MAT-Cell: A Multi-Agent Tree-Structured Reasoning Framework for Batch-Level Single-Cell Annotation

Automated cellular reasoning faces a core dichotomy: supervised methods fall into the Reference Trap and fail to generalize to out-of-distribution cell states, while large language models (LLMs), without grounded biological priors, suffer from a Signal-to-Noise Paradox that produces spurious associations. We propose MAT-Cell, a neuro-symbolic reasoning framework that reframes single-cell analysis from black-box classification into constructive, verifiable proof generation. MAT-Cell injects symbolic constraints through adaptive Retrieval-Augmented Generation (RAG) to ground neural reasoning in biological axioms and reduce transcriptomic noise. It further employs a dialectic verification process with homogeneous rebuttal agents to audit and prune reasoning paths, forming syllogistic derivation trees that enforce logical consistency.Across large-scale and cross-species benchmarks, MAT-Cell significantly outperforms state-of-the-art (SOTA) models and maintains robust per-formance in challenging scenarios where baselinemethods severely degrade. Code is available at https://gith ub.com/jiangliu91/MAT-Cell-A-Mul ti-Agent-Tree-Structured-Reasoni ng-Framework-for-Batch-Level-Sin gle-Cell-Annotation.

Curvature-Aware Optimization for High-Accuracy Physics-Informed Neural Networks

Efficient and robust optimization is essential for neural networks, enabling scientific machine learning models to converge rapidly to very high accuracy -- faithfully capturing complex physical behavior governed by differential equations. In this work, we present advanced optimization strategies to accelerate the convergence of physics-informed neural networks (PINNs) for challenging partial (PDEs) and ordinary differential equations (ODEs). Specifically, we provide efficient implementations of the Natural Gradient (NG) optimizer, Self-Scaling BFGS and Broyden optimizers, and demonstrate their performance on problems including the Helmholtz equation, Stokes flow, inviscid Burgers equation, Euler equations for high-speed flows, and stiff ODEs arising in pharmacokinetics and pharmacodynamics. Beyond optimizer development, we also propose new PINN-based methods for solving the inviscid Burgers and Euler equations, and compare the resulting solutions against high-order numerical methods to provide a rigorous and fair assessment. Finally, we address the challenge of scaling these quasi-Newton optimizers for batched training, enabling efficient and scalable solutions for large data-driven problems.

Efficient Logistic Regression with Mixture of Sigmoids

This paper studies the Exponential Weights (EW) algorithm with an isotropic Gaussian prior for online logistic regression. We show that the near-optimal worst-case regret bound $O(d\log(Bn))$ for EW, established by Kakade and Ng (2005) against the best linear predictor of norm at most $B$, can be achieved with total worst-case computational complexity $O(B^3 n^5)$. This substantially improves on the $O(B^{18}n^{37})$ complexity of prior work achieving the same guarantee (Foster et al., 2018). Beyond efficiency, we analyze the large-$B$ regime under linear separability: after rescaling by $B$, the EW posterior converges as $B\to\infty$ to a standard Gaussian truncated to the version cone. Accordingly, the predictor converges to a solid-angle vote over separating directions and, on every fixed-margin slice of this cone, the mode of the corresponding truncated Gaussian is aligned with the hard-margin SVM direction. Using this geometry, we derive non-asymptotic regret bounds showing that once $B$ exceeds a margin-dependent threshold, the regret becomes independent of $B$ and grows only logarithmically with the inverse margin. Overall, our results show that EW can be both computationally tractable and geometrically adaptive in online classification.

