Visual Decoding and Reconstruction via EEG Embeddings with Guided Diffusion

How to decode human vision through neural signals has attracted a long-standing interest in neuroscience and machine learning. Modern contrastive learning and generative models improved the performance of fMRI-based visual decoding and reconstruction. However, the high cost and low temporal resolution of fMRI limit their applications in brain-computer interfaces (BCIs), prompting a high need for EEG-based visual reconstruction. In this study, we present an EEG-based visual reconstruction framework. It consists of a plug-and-play EEG encoder called the Adaptive Thinking Mapper (ATM), which is aligned with image embeddings, and a two-stage EEG guidance image generator that first transforms EEG features into image priors and then reconstructs the visual stimuli with a pre-trained image generator. Our approach allows EEG embeddings to achieve superior performance in image classification and retrieval tasks. Our two-stage image generation strategy vividly reconstructs images seen by humans. Furthermore, we analyzed the impact of signals from different time windows and brain regions on decoding and reconstruction. The versatility of our framework is demonstrated in the magnetoencephalogram (MEG) data modality. We report that EEG-based visual decoding achieves SOTA performance, highlighting the portability, low cost, and high temporal resolution of EEG, enabling a wide range of BCI applications. The code of ATM is available at https://github.com/dongyangli-del/EEG_Image_decode.

Contrastive Learning of Shared Spatiotemporal EEG Representations Across Individuals for Naturalistic Neuroscience

Neural representations induced by naturalistic stimuli offer insights into how humans respond to peripheral stimuli in daily life. The key to understanding the general neural mechanisms underlying naturalistic stimuli processing involves aligning neural activities across individuals and extracting inter-subject shared neural representations. Targeting the Electroencephalogram (EEG) technique, known for its rich spatial and temporal information, this study presents a general framework for Contrastive Learning of Shared SpatioTemporal EEG Representations across individuals (CL-SSTER). Harnessing the representational capabilities of contrastive learning, CL-SSTER utilizes a neural network to maximize the similarity of EEG representations across individuals for identical stimuli, contrasting with those for varied stimuli. The network employed spatial and temporal convolutions to simultaneously learn the spatial and temporal patterns inherent in EEG. The versatility of CL-SSTER was demonstrated on three EEG datasets, including a synthetic dataset, a speech audio EEG dataset, and an emotional video EEG dataset. CL-SSTER attained the highest inter-subject correlation (ISC) values compared to the state-of-the-art ISC methods. The latent representations generated by CL-SSTER exhibited reliable spatiotemporal EEG patterns, which can be explained by specific aspects of the stimuli. CL-SSTER serves as an interpretable and scalable foundational framework for the identification of inter-subject shared neural representations in the realm of naturalistic neuroscience.

Integration of cognitive tasks into artificial general intelligence test for large models

During the evolution of large models, performance evaluation is necessarily performed on the intermediate models to assess their capabilities, and on the well-trained model to ensure safety before practical application. However, current model evaluations mainly rely on specific tasks and datasets, lacking a united framework for assessing the multidimensional intelligence of large models. In this perspective, we advocate for a comprehensive framework of artificial general intelligence (AGI) test, aimed at fulfilling the testing needs of large language models and multi-modal large models with enhanced capabilities. The AGI test framework bridges cognitive science and natural language processing to encompass the full spectrum of intelligence facets, including crystallized intelligence, a reflection of amassed knowledge and experience; fluid intelligence, characterized by problem-solving and adaptive reasoning; social intelligence, signifying comprehension and adaptation within multifaceted social scenarios; and embodied intelligence, denoting the ability to interact with its physical environment. To assess the multidimensional intelligence of large models, the AGI test consists of a battery of well-designed cognitive tests adopted from human intelligence tests, and then naturally encapsulates into an immersive virtual community. We propose that the complexity of AGI testing tasks should increase commensurate with the advancements in large models. We underscore the necessity for the interpretation of test results to avoid false negatives and false positives. We believe that cognitive science-inspired AGI tests will effectively guide the targeted improvement of large models in specific dimensions of intelligence and accelerate the integration of large models into human society.

