Translating Light-Sheet Microscopy Images to Virtual H&E Using CycleGAN

Histopathology analysis relies on Hematoxylin and Eosin (H&E) staining, but fluorescence microscopy offers complementary information. Converting fluorescence images to H&E-like appearance can aid interpretation and integration with standard workflows. We present a Cycle-Consistent Adversarial Network (CycleGAN) approach for unpaired image-to-image translation from multi-channel fluorescence microscopy to pseudo H&E stained histopathology images. The method combines C01 and C02 fluorescence channels into RGB and learns a bidirectional mapping between fluorescence and H&E domains without paired training data. The architecture uses ResNet-based generators with residual blocks and PatchGAN discriminators, trained with adversarial, cycle-consistency, and identity losses. Experiments on fluorescence microscopy datasets show the model generates realistic pseudo H&E images that preserve morphological structures while adopting H&E-like color characteristics. This enables visualization of fluorescence data in a format familiar to pathologists and supports integration with existing H&E-based analysis pipelines.

Toward Autonomous Laboratory Safety Monitoring with Vision Language Models: Learning to See Hazards Through Scene Structure

Laboratories are prone to severe injuries from minor unsafe actions, yet continuous safety monitoring -- beyond mandatory pre-lab safety training -- is limited by human availability. Vision language models (VLMs) offer promise for autonomous laboratory safety monitoring, but their effectiveness in realistic settings is unclear due to the lack of visual evaluation data, as most safety incidents are documented primarily as unstructured text. To address this gap, we first introduce a structured data generation pipeline that converts textual laboratory scenarios into aligned triples of (image, scene graph, ground truth), using large language models as scene graph architects and image generation models as renderers. Our experiments on the synthetic dataset of 1,207 samples across 362 unique scenarios and seven open- and closed-source models show that VLMs perform effectively given textual scene graph, but degrade substantially in visual-only settings indicating difficulty in extracting structured object relationships directly from pixels. To overcome this, we propose a post-training context-engineering approach, scene-graph-guided alignment, to bridge perceptual gaps in VLMs by translating visual inputs into structured scene graphs better aligned with VLM reasoning, improving hazard detection performance in visual only settings.

TranslateGemma Technical Report

We present TranslateGemma, a suite of open machine translation models based on the Gemma 3 foundation models. To enhance the inherent multilingual capabilities of Gemma 3 for the translation task, we employ a two-stage fine-tuning process. First, supervised fine-tuning is performed using a rich mixture of high-quality large-scale synthetic parallel data generated via state-of-the-art models and human-translated parallel data. This is followed by a reinforcement learning phase, where we optimize translation quality using an ensemble of reward models, including MetricX-QE and AutoMQM, targeting translation quality. We demonstrate the effectiveness of TranslateGemma with human evaluation on the WMT25 test set across 10 language pairs and with automatic evaluation on the WMT24++ benchmark across 55 language pairs. Automatic metrics show consistent and substantial gains over the baseline Gemma 3 models across all sizes. Notably, smaller TranslateGemma models often achieve performance comparable to larger baseline models, offering improved efficiency. We also show that TranslateGemma models retain strong multimodal capabilities, with enhanced performance on the Vistra image translation benchmark. The release of the open TranslateGemma models aims to provide the research community with powerful and adaptable tools for machine translation.

Advanced Geometric Correction Algorithms for 3D Medical Reconstruction: Comparison of Computed Tomography and Macroscopic Imaging

This paper introduces a hybrid two-stage registration framework for reconstructing three-dimensional (3D) kidney anatomy from macroscopic slices, using CT-derived models as the geometric reference standard. The approach addresses the data-scarcity and high-distortion challenges typical of macroscopic imaging, where fully learning-based registration (e.g., VoxelMorph) often fails to generalize due to limited training diversity and large nonrigid deformations that exceed the capture range of unconstrained convolutional filters. In the proposed pipeline, the Optimal Cross-section Matching (OCM) algorithm first performs constrained global alignment: translation, rotation, and uniform scaling to establish anatomically consistent slice initialization. Next, a lightweight deep-learning refinement network, inspired by VoxelMorph, predicts residual local deformations between consecutive slices. The core novelty of this architecture lies in its hierarchical decomposition of the registration manifold. This hybrid OCM+DL design integrates explicit geometric priors with the flexible learning capacity of neural networks, ensuring stable optimization and plausible deformation fields even with few training examples. Experiments on an original dataset of 40 kidneys demonstrated better results compared to single-stage baselines. The pipeline maintains physical calibration via Hough-based grid detection and employs Bezier-based contour smoothing for robust meshing and volume estimation. Although validated on kidney data, the proposed framework generalizes to other soft-tissue organs reconstructed from optical or photographic cross-sections. By decoupling interpretable global optimization from data-efficient deep refinement, the method advances the precision, reproducibility, and anatomical realism of multimodal 3D reconstructions for surgical planning, morphological assessment, and medical education.

