Deciphering natural language from brain activity through non-invasive devices remains a formidable challenge. Previous non-invasive decoders either require multiple experiments with identical stimuli to pinpoint cortical regions and enhance signal-to-noise ratios in brain activity, or they are limited to discerning basic linguistic elements such as letters and words. We propose a novel approach to decoding continuous language from single-trial non-invasive fMRI recordings, in which a three-dimensional convolutional network augmented with information bottleneck is developed to automatically identify responsive voxels to stimuli, and a character-based decoder is designed for the semantic reconstruction of continuous language characterized by inherent character structures. The resulting decoder can produce intelligible textual sequences that faithfully capture the meaning of perceived speech both within and across subjects, while existing decoders exhibit significantly inferior performance in cross-subject contexts. The ability to decode continuous language from single trials across subjects demonstrates the promising applications of non-invasive language brain-computer interfaces in both healthcare and neuroscience.
3D reconstruction has been widely used in autonomous navigation fields of mobile robotics. However, the former research can only provide the basic geometry structure without the capability of open-world scene understanding, limiting advanced tasks like human interaction and visual navigation. Moreover, traditional 3D scene understanding approaches rely on expensive labeled 3D datasets to train a model for a single task with supervision. Thus, geometric reconstruction with zero-shot scene understanding i.e. Open vocabulary 3D Understanding and Reconstruction, is crucial for the future development of mobile robots. In this paper, we propose OpenOcc, a novel framework unifying the 3D scene reconstruction and open vocabulary understanding with neural radiance fields. We model the geometric structure of the scene with occupancy representation and distill the pre-trained open vocabulary model into a 3D language field via volume rendering for zero-shot inference. Furthermore, a novel semantic-aware confidence propagation (SCP) method has been proposed to relieve the issue of language field representation degeneracy caused by inconsistent measurements in distilled features. Experimental results show that our approach achieves competitive performance in 3D scene understanding tasks, especially for small and long-tail objects.
Combinatorial optimization problems are widespread but inherently challenging due to their discrete nature.The primary limitation of existing methods is that they can only access a small fraction of the solution space at each iteration, resulting in limited efficiency for searching the global optimal. To overcome this challenge, diverging from conventional efforts of expanding the solver's search scope, we focus on enabling information to actively propagate to the solver through heat diffusion. By transforming the target function while preserving its optima, heat diffusion facilitates information flow from distant regions to the solver, providing more efficient navigation. Utilizing heat diffusion, we propose a framework for solving general combinatorial optimization problems. The proposed methodology demonstrates superior performance across a range of the most challenging and widely encountered combinatorial optimizations. Echoing recent advancements in harnessing thermodynamics for generative artificial intelligence, our study further reveals its significant potential in advancing combinatorial optimization.
This article presents a general Bayesian learning framework for multi-modal groupwise registration on medical images. The method builds on probabilistic modelling of the image generative process, where the underlying common anatomy and geometric variations of the observed images are explicitly disentangled as latent variables. Thus, groupwise registration is achieved through the solution to Bayesian inference. We propose a novel hierarchical variational auto-encoding architecture to realize the inference procedure of the latent variables, where the registration parameters can be calculated in a mathematically interpretable fashion. Remarkably, this new paradigm can learn groupwise registration in an unsupervised closed-loop self-reconstruction process, sparing the burden of designing complex intensity-based similarity measures. The computationally efficient disentangled architecture is also inherently scalable and flexible, allowing for groupwise registration on large-scale image groups with variable sizes. Furthermore, the inferred structural representations from disentanglement learning are capable of capturing the latent anatomy of the observations with visual semantics. Extensive experiments were conducted to validate the proposed framework, including four datasets from cardiac, brain and abdominal medical images. The results have demonstrated the superiority of our method over conventional similarity-based approaches in terms of accuracy, efficiency, scalability and interpretability.
Sensory perception originates from the responses of sensory neurons, which react to a collection of sensory signals linked to various physical attributes of a singular perceptual object. Unraveling how the brain extracts perceptual information from these neuronal responses is a pivotal challenge in both computational neuroscience and machine learning. Here we introduce a statistical mechanical theory, where perceptual information is first encoded in the correlated variability of sensory neurons and then reformatted into the firing rates of downstream neurons. Applying this theory, we illustrate the encoding of motion direction using neural covariance and demonstrate high-fidelity direction recovery by spiking neural networks. Networks trained under this theory also show enhanced performance in classifying natural images, achieving higher accuracy and faster inference speed. Our results challenge the traditional view of neural covariance as a secondary factor in neural coding, highlighting its potential influence on brain function.
