Enhancing 3D Medical Image Understanding with Pretraining Aided by 2D Multimodal Large Language Models

Understanding 3D medical image volumes is critical in the medical field, yet existing 3D medical convolution and transformer-based self-supervised learning (SSL) methods often lack deep semantic comprehension. Recent advancements in multimodal large language models (MLLMs) provide a promising approach to enhance image understanding through text descriptions. To leverage these 2D MLLMs for improved 3D medical image understanding, we propose Med3DInsight, a novel pretraining framework that integrates 3D image encoders with 2D MLLMs via a specially designed plane-slice-aware transformer module. Additionally, our model employs a partial optimal transport based alignment, demonstrating greater tolerance to noise introduced by potential noises in LLM-generated content. Med3DInsight introduces a new paradigm for scalable multimodal 3D medical representation learning without requiring human annotations. Extensive experiments demonstrate our state-of-the-art performance on two downstream tasks, i.e., segmentation and classification, across various public datasets with CT and MRI modalities, outperforming current SSL methods. Med3DInsight can be seamlessly integrated into existing 3D medical image understanding networks, potentially enhancing their performance. Our source code, generated datasets, and pre-trained models will be available at https://github.com/Qybc/Med3DInsight.

From Detection to Mitigation: Addressing Gender Bias in Chinese Texts via Efficient Tuning and Voting-Based Rebalancing

This paper presents our team's solution to Shared Task 7 of NLPCC-2025, which focuses on sentence-level gender bias detection and mitigation in Chinese. The task aims to promote fairness and controllability in natural language generation by automatically detecting, classifying, and mitigating gender bias. To address this challenge, we adopt a fine-tuning approach based on large language models (LLMs), efficiently adapt to the bias detection task via Low-Rank Adaptation (LoRA). In terms of data processing, we construct a more balanced training set to alleviate class imbalance and introduce heterogeneous samples from multiple sources to enhance model generalization. For the detection and classification sub-tasks, we employ a majority voting strategy that integrates outputs from multiple expert models to boost performance. Additionally, to improve bias generation detection and mitigation, we design a multi-temperature sampling mechanism to capture potential variations in bias expression styles. Experimental results demonstrate the effectiveness of our approach in bias detection, classification, and mitigation. Our method ultimately achieves an average score of 47.90%, ranking fourth in the shared task.

Classifier Language Models: Unifying Sparse Finetuning and Adaptive Tokenization for Specialized Classification Tasks

Semantic text classification requires the understanding of the contextual significance of specific tokens rather than surface-level patterns or keywords (as in rule-based or statistical text classification), making large language models (LLMs) well-suited for this task. However, semantic classification applications in industry, like customer intent detection or semantic role labeling, tend to be highly specialized. They require annotation by domain experts in contrast to general-purpose corpora for pretraining. Further, they typically require high inference throughputs which limits the model size from latency and cost perspectives. Thus, for a range of specialized classification tasks, the preferred solution is to develop customized classifiers by finetuning smaller language models (e.g., mini-encoders, small language models). In this work, we develop a token-driven sparse finetuning strategy to adapt small language models to specialized classification tasks. We identify and finetune a small sensitive subset of model parameters by leveraging task-specific token constructs in the finetuning dataset, while leaving most of the pretrained weights unchanged. Unlike adapter approaches such as low rank adaptation (LoRA), we do not introduce additional parameters to the model. Our approach identifies highly relevant semantic tokens (case study in the Appendix) and outperforms end-to-end finetuning, LoRA, layer selection, and prefix tuning on five diverse semantic classification tasks. We achieve greater stability and half the training costs vs. end-to-end finetuning.

Spoken in Jest, Detected in Earnest: A Systematic Review of Sarcasm Recognition -- Multimodal Fusion, Challenges, and Future Prospects

Sarcasm, a common feature of human communication, poses challenges in interpersonal interactions and human-machine interactions. Linguistic research has highlighted the importance of prosodic cues, such as variations in pitch, speaking rate, and intonation, in conveying sarcastic intent. Although previous work has focused on text-based sarcasm detection, the role of speech data in recognizing sarcasm has been underexplored. Recent advancements in speech technology emphasize the growing importance of leveraging speech data for automatic sarcasm recognition, which can enhance social interactions for individuals with neurodegenerative conditions and improve machine understanding of complex human language use, leading to more nuanced interactions. This systematic review is the first to focus on speech-based sarcasm recognition, charting the evolution from unimodal to multimodal approaches. It covers datasets, feature extraction, and classification methods, and aims to bridge gaps across diverse research domains. The findings include limitations in datasets for sarcasm recognition in speech, the evolution of feature extraction techniques from traditional acoustic features to deep learning-based representations, and the progression of classification methods from unimodal approaches to multimodal fusion techniques. In so doing, we identify the need for greater emphasis on cross-cultural and multilingual sarcasm recognition, as well as the importance of addressing sarcasm as a multimodal phenomenon, rather than a text-based challenge.

"Humor, Art, or Misinformation?": A Multimodal Dataset for Intent-Aware Synthetic Image Detection

Recent advances in multimodal AI have enabled progress in detecting synthetic and out-of-context content. However, existing efforts largely overlook the intent behind AI-generated images. To fill this gap, we introduce S-HArM, a multimodal dataset for intent-aware classification, comprising 9,576 "in the wild" image-text pairs from Twitter/X and Reddit, labeled as Humor/Satire, Art, or Misinformation. Additionally, we explore three prompting strategies (image-guided, description-guided, and multimodally-guided) to construct a large-scale synthetic training dataset with Stable Diffusion. We conduct an extensive comparative study including modality fusion, contrastive learning, reconstruction networks, attention mechanisms, and large vision-language models. Our results show that models trained on image- and multimodally-guided data generalize better to "in the wild" content, due to preserved visual context. However, overall performance remains limited, highlighting the complexity of inferring intent and the need for specialized architectures.