Advancing EEG/MEG Source Imaging with Geometric-Informed Basis Functions

Electroencephalography (EEG) and Magnetoencephalography (MEG) are pivotal in understanding brain activity but are limited by their poor spatial resolution. EEG/MEG source imaging (ESI) infers the high-resolution electric field distribution in the brain based on the low-resolution scalp EEG/MEG observations. However, the ESI problem is ill-posed, and how to bring neuroscience priors into ESI method is the key. Here, we present a novel method which utilizes the Brain Geometric-informed Basis Functions (GBFs) as priors to enhance EEG/MEG source imaging. Through comprehensive experiments on both synthetic data and real task EEG data, we demonstrate the superiority of GBFs over traditional spatial basis functions (e.g., Harmonic and MSP), as well as existing ESI methods (e.g., dSPM, MNE, sLORETA, eLORETA). GBFs provide robust ESI results under different noise levels, and result in biologically interpretable EEG sources. We believe the high-resolution EEG source imaging from GBFs will greatly advance neuroscience research.

Perturbing a Neural Network to Infer Effective Connectivity: Evidence from Synthetic EEG Data

Identifying causal relationships among distinct brain areas, known as effective connectivity, holds key insights into the brain's information processing and cognitive functions. Electroencephalogram (EEG) signals exhibit intricate dynamics and inter-areal interactions within the brain. However, methods for characterizing nonlinear causal interactions among multiple brain regions remain relatively underdeveloped. In this study, we proposed a data-driven framework to infer effective connectivity by perturbing the trained neural networks. Specifically, we trained neural networks (i.e., CNN, vanilla RNN, GRU, LSTM, and Transformer) to predict future EEG signals according to historical data and perturbed the networks' input to obtain effective connectivity (EC) between the perturbed EEG channel and the rest of the channels. The EC reflects the causal impact of perturbing one node on others. The performance was tested on the synthetic EEG generated by a biological-plausible Jansen-Rit model. CNN and Transformer obtained the best performance on both 3-channel and 90-channel synthetic EEG data, outperforming the classical Granger causality method. Our work demonstrated the potential of perturbing an artificial neural network, learned to predict future system dynamics, to uncover the underlying causal structure.

A Hybrid Brain-Computer Interface Using Motor Imagery and SSVEP Based on Convolutional Neural Network

The key to electroencephalography (EEG)-based brain-computer interface (BCI) lies in neural decoding, and its accuracy can be improved by using hybrid BCI paradigms, that is, fusing multiple paradigms. However, hybrid BCIs usually require separate processing processes for EEG signals in each paradigm, which greatly reduces the efficiency of EEG feature extraction and the generalizability of the model. Here, we propose a two-stream convolutional neural network (TSCNN) based hybrid brain-computer interface. It combines steady-state visual evoked potential (SSVEP) and motor imagery (MI) paradigms. TSCNN automatically learns to extract EEG features in the two paradigms in the training process, and improves the decoding accuracy by 25.4% compared with the MI mode, and 2.6% compared with SSVEP mode in the test data. Moreover, the versatility of TSCNN is verified as it provides considerable performance in both single-mode (70.2% for MI, 93.0% for SSVEP) and hybrid-mode scenarios (95.6% for MI-SSVEP hybrid). Our work will facilitate the real-world applications of EEG-based BCI systems.

Multi-objective optimization via evolutionary algorithm (MOVEA) for high-definition transcranial electrical stimulation of the human brain

Transcranial temporal interference stimulation (tTIS) has been reported to be effective in stimulating deep brain structures in experimental studies. However, a computational framework for optimizing the tTIS strategy and simulating the impact of tTIS on the brain is still lacking, as previous methods rely on predefined parameters and hardly adapt to additional constraints. Here, we propose a general framework, namely multi-objective optimization via evolutionary algorithm (MOVEA), to solve the nonconvex optimization problem for various stimulation techniques, including tTIS and transcranial alternating current stimulation (tACS). By optimizing the electrode montage in a two-stage structure, MOVEA can be compatible with additional constraints (e.g., the number of electrodes, additional avoidance regions), and MOVEA can accelerate to obtain the Pareto fronts. These Pareto fronts consist of a set of optimal solutions under different requirements, suggesting a trade-off relationship between conflicting objectives, such as intensity and focality. Based on MOVEA, we make comprehensive comparisons between tACS and tTIS in terms of intensity, focality and maneuverability for targets of different depths. Our results show that although the tTIS can only obtain a relatively low maximum achievable electric field strength, for example, the maximum intensity of motor area under tTIS is 0.42V /m, while 0.51V /m under tACS, it helps improve the focality by reducing 60% activated volume outside the target. We further perform ANOVA on the stimulation results of eight subjects with tACS and tTIS. Despite the individual differences in head models, our results suggest that tACS has a greater intensity and tTIS has a higher focality. These findings provide guidance on the choice between tACS and tTIS and indicate a great potential in tTIS-based personalized neuromodulation. Code will be released soon.

