Radiomics in Medical Imaging: Methods, Applications, and Challenges

Radiomics enables quantitative medical image analysis by converting imaging data into structured, high-dimensional feature representations for predictive modeling. Despite methodological developments and encouraging retrospective results, radiomics continue to face persistent challenges related to feature instability, limited reproducibility, validation bias, and restricted clinical translation. Existing reviews largely focus on application-specific outcomes or isolated pipeline components, with limited analysis of how interdependent design choices across acquisition, preprocessing, feature engineering, modeling, and evaluation collectively affect robustness and generalizability. This survey provides an end-to-end analysis of radiomics pipelines, examining how methodological decisions at each stage influence feature stability, model reliability, and translational validity. This paper reviews radiomic feature extraction, selection, and dimensionality reduction strategies; classical machine and deep learning-based modeling approaches; and ensemble and hybrid frameworks, with emphasis on validation protocols, data leakage prevention, and statistical reliability. Clinical applications are discussed with a focus on evaluation rigor rather than reported performance metrics. The survey identifies open challenges in standardization, domain shift, and clinical deployment, and outlines future directions such as hybrid radiomics-artificial intelligence models, multimodal fusion, federated learning, and standardized benchmarking.

IntraStyler: Exemplar-based Style Synthesis for Cross-modality Domain Adaptation

Image-level domain alignment is the de facto approach for unsupervised domain adaptation, where unpaired image translation is used to minimize the domain gap. Prior studies mainly focus on the domain shift between the source and target domains, whereas the intra-domain variability remains under-explored. To address the latter, an effective strategy is to diversify the styles of the synthetic target domain data during image translation. However, previous methods typically require intra-domain variations to be pre-specified for style synthesis, which may be impractical. In this paper, we propose an exemplar-based style synthesis method named IntraStyler, which can capture diverse intra-domain styles without any prior knowledge. Specifically, IntraStyler uses an exemplar image to guide the style synthesis such that the output style matches the exemplar style. To extract the style-only features, we introduce a style encoder to learn styles discriminatively based on contrastive learning. We evaluate the proposed method on the largest public dataset for cross-modality domain adaptation, CrossMoDA 2023. Our experiments show the efficacy of our method in controllable style synthesis and the benefits of diverse synthetic data for downstream segmentation. Code is available at https://github.com/han-liu/IntraStyler.

Investigating Associational Biases in Inter-Model Communication of Large Generative Models

Social bias in generative AI can manifest not only as performance disparities but also as associational bias, whereby models learn and reproduce stereotypical associations between concepts and demographic groups, even in the absence of explicit demographic information (e.g., associating doctors with men). These associations can persist, propagate, and potentially amplify across repeated exchanges in inter-model communication pipelines, where one generative model's output becomes another's input. This is especially salient for human-centred perception tasks, such as human activity recognition and affect prediction, where inferences about behaviour and internal states can lead to errors or stereotypical associations that propagate into unequal treatment. In this work, focusing on human activity and affective expression, we study how such associations evolve within an inter-model communication pipeline that alternates between image generation and image description. Using the RAF-DB and PHASE datasets, we quantify demographic distribution drift induced by model-to-model information exchange and assess whether these drifts are systematic using an explainability pipeline. Our results reveal demographic drifts toward younger representations for both actions and emotions, as well as toward more female-presenting representations, primarily for emotions. We further find evidence that some predictions are supported by spurious visual regions (e.g., background or hair) rather than concept-relevant cues (e.g., body or face). We also examine whether these demographic drifts translate into measurable differences in downstream behaviour, i.e., while predicting activity and emotion labels. Finally, we outline mitigation strategies spanning data-centric, training and deployment interventions, and emphasise the need for careful safeguards when deploying interconnected models in human-centred AI systems.

