human annotator labels representative clusters rather than individual objects, reducing annotation effort by orders of magnitude. We evaluate the pipeline on 3,696 tissue components across 13 diverse tissue types from three species (human, rat, rabbit), measuring how well unsupervised clusters align with independent human labels via per-tile Hungarian-algorithm matching. Our system achieves a weighted cluster-label alignment accuracy of 96.8%, with 7 of 13 tissue types reaching perfect agreement. The pipeline, a companion labelling web application, and all evaluation code are released as open-source software.

NetworkNet: A Deep Neural Network Approach for Random Networks with Sparse Nodal Attributes and Complex Nodal Heterogeneity

Heterogeneous network data with rich nodal information become increasingly prevalent across multidisciplinary research, yet accurately modeling complex nodal heterogeneity and simultaneously selecting influential nodal attributes remains an open challenge. This problem is central to many applications in economics and sociology, when both nodal heterogeneity and high-dimensional individual characteristics highly affect network formation. We propose a statistically grounded, unified deep neural network approach for modeling nodal heterogeneity in random networks with high-dimensional nodal attributes, namely ``NetworkNet''. A key innovation of NetworkNet lies in a tailored neural architecture that explicitly parameterizes attribute-driven heterogeneity, and at the same time, embeds a scalable attribute selection mechanism. NetworkNet consistently estimates two types of latent heterogeneity functions, i.e., nodal expansiveness and popularity, while simultaneously performing data-driven attribute selection to extract influential nodal attributes. By unifying classical statistical network modeling with deep learning, NetworkNet delivers the expressive power of DNNs with methodological interpretability, algorithmic scalability, and statistical rigor with a non-asymptotic approximation error bound. Empirically, simulations demonstrate strong performance in both heterogeneity estimation and high-dimensional attribute selection. We further apply NetworkNet to a large-scale author-citation network among statisticians, revealing new insights into the dynamic evolution of research fields and scholarly impact.

At FullTilt: Real-Time Open-Set 3D Macromolecule Detection Directly from Tilted 2D Projections

Open-set 3D macromolecule detection in cryogenic electron tomography eliminates the need for target-specific model retraining. However, strict VRAM constraints prohibit processing an entire 3D tomogram, forcing current methods to rely on slow sliding-window inference over extracted subvolumes. To overcome this, we propose FullTilt, an end-to-end framework that redefines 3D detection by operating directly on aligned 2D tilt-series. Because a tilt-series contains significantly fewer images than slices in a reconstructed tomogram, FullTilt eliminates redundant volumetric computation, accelerating inference by orders of magnitude. To process the entire tilt-series simultaneously, we introduce a tilt-series encoder to efficiently fuse cross-view information. We further propose a multiclass visual prompt encoder for flexible prompting, a tilt-aware query initializer to effectively anchor 3D queries, and an auxiliary geometric primitives module to enhance the model's understanding of multi-view geometry while improving robustness to adverse imaging artifacts. Extensive evaluations on three real-world datasets demonstrate that FullTilt achieves state-of-the-art zero-shot performance while drastically reducing runtime and VRAM requirements, paving the way for rapid, large-scale visual proteomics analysis. All code and data will be publicly available upon publication.

Multi-task Just Recognizable Difference for Video Coding for Machines: Database, Model, and Coding Application

