AMPBench-MT: A Homology-Controlled Benchmark for Antimicrobial Peptide Potency, Spectrum, and Safety Prediction

Computational AMP discovery is often evaluated through AMP/non-AMP recognition, yet follow-up decisions depend on assay-derived evidence such as target-species potency, hemolysis, toxicity, and selectivity. Existing AMP and peptide benchmarks cover binary recognition, multilabel annotation, assay regression, or broader peptide-model comparison, but they do not jointly place AMP recognition, species-conditioned potency, spectrum, safety-facing proxy endpoints, and cross-endpoint behavior within one sequence-homology-controlled protocol. To address this problem, we introduce AMPBench-MT, a provenance-preserving benchmark that standardizes canonical peptide records and organizes them into binary recognition, species-conditioned pMIC regression, and endpoint-specific potency and safety-facing readouts. Across 161 endpoint-specific model evaluations, high binary performance does not reliably indicate assay-endpoint behavior. Frozen protein-language-model embeddings form the leading pMIC error cluster, while graph and classical regressors remain close. Spectrum labels further reveal that PR-oriented metrics can be misleading under scarce observed negatives, whereas low-toxicity, HC50 hemolysis, and selectivity expose smaller but more assay-facing signals. AMPBench-MT shows that AMP evaluation should move beyond recognition leaderboards toward endpoint-aware evidence auditing. Our proposed benchmark is available at https://huggingface.co/datasets/ZihengZhou06/AMPBench-MT.

Mutual Modality Trust with Lightweight Reconstruction Regularization for Fine-grained Tire Pattern Recognition

Visual tire recognition serves as a core supporting technique for vehicle safety monitoring, autonomous driving perception and automated automotive maintenance. Existing fine-grained tire recognition techniques suffer from three prominent limitations. They tend to depend on only one visual source, lack the capacity to jointly model spatial and frequency cues for minute tread texture extraction, and suffer severe overfitting given limited annotated tire imagery. This paper proposes a lightweight fine-grained tire pattern recognition method incorporating dual-branch independent inference and enhanced feature fusion to boost recognition performance. The framework employs two task-specialized branches dedicated to tire surface and tread indentation, respectively, to extract modality-specific discriminative features. Each branch conducts independent prediction, while cross-branch feature fusion exploits Mutual Modality Trust (M$^2$T) to realize complementary feature enhancement across two modalities. Besides, a frequency-domain hierarchical guidance module is devised, which leverages bandpass filters to decompose feature maps into high- and low-frequency components and enables fine-grained cross-layer feature modulation. Furthermore, a Lightweight Reconstruction Regularization (LR$^2$) is introduced to retain abundant intrinsic information within feature embeddings, substantially improving feature stability and recognition robustness under limited labeled training data. In addition, we establish a surface-indentation multi-source dataset namely MTire299 for fine-grained tire tread recognition, which covers 299 categories with a total of 14795 paired image samples. Extensive experiments conducted on two public tire datasets validate the superiority and efficacy of the proposed algorithm.

Critic Experience Bank: Self-Evolving Step-Level Confidence Estimation for LLM Agents

LLM agents act in external environments where each action changes the state that later decisions condition on, and where a single wrong step can waste interaction budget or trigger irreversible side effects long before the final failure is observed. Reliable deployment therefore requires \emph{step-level confidence estimation}: a calibrated probability that each proposed action is productive, available \emph{before} the action is executed. Existing LLM confidence estimators are designed to score a response from the given prompt, but agent confidence also depends on execution consequences: whether similar actions in similar situations actually advanced the task after the environment responded. We introduce the \method (\methodshort), a self-evolving critic framework in which an LLM critic accumulates evidence from its own past judgments and their observed consequences. After each trajectory, a hindsight LLM that sees the full execution feedback votes on whether each step was productive. The resulting pseudo-labels populate a memory bank from which related productive and unproductive experiences are retrieved into the critic's prompt whenever a similar step recurs. \methodshort requires no training and uses no ground truth step labels. Across three agent benchmarks and three critic backbones, \methodshort attains the best calibration (ECE and Brier) and ranking (AUC) in every dataset--critic combination, reducing ECE by up to $54\%$ relative to the strongest training-free baseline.

