Abstract:Large language model-based multi-agent systems have recently shown strong potential for complex, long-horizon tasks. However, existing methods mainly rely on coarse prompt-level differentiation without parameter adaptation for diverse subtasks, resulting in insufficient inter-agent heterogeneity and limited specialized capability that bottleneck performance on tasks with complex requirements. To address this, we introduce a Task-Oriented Multi-Agent System with Mixture of Role-Subtask Experts (MoRSE) that distinguishes agents with (role, subtask)-conditional specialization at both the task structure and parameter levels. To make agents' responsibility explicit at the task structure level, we formulate a task-oriented multi-agent system that decomposes each task into a dependency-aware Directed Acyclic Graph of subtasks and assigns each agent a specific (role, subtask), introducing task-level specialization across collaborating agents. Additionally, to address the diverse role and subtask parameter adaptation demands, we propose a dynamic Mixture of (role, subtask) LoRA Experts module with a prototype-based semantic router for subtasks, augmenting agents with parameter-level specialization on a shared LLM substrate cost-effectively. Then, to co-optimize experts and router stably under sparse task rewards, we further propose a hierarchical group-relative policy optimization with two-layer credit assignment that isolates expert updates from the cross-route variance introduced by routing decisions, disentangling expert quality from routing quality. Experiments on code-generation benchmarks across three backbones demonstrate the effectiveness of our approach, with improvements in both whole-task and step-wise performance, and the gains from trained specialization generalize across held-out task categories and domains.
Abstract:Hyperbolic geometry has recently emerged as a powerful representation space for multimodal learning, as it naturally captures hierarchical semantic structure across modalities. Despite this progress, how such representations behave under continual learning poses fundamentally different challenges that remain underexplored. This work provides a geometric perspective on this problem and establishes a theoretical foundation for representation preservation in hyperbolic space, showing that preventing forgetting requires cross-modal invariance under a shared hyperbolic isometry. We further show that forgetting in hyperbolic continual learning involves both semantic relation drift and hierarchy-related distortion, motivating preservation of both cross-modal relational structure and hierarchical geometry. Guided by these insights, a principled continual learning framework is derived that preserves essential geometric structure while allowing effective adaptation to new tasks. Experiments on continual multimodal benchmarks corroborate the effectiveness of the proposed approach.
Abstract:Real-world LLM personalization is often constrained by sparse and skewed user histories: most users provide only a handful of interactions, while even frequent users' logs capture an incomplete and biased view of their preferences. As a result, weakly observed user attributes are difficult to infer, leading to brittle personalization when test-time requests shift toward under-supported facets. Motivated by this limitation, we present CoPersona, a graph-based collaborative personalization framework that completes sparse user profiles by borrowing signals from behaviorally similar peers. However, directly transferring signals is difficult because uneven facet coverage introduces bias into interaction histories, obscuring user similarity in the unstructured global space. To address this issue, CoPersona decomposes interaction histories into multiple facet-level representations and explicitly models peer-to-peer, facet-level alignment through a multiplex persona graph. To effectively leverage peer information at inference time, we employ a dual-branch architecture that combines non-parametric peer retrieval with parametric graph reasoning. Experiments across multiple domains and model scales demonstrate consistent improvements over strong baselines, validating CoPersona as an effective approach for robust LLM personalization.
Abstract:Post-training of reasoning language models is commonly driven by supervised distillation and reinforcement learning with verifiable rewards. Distillation often relies on chain-of-thought annotations that are expensive to obtain and may themselves be noisy, incomplete, or partially incorrect; even when the final solution is correct, an imperfect rationale can interfere with learning. Reinforcement learning with verified rewards, on the other hand, typically compresses evaluative feedback into a scalar signal, obscuring which aspects of a response should be improved. We propose \textbf{Rubric-Conditioned Self-Distillation}, a framework that incorporates rubrics as structured, fine-grained feedback for on-policy self-distillation. Our method conditions the teacher model on criterion-level rubrics and uses it to provide token-level guidance on the student's own sampled trajectories. This design avoids treating a single reference rationale as the sole supervision target. Instead, rubrics specify what a strong response should satisfy, enabling more fine-grained credit assignment over the reasoning process than scalar reward optimization. We instantiate this framework with a two-stage pipeline that first learns to generate task-specific rubrics and then trains a rubric-guided reasoner. We evaluate on a diverse suite of science reasoning benchmarks and results show that rubric-conditioned self-distillation effectively converts rubric-level criteria into token-level guidance over the reasoning process, surpassing GRPO by 1.0 points and OPSD by 0.9 points on average.
