Do Noises Bother Human and Neural Networks In the Same Way? A Medical Image Analysis Perspective

Deep learning had already demonstrated its power in medical images, including denoising, classification, segmentation, etc. All these applications are proposed to automatically analyze medical images beforehand, which brings more information to radiologists during clinical assessment for accuracy improvement. Recently, many medical denoising methods had shown their significant artifact reduction result and noise removal both quantitatively and qualitatively. However, those existing methods are developed around human-vision, i.e., they are designed to minimize the noise effect that can be perceived by human eyes. In this paper, we introduce an application-guided denoising framework, which focuses on denoising for the following neural networks. In our experiments, we apply the proposed framework to different datasets, models, and use cases. Experimental results show that our proposed framework can achieve a better result than human-vision denoising network.

CSCL: Critical Semantic-Consistent Learning for Unsupervised Domain Adaptation

Unsupervised domain adaptation without consuming annotation process for unlabeled target data attracts appealing interests in semantic segmentation. However, 1) existing methods neglect that not all semantic representations across domains are transferable, which cripples domain-wise transfer with untransferable knowledge; 2) they fail to narrow category-wise distribution shift due to category-agnostic feature alignment. To address above challenges, we develop a new Critical Semantic-Consistent Learning (CSCL) model, which mitigates the discrepancy of both domain-wise and category-wise distributions. Specifically, a critical transfer based adversarial framework is designed to highlight transferable domain-wise knowledge while neglecting untransferable knowledge. Transferability-critic guides transferability-quantizer to maximize positive transfer gain under reinforcement learning manner, although negative transfer of untransferable knowledge occurs. Meanwhile, with the help of confidence-guided pseudo labels generator of target samples, a symmetric soft divergence loss is presented to explore inter-class relationships and facilitate category-wise distribution alignment. Experiments on several datasets demonstrate the superiority of our model.

Towards Cardiac Intervention Assistance: Hardware-aware Neural Architecture Exploration for Real-Time 3D Cardiac Cine MRI Segmentation

Real-time cardiac magnetic resonance imaging (MRI) plays an increasingly important role in guiding various cardiac interventions. In order to provide better visual assistance, the cine MRI frames need to be segmented on-the-fly to avoid noticeable visual lag. In addition, considering reliability and patient data privacy, the computation is preferably done on local hardware. State-of-the-art MRI segmentation methods mostly focus on accuracy only, and can hardly be adopted for real-time application or on local hardware. In this work, we present the first hardware-aware multi-scale neural architecture search (NAS) framework for real-time 3D cardiac cine MRI segmentation. The proposed framework incorporates a latency regularization term into the loss function to handle real-time constraints, with the consideration of underlying hardware. In addition, the formulation is fully differentiable with respect to the architecture parameters, so that stochastic gradient descent (SGD) can be used for optimization to reduce the computation cost while maintaining optimization quality. Experimental results on ACDC MICCAI 2017 dataset demonstrate that our hardware-aware multi-scale NAS framework can reduce the latency by up to 3.5 times and satisfy the real-time constraints, while still achieving competitive segmentation accuracy, compared with the state-of-the-art NAS segmentation framework.

ICA-UNet: ICA Inspired Statistical UNet for Real-time 3D Cardiac Cine MRI Segmentation

Real-time cine magnetic resonance imaging (MRI) plays an increasingly important role in various cardiac interventions. In order to enable fast and accurate visual assistance, the temporal frames need to be segmented on-the-fly. However, state-of-the-art MRI segmentation methods are used either offline because of their high computation complexity, or in real-time but with significant accuracy loss and latency increase (causing visually noticeable lag). As such, they can hardly be adopted to assist visual guidance. In this work, inspired by a new interpretation of Independent Component Analysis (ICA) for learning, we propose a novel ICA-UNet for real-time 3D cardiac cine MRI segmentation. Experiments using the MICCAI ACDC 2017 dataset show that, compared with the state-of-the-arts, ICA-UNet not only achieves higher Dice scores, but also meets the real-time requirements for both throughput and latency (up to 12.6X reduction), enabling real-time guidance for cardiac interventions without visual lag.

BUNET: Blind Medical Image Segmentation Based on Secure UNET

The strict security requirements placed on medical records by various privacy regulations become major obstacles in the age of big data. To ensure efficient machine learning as a service schemes while protecting data confidentiality, in this work, we propose blind UNET (BUNET), a secure protocol that implements privacy-preserving medical image segmentation based on the UNET architecture. In BUNET, we efficiently utilize cryptographic primitives such as homomorphic encryption and garbled circuits (GC) to design a complete secure protocol for the UNET neural architecture. In addition, we perform extensive architectural search in reducing the computational bottleneck of GC-based secure activation protocols with high-dimensional input data. In the experiment, we thoroughly examine the parameter space of our protocol, and show that we can achieve up to 14x inference time reduction compared to the-state-of-the-art secure inference technique on a baseline architecture with negligible accuracy degradation.