Distortion-Corrected Diffusion MRI Using Rotated-View EPI and Joint Field-Map/Image Estimation with Gaussian Primitives

Echo Planar Imaging (EPI) is the standard acquisition technique for diffusion and functional neuroimaging, enabling rapid imaging but suffering from geometric distortions caused by B0 field inhomogeneities. Existing correction methods first reconstruct distorted images using parallel imaging, then estimate the B0 field and correct the distortion in the image domain. In this sequential process, reconstruction artifacts at high acceleration factors and low SNR at high diffusion b-values degrade B0 estimation and limit the overall correction quality. We propose a physics-informed framework that jointly estimates the B0 field and distortion-free image directly from k-space data, without depending on an intermediate parallel-imaging reconstruction for the correction. The image and the B0 field are each represented as a superposition of Gaussian primitives embedded within an MRI physics forward model. The explicit, continuous parameterization captures both smooth regions and tissue boundaries and supports rotated-view EPI acquisitions without interpolation. The diffusion-weighted image is modeled as real and non-negative, with the image phase absorbed into a per-shot phase factor. Rotated views distribute distortions across multiple phase-encoding orientations, improving point spread function isotropy and providing stronger constraints for B0 estimation. On in vivo brain diffusion EPI, the proposed method attains the closest brain-boundary agreement with a distortion-free structural reference, with the largest improvement over sequential methods at high b-value and high acceleration. Extensive visual comparisons further show improved detail fidelity and noise suppression.

Confidence-Orchestrated Self-Evolution against Uncertain LLM Feedback

Self-evolving large language models (LLMs) learn by generating their own training tasks and solutions, reducing reliance on human-curated supervision. However, in many reasoning domains, the model must also validate generated tasks and judge generated answers to obtain training signals. This creates a training-signal challenge: erroneous self-judgments become erroneous gradient updates. Existing approaches either rely on external verifiers, which limits generality, or treat noisy self-generated feedback as supervision. We propose COSE (Confidence-Orchestrated Self-Evolution), which uses the LLM's intrinsic confidence as a lightweight uncertainty signal to modulate learning. COSE introduces confidence-weighted PPO updates and confidence-prioritized replay. Across 19 held-out benchmarks and four Qwen/Llama backbones (0.6B--4B), COSE consistently improves over base models and achieves the best average performance in general reasoning and mathematics, while remaining competitive on code. Code and data are available at https://anonymous.4open.science/r/COSE_-B5C2.

GE-Sim 2.0: A Roadmap Towards Comprehensive Closed-loop Video World Simulators for Robotic Manipulation

We introduce GE-Sim 2.0 (Genie Envisioner World Simulator 2.0), a closed-loop video world simulator for robotic manipulation. Building on the action-conditioned video generation framework of Genie Envisioner, GE-Sim 2.0 is re-trained on thousands of hours of real-world robot data spanning teleoperation, contact-rich interaction, and on-robot policy deployment, substantially improving action-following fidelity and trajectory coverage. On top of this foundation, three new modules close the loop from video simulation to policy learning: a state expert that decodes proprioceptive state from video latents to support next-chunk prediction by downstream VLA policies; a world judge that scores generated rollouts against task instructions, yielding machine-verifiable success signals and rewards in place of manual inspection; and an acceleration framework that delivers a 25-frame rollout in 2.3 seconds on a single H100, with up to 4* frame skipping at inference for long-horizon evaluation. GE-Sim 2.0 tops the public WorldArena leaderboard at only 2B parameters, outperforming both dedicated robotic world models and closed-source general video generators, and policies trained against its rollouts and rewards translate into measurable real-world gains, establishing GE-Sim 2.0 as a practical platform for scalable evaluation and closed-loop learning of manipulation policies.