Abstract:Predicting immune biomarkers associated with the tumor immune microenvironment (TIME) is critical for advancing precision oncology, yet existing approaches are largely limited to single image modalities and suffer from insufficient resolution and incomplete utilization of complementary clinical and biological information. Here we introduce MixTIME, a multimodal foundation model that leverages a mixture-of-experts (MoE) architecture to integrate pathology foundation models trained across distinct modalities: image only (UNIv2), image text (CONCHv1.5), and image transcriptomic (STPath) representations for pixel-level and slide-level prediction of multiplex immunofluorescence (mIF) protein expression from hematoxylin and eosin (HE) whole-slide images. MixTIME employs a learnable router to dynamically weight expert contributions and is trained with a distribution- and tendency-aware loss function. Benchmarked on two datasets of different scales, MixTIME achieves state-of-the-art performance across 17 protein markers as measured by correlation metrics. The predicted mIF profiles substantially enhance downstream tasks, including spatial domain identification, survival prediction, and AI-assisted pathology report generation validated by expert pathologists from multiple institutes across the world. Furthermore, MixTIME enables longitudinal tracking of protein expression dynamics across clinical time points and reveals protein gene interaction patterns linked to drug resistance and immune suppression in tumor microenvironments. Collectively, MixTIME provides a scalable framework for multimodal biomarker discovery and clinical translation in computational pathology.
Abstract:AI agents are increasingly being developed to accelerate scientific discovery, yet their practical capabilities in real research settings remain poorly understood. Existing benchmarks for AI agents rarely capture the complexity, heterogeneity, and extended reasoning required by scientific work, whereas benchmarks for scientific tasks often reduce research to static, direct problems and provide limited support for interactive evaluation. Here, we introduce SciAgentArena, a systematic benchmark for evaluating AI agents in real-world scientific research scenarios drawn from emerging needs across multiple domains. SciAgentArena comprises approximately 200 tasks with stepwise verification and an interactive, agent-agnostic environment for assessing diverse AI agents. Using this benchmark, we find that current agents can contribute effectively to well-specified data-analysis workflows, particularly when the task structure and evaluation criteria are clear. However, their performance remains uneven across scientific contexts: agents struggle to generate genuinely novel insights, sustain self-directed exploration, and formulate robust solutions for open-ended research questions. We further characterize common failure modes across agents and identify opportunities for improving their reliability, autonomy, and scientific reasoning. Together, SciAgentArena provides a practical framework for measuring progress in AI agents for science and for guiding the design of future agents capable of addressing complex scientific challenges. Full codes, tasks, and datasets can be accessed via this link: https://sciagentarena.github.io/.
Abstract:Non-monotonic sequence generation methods, such as masked diffusion models, provide a flexible alternative to left-to-right autoregressive modeling by allowing tokens to be generated in non-fixed and prescribed orders. Despite their practical advantages, most existing non-monotonic models are order-agnostic and rely on a fixed-length grid, limiting their ability to support variable-length generation and adaptive insertion order. In this work, we introduce a probabilistic framework for learning insertion order in variable-length insertion models. We formalize a bijective correspondence between insertion trajectories and permutations, which enables an exact reparameterization of the data likelihood as a sum over permutations. Building on this result, we propose the Insertion Process (IP), a stochastic generative model that jointly learns where to insert, what to insert, and when to terminate, trained via permutation-based variational inference. Unlike prior fixed-canvas approaches, IP natively supports variable-length generation and learns data-driven preferences over insertion orders. Experiments on goal-conditioned planning and molecular string generation demonstrate that learning insertion order improves both modeling quality and generalization in domains without a canonical left-to-right structure.