SinLlama -- A Large Language Model for Sinhala

Low-resource languages such as Sinhala are often overlooked by open-source Large Language Models (LLMs). In this research, we extend an existing multilingual LLM (Llama-3-8B) to better serve Sinhala. We enhance the LLM tokenizer with Sinhala specific vocabulary and perform continual pre-training on a cleaned 10 million Sinhala corpus, resulting in the SinLlama model. This is the very first decoder-based open-source LLM with explicit Sinhala support. When SinLlama was instruction fine-tuned for three text classification tasks, it outperformed base and instruct variants of Llama-3-8B by a significant margin.

PromptGuard: An Orchestrated Prompting Framework for Principled Synthetic Text Generation for Vulnerable Populations using LLMs with Enhanced Safety, Fairness, and Controllability

The proliferation of Large Language Models (LLMs) in real-world applications poses unprecedented risks of generating harmful, biased, or misleading information to vulnerable populations including LGBTQ+ individuals, single parents, and marginalized communities. While existing safety approaches rely on post-hoc filtering or generic alignment techniques, they fail to proactively prevent harmful outputs at the generation source. This paper introduces PromptGuard, a novel modular prompting framework with our breakthrough contribution: VulnGuard Prompt, a hybrid technique that prevents harmful information generation using real-world data-driven contrastive learning. VulnGuard integrates few-shot examples from curated GitHub repositories, ethical chain-of-thought reasoning, and adaptive role-prompting to create population-specific protective barriers. Our framework employs theoretical multi-objective optimization with formal proofs demonstrating 25-30% analytical harm reduction through entropy bounds and Pareto optimality. PromptGuard orchestrates six core modules: Input Classification, VulnGuard Prompting, Ethical Principles Integration, External Tool Interaction, Output Validation, and User-System Interaction, creating an intelligent expert system for real-time harm prevention. We provide comprehensive mathematical formalization including convergence proofs, vulnerability analysis using information theory, and theoretical validation framework using GitHub-sourced datasets, establishing mathematical foundations for systematic empirical research.

Hierarchical Text Classification Using Black Box Large Language Models

Hierarchical Text Classification (HTC) aims to assign texts to structured label hierarchies; however, it faces challenges due to data scarcity and model complexity. This study explores the feasibility of using black box Large Language Models (LLMs) accessed via APIs for HTC, as an alternative to traditional machine learning methods that require extensive labeled data and computational resources. We evaluate three prompting strategies -- Direct Leaf Label Prediction (DL), Direct Hierarchical Label Prediction (DH), and Top-down Multi-step Hierarchical Label Prediction (TMH) -- in both zero-shot and few-shot settings, comparing the accuracy and cost-effectiveness of these strategies. Experiments on two datasets show that a few-shot setting consistently improves classification accuracy compared to a zero-shot setting. While a traditional machine learning model achieves high accuracy on a dataset with a shallow hierarchy, LLMs, especially DH strategy, tend to outperform the machine learning model on a dataset with a deeper hierarchy. API costs increase significantly due to the higher input tokens required for deeper label hierarchies on DH strategy. These results emphasize the trade-off between accuracy improvement and the computational cost of prompt strategy. These findings highlight the potential of black box LLMs for HTC while underscoring the need to carefully select a prompt strategy to balance performance and cost.

MedVista3D: Vision-Language Modeling for Reducing Diagnostic Errors in 3D CT Disease Detection, Understanding and Reporting

Radiologic diagnostic errors-under-reading errors, inattentional blindness, and communication failures-remain prevalent in clinical practice. These issues often stem from missed localized abnormalities, limited global context, and variability in report language. These challenges are amplified in 3D imaging, where clinicians must examine hundreds of slices per scan. Addressing them requires systems with precise localized detection, global volume-level reasoning, and semantically consistent natural language reporting. However, existing 3D vision-language models are unable to meet all three needs jointly, lacking local-global understanding for spatial reasoning and struggling with the variability and noise of uncurated radiology reports. We present MedVista3D, a multi-scale semantic-enriched vision-language pretraining framework for 3D CT analysis. To enable joint disease detection and holistic interpretation, MedVista3D performs local and global image-text alignment for fine-grained representation learning within full-volume context. To address report variability, we apply language model rewrites and introduce a Radiology Semantic Matching Bank for semantics-aware alignment. MedVista3D achieves state-of-the-art performance on zero-shot disease classification, report retrieval, and medical visual question answering, while transferring well to organ segmentation and prognosis prediction. Code and datasets will be released.

A Generative Foundation Model for Chest Radiography

The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop `ChexGen', a generative vision-language foundation model that introduces a unified framework for text-, mask-, and bounding box-guided synthesis of chest radiographs. Built upon the latent diffusion transformer architecture, ChexGen was pretrained on the largest curated chest X-ray dataset to date, consisting of 960,000 radiograph-report pairs. ChexGen achieves accurate synthesis of radiographs through expert evaluations and quantitative metrics. We demonstrate the utility of ChexGen for training data augmentation and supervised pretraining, which led to performance improvements across disease classification, detection, and segmentation tasks using a small fraction of training data. Further, our model enables the creation of diverse patient cohorts that enhance model fairness by detecting and mitigating demographic biases. Our study supports the transformative role of generative foundation models in building more accurate, data-efficient, and equitable medical AI systems.