RefDecoder: Enhancing Visual Generation with Conditional Video Decoding

Video generation powers a vast array of downstream applications. However, while the de facto standard, i.e., latent diffusion models, typically employ heavily conditioned denoising networks, their decoders often remain unconditional. We observe that this architectural asymmetry leads to significant loss of detail and inconsistency relative to the input image. To address this, we argue that the decoder requires equal conditioning to preserve structural integrity. We introduce RefDecoder, a reference-conditioned video VAE decoder by injecting high-fidelity reference image signal directly into the decoding process via reference attention. Specifically, a lightweight image encoder maps the reference frame into the detail-rich high-dimensional tokens, which are co-processed with the denoised video latent tokens at each decoder up-sampling stage. We demonstrate consistent improvements across several distinct decoder backbones (e.g., Wan 2.1 and VideoVAE+), achieving up to +2.1dB PSNR over the unconditional baselines on the Inter4K, WebVid, and Large Motion reconstruction benchmarks. Notably, RefDecoder can be directly swapped into existing video generation systems without additional fine-tuning, and we report across-the-board improvements in subject consistency, background consistency, and overall quality scores on the VBench I2V benchmark. Beyond I2V, RefDecoder generalizes well to a wide range of visual generation tasks such as style transfer and video editing refinement.

A multi-stage soft computing framework for complex disease modelling and decision support: A liver cirrhosis case study

Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling complex diseases from biomedical data is computationally challenging due to high dimensionality, strong feature correlations, noise, and limited labelled samples. Conventional Machine Learning (ML) pipelines often struggle with robustness, interpretability, and generalisation under such conditions. In this study, we propose an ML-driven multi-stage decision framework for complex disease modelling and therapeutic exploration. The framework integrates single-cell transcriptomic profiling, high-dimensional network-based feature stabilisation, multi-model learning, deep representation construction, and post-hoc decision support. Specifically, single-cell sequencing data were analysed to identify key cellular subpopulations, followed by high-dimensional weighted gene co-expression network analysis (hdWGCNA) to stabilise gene modules under sparsity and noise. To enhance non-linear feature interaction modelling, tabular molecular features were restructured into two-dimensional disease maps and analysed using a CNN. Finally, molecular docking was incorporated as a decision-support module to evaluate candidate therapeutic compounds. Using liver cirrhosis as a representative case, the framework identified a disease-associated endothelial subpopulation and extracted seven robust signature genes (HSPB1, GADD45A, CLDN5, ATP1B3, C1QBP, ENPP2, and PARL). The CNN-based representation learning module outperformed conventional pipelines in classification. The framework is disease-agnostic and readily extends to other omics-driven biomedical applications involving uncertainty, heterogeneity, and limited samples.

Composed Vision-Language Retrieval for Skin Cancer Case Search via Joint Alignment of Global and Local Representations

Medical image retrieval aims to identify clinically relevant lesion cases to support diagnostic decision making, education, and quality control. In practice, retrieval queries often combine a reference lesion image with textual descriptors such as dermoscopic features. We study composed vision-language retrieval for skin cancer, where each query consists of an image to text pair and the database contains biopsy-confirmed, multi-class disease cases. We propose a transformer based framework that learns hierarchical composed query representations and performs joint global-local alignment between queries and candidate images. Local alignment aggregates discriminative regions via multiple spatial attention masks, while global alignment provides holistic semantic supervision. The final similarity is computed through a convex, domain-informed weighting that emphasizes clinically salient local evidence while preserving global consistency. Experiments on the public Derm7pt dataset demonstrate consistent improvements over state-of-the-art methods. The proposed framework enables efficient access to relevant medical records and supports practical clinical deployment.