In this paper, we introduce Recon3DMind, a groundbreaking task focused on reconstructing 3D visuals from Functional Magnetic Resonance Imaging (fMRI) signals. This represents a major step forward in cognitive neuroscience and computer vision. To support this task, we present the fMRI-Shape dataset, utilizing 360-degree view videos of 3D objects for comprehensive fMRI signal capture. Containing 55 categories of common objects from daily life, this dataset will bolster future research endeavors. We also propose MinD-3D, a novel and effective three-stage framework that decodes and reconstructs the brain's 3D visual information from fMRI signals. This method starts by extracting and aggregating features from fMRI frames using a neuro-fusion encoder, then employs a feature bridge diffusion model to generate corresponding visual features, and ultimately recovers the 3D object through a generative transformer decoder. Our experiments demonstrate that this method effectively extracts features that are valid and highly correlated with visual regions of interest (ROIs) in fMRI signals. Notably, it not only reconstructs 3D objects with high semantic relevance and spatial similarity but also significantly deepens our understanding of the human brain's 3D visual processing capabilities. Project page at: https://jianxgao.github.io/MinD-3D.
Synthesizing medical images while preserving their structural information is crucial in medical research. In such scenarios, the preservation of anatomical content becomes especially important. Although recent advances have been made by incorporating instance-level information to guide translation, these methods overlook the spatial coherence of structural-level representation and the anatomical invariance of content during translation. To address these issues, we introduce hierarchical granularity discrimination, which exploits various levels of semantic information present in medical images. Our strategy utilizes three levels of discrimination granularity: pixel-level discrimination using a Brain Memory Bank, structure-level discrimination on each brain structure with a re-weighting strategy to focus on hard samples, and global-level discrimination to ensure anatomical consistency during translation. The image translation performance of our strategy has been evaluated on three independent datasets (UK Biobank, IXI, and BraTS 2018), and it has outperformed state-of-the-art algorithms. Particularly, our model excels not only in synthesizing normal structures but also in handling abnormal (pathological) structures, such as brain tumors, despite the variations in contrast observed across different imaging modalities due to their pathological characteristics. The diagnostic value of synthesized MR images containing brain tumors has been evaluated by radiologists. This indicates that our model may offer an alternative solution in scenarios where specific MR modalities of patients are unavailable. Extensive experiments further demonstrate the versatility of our method, providing unique insights into medical image translation.
The exploration of brain activity and its decoding from fMRI data has been a longstanding pursuit, driven by its potential applications in brain-computer interfaces, medical diagnostics, and virtual reality. Previous approaches have primarily focused on individual subject analysis, highlighting the need for a more universal and adaptable framework, which is the core motivation behind our work. In this work, we propose fMRI-PTE, an innovative auto-encoder approach for fMRI pre-training, with a focus on addressing the challenges of varying fMRI data dimensions due to individual brain differences. Our approach involves transforming fMRI signals into unified 2D representations, ensuring consistency in dimensions and preserving distinct brain activity patterns. We introduce a novel learning strategy tailored for pre-training 2D fMRI images, enhancing the quality of reconstruction. fMRI-PTE's adaptability with image generators enables the generation of well-represented fMRI features, facilitating various downstream tasks, including within-subject and cross-subject brain activity decoding. Our contributions encompass introducing fMRI-PTE, innovative data transformation, efficient training, a novel learning strategy, and the universal applicability of our approach. Extensive experiments validate and support our claims, offering a promising foundation for further research in this domain.
In this work, we present a computing platform named digital twin brain (DTB) that can simulate spiking neuronal networks of the whole human brain scale and more importantly, a personalized biological brain structure. In comparison to most brain simulations with a homogeneous global structure, we highlight that the sparseness, couplingness and heterogeneity in the sMRI, DTI and PET data of the brain has an essential impact on the efficiency of brain simulation, which is proved from the scaling experiments that the DTB of human brain simulation is communication-intensive and memory-access intensive computing systems rather than computation-intensive. We utilize a number of optimization techniques to balance and integrate the computation loads and communication traffics from the heterogeneous biological structure to the general GPU-based HPC and achieve leading simulation performance for the whole human brain-scaled spiking neuronal networks. On the other hand, the biological structure, equipped with a mesoscopic data assimilation, enables the DTB to investigate brain cognitive function by a reverse-engineering method, which is demonstrated by a digital experiment of visual evaluation on the DTB. Furthermore, we believe that the developing DTB will be a promising powerful platform for a large of research orients including brain-inspiredintelligence, rain disease medicine and brain-machine interface.
Building robust, interpretable, and secure artificial intelligence system requires some degree of quantifying and representing uncertainty via a probabilistic perspective, as it allows to mimic human cognitive abilities. However, probabilistic computation presents significant challenges due to its inherent complexity. In this paper, we develop an efficient and interpretable probabilistic computation framework by truncating the probabilistic representation up to its first two moments, i.e., mean and covariance. We instantiate the framework by training a deterministic surrogate of a stochastic network that learns the complex probabilistic representation via combinations of simple activations, encapsulating the non-linearities coupling of the mean and covariance. We show that when the mean is supervised for optimizing the task objective, the unsupervised covariance spontaneously emerging from the non-linear coupling with the mean faithfully captures the uncertainty associated with model predictions. Our research highlights the inherent computability and simplicity of probabilistic computation, enabling its wider application in large-scale settings.