Image augmentation is a data augmentation method that generates more training data from the existing training samples. Image Augmentation is especially useful in domains where training data is limited or expensive to obtain, like in biomedical applications.
Data augmentation has long been a cornerstone for reducing overfitting in vision models, with methods like AutoAugment automating the design of task-specific augmentations. Recent advances in generative models, such as conditional diffusion and few-shot NeRFs, offer a new paradigm for data augmentation by synthesizing data with significantly greater diversity and realism. However, unlike traditional augmentations like cropping or rotation, these methods introduce substantial changes that enhance robustness but also risk degrading performance if the augmentations are poorly matched to the task. In this work, we present EvoAug, an automated augmentation learning pipeline, which leverages these generative models alongside an efficient evolutionary algorithm to learn optimal task-specific augmentations. Our pipeline introduces a novel approach to image augmentation that learns stochastic augmentation trees that hierarchically compose augmentations, enabling more structured and adaptive transformations. We demonstrate strong performance across fine-grained classification and few-shot learning tasks. Notably, our pipeline discovers augmentations that align with domain knowledge, even in low-data settings. These results highlight the potential of learned generative augmentations, unlocking new possibilities for robust model training.
With the rapid advancement of image generative models, generative data augmentation has become an effective way to enrich training images, especially when only small-scale datasets are available. At the same time, in practical applications, generative data augmentation can be vulnerable to clean-label backdoor attacks, which aim to bypass human inspection. However, based on theoretical analysis and preliminary experiments, we observe that directly applying existing pixel-level clean-label backdoor attack methods (e.g., COMBAT) to generated images results in low attack success rates. This motivates us to move beyond pixel-level triggers and focus instead on the latent feature level. To this end, we propose InvLBA, an invisible clean-label backdoor attack method for generative data augmentation by latent perturbation. We theoretically prove that the generalization of the clean accuracy and attack success rates of InvLBA can be guaranteed. Experiments on multiple datasets show that our method improves the attack success rate by 46.43% on average, with almost no reduction in clean accuracy and high robustness against SOTA defense methods.
Chimeric antigen receptor (CAR)-T and NK cell immunotherapies have transformed cancer treatment, and recent studies suggest that the quality of the CAR-T/NK cell immunological synapse (IS) may serve as a functional biomarker for predicting therapeutic efficacy. Accurate detection and segmentation of CAR-T/NK IS structures using artificial neural networks (ANNs) can greatly increase the speed and reliability of IS quantification. However, a persistent challenge is the limited size of annotated microscopy datasets, which restricts the ability of ANNs to generalize. To address this challenge, we integrate two complementary data-augmentation frameworks. First, we employ Instance Aware Automatic Augmentation (IAAA), an automated, instance-preserving augmentation method that generates synthetic CAR-T/NK IS images and corresponding segmentation masks by applying optimized augmentation policies to original IS data. IAAA supports multiple imaging modalities (e.g., fluorescence and brightfield) and can be applied directly to CAR-T/NK IS images derived from patient samples. In parallel, we introduce a Semantic-Aware AI Augmentation (SAAA) pipeline that combines a diffusion-based mask generator with a Pix2Pix conditional image synthesizer. This second method enables the creation of diverse, anatomically realistic segmentation masks and produces high-fidelity CAR-T/NK IS images aligned with those masks, further expanding the training corpus beyond what IAAA alone can provide. Together, these augmentation strategies generate synthetic images whose visual and structural properties closely match real IS data, significantly improving CAR-T/NK IS detection and segmentation performance. By enhancing the robustness and accuracy of IS quantification, this work supports the development of more reliable imaging-based biomarkers for predicting patient response to CAR-T/NK immunotherapy.
Logical anomalies are violations of predefined constraints on object quantity, spatial layout, and compositional relationships in industrial images. While prior work largely treats anomaly detection as a binary decision, such formulations cannot indicate which logical rule is broken and therefore offer limited value for quality assurance. We introduce Logical Anomaly Classification (LAC), a task that unifies anomaly detection and fine-grained violation classification in a single inference step. To tackle LAC, we propose LogiCls, a vision-language framework that decomposes complex logical constraints into a sequence of verifiable subqueries. We further present a data-centric instruction synthesis pipeline that generates chain-of-thought (CoT) supervision for these subqueries, coupling precise grounding annotations with diverse image-text augmentations to adapt vision language models (VLMs) to logic-sensitive reasoning. Training is stabilized by a difficulty-aware resampling strategy that emphasizes challenging subqueries and long tail constraint types. Extensive experiments demonstrate that LogiCls delivers robust, interpretable, and accurate industrial logical anomaly classification, providing both the predicted violation categories and their evidence trails.
Long-horizon omnimodal question answering answers questions by reasoning over text, images, audio, and video. Despite recent progress on OmniLLMs, low-resource long audio-video QA still suffers from costly dense encoding, weak fine-grained retrieval, limited proactive planning, and no clear end-to-end optimization.To address these issues, we propose OmniRAG-Agent, an agentic omnimodal QA method for budgeted long audio-video reasoning. It builds an image-audio retrieval-augmented generation module that lets an OmniLLM fetch short, relevant frames and audio snippets from external banks. Moreover, it uses an agent loop that plans, calls tools across turns, and merges retrieved evidence to answer complex queries. Furthermore, we apply group relative policy optimization to jointly improve tool use and answer quality over time. Experiments on OmniVideoBench, WorldSense, and Daily-Omni show that OmniRAG-Agent consistently outperforms prior methods under low-resource settings and achieves strong results, with ablations validating each component.