AgentXRay: White-Boxing Agentic Systems via Workflow Reconstruction

Large Language Models have shown strong capabilities in complex problem solving, yet many agentic systems remain difficult to interpret and control due to opaque internal workflows. While some frameworks offer explicit architectures for collaboration, many deployed agentic systems operate as black boxes to users. We address this by introducing Agentic Workflow Reconstruction (AWR), a new task aiming to synthesize an explicit, interpretable stand-in workflow that approximates a black-box system using only input--output access. We propose AgentXRay, a search-based framework that formulates AWR as a combinatorial optimization problem over discrete agent roles and tool invocations in a chain-structured workflow space. Unlike model distillation, AgentXRay produces editable white-box workflows that match target outputs under an observable, output-based proxy metric, without accessing model parameters. To navigate the vast search space, AgentXRay employs Monte Carlo Tree Search enhanced by a scoring-based Red-Black Pruning mechanism, which dynamically integrates proxy quality with search depth. Experiments across diverse domains demonstrate that AgentXRay achieves higher proxy similarity and reduces token consumption compared to unpruned search, enabling deeper workflow exploration under fixed iteration budgets.

Towards a Science of Collective AI: LLM-based Multi-Agent Systems Need a Transition from Blind Trial-and-Error to Rigorous Science

Recent advancements in Large Language Models (LLMs) have greatly extended the capabilities of Multi-Agent Systems (MAS), demonstrating significant effectiveness across a wide range of complex and open-ended domains. However, despite this rapid progress, the field still relies heavily on empirical trial-and-error. It lacks a unified and principled scientific framework necessary for systematic optimization and improvement. This bottleneck stems from the ambiguity of attribution: first, the absence of a structured taxonomy of factors leaves researchers restricted to unguided adjustments; second, the lack of a unified metric fails to distinguish genuine collaboration gain from mere resource accumulation. In this paper, we advocate for a transition to design science through an integrated framework. We advocate to establish the collaboration gain metric ($Γ$) as the scientific standard to isolate intrinsic gains from increased budgets. Leveraging $Γ$, we propose a factor attribution paradigm to systematically identify collaboration-driving factors. To support this, we construct a systematic MAS factor library, structuring the design space into control-level presets and information-level dynamics. Ultimately, this framework facilitates the transition from blind experimentation to rigorous science, paving the way towards a true science of Collective AI.

Coupled Flow Matching

We introduce Coupled Flow Matching (CPFM), a framework that integrates controllable dimensionality reduction and high-fidelity reconstruction. CPFM learns coupled continuous flows for both the high-dimensional data x and the low-dimensional embedding y, which enables sampling p(y|x) via a latent-space flow and p(x|y) via a data-space flow. Unlike classical dimension-reduction methods, where information discarded during compression is often difficult to recover, CPFM preserves the knowledge of residual information within the weights of a flow network. This design provides bespoke controllability: users may decide which semantic factors to retain explicitly in the latent space, while the complementary information remains recoverable through the flow network. Coupled flow matching builds on two components: (i) an extended Gromov-Wasserstein optimal transport objective that establishes a probabilistic correspondence between data and embeddings, and (ii) a dual-conditional flow-matching network that extrapolates the correspondence to the underlying space. Experiments on multiple benchmarks show that CPFM yields semantically rich embeddings and reconstructs data with higher fidelity than existing baselines.

MemeCMD: An Automatically Generated Chinese Multi-turn Dialogue Dataset with Contextually Retrieved Memes

Memes are widely used in online social interactions, providing vivid, intuitive, and often humorous means to express intentions and emotions. Existing dialogue datasets are predominantly limited to either manually annotated or pure-text conversations, lacking the expressiveness and contextual nuance that multimodal interactions provide.To address these challenges, we introduce MemeCMD, an automatically generated Chinese Multi-turn Dialogue dataset with contextually retrieved memes. Our dataset combines a large-scale, MLLM-annotated meme library with dialogues auto-generated by dual agents across diverse scenarios. We introduce a retrieval framework and adaptive threshold to ensure contextually relevant, naturally spaced meme usage. Experiments demonstrate the effectiveness of our approach in generating contextually appropriate and diverse meme-incorporated dialogues, offering a scalable and privacy-preserving resource for advancing multimodal conversational AI.