Domain Adaptation of Carotid Ultrasound Images using Generative Adversarial Network

Deep learning has been extensively used in medical imaging applications, assuming that the test and training datasets belong to the same probability distribution. However, a common challenge arises when working with medical images generated by different systems or even the same system with different parameter settings. Such images contain diverse textures and reverberation noise that violate the aforementioned assumption. Consequently, models trained on data from one device or setting often struggle to perform effectively with data from other devices or settings. In addition, retraining models for each specific device or setting is labor-intensive and costly. To address these issues in ultrasound images, we propose a novel Generative Adversarial Network (GAN)-based model. We formulated the domain adaptation tasks as an image-to-image translation task, in which we modified the texture patterns and removed reverberation noise in the test data images from the source domain to align with those in the target domain images while keeping the image content unchanged. We applied the proposed method to two datasets containing carotid ultrasound images from three different domains. The experimental results demonstrate that the model successfully translated the texture pattern of images and removed reverberation noise from the ultrasound images. Furthermore, we evaluated the CycleGAN approaches for a comparative study with the proposed model. The experimental findings conclusively demonstrated that the proposed model achieved domain adaptation (histogram correlation (0.960 (0.019), & 0.920 (0.043) and bhattacharya distance (0.040 (0.020), & 0.085 (0.048)), compared to no adaptation (0.916 (0.062) & 0.890 (0.077), 0.090 (0.070) & 0.121 (0.095)) for both datasets.

Edit2Restore:Few-Shot Image Restoration via Parameter-Efficient Adaptation of Pre-trained Editing Models

Image restoration has traditionally required training specialized models on thousands of paired examples per degradation type. We challenge this paradigm by demonstrating that powerful pre-trained text-conditioned image editing models can be efficiently adapted for multiple restoration tasks through parameter-efficient fine-tuning with remarkably few examples. Our approach fine-tunes LoRA adapters on FLUX.1 Kontext, a state-of-the-art 12B parameter flow matching model for image-to-image translation, using only 16-128 paired images per task, guided by simple text prompts that specify the restoration operation. Unlike existing methods that train specialized restoration networks from scratch with thousands of samples, we leverage the rich visual priors already encoded in large-scale pre-trained editing models, dramatically reducing data requirements while maintaining high perceptual quality. A single unified LoRA adapter, conditioned on task-specific text prompts, effectively handles multiple degradations including denoising, deraining, and dehazing. Through comprehensive ablation studies, we analyze: (i) the impact of training set size on restoration quality, (ii) trade-offs between task-specific versus unified multi-task adapters, (iii) the role of text encoder fine-tuning, and (iv) zero-shot baseline performance. While our method prioritizes perceptual quality over pixel-perfect reconstruction metrics like PSNR/SSIM, our results demonstrate that pre-trained image editing models, when properly adapted, offer a compelling and data-efficient alternative to traditional image restoration approaches, opening new avenues for few-shot, prompt-guided image enhancement. The code to reproduce our results are available at: https://github.com/makinyilmaz/Edit2Restore

ColorConceptBench: A Benchmark for Probabilistic Color-Concept Understanding in Text-to-Image Models

While text-to-image (T2I) models have advanced considerably, their capability to associate colors with implicit concepts remains underexplored. To address the gap, we introduce ColorConceptBench, a new human-annotated benchmark to systematically evaluate color-concept associations through the lens of probabilistic color distributions. ColorConceptBench moves beyond explicit color names or codes by probing how models translate 1,281 implicit color concepts using a foundation of 6,369 human annotations. Our evaluation of seven leading T2I models reveals that current models lack sensitivity to abstract semantics, and crucially, this limitation appears resistant to standard interventions (e.g., scaling and guidance). This demonstrates that achieving human-like color semantics requires more than larger models, but demands a fundamental shift in how models learn and represent implicit meaning.

Optimization and Mobile Deployment for Anthropocene Neural Style Transfer

This paper presents AnthropoCam, a mobile-based neural style transfer (NST) system optimized for the visual synthesis of Anthropocene environments. Unlike conventional artistic NST, which prioritizes painterly abstraction, stylizing human-altered landscapes demands a careful balance between amplifying material textures and preserving semantic legibility. Industrial infrastructures, waste accumulations, and modified ecosystems contain dense, repetitive patterns that are visually expressive yet highly susceptible to semantic erosion under aggressive style transfer. To address this challenge, we systematically investigate the impact of NST parameter configurations on the visual translation of Anthropocene textures, including feature layer selection, style and content loss weighting, training stability, and output resolution. Through controlled experiments, we identify an optimal parameter manifold that maximizes stylistic expression while preventing semantic erasure. Our results demonstrate that appropriate combinations of convolutional depth, loss ratios, and resolution scaling enable the faithful transformation of anthropogenic material properties into a coherent visual language. Building on these findings, we implement a low-latency, feed-forward NST pipeline deployed on mobile devices. The system integrates a React Native frontend with a Flask-based GPU backend, achieving high-resolution inference within 3-5 seconds on general mobile hardware. This enables real-time, in-situ visual intervention at the site of image capture, supporting participatory engagement with Anthropocene landscapes. By coupling domain-specific NST optimization with mobile deployment, AnthropoCam reframes neural style transfer as a practical and expressive tool for real-time environmental visualization in the Anthropocene.