Just Recognizable Difference (JRD) boosts coding efficiency for machine vision through visibility threshold modeling, but is currently limited to a single-task scenario. To address this issue, we propose a Multi-Task JRD (MT-JRD) dataset and an Attribute-assisted MT-JRD (AMT-JRD) model for Video Coding for Machines (VCM), enhancing both prediction accuracy and coding efficiency. First, we construct a dataset comprising 27,264 JRD annotations from machines, supporting three representative tasks including object detection, instance segmentation, and keypoint detection. Secondly, we propose the AMT-JRD prediction model, which integrates Generalized Feature Extraction Module (GFEM) and Specialized Feature Extraction Module (SFEM) to facilitate joint learning across multiple tasks. Thirdly, we innovatively incorporate object attribute information into object-wise JRD prediction through the Attribute Feature Fusion Module (AFFM), which introduces prior knowledge about object size and location. This design effectively compensates for the limitations of relying solely on image features and enhances the model's capacity to represent the perceptual mechanisms of machine vision. Finally, we apply the AMT-JRD model to VCM, where the accurately predicted JRDs are applied to reduce the coding bit rate while preserving accuracy across multiple machine vision tasks. Extensive experimental results demonstrate that AMT-JRD achieves precise and robust multi-task prediction with a mean absolute error of 3.781 and error variance of 5.332 across three tasks, outperforming the state-of-the-art single-task prediction model by 6.7% and 6.3%, respectively. Coding experiments further reveal that compared to the baseline VVC and JPEG, the AMT-JRD-based VCM improves an average of 3.861% and 7.886% Bjontegaard Delta-mean Average Precision (BD-mAP), respectively.

VLMShield: Efficient and Robust Defense of Vision-Language Models against Malicious Prompts

Vision-Language Models (VLMs) face significant safety vulnerabilities from malicious prompt attacks due to weakened alignment during visual integration. Existing defenses suffer from efficiency and robustness. To address these challenges, we first propose the Multimodal Aggregated Feature Extraction (MAFE) framework that enables CLIP to handle long text and fuse multimodal information into unified representations. Through empirical analysis of MAFE-extracted features, we discover distinct distributional patterns between benign and malicious prompts. Building upon this finding, we develop VLMShield, a lightweight safety detector that efficiently identifies multimodal malicious attacks as a plug-and-play solution. Extensive experiments demonstrate superior performance across multiple dimensions, including robustness, efficiency, and utility. Through our work, we hope to pave the way for more secure multimodal AI deployment. Code is available at [this https URL](https://github.com/pgqihere/VLMShield).

Graph Topology Information Enhanced Heterogeneous Graph Representation Learning

Real-world heterogeneous graphs are inherently noisy and usually not in the optimal graph structures for downstream tasks, which often adversely affects the performance of GRL models in downstream tasks. Although Graph Structure Learning (GSL) methods have been proposed to learn graph structures and downstream tasks simultaneously, existing methods are predominantly designed for homogeneous graphs, while GSL for heterogeneous graphs remains largely unexplored. Two challenges arise in this context. Firstly, the quality of the input graph structure has a more profound impact on GNN-based heterogeneous GRL models compared to their homogeneous counterparts. Secondly, most existing homogenous GRL models encounter memory consumption issues when applied directly to heterogeneous graphs. In this paper, we propose a novel Graph Topology learning Enhanced Heterogeneous Graph Representation Learning framework (ToGRL).ToGRL learns high-quality graph structures and representations for downstream tasks by incorporating task-relevant latent topology information. Specifically, a novel GSL module is first proposed to extract downstream task-related topology information from a raw graph structure and project it into topology embeddings. These embeddings are utilized to construct a new graph with smooth graph signals. This two-stage approach to GSL separates the optimization of the adjacency matrix from node representation learning to reduce memory consumption. Following this, a representation learning module takes the new graph as input to learn embeddings for downstream tasks. ToGRL also leverages prompt tuning to better utilize the knowledge embedded in learned representations, thus enhancing adaptability to downstream tasks. Extensive experiments on five real-world datasets show that our ToGRL outperforms state-of-the-art methods by a large margin.

AttnDiff: Attention-based Differential Fingerprinting for Large Language Models

Protecting the intellectual property of open-weight large language models (LLMs) requires verifying whether a suspect model is derived from a victim model despite common laundering operations such as fine-tuning (including PPO/DPO), pruning/compression, and model merging. We propose \textsc{AttnDiff}, a data-efficient white-box framework that extracts fingerprints from models via intrinsic information-routing behavior. \textsc{AttnDiff} probes minimally edited prompt pairs that induce controlled semantic conflicts, captures differential attention patterns, summarizes them with compact spectral descriptors, and compares models using CKA. Across Llama-2/3 and Qwen2.5 (3B--14B) and additional open-source families, it yields high similarity for related derivatives while separating unrelated model families (e.g., $>0.98$ vs.\ $<0.22$ with $M=60$ probes). With 5--60 multi-domain probes, it supports practical provenance verification and accountability.

