SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

Modern neuroscience relies on integrating multi-scale, multimodal datasets to uncover the neural principles underlying intelligence. However, analytical challenges posed by highly heterogeneous data and fragmented workflows increasingly constrain discoveries. Here we introduce SeekBrain, an autonomous multi-agent framework designed to accelerate neuroscience discovery through domain-grounded hierarchical planning and cross-modal data analysis. SeekBrain dynamically constructs a repertoire of analysis recipes extracted from code-paper pairs. By coupling this codified expertise with agentic planning and execution engines, the framework scalably generates hypotheses and analytical pipelines on demand. Systematic evaluation on the expert-annotated BrainArena benchmark demonstrates that SeekBrain substantially outperforms state-of-the-art agent baselines across various analysis tasks. Crucially, when deployed in real-world research, SeekBrain integrated behavioral, neural, and anatomical data to reveal structured, distributed neural representations of larval zebrafish behavior and a shared axis of regional decoding strength across the brain in a mouse decision-making task. These results establish SeekBrain as a scalable and practical tool for accelerating data-driven discoveries in neuroscience.

ReWorld: Learning Better Representations for World Action Models

World Action Models (WAMs) model future environment evolution under action conditioning, offering a scalable paradigm for autonomous driving. However, existing approaches focus largely on model architecture design, and how a WAM can efficiently learn better world representations for planning remains underexplored. To address this gap, we propose ReWorld, the first representation learning framework specifically designed for autonomous-driving world action models. In WAMs, standard training supervises only the output ends of the generation and planning modules, leaving the intermediate representations that carry world knowledge to be shaped only indirectly, as byproducts of fitting these outputs. The core idea of ReWorld is to treat intermediate representations as direct targets of optimization, shaping them along three complementary dimensions. On the Video DiT responsible for generation, we impose future-predictive supervision on its intermediate representations. On the Action DiT responsible for planning, we first align its intermediate representations cross-modally with the video world representation, then further shape them to be discriminative around safety-critical boundaries via hard-negative supervision. In addition, we systematically analyze the effectiveness of existing representation learning methods in video generation world models, and discuss why their performance is limited on this task. Experiments on nuScenes and NAVSIM show that ReWorld improves fine-tuned video generation by 23.9% in FVD (81.3 to 61.9), raises closed-loop PDMS from 89.1 to 90.4 without any post-training such as RL or post-processing, and accelerates from-scratch convergence by approximately 2x.

Food-R1: A Unified Multi-Task Food Vision-Language Model with Reinforcement Learning

Recent studies have explored Vision-Language Models (VLMs) for food analysis. However, most existing methods rely primarily on supervised fine-tuning (SFT), which often limits reasoning and generalization capabilities. Moreover, high-quality large-scale nutritional annotations remain scarce. To address these issues, we introduce CalorieBench-80K, a large-scale benchmark with curated calorie labels and dietary advice annotations. To the best of our knowledge, it is the first food image benchmark to incorporate Chain-of-Thought (CoT) annotations for calorie reasoning. We also propose Food-R1, a unified food VLM trained in a multi-task learning paradigm to equip the model with broad capabilities. Food-R1 undergoes CoT-based cold-start instruction tuning, followed by reinforcement fine-tuning (RFT) using Group Relative Policy Optimization (GRPO) to improve reasoning and performance. Experiments on CalorieBench-80K and representative benchmarks show that Food-R1 consistently outperforms strong baselines across food-related tasks. The code, model weights, and benchmark annotations are available at the project repository.