Spectral Super-Resolution via Adversarial Unfolding and Data-Driven Spectrum Regularization: From Multispectral Satellite Data to NASA Hyperspectral Image

The European Space Agency's Sentinel-2 satellite provides global multispectral coverage for remote sensing (RS) applications. However, limited spectral resolution (12 bands) and non-unified spatial resolution (60/20/10 m) restrict their practicality. In contrast, the high spectral-spatial resolution sensor (e.g., NASA's AVIRIS-NG) covers only the American region due to practical considerations. This raises a fundamental question: ``Can a global hyperspectral coverage be achieved by reconstructing Sentinel-2 data to NASA hyperspectral images?'' This study aims to achieve spectral super-resolution from 12-to-186 and unify the spatial resolution of Sentinel-2 data to 5 m. To enable a reliable and efficient reconstruction, we formulate a novel deep unfolding framework regularized by a data-driven spectrum prior from PriorNet, instead of relying on implicit deep priors as conventional deep unfolding does. Moreover, an adversarial term is integrated into the unfolded architecture, enabling the discriminator to guide the reconstruction in both the training and testing phases; we term this novel concept unfolding adversarial learning (UAL). Experiments show that our UALNet outperforms the next-best Transformer in PSNR, SSIM, and SAM, while requiring only 15% MACs and 20 times fewer parameters. The associated code will be publicly available at https://sites.google.com/view/chiahsianglin/software.

Assessing Ionospheric Scintillation Risk for Direct-to-Cellular Communications using Frequency-Scaled GNSS Observations

One of the key issues facing Direct-to-Cellular (D2C) satellite communication systems is ionospheric scintillation on the uplink and downlink, which can significantly degrade link quality. This work investigates the spatial and temporal characteristics of amplitude scintillation at D2C frequencies by scaling L-band scintillation observations from Global Navigation Satellite Systems (GNSS) receivers to bands relevant to D2C operation, including the low-band, and 3GPP's N255 and N256. These observations are then compared to scaled radio-occultation scintillation observations from the FORMOSAT-7/COSMIC-2 (F7/C2) mission, which can be used in regions that do not possess ground-based scintillation monitoring stations. As a proof of concept, five years of ground-based GNSS scintillation data from Sharjah, United Arab Emirates, together with two years of F7/C2 observations over the same region, corresponding to the ascending phase of Solar Cycle 25, are analyzed. Both space-based and ground-based observations indicate a pronounced diurnal scintillation peak between 20--22 local time, particularly during the equinoxes, with occurrence rates increasing with solar activity. Ground-based observations also reveal a strong azimuth dependence, with most scintillation events occurring on southward satellite links. The scintillation occurrence rate at the low-band is more than twice that observed at N255 and N256, highlighting the increased robustness of higher D2C bands to ionospheric scintillation. These results demonstrate how GNSS scintillation observations can be leveraged to characterize and anticipate scintillation-induced D2C link impairments, which help in D2C system design and the implementation of scintillation mitigation strategies.

Red-teaming the Multimodal Reasoning: Jailbreaking Vision-Language Models via Cross-modal Entanglement Attacks

Vision-Language Models (VLMs) with multimodal reasoning capabilities are high-value attack targets, given their potential for handling complex multimodal harmful tasks. Mainstream black-box jailbreak attacks on VLMs work by distributing malicious clues across modalities to disperse model attention and bypass safety alignment mechanisms. However, these adversarial attacks rely on simple and fixed image-text combinations that lack attack complexity scalability, limiting their effectiveness for red-teaming VLMs' continuously evolving reasoning capabilities. We propose \textbf{CrossTALK} (\textbf{\underline{Cross}}-modal en\textbf{\underline{TA}}ng\textbf{\underline{L}}ement attac\textbf{\underline{K}}), which is a scalable approach that extends and entangles information clues across modalities to exceed VLMs' trained and generalized safety alignment patterns for jailbreak. Specifically, {knowledge-scalable reframing} extends harmful tasks into multi-hop chain instructions, {cross-modal clue entangling} migrates visualizable entities into images to build multimodal reasoning links, and {cross-modal scenario nesting} uses multimodal contextual instructions to steer VLMs toward detailed harmful outputs. Experiments show our COMET achieves state-of-the-art attack success rate.

