DDIPrompt: Drug-Drug Interaction Event Prediction based on Graph Prompt Learning

Recently, Graph Neural Networks have become increasingly prevalent in predicting adverse drug-drug interactions (DDI) due to their proficiency in modeling the intricate associations between atoms and functional groups within and across drug molecules. However, they are still hindered by two significant challenges: (1) the issue of highly imbalanced event distribution, which is a common but critical problem in medical datasets where certain interactions are vastly underrepresented. This imbalance poses a substantial barrier to achieving accurate and reliable DDI predictions. (2) the scarcity of labeled data for rare events, which is a pervasive issue in the medical field where rare yet potentially critical interactions are often overlooked or under-studied due to limited available data. In response, we offer DDIPrompt, an innovative panacea inspired by the recent advancements in graph prompting. Our framework aims to address these issues by leveraging the intrinsic knowledge from pre-trained models, which can be efficiently deployed with minimal downstream data. Specifically, to solve the first challenge, DDIPrompt employs augmented links between drugs, considering both structural and interactive proximity. It features a hierarchical pre-training strategy that comprehends intra-molecular structures and inter-molecular interactions, fostering a comprehensive and unbiased understanding of drug properties. For the second challenge, we implement a prototype-enhanced prompting mechanism during inference. This mechanism, refined by few-shot examples from each category, effectively harnesses the rich pre-training knowledge to enhance prediction accuracy, particularly for these rare but crucial interactions. Comprehensive evaluations on two benchmark datasets demonstrate the superiority of DDIPrompt, particularly in predicting rare DDI events.

End-to-End 3D Hand Pose Estimation from Stereo Cameras

This work proposes an end-to-end approach to estimate full 3D hand pose from stereo cameras. Most existing methods of estimating hand pose from stereo cameras apply stereo matching to obtain depth map and use depth-based solution to estimate hand pose. In contrast, we propose to bypass the stereo matching and directly estimate the 3D hand pose from the stereo image pairs. The proposed neural network architecture extends from any keypoint predictor to estimate the sparse disparity of the hand joints. In order to effectively train the model, we propose a large scale synthetic dataset that is composed of stereo image pairs and ground truth 3D hand pose annotations. Experiments show that the proposed approach outperforms the existing methods based on the stereo depth.

YACLC: A Chinese Learner Corpus with Multidimensional Annotation

Learner corpus collects language data produced by L2 learners, that is second or foreign-language learners. This resource is of great relevance for second language acquisition research, foreign-language teaching, and automatic grammatical error correction. However, there is little focus on learner corpus for Chinese as Foreign Language (CFL) learners. Therefore, we propose to construct a large-scale, multidimensional annotated Chinese learner corpus. To construct the corpus, we first obtain a large number of topic-rich texts generated by CFL learners. Then we design an annotation scheme including a sentence acceptability score as well as grammatical error and fluency-based corrections. We build a crowdsourcing platform to perform the annotation effectively (https://yaclc.wenmind.net). We name the corpus YACLC (Yet Another Chinese Learner Corpus) and release it as part of the CUGE benchmark (http://cuge.baai.ac.cn). By analyzing the original sentences and annotations in the corpus, we found that YACLC has a considerable size and very high annotation quality. We hope this corpus can further enhance the studies on Chinese International Education and Chinese automatic grammatical error correction.

Pedestrian Motion Tracking by Using Inertial Sensors on the Smartphone

Inertial Measurement Unit (IMU) has long been a dream for stable and reliable motion estimation, especially in indoor environments where GPS strength limits. In this paper, we propose a novel method for position and orientation estimation of a moving object only from a sequence of IMU signals collected from the phone. Our main observation is that human motion is monotonous and periodic. We adopt the Extended Kalman Filter and use the learning-based method to dynamically update the measurement noise of the filter. Our pedestrian motion tracking system intends to accurately estimate planar position, velocity, heading direction without restricting the phone's daily use. The method is not only tested on the self-collected signals, but also provides accurate position and velocity estimations on the public RIDI dataset, i.e., the absolute transmit error is 1.28m for a 59-second sequence.

Boundary Content Graph Neural Network for Temporal Action Proposal Generation

Temporal action proposal generation plays an important role in video action understanding, which requires localizing high-quality action content precisely. However, generating temporal proposals with both precise boundaries and high-quality action content is extremely challenging. To address this issue, we propose a novel Boundary Content Graph Neural Network (BC-GNN) to model the insightful relations between the boundary and action content of temporal proposals by the graph neural networks. In BC-GNN, the boundaries and content of temporal proposals are taken as the nodes and edges of the graph neural network, respectively, where they are spontaneously linked. Then a novel graph computation operation is proposed to update features of edges and nodes. After that, one updated edge and two nodes it connects are used to predict boundary probabilities and content confidence score, which will be combined to generate a final high-quality proposal. Experiments are conducted on two mainstream datasets: ActivityNet-1.3 and THUMOS14. Without the bells and whistles, BC-GNN outperforms previous state-of-the-art methods in both temporal action proposal and temporal action detection tasks.

3D Hand Shape and Pose Estimation from a Single RGB Image

This work addresses a novel and challenging problem of estimating the full 3D hand shape and pose from a single RGB image. Most current methods in 3D hand analysis from monocular RGB images only focus on estimating the 3D locations of hand keypoints, which cannot fully express the 3D shape of hand. In contrast, we propose a Graph Convolutional Neural Network (Graph CNN) based method to reconstruct a full 3D mesh of hand surface that contains richer information of both 3D hand shape and pose. To train networks with full supervision, we create a large-scale synthetic dataset containing both ground truth 3D meshes and 3D poses. When fine-tuning the networks on real-world datasets without 3D ground truth, we propose a weakly-supervised approach by leveraging the depth map as a weak supervision in training. Through extensive evaluations on our proposed new datasets and two public datasets, we show that our proposed method can produce accurate and reasonable 3D hand mesh, and can achieve superior 3D hand pose estimation accuracy when compared with state-of-the-art methods.