NeuroFlow: Toward Unified Visual Encoding and Decoding from Neural Activity

Visual encoding and decoding models act as gateways to understanding the neural mechanisms underlying human visual perception. Typically, visual encoding models that predict brain activity from stimuli and decoding models that reproduce stimuli from brain activity are treated as distinct tasks, requiring separate models and training procedures. This separation is inefficient and fails to model the consistency between encoding and decoding processes. To address this limitation, we propose NeuroFlow, the first unified framework that jointly models visual encoding and decoding from neural activity within a single flow model. NeuroFlow introduces two key components: (1) NeuroVAE is designed as a variational backbone to model neural variability and establish a compact, semantically structured latent space for bidirectional modeling across visual and neural modalities. (2) Cross-modal Flow Matching (XFM) bypasses the typical paradigm of noise-to-data diffusion guided by a specific modality condition, instead learning a reversibly consistent flow model between visual and neural latent distributions. For the first time, visual encoding and decoding are reformulated as a time-dependent, reversible process within a shared latent space for unified modeling. Empirical results demonstrate that NeuroFlow achieves superior overall performance in visual encoding and decoding tasks with higher computational efficiency compared to any isolated methods. We further analyze principal factors that steer the model toward encoding-decoding consistency and, through brain functional analyses, demonstrate that NeuroFlow captures consistent activation patterns underlying neural variability. NeuroFlow marks a major step toward unified visual encoding and decoding from neural activity, providing mechanistic insights that inform future bidirectional visual brain-computer interfaces.

Unlocking Positive Transfer in Incrementally Learning Surgical Instruments: A Self-reflection Hierarchical Prompt Framework

To continuously enhance model adaptability in surgical video scene parsing, recent studies incrementally update it to progressively learn to segment an increasing number of surgical instruments over time. However, prior works constantly overlooked the potential of positive forward knowledge transfer, i.e., how past knowledge could help learn new classes, and positive backward knowledge transfer, i.e., how learning new classes could help refine past knowledge. In this paper, we propose a self-reflection hierarchical prompt framework that unlocks the power of positive forward and backward knowledge transfer in class incremental segmentation, aiming to proficiently learn new instruments, improve existing skills of regular instruments, and avoid catastrophic forgetting of old instruments. Our framework is built on a frozen, pre-trained model that adaptively appends instrument-aware prompts for new classes throughout training episodes. To enable positive forward knowledge transfer, we organize instrument prompts into a hierarchical prompt parsing tree with the instrument-shared prompt partition as the root node, n-part-shared prompt partitions as intermediate nodes and instrument-distinct prompt partitions as leaf nodes, to expose the reusable historical knowledge for new classes to simplify their learning. Conversely, to encourage positive backward knowledge transfer, we conduct self-reflection refining on existing knowledge by directed-weighted graph propagation, examining the knowledge associations recorded in the tree to improve its representativeness without causing catastrophic forgetting. Our framework is applicable to both CNN-based models and advanced transformer-based foundation models, yielding more than 5% and 11% improvements over the competing methods on two public benchmarks respectively.

LLM-Driven Multi-Turn Task-Oriented Dialogue Synthesis for Realistic Reasoning

The reasoning capability of large language models (LLMs), defined as their ability to analyze, infer, and make decisions based on input information, is essential for building intelligent task-oriented dialogue systems. However, existing benchmarks do not sufficiently reflect the complexity of real-world scenarios, which limits their effectiveness in evaluating and enhancing LLM reasoning in practical contexts. Many current reasoning datasets are overly simplistic and abstract, often disconnected from realistic task flows, domain constraints, and operational rules, making it difficult to effectively evaluate LLMs' logical reasoning ability. In addition, data contamination from pretraining corpora undermines the reliability of evaluation results, and traditional crowdsourcing methods for dataset construction are labor-intensive and difficult to scale. To address these challenges, we propose a LLM-driven framework for synthesizing multi-turn, task-oriented dialogues grounded in realistic reasoning scenarios, leveraging trilevel optimization to enhance dialogue quality. Our method generates dialogues grounded in authentic task scenarios, enriched with real-world information, and exhibiting strong contextual coherence. Corresponding reasoning tasks are carefully designed around these dialogues and iteratively refined to continuously improve the tasks' quality and challenge. The resulting dataset serves as a valuable benchmark for assessing and advancing the realistic logical reasoning capabilities of LLMs. Experimental results show that our synthetic data-based reasoning tasks introduce non-trivial reasoning challenges and provide meaningful support for improving the reasoning capabilities of LLMs.

Explainable Interictal Epileptiform Discharge Detection Method Based on Scalp EEG and Retrieval-Augmented Generation

The detection of interictal epileptiform discharge (IED) is crucial for the diagnosis of epilepsy, but automated methods often lack interpretability. This study proposes IED-RAG, an explainable multimodal framework for joint IED detection and report generation. Our approach employs a dual-encoder to extract electrophysiological and semantic features, aligned via contrastive learning in a shared EEG-text embedding space. During inference, clinically relevant EEG-text pairs are retrieved from a vector database as explicit evidence to condition a large language model (LLM) for the generation of evidence-based reports. Evaluated on a private dataset from Wuhan Children's Hospital and the public TUH EEG Events Corpus (TUEV), the framework achieved balanced accuracies of 89.17\% and 71.38\%, with BLEU scores of 89.61\% and 64.14\%, respectively. The results demonstrate that retrieval of explicit evidence enhances both diagnostic performance and clinical interpretability compared to standard black-box methods.