Sim-to-Real Transfer via a Style-Identified Cycle Consistent Generative Adversarial Network: Zero-Shot Deployment on Robotic Manipulators through Visual Domain Adaptation

The sample efficiency challenge in Deep Reinforcement Learning (DRL) compromises its industrial adoption due to the high cost and time demands of real-world training. Virtual environments offer a cost-effective alternative for training DRL agents, but the transfer of learned policies to real setups is hindered by the sim-to-real gap. Achieving zero-shot transfer, where agents perform directly in real environments without additional tuning, is particularly desirable for its efficiency and practical value. This work proposes a novel domain adaptation approach relying on a Style-Identified Cycle Consistent Generative Adversarial Network (StyleID-CycleGAN or SICGAN), an original Cycle Consistent Generative Adversarial Network (CycleGAN) based model. SICGAN translates raw virtual observations into real-synthetic images, creating a hybrid domain for training DRL agents that combines virtual dynamics with real-like visual inputs. Following virtual training, the agent can be directly deployed, bypassing the need for real-world training. The pipeline is validated with two distinct industrial robots in the approaching phase of a pick-and-place operation. In virtual environments agents achieve success rates of 90 to 100\%, and real-world deployment confirms robust zero-shot transfer (i.e., without additional training in the physical environment) with accuracies above 95\% for most workspace regions. We use augmented reality targets to improve the evaluation process efficiency, and experimentally demonstrate that the agent successfully generalizes to real objects of varying colors and shapes, including LEGO\textsuperscript{\textregistered}~cubes and a mug. These results establish the proposed pipeline as an efficient, scalable solution to the sim-to-real problem.

STARS: Shared-specific Translation and Alignment for missing-modality Remote Sensing Semantic Segmentation

Multimodal remote sensing technology significantly enhances the understanding of surface semantics by integrating heterogeneous data such as optical images, Synthetic Aperture Radar (SAR), and Digital Surface Models (DSM). However, in practical applications, the missing of modality data (e.g., optical or DSM) is a common and severe challenge, which leads to performance decline in traditional multimodal fusion models. Existing methods for addressing missing modalities still face limitations, including feature collapse and overly generalized recovered features. To address these issues, we propose \textbf{STARS} (\textbf{S}hared-specific \textbf{T}ranslation and \textbf{A}lignment for missing-modality \textbf{R}emote \textbf{S}ensing), a robust semantic segmentation framework for incomplete multimodal inputs. STARS is built on two key designs. First, we introduce an asymmetric alignment mechanism with bidirectional translation and stop-gradient, which effectively prevents feature collapse and reduces sensitivity to hyperparameters. Second, we propose a Pixel-level Semantic sampling Alignment (PSA) strategy that combines class-balanced pixel sampling with cross-modality semantic alignment loss, to mitigate alignment failures caused by severe class imbalance and improve minority-class recognition.

End-to-end example-based sim-to-real RL policy transfer based on neural stylisation with application to robotic cutting

Whereas reinforcement learning has been applied with success to a range of robotic control problems in complex, uncertain environments, reliance on extensive data - typically sourced from simulation environments - limits real-world deployment due to the domain gap between simulated and physical systems, coupled with limited real-world sample availability. We propose a novel method for sim-to-real transfer of reinforcement learning policies, based on a reinterpretation of neural style transfer from image processing to synthesise novel training data from unpaired unlabelled real world datasets. We employ a variational autoencoder to jointly learn self-supervised feature representations for style transfer and generate weakly paired source-target trajectories to improve physical realism of synthesised trajectories. We demonstrate the application of our approach based on the case study of robot cutting of unknown materials. Compared to baseline methods, including our previous work, CycleGAN, and conditional variational autoencoder-based time series translation, our approach achieves improved task completion time and behavioural stability with minimal real-world data. Our framework demonstrates robustness to geometric and material variation, and highlights the feasibility of policy adaptation in challenging contact-rich tasks where real-world reward information is unavailable.

