StanceFlip: A Comprehensive Multi-Dimensional Benchmark for Multimodal Conversational Stance Flipping Forecasting

Conversational stance detection has shifted from static text analysis to dynamic multimodal modeling. However, existing benchmarks exhibit three key limitations: failure to capture the dynamic evolution of beliefs, particularly during stance reversals; difficulty in disentangling affective states from logical reasoning; and neglect of the critical role of multimodal cues in resolving pragmatic ambiguities such as sarcasm. To address these limitations, we propose StanceFlip, a benchmark designed for multimodal conversational stance flipping forecasting over multi-turn dialogues across five modalities and multi-scenarios, which includes two novel subtasks: 1) Multimodal Stance Sextuple Extraction, extracting holder, target, emotion, sentiment, stance, and rationale as static state snapshots of dialogue to capture fine-grained cognitive structures. 2) Dynamic Stance Flip Attribution, tracking stance reversals across the conversation and identifying their underlying triggers. Alongside the dataset, we propose a dedicated framework, named ConStaFF, for Multimodal Conversational Stance Flipping Forecasting (MCSFF). Built upon a large language model, ConStaFF performs end-to-end stance reasoning, with a Thought-of-Stance (ToS) reasoning framework and a self-reflective verification mechanism integrated for structured stance modeling and faithful flip attribution. Specifically, ToS decomposes the reasoning process into specialized cognitive personas to formulate target propositions, resolve cross-modal conflicts, and infer historical stance trajectories. Extensive experiments show that our approach achieves state-of-the-art performance on both sextuple extraction and flip-trigger attribution, outperforming strong multimodal large language model baselines by substantial margins.

Biological Sequence with Language Model Prompting: A Survey

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis and synthesis, attracting widespread attention from academics and medicine. In this paper, we systematically investigate the application of prompt-based methods with LLMs to biological sequences, including DNA, RNA, proteins, and drug discovery tasks. Specifically, we focus on how prompt engineering enables LLMs to tackle domain-specific problems, such as promoter sequence prediction, protein structure modeling, and drug-target binding affinity prediction, often with limited labeled data. Furthermore, our discussion highlights the transformative potential of prompting in bioinformatics while addressing key challenges such as data scarcity, multimodal fusion, and computational resource limitations. Our aim is for this paper to function both as a foundational primer for newcomers and a catalyst for continued innovation within this dynamic field of study.