Attention-Guided Dual-Stream Learning for Group Engagement Recognition: Fusing Transformer-Encoded Motion Dynamics with Scene Context via Adaptive Gating

Student engagement is crucial for improving learning outcomes in group activities. Highly engaged students perform better both individually and contribute to overall group success. However, most existing automated engagement recognition methods are designed for online classrooms or estimate engagement at the individual level. Addressing this gap, we propose DualEngage, a novel two-stream framework for group-level engagement recognition from in-classroom videos. It models engagement as a joint function of both individual and group-level behaviors. The primary stream models person-level motion dynamics by detecting and tracking students, extracting dense optical flow with the Recurrent All-Pairs Field Transforms network, encoding temporal motion patterns using a transformer encoder, and finally aggregating per-student representations through attention pooling into a unified representation. The secondary stream captures scene-level spatiotemporal information from the full video clip, leveraging a pretrained three-dimensional Residual Network. The two-stream representations are combined via softmax-gated fusion, which dynamically weights each stream's contribution based on the joint context of both features. DualEngage learns a joint representation of individual actions with overarching group dynamics. We evaluate the proposed approach using fivefold cross-validation on the Classroom Group Engagement Dataset developed by Ocean University of China, achieving an average classification accuracy of 0.9621+/-0.0161 with a macro-averaged F1 of 0.9530+/-0.0204. To understand the contribution of each branch, we further conduct an ablation study comparing single-stream variants against the two-stream model. This work is among the first in classroom engagement recognition to adopt a dual-stream design that explicitly leverages motion cues as an estimator.

Dual-Exposure Imaging with Events

By combining complementary benefits of short- and long-exposure images, Dual-Exposure Imaging (DEI) enhances image quality in low-light scenarios. However, existing DEI approaches inevitably suffer from producing artifacts due to spatial displacement from scene motion and image feature discrepancies from different exposure times. To tackle this problem, we propose a novel Event-based DEI (E-DEI) algorithm, which reconstructs high-quality images from dual-exposure image pairs and events, leveraging high temporal resolution of event cameras to provide accurate inter-/intra-frame dynamic information. Specifically, we decompose this complex task into an integration of two sub-tasks, i.e., event-based motion deblurring and low-light image enhancement tasks, which guides us to design E-DEI network as a dual-path parallel feature propagation architecture. We propose a Dual-path Feature Alignment and Fusion (DFAF) module to effectively align and fuse features extracted from dual-exposure images with assistance of events. Furthermore, we build a real-world Dataset containing Paired low-/normal-light Images and Events (PIED). Experiments on multiple datasets show the superiority of our method. The code and dataset are available at github.

Optimizing Service Operations via LLM-Powered Multi-Agent Simulation

Service system performance depends on how participants respond to design choices, but modeling these responses is hard due to the complexity of human behavior. We introduce an LLM-powered multi-agent simulation (LLM-MAS) framework for optimizing service operations. We pose the problem as stochastic optimization with decision-dependent uncertainty: design choices are embedded in prompts and shape the distribution of outcomes from interacting LLM-powered agents. By embedding key numerical information in prompts and extracting it from LLM-generated text, we model this uncertainty as a controlled Markov chain. We develop an on-trajectory learning algorithm that, on a single simulation run, simultaneously constructs zeroth-order gradient estimates and updates design parameters to optimize steady-state performance. We also incorporate variance reduction techniques. In a sustainable supply chain application, our method outperforms benchmarks, including blackbox optimization and using LLMs as numerical solvers or as role-playing system designers. A case study on optimal contest design with real behavioral data shows that LLM-MAS is both as a cost-effective evaluator of known designs and an exploratory tool that can uncover strong designs overlooked by traditional approaches.