Image-to-image translation is the process of converting an image from one domain to another using deep learning techniques.
Human-Object Interaction (HOI) video reenactment with realistic motion remains a frontier in expressive digital human creation. Existing approaches primarily handle simple image-plane motion (e.g., in-plane translations), struggling with complex non-planar manipulations like out-of-plane reorientation. In this paper, we propose MVHOI, a two-stage HOI video reenactment framework that bridges multi-view reference conditions and video foundation models via a 3D Foundation Model (3DFM). The 3DFM first produces view-consistent object priors conditioned on implicit motion dynamics across novel viewpoints. A controllable video generation model then synthesizes high-fidelity object texture by incorporating multi-view reference images, ensuring appearance consistency via a reasonable retrieval mechanism. By enabling these two stages to mutually reinforce one another during the inference phase, our framework shows superior performance in generating long-duration HOI videos with intricate object manipulations. Extensive experiments show substantial improvements over prior approaches, especially for HOI with complex 3D object manipulations.
As plots play a critical role in modern data visualization and analysis, Plot2API is launched to help non-experts and beginners create their desired plots by directly recommending graphical APIs from reference plot images by neural networks. However, previous works on Plot2API have primarily focused on the recommendation for standard plot images, while overlooking the hand-drawn plot images that are more accessible to non-experts and beginners. To make matters worse, both Plot2API models trained on standard plot images and powerful multi-modal large language models struggle to effectively recommend APIs for hand-drawn plot images due to the domain gap and lack of expertise. To facilitate non-experts and beginners, we introduce a hand-drawn plot dataset named HDpy-13 to improve the performance of graphical API recommendations for hand-drawn plot images. Additionally, to alleviate the considerable strain of parameter growth and computational resource costs arising from multi-domain and multi-language challenges in Plot2API, we propose Plot-Adapter that allows for the training and storage of separate adapters rather than requiring an entire model for each language and domain. In particular, Plot-Adapter incorporates a lightweight CNN block to improve the ability to capture local features and implements projection matrix sharing to reduce the number of fine-tuning parameters further. Experimental results demonstrate both the effectiveness of HDpy-13 and the efficiency of Plot-Adapter.
Coronary artery disease, the leading cause of cardiovascular mortality worldwide, can be assessed non-invasively by coronary computed tomography angiography (CCTA). Despite progress in automated CCTA analysis using deep learning, clinical translation is constrained by the scarcity of expert-annotated datasets. Furthermore, widely adopted label-free pretraining strategies, such as masked image modeling, are intrinsically biased toward global anatomical statistics, frequently failing to capture the spatially localized pathological features of coronary plaques. Here, we introduce CORA, a 3D vision foundation model for comprehensive cardiovascular risk assessment. CORA learns directly from volumetric CCTA via a pathology-centric, synthesis-driven self-supervised framework. By utilizing an anatomy-guided lesion synthesis engine, the model is explicitly trained to detect simulated vascular abnormalities, biasing representation learning toward clinically relevant disease features rather than dominant background anatomy. We trained CORA on a large-scale cohort of 12,801 unlabeled CCTA volumes and comprehensively evaluated the model across multi-center datasets from nine independent hospitals. Across diagnostic and anatomical tasks, including plaque characterization, stenosis detection, and coronary artery segmentation, CORA consistently outperformed the state-of-the-art 3D vision foundation models, achieving up to a 29\% performance gain. Crucially, by coupling the imaging encoder with a large language model, we extended CORA into a multimodal framework that significantly improved 30-day major adverse cardiac event (MACE) risk stratification. Our results establish CORA as a scalable and extensible foundation for unified anatomical assessment and cardiovascular risk prediction.
Most existing image keypoint detection and description methods rely on datasets with accurate pose and depth annotations, limiting scalability and generalization, and often degrading navigation and localization performance. We propose ViBA, a sustainable learning framework that integrates geometric optimization with feature learning for continuous online training on unconstrained video streams. Embedded in a standard visual odometry pipeline, it consists of an implicitly differentiable geometric residual framework: (i) an initial tracking network for inter-frame correspondences, (ii) depth-based outlier filtering, and (iii) differentiable global bundle adjustment that jointly refines camera poses and feature positions by minimizing reprojection errors. By combining geometric consistency from BA with long-term temporal consistency across frames, ViBA enforces stable and accurate feature representations. We evaluate ViBA on EuRoC and UMA datasets. Compared with state-of-the-art methods such as SuperPoint+SuperGlue, ALIKED, and LightGlue, ViBA reduces mean absolute translation error (ATE) by 12-18% and absolute rotation error (ARE) by 5-10% across sequences, while maintaining real-time inference speeds (FPS 36-91). When evaluated on unseen sequences, it retains over 90% localization accuracy, demonstrating robust generalization. These results show that ViBA supports continuous online learning with geometric and temporal consistency, consistently improving navigation and localization in real-world scenarios.
Cosine similarity is often used to measure the similarity of vectors. These vectors might be the representations of neural network models. However, it is not guaranteed that cosine similarity of model representations will tell us anything about model behaviour. In this paper we show that when using a softmax classifier, be it an image classifier or an autoregressive language model, measuring the cosine similarity between label representations (called unembeddings in the paper) does not give any information on the probabilities assigned by the model. Specifically, we prove that for any softmax classifier model, given two label representations, it is possible to make another model which gives the same probabilities for all labels and inputs, but where the cosine similarity between the representations is now either 1 or -1. We give specific examples of models with very high or low cosine simlarity between representations and show how to we can make equivalent models where the cosine similarity is now -1 or 1. This translation ambiguity can be fixed by centering the label representations, however, labels with representations with low cosine similarity can still have high probability for the same inputs. Fixing the length of the representations still does not give a guarantee that high(or low) cosine similarity will give high(or low) probability to the labels for the same inputs. This means that when working with softmax classifiers, cosine similarity values between label representations should not be used to explain model probabilities.
Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.
Purpose: To develop a computationally viable autofocus method for estimating 3D rigid motion in MR imaging. Theory and Methods: The proposed method, REACT, assumes a piecewise-constant motion trajectory and estimates the rigid motion parameters of individual temporal segments by optimizing an image-quality metric. Coordinate descent is adopted to decompose the high-dimensional optimization problem into a series of subproblems, each updating the motion parameters of a single temporal segment. The cost function of each subproblem is assumed to be approximately locally convex under suitable acquisition conditions. Each subproblem is then solved using a derivative-free solver, thereby avoiding an exhaustive grid search. Numerical simulations were conducted to investigate the local convexity assumption. REACT was evaluated for respiratory motion correction on in vivo free-breathing coronary MR angiography datasets acquired using a 3D cones trajectory with image-based navigators (iNAVs). An autofocus nonrigid motion correction method was also evaluated for comparison. Coronary artery sharpness was quantified using unbounded image edge profile acutance (u-IEPA). Results: In numerical simulations, the objective surfaces of the subproblems were approximately locally convex when the current motion estimate was close to the desired solution. In the in vivo study, REACT yielded higher u-IEPA than the conventional iNAV-based translational motion-estimation method for both the left anterior descending artery (LAD) and right coronary artery. REACT also yielded higher u-IEPA for the LAD than the autofocus nonrigid motion correction method. Conclusion: This study demonstrates the feasibility of coordinate descent for autofocus motion correction in MR imaging.
Multiplex immunofluorescence (mIF) enables simultaneous single-cell quantification of multiple biomarkers within intact tissue architecture, yet its high reagent cost, multi-round staining protocols, and need for specialized imaging platforms limit routine clinical adoption. Virtual staining can synthesize mIF channels from widely available brightfield immunohistochemistry (IHC), but current translators optimize pixel-level fidelity without explicitly constraining nuclear morphology. In pathology, this gap is clinically consequential: subtle distortions in nuclei count, shape, or spatial arrangement propagate directly to quantification endpoints such as the Ki67 proliferation index, where errors of a few percent can shift treatment-relevant risk categories. This work introduces a supervision-free, architecture-agnostic conditioning strategy that injects a continuous cell probability map from a pretrained nuclei segmentation foundation model as an explicit input prior, together with a variance-preserving regularization term that matches local intensity statistics to maintain cell-level heterogeneity in synthesized fluorescence channels. The soft prior retains gradient-level boundary information lost by binary thresholding, providing a richer conditioning signal without task-specific tuning. Controlled experiments across Pix2Pix with U-Net and ResNet generators, deterministic regression U-Net, and conditional diffusion on two independent datasets demonstrate consistent improvements in nuclei count fidelity and perceptual quality, as the sole modifications. Code will be made publicly available upon acceptance.
In the design and safety analysis of advanced reactor systems, constructing input files for system-level thermal-hydraulics codes such as the System Analysis Module (SAM) remains a labor-intensive task. Analysts must extract and reconcile design data from heterogeneous engineering documents and manually translate it into solver-specific syntax. In this paper, we present AutoSAM, an agentic framework that automates SAM input file generation. The framework combines a large language model agent with retrieval-augmented generation over the solver's user guide and theory manual, together with specialized tools for analyzing PDFs, images, spreadsheets, and text files. AutoSAM ingests unstructured engineering documents, including system diagrams, design reports, and data tables, extracts simulation-relevant parameters into a human-auditable intermediate representation, and synthesizes validated, solver-compatible input decks. Its multimodal retrieval pipeline integrates scientific text extraction, vision-based figure interpretation, semantic embedding, and query answering. We evaluate AutoSAM on four case studies of increasing complexity: a single-pipe steady-state model, a solid-fuel channel with temperature reactivity feedback, the Advanced Burner Test Reactor core, and the Molten Salt Reactor Experiment primary loop. Across all cases, the agent produces runnable SAM models consistent with expected thermal-hydraulic behavior while explicitly identifying missing data and labeling assumed values. The framework achieves 100% utilization of structured inputs, about 88% extraction from PDF text, and 100% completeness in vision-based geometric extraction. These results demonstrate a practical path toward prompt-driven reactor modeling, in which analysts provide system descriptions and supporting documentation while the agent translates them into transparent, and executable, SAM simulations.
Embodied agents for creative tasks like photography must bridge the semantic gap between high-level language commands and geometric control. We introduce PhotoAgent, an agent that achieves this by integrating Large Multimodal Models (LMMs) reasoning with a novel control paradigm. PhotoAgent first translates subjective aesthetic goals into solvable geometric constraints via LMM-driven, chain-of-thought (CoT) reasoning, allowing an analytical solver to compute a high-quality initial viewpoint. This initial pose is then iteratively refined through visual reflection within a photorealistic internal world model built with 3D Gaussian Splatting (3DGS). This ``mental simulation'' replaces costly and slow physical trial-and-error, enabling rapid convergence to aesthetically superior results. Evaluations confirm that PhotoAgent excels in spatial reasoning and achieves superior final image quality.