Retinal diseases spanning a broad spectrum can be effectively identified and diagnosed using complementary signals from multimodal data. However, multimodal diagnosis in ophthalmic practice is typically challenged in terms of data heterogeneity, potential invasiveness, registration complexity, and so on. As such, a unified framework that integrates multimodal data synthesis and fusion is proposed for retinal disease classification and grading. Specifically, the synthesized multimodal data incorporates fundus fluorescein angiography (FFA), multispectral imaging (MSI), and saliency maps that emphasize latent lesions as well as optic disc/cup regions. Parallel models are independently trained to learn modality-specific representations that capture cross-pathophysiological signatures. These features are then adaptively calibrated within and across modalities to perform information pruning and flexible integration according to downstream tasks. The proposed learning system is thoroughly interpreted through visualizations in both image and feature spaces. Extensive experiments on two public datasets demonstrated the superiority of our approach over state-of-the-art ones in the tasks of multi-label classification (F1-score: 0.683, AUC: 0.953) and diabetic retinopathy grading (Accuracy:0.842, Kappa: 0.861). This work not only enhances the accuracy and efficiency of retinal disease screening but also offers a scalable framework for data augmentation across various medical imaging modalities.
Multimodal Large Language Models (MLLMs) have significantly advanced vision-language understanding. However, even state-of-the-art models struggle with geometric reasoning, revealing a critical bottleneck: the extreme scarcity of high-quality image-text pairs. Human annotation is prohibitively expensive, while automated methods fail to ensure fidelity and training effectiveness. Existing approaches either passively adapt to available images or employ inefficient random exploration with filtering, decoupling generation from learning needs. We propose Socratic-Geo, a fully autonomous framework that dynamically couples data synthesis with model learning through multi-agent interaction. The Teacher agent generates parameterized Python scripts with reflective feedback (Reflect for solvability, RePI for visual validity), ensuring image-text pair purity. The Solver agent optimizes reasoning through preference learning, with failure paths guiding Teacher's targeted augmentation. Independently, the Generator learns image generation capabilities on accumulated "image-code-instruction" triplets, distilling programmatic drawing intelligence into visual generation. Starting from only 108 seed problems, Socratic-Solver achieves 49.11 on six benchmarks using one-quarter of baseline data, surpassing strong baselines by 2.43 points. Socratic-Generator achieves 42.4% on GenExam, establishing new state-of-the-art for open-source models, surpassing Seedream-4.0 (39.8%) and approaching Gemini-2.5-Flash-Image (43.1%).
Multi-organ segmentation is a widely applied clinical routine and automated organ segmentation tools dramatically improve the pipeline of the radiologists. Recently, deep learning (DL) based segmentation models have shown the capacity to accomplish such a task. However, the training of the segmentation networks requires large amount of data with manual annotations, which is a major concern due to the data scarcity from clinic. Working with limited data is still common for researches on novel imaging modalities. To enhance the effectiveness of DL models trained with limited data, data augmentation (DA) is a crucial regularization technique. Traditional DA (TDA) strategies focus on basic intra-image operations, i.e. generating images with different orientations and intensity distributions. In contrast, the interimage and object-level DA operations are able to create new images from separate individuals. However, such DA strategies are not well explored on the task of multi-organ segmentation. In this paper, we investigated four possible inter-image DA strategies: CutMix, CarveMix, ObjectAug and AnatoMix, on two organ segmentation datasets. The result shows that CutMix, CarveMix and AnatoMix can improve the average dice score by 4.9, 2.0 and 1.9, compared with the state-of-the-art nnUNet without DA strategies. These results can be further improved by adding TDA strategies. It is revealed in our experiments that Cut-Mix is a robust but simple DA strategy to drive up the segmentation performance for multi-organ segmentation, even when CutMix produces intuitively 'wrong' images. Our implementation is publicly available for future benchmarks.
Synthetic data, an appealing alternative to extensive expert-annotated data for medical image segmentation, consistently fails to improve segmentation performance despite its visual realism. The reason being that synthetic and real medical images exist in different semantic feature spaces, creating a domain gap that current semi-supervised learning methods cannot bridge. We propose SRA-Seg, a framework explicitly designed to align synthetic and real feature distributions for medical image segmentation. SRA-Seg introduces a similarity-alignment (SA) loss using frozen DINOv2 embeddings to pull synthetic representations toward their nearest real counterparts in semantic space. We employ soft edge blending to create smooth anatomical transitions and continuous labels, eliminating the hard boundaries from traditional copy-paste augmentation. The framework generates pseudo-labels for synthetic images via an EMA teacher model and applies soft-segmentation losses that respect uncertainty in mixed regions. Our experiments demonstrate strong results: using only 10% labeled real data and 90% synthetic unlabeled data, SRA-Seg achieves 89.34% Dice on ACDC and 84.42% on FIVES, significantly outperforming existing semi-supervised methods and matching the performance of methods using real unlabeled data.
Defect depth quantification in additively manufactured (AM) components remains a significant challenge for non-destructive testing (NDT). This study proposes a Pixel-wise Quantitative Thermography Neural Network (PQT-Net) to address this challenge for polylactic acid (PLA) parts. A key innovation is a novel data augmentation strategy that reconstructs thermal sequence data into two-dimensional stripe images, preserving the complete temporal evolution of heat diffusion for each pixel. The PQT-Net architecture incorporates a pre-trained EfficientNetV2-S backbone and a custom Residual Regression Head (RRH) with learnable parameters to refine outputs. Comparative experiments demonstrate the superiority of PQT-Net over other deep learning models, achieving a minimum Mean Absolute Error (MAE) of 0.0094 mm and a coefficient of determination (R) exceeding 99%. The high precision of PQT-Net underscores its potential for robust quantitative defect characterization in AM.