MyoPS-Net: Myocardial Pathology Segmentation with Flexible Combination of Multi-Sequence CMR Images

Myocardial pathology segmentation (MyoPS) can be a prerequisite for the accurate diagnosis and treatment planning of myocardial infarction. However, achieving this segmentation is challenging, mainly due to the inadequate and indistinct information from an image. In this work, we develop an end-to-end deep neural network, referred to as MyoPS-Net, to flexibly combine five-sequence cardiac magnetic resonance (CMR) images for MyoPS. To extract precise and adequate information, we design an effective yet flexible architecture to extract and fuse cross-modal features. This architecture can tackle different numbers of CMR images and complex combinations of modalities, with output branches targeting specific pathologies. To impose anatomical knowledge on the segmentation results, we first propose a module to regularize myocardium consistency and localize the pathologies, and then introduce an inclusiveness loss to utilize relations between myocardial scars and edema. We evaluated the proposed MyoPS-Net on two datasets, i.e., a private one consisting of 50 paired multi-sequence CMR images and a public one from MICCAI2020 MyoPS Challenge. Experimental results showed that MyoPS-Net could achieve state-of-the-art performance in various scenarios. Note that in practical clinics, the subjects may not have full sequences, such as missing LGE CMR or mapping CMR scans. We therefore conducted extensive experiments to investigate the performance of the proposed method in dealing with such complex combinations of different CMR sequences. Results proved the superiority and generalizability of MyoPS-Net, and more importantly, indicated a practical clinical application.

TotalSegmentator: robust segmentation of 104 anatomical structures in CT images

In this work we focus on automatic segmentation of multiple anatomical structures in (whole body) CT images. Many segmentation algorithms exist for this task. However, in most cases they suffer from 3 problems: 1. They are difficult to use (the code and data is not publicly available or difficult to use). 2. They do not generalize (often the training dataset was curated to only contain very clean images which do not reflect the image distribution found during clinical routine), 3. The algorithm can only segment one anatomical structure. For more structures several algorithms have to be used which increases the effort required to set up the system. In this work we publish a new dataset and segmentation toolkit which solves all three of these problems: In 1204 CT images we segmented 104 anatomical structures (27 organs, 59 bones, 10 muscles, 8 vessels) covering a majority of relevant classes for most use cases. We show an improved workflow for the creation of ground truth segmentations which speeds up the process by over 10x. The CT images were randomly sampled from clinical routine, thus representing a real world dataset which generalizes to clinical application. The dataset contains a wide range of different pathologies, scanners, sequences and sites. Finally, we train a segmentation algorithm on this new dataset. We call this algorithm TotalSegmentator and make it easily available as a pretrained python pip package (pip install totalsegmentator). Usage is as simple as TotalSegmentator -i ct.nii.gz -o seg and it works well for most CT images. The code is available at https://github.com/wasserth/TotalSegmentator and the dataset at https://doi.org/10.5281/zenodo.6802613.

Glow-WaveGAN 2: High-quality Zero-shot Text-to-speech Synthesis and Any-to-any Voice Conversion

The zero-shot scenario for speech generation aims at synthesizing a novel unseen voice with only one utterance of the target speaker. Although the challenges of adapting new voices in zero-shot scenario exist in both stages -- acoustic modeling and vocoder, previous works usually consider the problem from only one stage. In this paper, we extend our previous Glow-WaveGAN to Glow-WaveGAN 2, aiming to solve the problem from both stages for high-quality zero-shot text-to-speech and any-to-any voice conversion. We first build a universal WaveGAN model for extracting latent distribution $p(z)$ of speech and reconstructing waveform from it. Then a flow-based acoustic model only needs to learn the same $p(z)$ from texts, which naturally avoids the mismatch between the acoustic model and the vocoder, resulting in high-quality generated speech without model fine-tuning. Based on a continuous speaker space and the reversible property of flows, the conditional distribution can be obtained for any speaker, and thus we can further conduct high-quality zero-shot speech generation for new speakers. We particularly investigate two methods to construct the speaker space, namely pre-trained speaker encoder and jointly-trained speaker encoder. The superiority of Glow-WaveGAN 2 has been proved through TTS and VC experiments conducted on LibriTTS corpus and VTCK corpus.