Investigating Associational Biases in Inter-Model Communication of Large Generative Models

Social bias in generative AI can manifest not only as performance disparities but also as associational bias, whereby models learn and reproduce stereotypical associations between concepts and demographic groups, even in the absence of explicit demographic information (e.g., associating doctors with men). These associations can persist, propagate, and potentially amplify across repeated exchanges in inter-model communication pipelines, where one generative model's output becomes another's input. This is especially salient for human-centred perception tasks, such as human activity recognition and affect prediction, where inferences about behaviour and internal states can lead to errors or stereotypical associations that propagate into unequal treatment. In this work, focusing on human activity and affective expression, we study how such associations evolve within an inter-model communication pipeline that alternates between image generation and image description. Using the RAF-DB and PHASE datasets, we quantify demographic distribution drift induced by model-to-model information exchange and assess whether these drifts are systematic using an explainability pipeline. Our results reveal demographic drifts toward younger representations for both actions and emotions, as well as toward more female-presenting representations, primarily for emotions. We further find evidence that some predictions are supported by spurious visual regions (e.g., background or hair) rather than concept-relevant cues (e.g., body or face). We also examine whether these demographic drifts translate into measurable differences in downstream behaviour, i.e., while predicting activity and emotion labels. Finally, we outline mitigation strategies spanning data-centric, training and deployment interventions, and emphasise the need for careful safeguards when deploying interconnected models in human-centred AI systems.

When Humans Judge Irises: Pupil Size Normalization as an Aid and Synthetic Irises as a Challenge

Iris recognition is a mature biometric technology offering remarkable precision and speed, and allowing for large-scale deployments to populations exceeding a billion enrolled users (e.g., AADHAAR in India). However, in forensic applications, a human expert may be needed to review and confirm a positive identification before an iris matching result can be presented as evidence in court, especially in cases where processed samples are degraded (e.g., in post-mortem cases) or where there is a need to judge whether the sample is authentic, rather than a result of a presentation attack. This paper presents a study that examines human performance in iris verification in two controlled scenarios: (a) under varying pupil sizes, with and without a linear/nonlinear alignment of the pupil size between compared images, and (b) when both genuine and impostor iris image pairs are synthetically generated. The results demonstrate that pupil size normalization carried out by a modern autoencoder-based identity-preserving image-to-image translation model significantly improves verification accuracy. Participants were also able to determine whether iris pairs corresponded to the same or different eyes when both images were either authentic or synthetic. However, accuracy declined when subjects were comparing authentic irises against high-quality, same-eye synthetic counterparts. These findings (a) demonstrate the importance of pupil-size alignment for iris matching tasks in which humans are involved, and (b) indicate that despite the high fidelity of modern generative models, same-eye synthetic iris images are more often judged by humans as different-eye images, compared to same-eye authentic image pairs. We offer data and human judgments along with this paper to allow full replicability of this study and future works.

Optimization and Mobile Deployment for Anthropocene Neural Style Transfer

This paper presents AnthropoCam, a mobile-based neural style transfer (NST) system optimized for the visual synthesis of Anthropocene environments. Unlike conventional artistic NST, which prioritizes painterly abstraction, stylizing human-altered landscapes demands a careful balance between amplifying material textures and preserving semantic legibility. Industrial infrastructures, waste accumulations, and modified ecosystems contain dense, repetitive patterns that are visually expressive yet highly susceptible to semantic erosion under aggressive style transfer. To address this challenge, we systematically investigate the impact of NST parameter configurations on the visual translation of Anthropocene textures, including feature layer selection, style and content loss weighting, training stability, and output resolution. Through controlled experiments, we identify an optimal parameter manifold that maximizes stylistic expression while preventing semantic erasure. Our results demonstrate that appropriate combinations of convolutional depth, loss ratios, and resolution scaling enable the faithful transformation of anthropogenic material properties into a coherent visual language. Building on these findings, we implement a low-latency, feed-forward NST pipeline deployed on mobile devices. The system integrates a React Native frontend with a Flask-based GPU backend, achieving high-resolution inference within 3-5 seconds on general mobile hardware. This enables real-time, in-situ visual intervention at the site of image capture, supporting participatory engagement with Anthropocene landscapes. By coupling domain-specific NST optimization with mobile deployment, AnthropoCam reframes neural style transfer as a practical and expressive tool for real-time environmental visualization in the Anthropocene.