Few-Shot LoRA Adaptation of a Flow-Matching Foundation Model for Cross-Spectral Object Detection

Foundation models for vision are predominantly trained on RGB data, while many safety-critical applications rely on non-visible modalities such as infrared (IR) and synthetic aperture radar (SAR). We study whether a single flow-matching foundation model pre-trained primarily on RGB images can be repurposed as a cross-spectral translator using only a few co-measured examples, and whether the resulting synthetic data can enhance downstream detection. Starting from FLUX.1 Kontext, we insert low-rank adaptation (LoRA) modules and fine-tune them on just 100 paired images per domain for two settings: RGB to IR on the KAIST dataset and RGB to SAR on the M4-SAR dataset. The adapted model translates RGB images into pixel-aligned IR/SAR, enabling us to reuse existing bounding boxes and train object detection models purely in the target modality. Across a grid of LoRA hyperparameters, we find that LPIPS computed on only 50 held-out pairs is a strong proxy for downstream performance: lower LPIPS consistently predicts higher mAP for YOLOv11n on both IR and SAR, and for DETR on KAIST IR test data. Using the best LPIPS-selected LoRA adapter, synthetic IR from external RGB datasets (LLVIP, FLIR ADAS) improves KAIST IR pedestrian detection, and synthetic SAR significantly boosts infrastructure detection on M4-SAR when combined with limited real SAR. Our results suggest that few-shot LoRA adaptation of flow-matching foundation models is a promising path toward foundation-style support for non-visible modalities.

Application Research of a Deep Learning Model Integrating CycleGAN and YOLO in PCB Infrared Defect Detection

This paper addresses the critical bottleneck of infrared (IR) data scarcity in Printed Circuit Board (PCB) defect detection by proposing a cross-modal data augmentation framework integrating CycleGAN and YOLOv8. Unlike conventional methods relying on paired supervision, we leverage CycleGAN to perform unpaired image-to-image translation, mapping abundant visible-light PCB images into the infrared domain. This generative process synthesizes high-fidelity pseudo-IR samples that preserve the structural semantics of defects while accurately simulating thermal distribution patterns. Subsequently, we construct a heterogeneous training strategy that fuses generated pseudo-IR data with limited real IR samples to train a lightweight YOLOv8 detector. Experimental results demonstrate that this method effectively enhances feature learning under low-data conditions. The augmented detector significantly outperforms models trained on limited real data alone and approaches the performance benchmarks of fully supervised training, proving the efficacy of pseudo-IR synthesis as a robust augmentation strategy for industrial inspection.

SoS: Analysis of Surface over Semantics in Multilingual Text-To-Image Generation

Text-to-image (T2I) models are increasingly employed by users worldwide. However, prior research has pointed to the high sensitivity of T2I towards particular input languages - when faced with languages other than English (i.e., different surface forms of the same prompt), T2I models often produce culturally stereotypical depictions, prioritizing the surface over the prompt's semantics. Yet a comprehensive analysis of this behavior, which we dub Surface-over-Semantics (SoS), is missing. We present the first analysis of T2I models' SoS tendencies. To this end, we create a set of prompts covering 171 cultural identities, translated into 14 languages, and use it to prompt seven T2I models. To quantify SoS tendencies across models, languages, and cultures, we introduce a novel measure and analyze how the tendencies we identify manifest visually. We show that all but one model exhibit strong surface-level tendency in at least two languages, with this effect intensifying across the layers of T2I text encoders. Moreover, these surface tendencies frequently correlate with stereotypical visual depictions.