Learning Noise-independent Speech Representation for High-quality Voice Conversion for Noisy Target Speakers

Building a voice conversion system for noisy target speakers, such as users providing noisy samples or Internet found data, is a challenging task since the use of contaminated speech in model training will apparently degrade the conversion performance. In this paper, we leverage the advances of our recently proposed Glow-WaveGAN and propose a noise-independent speech representation learning approach for high-quality voice conversion for noisy target speakers. Specifically, we learn a latent feature space where we ensure that the target distribution modeled by the conversion model is exactly from the modeled distribution of the waveform generator. With this premise, we further manage to make the latent feature to be noise-invariant. Specifically, we introduce a noise-controllable WaveGAN, which directly learns the noise-independent acoustic representation from waveform by the encoder and conducts noise control in the hidden space through a FiLM module in the decoder. As for the conversion model, importantly, we use a flow-based model to learn the distribution of noise-independent but speaker-related latent features from phoneme posteriorgrams. Experimental results demonstrate that the proposed model achieves high speech quality and speaker similarity in the voice conversion for noisy target speakers.

End-to-End Voice Conversion with Information Perturbation

The ideal goal of voice conversion is to convert the source speaker's speech to sound naturally like the target speaker while maintaining the linguistic content and the prosody of the source speech. However, current approaches are insufficient to achieve comprehensive source prosody transfer and target speaker timbre preservation in the converted speech, and the quality of the converted speech is also unsatisfied due to the mismatch between the acoustic model and the vocoder. In this paper, we leverage the recent advances in information perturbation and propose a fully end-to-end approach to conduct high-quality voice conversion. We first adopt information perturbation to remove speaker-related information in the source speech to disentangle speaker timbre and linguistic content and thus the linguistic information is subsequently modeled by a content encoder. To better transfer the prosody of the source speech to the target, we particularly introduce a speaker-related pitch encoder which can maintain the general pitch pattern of the source speaker while flexibly modifying the pitch intensity of the generated speech. Finally, one-shot voice conversion is set up through continuous speaker space modeling. Experimental results indicate that the proposed end-to-end approach significantly outperforms the state-of-the-art models in terms of intelligibility, naturalness, and speaker similarity.

VCVTS: Multi-speaker Video-to-Speech synthesis via cross-modal knowledge transfer from voice conversion

Though significant progress has been made for speaker-dependent Video-to-Speech (VTS) synthesis, little attention is devoted to multi-speaker VTS that can map silent video to speech, while allowing flexible control of speaker identity, all in a single system. This paper proposes a novel multi-speaker VTS system based on cross-modal knowledge transfer from voice conversion (VC), where vector quantization with contrastive predictive coding (VQCPC) is used for the content encoder of VC to derive discrete phoneme-like acoustic units, which are transferred to a Lip-to-Index (Lip2Ind) network to infer the index sequence of acoustic units. The Lip2Ind network can then substitute the content encoder of VC to form a multi-speaker VTS system to convert silent video to acoustic units for reconstructing accurate spoken content. The VTS system also inherits the advantages of VC by using a speaker encoder to produce speaker representations to effectively control the speaker identity of generated speech. Extensive evaluations verify the effectiveness of proposed approach, which can be applied in both constrained vocabulary and open vocabulary conditions, achieving state-of-the-art performance in generating high-quality speech with high naturalness, intelligibility and speaker similarity. Our demo page is released here: https://wendison.github.io/VCVTS-demo/