ALIEN: Analytic Latent Watermarking for Controllable Generation

Watermarking is a technical alternative to safeguarding intellectual property and reducing misuse. Existing methods focus on optimizing watermarked latent variables to balance watermark robustness and fidelity, as Latent diffusion models (LDMs) are considered a powerful tool for generative tasks. However, reliance on computationally intensive heuristic optimization for iterative signal refinement results in high training overhead and local optima entrapment.To address these issues, we propose an \underline{A}na\underline{l}ytical Watermark\underline{i}ng Framework for Controllabl\underline{e} Generatio\underline{n} (ALIEN). We develop the first analytical derivation of the time-dependent modulation coefficient that guides the diffusion of watermark residuals to achieve controllable watermark embedding pattern.Experimental results show that ALIEN-Q outperforms the state-of-the-art by 33.1\% across 5 quality metrics, and ALIEN-R demonstrates 14.0\% improved robustness against generative variant and stability threats compared to the state-of-the-art across 15 distinct conditions. Code can be available at https://anonymous.4open.science/r/ALIEN/.

MAD-NG: Meta-Auto-Decoder Neural Galerkin Method for Solving Parametric Partial Differential Equations

Parametric partial differential equations (PDEs) are fundamental for modeling a wide range of physical and engineering systems influenced by uncertain or varying parameters. Traditional neural network-based solvers, such as Physics-Informed Neural Networks (PINNs) and Deep Galerkin Methods, often face challenges in generalization and long-time prediction efficiency due to their dependence on full space-time approximations. To address these issues, we propose a novel and scalable framework that significantly enhances the Neural Galerkin Method (NGM) by incorporating the Meta-Auto-Decoder (MAD) paradigm. Our approach leverages space-time decoupling to enable more stable and efficient time integration, while meta-learning-driven adaptation allows rapid generalization to unseen parameter configurations with minimal retraining. Furthermore, randomized sparse updates effectively reduce computational costs without compromising accuracy. Together, these advancements enable our method to achieve physically consistent, long-horizon predictions for complex parameterized evolution equations with significantly lower computational overhead. Numerical experiments on benchmark problems demonstrate that our methods performs comparatively well in terms of accuracy, robustness, and adaptability.

Deep learning-enhanced dual-mode multiplexed optical sensor for point-of-care diagnostics of cardiovascular diseases

Rapid and accessible cardiac biomarker testing is essential for the timely diagnosis and risk assessment of myocardial infarction (MI) and heart failure (HF), two interrelated conditions that frequently coexist and drive recurrent hospitalizations with high mortality. However, current laboratory and point-of-care testing systems are limited by long turnaround times, narrow dynamic ranges for the tested biomarkers, and single-analyte formats that fail to capture the complexity of cardiovascular disease. Here, we present a deep learning-enhanced dual-mode multiplexed vertical flow assay (xVFA) with a portable optical reader and a neural network-based quantification pipeline. This optical sensor integrates colorimetric and chemiluminescent detection within a single paper-based cartridge to complementarily cover a large dynamic range (spanning ~6 orders of magnitude) for both low- and high-abundance biomarkers, while maintaining quantitative accuracy. Using 50 uL of serum, the optical sensor simultaneously quantifies cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) within 23 min. The xVFA achieves sub-pg/mL sensitivity for cTnI and sub-ng/mL sensitivity for CK-MB and NT-proBNP, spanning the clinically relevant ranges for these biomarkers. Neural network models trained and blindly tested on 92 patient serum samples yielded a robust quantification performance (Pearson's r > 0.96 vs. reference assays). By combining high sensitivity, multiplexing, and automation in a compact and cost-effective optical sensor format, the dual-mode xVFA enables rapid and quantitative cardiovascular diagnostics at the point of care.

Next-generation reservoir computing validated by classification task

An emerging computing paradigm, so-called next-generation reservoir computing (NG-RC) is investigated. True to its namesake, NG-RC requires no actual reservoirs for input data mixing but rather computing the polynomial terms directly from the time series inputs. However, benchmark tests so far reported have been one-sided, limited to prediction tasks of temporal waveforms such as Lorenz 63 attractor and Mackey-Glass chaotic signal. We will demonstrate for the first time that NG-RC can perform classification task as good as conventional RC. This validates the versatile computational capability of NG-RC in tasks of both prediction and classification.