Evolving Metric Learning for Incremental and Decremental Features

Online metric learning has been widely exploited for large-scale data classification due to the low computational cost. However, amongst online practical scenarios where the features are evolving (e.g., some features are vanished and some new features are augmented), most metric learning models cannot be successfully applied into these scenarios although they can tackle the evolving instances efficiently. To address the challenge, we propose a new online Evolving Metric Learning (EML) model for incremental and decremental features, which can handle the instance and feature evolutions simultaneously by incorporating with a smoothed Wasserstein metric distance. Specifically, our model contains two essential stages: the Transforming stage (T-stage) and the Inheriting stage (I-stage). For the T-stage, we propose to extract important information from vanished features while neglecting non-informative knowledge, and forward it into survived features by transforming them into a low-rank discriminative metric space. It further explores the intrinsic low-rank structure of heterogeneous samples to reduce the computation and memory burden especially for highly-dimensional large-scale data. For the I-stage, we inherit the metric performance of survived features from the T-stage and then expand to include the augmented new features. Moreover, the smoothed Wasserstein distance is utilized to characterize the similarity relations among the complex and heterogeneous data, since the evolving features in the different stages are not strictly aligned. In addition to tackling the challenges in one-shot case, we also extend our model into multi-shot scenario. After deriving an efficient optimization method for both T-stage and I-stage, extensive experiments on several benchmark datasets verify the superiority of our model.

What Can Be Transferred: Unsupervised Domain Adaptation for Endoscopic Lesions Segmentation

Unsupervised domain adaptation has attracted growing research attention on semantic segmentation. However, 1) most existing models cannot be directly applied into lesions transfer of medical images, due to the diverse appearances of same lesion among different datasets; 2) equal attention has been paid into all semantic representations instead of neglecting irrelevant knowledge, which leads to negative transfer of untransferable knowledge. To address these challenges, we develop a new unsupervised semantic transfer model including two complementary modules (i.e., T_D and T_F ) for endoscopic lesions segmentation, which can alternatively determine where and how to explore transferable domain-invariant knowledge between labeled source lesions dataset (e.g., gastroscope) and unlabeled target diseases dataset (e.g., enteroscopy). Specifically, T_D focuses on where to translate transferable visual information of medical lesions via residual transferability-aware bottleneck, while neglecting untransferable visual characterizations. Furthermore, T_F highlights how to augment transferable semantic features of various lesions and automatically ignore untransferable representations, which explores domain-invariant knowledge and in return improves the performance of T_D. To the end, theoretical analysis and extensive experiments on medical endoscopic dataset and several non-medical public datasets well demonstrate the superiority of our proposed model.

Deep Learning System to Screen Coronavirus Disease 2019 Pneumonia

We found that the real time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab has a relatively low positive rate in the early stage to determine COVID-19 (named by the World Health Organization). The manifestations of computed tomography (CT) imaging of COVID-19 had their own characteristics, which are different from other types of viral pneumonia, such as Influenza-A viral pneumonia. Therefore, clinical doctors call for another early diagnostic criteria for this new type of pneumonia as soon as possible.This study aimed to establish an early screening model to distinguish COVID-19 pneumonia from Influenza-A viral pneumonia and healthy cases with pulmonary CT images using deep learning techniques. The candidate infection regions were first segmented out using a 3-dimensional deep learning model from pulmonary CT image set. These separated images were then categorized into COVID-19, Influenza-A viral pneumonia and irrelevant to infection groups, together with the corresponding confidence scores using a location-attention classification model. Finally the infection type and total confidence score of this CT case were calculated with Noisy-or Bayesian function.The experiments result of benchmark dataset showed that the overall accuracy was 86.7 % from the perspective of CT cases as a whole.The deep learning models established in this study were effective for the early screening of COVID-19 patients and demonstrated to be a promising supplementary diagnostic method for frontline clinical doctors.

ColluEagle: Collusive review spammer detection using Markov random fields

Product reviews are extremely valuable for online shoppers in providing purchase decisions. Driven by immense profit incentives, fraudsters deliberately fabricate untruthful reviews to distort the reputation of online products. As online reviews become more and more important, group spamming, i.e., a team of fraudsters working collaboratively to attack a set of target products, becomes a new fashion. Previous works use review network effects, i.e. the relationships among reviewers, reviews, and products, to detect fake reviews or review spammers, but ignore time effects, which are critical in characterizing group spamming. In this paper, we propose a novel Markov random field (MRF)-based method (ColluEagle) to detect collusive review spammers, as well as review spam campaigns, considering both network effects and time effects. First we identify co-review pairs, a review phenomenon that happens between two reviewers who review a common product in a similar way, and then model reviewers and their co-review pairs as a pairwise-MRF, and use loopy belief propagation to evaluate the suspiciousness of reviewers. We further design a high quality yet easy-to-compute node prior for ColluEagle, through which the review spammer groups can also be subsequently identified. Experiments show that ColluEagle can not only detect collusive spammers with high precision, significantly outperforming state-of-the-art baselines --- FraudEagle and SpEagle, but also identify highly suspicious review spammer campaigns.

MRNN: A Multi-Resolution Neural Network with Duplex Attention for Document Retrieval in the Context of Question Answering

The primary goal of ad-hoc retrieval (document retrieval in the context of question answering) is to find relevant documents satisfied the information need posted in a natural language query. It requires a good understanding of the query and all the documents in a corpus, which is difficult because the meaning of natural language texts depends on the context, syntax,and semantics. Recently deep neural networks have been used to rank search results in response to a query. In this paper, we devise a multi-resolution neural network(MRNN) to leverage the whole hierarchy of representations for document retrieval. The proposed MRNN model is capable of deriving a representation that integrates representations of different levels of abstraction from all the layers of the learned hierarchical representation.Moreover, a duplex attention component is designed to refinethe multi-resolution representation so that an optimal contextfor matching the query and document can be determined. More specifically, the first attention mechanism determines optimal context from the learned multi-resolution representation for the query and document. The latter attention mechanism aims to fine-tune the representation so that the query and the relevant document are closer in proximity. The empirical study shows that MRNN with the duplex attention is significantly superior to existing models used for ad-hoc retrieval on benchmark datasets including SQuAD, WikiQA, QUASAR, and TrecQA.