Deep Graph Learning for Spatially-Varying Indoor Lighting Prediction

Lighting prediction from a single image is becoming increasingly important in many vision and augmented reality (AR) applications in which shading and shadow consistency between virtual and real objects should be guaranteed. However, this is a notoriously ill-posed problem, especially for indoor scenarios, because of the complexity of indoor luminaires and the limited information involved in 2D images. In this paper, we propose a graph learning-based framework for indoor lighting estimation. At its core is a new lighting model (dubbed DSGLight) based on depth-augmented Spherical Gaussians (SG) and a Graph Convolutional Network (GCN) that infers the new lighting representation from a single LDR image of limited field-of-view. Our lighting model builds 128 evenly distributed SGs over the indoor panorama, where each SG encoding the lighting and the depth around that node. The proposed GCN then learns the mapping from the input image to DSGLight. Compared with existing lighting models, our DSGLight encodes both direct lighting and indirect environmental lighting more faithfully and compactly. It also makes network training and inference more stable. The estimated depth distribution enables temporally stable shading and shadows under spatially-varying lighting. Through thorough experiments, we show that our method obviously outperforms existing methods both qualitatively and quantitatively.

MsEmoTTS: Multi-scale emotion transfer, prediction, and control for emotional speech synthesis

Expressive synthetic speech is essential for many human-computer interaction and audio broadcast scenarios, and thus synthesizing expressive speech has attracted much attention in recent years. Previous methods performed the expressive speech synthesis either with explicit labels or with a fixed-length style embedding extracted from reference audio, both of which can only learn an average style and thus ignores the multi-scale nature of speech prosody. In this paper, we propose MsEmoTTS, a multi-scale emotional speech synthesis framework, to model the emotion from different levels. Specifically, the proposed method is a typical attention-based sequence-to-sequence model and with proposed three modules, including global-level emotion presenting module (GM), utterance-level emotion presenting module (UM), and local-level emotion presenting module (LM), to model the global emotion category, utterance-level emotion variation, and syllable-level emotion strength, respectively. In addition to modeling the emotion from different levels, the proposed method also allows us to synthesize emotional speech in different ways, i.e., transferring the emotion from reference audio, predicting the emotion from input text, and controlling the emotion strength manually. Extensive experiments conducted on a Chinese emotional speech corpus demonstrate that the proposed method outperforms the compared reference audio-based and text-based emotional speech synthesis methods on the emotion transfer speech synthesis and text-based emotion prediction speech synthesis respectively. Besides, the experiments also show that the proposed method can control the emotion expressions flexibly. Detailed analysis shows the effectiveness of each module and the good design of the proposed method.

A Color Image Steganography Based on Frequency Sub-band Selection

Color image steganography based on deep learning is the art of hiding information in the color image. Among them, image hiding steganography(hiding image with image) has attracted much attention in recent years because of its great steganographic capacity. However, images generated by image hiding steganography may show some obvious color distortion or artificial texture traces. We propose a color image steganographic model based on frequency sub-band selection to solve the above problems. Firstly, we discuss the relationship between the characteristics of different color spaces/frequency sub-bands and the generated image quality. Then, we select the B channel of the RGB image as the embedding channel and the high-frequency sub-band as the embedding domain. DWT(discrete wavelet transformation) transforms B channel information and secret gray image into frequency domain information, and then the secret image is embedded and extracted in the frequency domain. Comprehensive experiments demonstrate that images generated by our model have better image quality, and the imperceptibility is significantly increased.

Referee: Towards reference-free cross-speaker style transfer with low-quality data for expressive speech synthesis

Cross-speaker style transfer (CSST) in text-to-speech (TTS) synthesis aims at transferring a speaking style to the synthesised speech in a target speaker's voice. Most previous CSST approaches rely on expensive high-quality data carrying desired speaking style during training and require a reference utterance to obtain speaking style descriptors as conditioning on the generation of a new sentence. This work presents Referee, a robust reference-free CSST approach for expressive TTS, which fully leverages low-quality data to learn speaking styles from text. Referee is built by cascading a text-to-style (T2S) model with a style-to-wave (S2W) model. Phonetic PosteriorGram (PPG), phoneme-level pitch and energy contours are adopted as fine-grained speaking style descriptors, which are predicted from text using the T2S model. A novel pretrain-refinement method is adopted to learn a robust T2S model by only using readily accessible low-quality data. The S2W model is trained with high-quality target data, which is adopted to effectively aggregate style descriptors and generate high-fidelity speech in the target speaker's voice. Experimental results are presented, showing that Referee outperforms a global-style-token (GST)-based baseline approach in CSST.