MAC-Gaze: Motion-Aware Continual Calibration for Mobile Gaze Tracking

Mobile gaze tracking faces a fundamental challenge: maintaining accuracy as users naturally change their postures and device orientations. Traditional calibration approaches, like one-off, fail to adapt to these dynamic conditions, leading to degraded performance over time. We present MAC-Gaze, a Motion-Aware continual Calibration approach that leverages smartphone Inertial measurement unit (IMU) sensors and continual learning techniques to automatically detect changes in user motion states and update the gaze tracking model accordingly. Our system integrates a pre-trained visual gaze estimator and an IMU-based activity recognition model with a clustering-based hybrid decision-making mechanism that triggers recalibration when motion patterns deviate significantly from previously encountered states. To enable accumulative learning of new motion conditions while mitigating catastrophic forgetting, we employ replay-based continual learning, allowing the model to maintain performance across previously encountered motion conditions. We evaluate our system through extensive experiments on the publicly available RGBDGaze dataset and our own 10-hour multimodal MotionGaze dataset (481K+ images, 800K+ IMU readings), encompassing a wide range of postures under various motion conditions including sitting, standing, lying, and walking. Results demonstrate that our method reduces gaze estimation error by 19.9% on RGBDGaze (from 1.73 cm to 1.41 cm) and by 31.7% on MotionGaze (from 2.81 cm to 1.92 cm) compared to traditional calibration approaches. Our framework provides a robust solution for maintaining gaze estimation accuracy in mobile scenarios.

Approximate Maximum Likelihood Inference for Acoustic Spatial Capture-Recapture with Unknown Identities, Using Monte Carlo Expectation Maximization

Acoustic spatial capture-recapture (ASCR) surveys with an array of synchronized acoustic detectors can be an effective way of estimating animal density or call density. However, constructing the capture histories required for ASCR analysis is challenging, as recognizing which detections at different detectors are of which calls is not a trivial task. Because calls from different distances take different times to arrive at detectors, the order in which calls are detected is not necessarily the same as the order in which they are made, and without knowing which detections are of the same call, we do not know how many different calls are detected. We propose a Monte Carlo expectation-maximization (MCEM) estimation method to resolve this unknown call identity problem. To implement the MCEM method in this context, we sample the latent variables from a complete-data likelihood model in the expectation step and use a semi-complete-data likelihood or conditional likelihood in the maximization step. We use a parametric bootstrap to obtain confidence intervals. When we apply our method to a survey of moss frogs, it gives an estimate within 15% of the estimate obtained using data with call capture histories constructed by experts, and unlike this latter estimate, our confidence interval incorporates the uncertainty about call identities. Simulations show it to have a low bias (6%) and coverage probabilities close to the nominal 95% value.

AI-Enhanced 7-Point Checklist for Melanoma Detection Using Clinical Knowledge Graphs and Data-Driven Quantification

The 7-point checklist (7PCL) is widely used in dermoscopy to identify malignant melanoma lesions needing urgent medical attention. It assigns point values to seven attributes: major attributes are worth two points each, and minor ones are worth one point each. A total score of three or higher prompts further evaluation, often including a biopsy. However, a significant limitation of current methods is the uniform weighting of attributes, which leads to imprecision and neglects their interconnections. Previous deep learning studies have treated the prediction of each attribute with the same importance as predicting melanoma, which fails to recognize the clinical significance of the attributes for melanoma. To address these limitations, we introduce a novel diagnostic method that integrates two innovative elements: a Clinical Knowledge-Based Topological Graph (CKTG) and a Gradient Diagnostic Strategy with Data-Driven Weighting Standards (GD-DDW). The CKTG integrates 7PCL attributes with diagnostic information, revealing both internal and external associations. By employing adaptive receptive domains and weighted edges, we establish connections among melanoma's relevant features. Concurrently, GD-DDW emulates dermatologists' diagnostic processes, who first observe the visual characteristics associated with melanoma and then make predictions. Our model uses two imaging modalities for the same lesion, ensuring comprehensive feature acquisition. Our method shows outstanding performance in predicting malignant melanoma and its features, achieving an average AUC value of 85%. This was validated on the EDRA dataset, the largest publicly available dataset for the 7-point checklist algorithm. Specifically, the integrated weighting system can provide clinicians with valuable data-driven benchmarks for their evaluations.