Explainable fMRI-based Brain Decoding via Spatial Temporal-pyramid Graph Convolutional Network

Brain decoding, aiming to identify the brain states using neural activity, is important for cognitive neuroscience and neural engineering. However, existing machine learning methods for fMRI-based brain decoding either suffer from low classification performance or poor explainability. Here, we address this issue by proposing a biologically inspired architecture, Spatial Temporal-pyramid Graph Convolutional Network (STpGCN), to capture the spatial-temporal graph representation of functional brain activities. By designing multi-scale spatial-temporal pathways and bottom-up pathways that mimic the information process and temporal integration in the brain, STpGCN is capable of explicitly utilizing the multi-scale temporal dependency of brain activities via graph, thereby achieving high brain decoding performance. Additionally, we propose a sensitivity analysis method called BrainNetX to better explain the decoding results by automatically annotating task-related brain regions from the brain-network standpoint. We conduct extensive experiments on fMRI data under 23 cognitive tasks from Human Connectome Project (HCP) S1200. The results show that STpGCN significantly improves brain decoding performance compared to competing baseline models; BrainNetX successfully annotates task-relevant brain regions. Post hoc analysis based on these regions further validates that the hierarchical structure in STpGCN significantly contributes to the explainability, robustness and generalization of the model. Our methods not only provide insights into information representation in the brain under multiple cognitive tasks but also indicate a bright future for fMRI-based brain decoding.

Partial Least Square Regression via Three-factor SVD-type Manifold Optimization for EEG Decoding

Partial least square regression (PLSR) is a widely-used statistical model to reveal the linear relationships of latent factors that comes from the independent variables and dependent variables. However, traditional methods to solve PLSR models are usually based on the Euclidean space, and easily getting stuck into a local minimum. To this end, we propose a new method to solve the partial least square regression, named PLSR via optimization on bi-Grassmann manifold (PLSRbiGr). Specifically, we first leverage the three-factor SVD-type decomposition of the cross-covariance matrix defined on the bi-Grassmann manifold, converting the orthogonal constrained optimization problem into an unconstrained optimization problem on bi-Grassmann manifold, and then incorporate the Riemannian preconditioning of matrix scaling to regulate the Riemannian metric in each iteration. PLSRbiGr is validated with a variety of experiments for decoding EEG signals at motor imagery (MI) and steady-state visual evoked potential (SSVEP) task. Experimental results demonstrate that PLSRbiGr outperforms competing algorithms in multiple EEG decoding tasks, which will greatly facilitate small sample data learning.

Immunofluorescence Capillary Imaging Segmentation: Cases Study

Nonunion is one of the challenges faced by orthopedics clinics for the technical difficulties and high costs in photographing interosseous capillaries. Segmenting vessels and filling capillaries are critical in understanding the obstacles encountered in capillary growth. However, existing datasets for blood vessel segmentation mainly focus on the large blood vessels of the body, and the lack of labeled capillary image datasets greatly limits the methodological development and applications of vessel segmentation and capillary filling. Here, we present a benchmark dataset, named IFCIS-155, consisting of 155 2D capillary images with segmentation boundaries and vessel fillings annotated by biomedical experts, and 19 large-scale, high-resolution 3D capillary images. To obtain better images of interosseous capillaries, we leverage state-of-the-art immunofluorescence imaging techniques to highlight the rich vascular morphology of interosseous capillaries. We conduct comprehensive experiments to verify the effectiveness of the dataset and the benchmarking deep learning models (\eg UNet/UNet++ and the modified UNet/UNet++). Our work offers a benchmark dataset for training deep learning models for capillary image segmentation and provides a potential tool for future capillary research. The IFCIS-155 dataset and code are all publicly available at \url{https://github.com/ncclabsustech/IFCIS-55}.