Spark-Prover-X1: Formal Theorem Proving Through Diverse Data Training

Large Language Models (LLMs) have shown significant promise in automated theorem proving, yet progress is often constrained by the scarcity of diverse and high-quality formal language data. To address this issue, we introduce Spark-Prover-X1, a 7B parameter model trained via an three-stage framework designed to unlock the reasoning potential of more accessible and moderately-sized LLMs. The first stage infuses deep knowledge through continuous pre-training on a broad mathematical corpus, enhanced by a suite of novel data tasks. Key innovation is a "CoT-augmented state prediction" task to achieve fine-grained reasoning. The second stage employs Supervised Fine-tuning (SFT) within an expert iteration loop to specialize both the Spark-Prover-X1-7B and Spark-Formalizer-X1-7B models. Finally, a targeted round of Group Relative Policy Optimization (GRPO) is applied to sharpen the prover's capabilities on the most challenging problems. To facilitate robust evaluation, particularly on problems from real-world examinations, we also introduce ExamFormal-Bench, a new benchmark dataset of 402 formal problems. Experimental results demonstrate that Spark-Prover achieves state-of-the-art performance among similarly-sized open-source models within the "Whole-Proof Generation" paradigm. It shows exceptional performance on difficult competition benchmarks, notably solving 27 problems on PutnamBench (pass@32) and achieving 24.0\% on CombiBench (pass@32). Our work validates that this diverse training data and progressively refined training pipeline provides an effective path for enhancing the formal reasoning capabilities of lightweight LLMs. Both Spark-Prover-X1-7B and Spark-Formalizer-X1-7B, along with the ExamFormal-Bench dataset, are made publicly available at: https://www.modelscope.cn/organization/iflytek, https://gitcode.com/ifly_opensource.

CapeNext: Rethinking and refining dynamic support information for category-agnostic pose estimation

Recent research in Category-Agnostic Pose Estimation (CAPE) has adopted fixed textual keypoint description as semantic prior for two-stage pose matching frameworks. While this paradigm enhances robustness and flexibility by disentangling the dependency of support images, our critical analysis reveals two inherent limitations of static joint embedding: (1) polysemy-induced cross-category ambiguity during the matching process(e.g., the concept "leg" exhibiting divergent visual manifestations across humans and furniture), and (2) insufficient discriminability for fine-grained intra-category variations (e.g., posture and fur discrepancies between a sleeping white cat and a standing black cat). To overcome these challenges, we propose a new framework that innovatively integrates hierarchical cross-modal interaction with dual-stream feature refinement, enhancing the joint embedding with both class-level and instance-specific cues from textual description and specific images. Experiments on the MP-100 dataset demonstrate that, regardless of the network backbone, CapeNext consistently outperforms state-of-the-art CAPE methods by a large margin.

SRLF: An Agent-Driven Set-Wise Reflective Learning Framework for Sequential Recommendation

LLM-based agents are emerging as a promising paradigm for simulating user behavior to enhance recommender systems. However, their effectiveness is often limited by existing studies that focus on modeling user ratings for individual items. This point-wise approach leads to prevalent issues such as inaccurate user preference comprehension and rigid item-semantic representations. To address these limitations, we propose the novel Set-wise Reflective Learning Framework (SRLF). Our framework operationalizes a closed-loop "assess-validate-reflect" cycle that harnesses the powerful in-context learning capabilities of LLMs. SRLF departs from conventional point-wise assessment by formulating a holistic judgment on an entire set of items. It accomplishes this by comprehensively analyzing both the intricate interrelationships among items within the set and their collective alignment with the user's preference profile. This method of set-level contextual understanding allows our model to capture complex relational patterns essential to user behavior, making it significantly more adept for sequential recommendation. Extensive experiments validate our approach, confirming that this set-wise perspective is crucial for achieving state-of-the-art performance in sequential recommendation tasks.