Abstract:Financial markets are characterized by extreme non-stationarity, low signal-to-noise ratios, and strong dependence on external information such as news, company fundamentals, and macroeconomic signals. Yet, existing approaches either abstract time-series into text or decouple forecasting from language-based reasoning, leading to a fundamental mismatch between qualitative reasoning and quantitative outcomes. To address this, we introduce StockR1, a time-series-enhanced LLM that unifies stock forecasting and financial reasoning through a verifiable forecast action. Based on a tool-call design, the model first emits a forecast action, which is a structured and interpretable representation of its qualitative market outlook. It then invokes a time-series decoder conditioned on this action to generate distributional future trajectories, leading to more informed question answering and financial reasoning. We optimize the full pipeline with reinforcement learning, where rewards jointly reflect answer validity, forecast accuracy, and consistency between generated actions and observed time-series dynamics. In addition, rewards are reweighted by a sample-level uncertainty scalar, encouraging the model to accommodate varying uncertainty in market dynamics. We evaluate StockR1 on financial question answering and stock forecasting over a large-scale 10-year benchmark. Our method consistently outperforms time-series baselines and general-purpose LLMs, improving reasoning accuracy by 17.7% (4B) and 25.9% (8B). These findings demonstrate that structuring the forecast actions establishes a powerful synergy between language reasoning and temporal prediction, enabling LLMs to reason through verifiable, interpretable, and numerically grounded decisions.
Abstract:Deep research agents increasingly automate complex information-seeking tasks, producing evidence-grounded reports via multi-step reasoning, tool use, and synthesis. Their growing role demands scalable, reliable evaluation, positioning LLM-as-judge as a supervision paradigm for assessing factual accuracy, evidence use, and reasoning quality. Yet the reliability of these judges for deep research agents remains poorly understood, posing a critical meta-evaluation problem: before deploying LLM judges to supervise research agents, we must first evaluate the judges themselves. Existing meta-evaluations fall short in two ways: (1) reliance on coarse, subjective human-preference agreement; (2) focus on instruction-following or verifiable tasks, leaving open-ended agent executions unexplored. To address these gaps, we introduce REFLECT (REliable Fine-grained LLM judge Evaluation via Controlled inTervention), a meta-evaluation benchmark targeting fine-grained failure detection in agentic environments. REFLECT defines a detailed taxonomy of process- and outcome-level failure modes, instantiated by performing controlled and localized interventions on quality-screened agent execution traces. This yields verifiable, comprehensive, and fine-grained instances for validating the judge models. Our experiments show that current LLM judges remain unreliable: even the best-performing models achieve overall accuracies below 55% across reasoning, tool-use, and report-quality failures, with especially poor performance on evidence verification. Together, our taxonomy and findings expose systematic judge limitations, reveal tradeoffs in cost and reliability, and offer actionable guidance for building more reliable evaluation pipelines for deep research agents.
Abstract:The key-value (KV) cache is a major bottleneck in long-context inference, where memory and computation grow with sequence length. Existing KV eviction methods reduce this cost but typically degrade performance relative to full-cache inference. Our key insight is that full-cache attention is not always optimal: in long contexts, irrelevant tokens can dilute attention away from useful evidence, so selective, learnable eviction can improve generation rather than merely approximate the full cache. We introduce a global retention-based KV eviction method that learns each token's future utility under a unified memory budget. Lightweight retention gates assign utility scores to cached KV entries, and a shared final scoring projection calibrates these scores across all layers and heads. This enables a single global eviction policy in which tokens from different layers, heads, and modalities compete directly for cache capacity. We further provide theoretical analysis showing that preferentially retaining useful tokens reduces attention dilution, and we justify geometric retention as a query-agnostic proxy for future utility. Across diverse long-context language and vision-language reasoning, and multi-turn dialogue benchmarks, our method substantially reduces KV memory while matching or surpassing full-cache inference. These results suggest that learned, globally calibrated KV eviction is not only a compression technique, but also a mechanism for improving long-context reasoning.