MetaAgent-X : Breaking the Ceiling of Automatic Multi-Agent Systems via End-to-End Reinforcement Learning

Automatic multi-agent systems aim to instantiate agent workflows without relying on manually designed or fixed orchestration. However, existing automatic MAS approaches remain only partially adaptive: they either perform training-free test-time search or optimize the meta-level designer while keeping downstream execution agents frozen, which creating a frozen-executor ceiling and leaving the end-to-end training of self-designing and self-executing agentic models unexplored. To address this, we introduce MetaAgent-X, an end-to-end reinforcement learning framework that jointly optimizes automatic MAS design and execution. MetaAgent-X enables script-based MAS generation, execution rollout collection, and credit assignment for both designer and executor trajectories. To support stable and scalable optimization, we propose Executor Designer Hierarchical Rollout and Stagewise Co-evolution to improve training stability and expose the dynamics of designer-executor co-evolution. MetaAgent-X consistently outperforms existing automatic MAS baselines, achieving up to 21.7% gains. Comprehensive ablations show that both designer and executor improve throughout training, and that effective automatic MAS learning follows a stagewise co-evolution process. These results establish end-to-end trainable automatic MAS as a practical paradigm for building self-designing and self-executing agentic models.

Semi-Supervised Flow Matching for Mosaiced and Panchromatic Fusion Imaging

Fusing a low resolution (LR) mosaiced hyperspectral image (HSI) with a high resolution (HR) panchromatic (PAN) image offers a promising avenue for video-rate HR-HSI imaging via single-shot acquisition, yet its severely ill-posed nature remains a significant challenge. In this work, we propose a novel semi-supervised flow matching framework for mosaiced and PAN image fusion. Unlike previous diffusion-based approaches constrained by specific protocols or handcrafted assumptions, our method seamlessly integrates an unsupervised scheme with flow matching, resulting in a generalizable and efficient generative framework. Specifically, our method follows a two-stage training pipeline. First, we pretrain an unsupervised prior network to produce an initial pseudo HR-HSI. Building on this, we then train a conditional flow matching model to generate the target HR-HSI, introducing a random voting mechanism that iteratively refines the initial HR-HSI estimate, enabling robust and effective fusion. During inference, we employ a conflict-free gradient guidance strategy that ensures spectrally and spatially consistent HR-HSI reconstruction. Experiments on multiple benchmark datasets demonstrate that our method achieves superior quantitative and qualitative performance by a significant margin compared to representative baselines. Beyond mosaiced and PAN fusion, our approach provides a flexible generative framework that can be readily extended to other image fusion tasks and integrated with unsupervised or blind image restoration algorithms.

INSPATIO-WORLD: A Real-Time 4D World Simulator via Spatiotemporal Autoregressive Modeling

Building world models with spatial consistency and real-time interactivity remains a fundamental challenge in computer vision. Current video generation paradigms often struggle with a lack of spatial persistence and insufficient visual realism, making it difficult to support seamless navigation in complex environments. To address these challenges, we propose INSPATIO-WORLD, a novel real-time framework capable of recovering and generating high-fidelity, dynamic interactive scenes from a single reference video. At the core of our approach is a Spatiotemporal Autoregressive (STAR) architecture, which enables consistent and controllable scene evolution through two tightly coupled components: Implicit Spatiotemporal Cache aggregates reference and historical observations into a latent world representation, ensuring global consistency during long-horizon navigation; Explicit Spatial Constraint Module enforces geometric structure and translates user interactions into precise and physically plausible camera trajectories. Furthermore, we introduce Joint Distribution Matching Distillation (JDMD). By using real-world data distributions as a regularizing guide, JDMD effectively overcomes the fidelity degradation typically caused by over-reliance on synthetic data. Extensive experiments demonstrate that INSPATIO-WORLD significantly outperforms existing state-of-the-art (SOTA) models in spatial consistency and interaction precision, ranking first among real-time interactive methods on the WorldScore-Dynamic benchmark, and establishing a practical pipeline for navigating 4D environments reconstructed from monocular videos.

PixelPrune: Pixel-Level Adaptive Visual Token Reduction via Predictive Coding

Document understanding and GUI interaction are among the highest-value applications of Vision-Language Models (VLMs), yet they impose exceptionally heavy computational burden: fine-grained text and small UI elements demand high-resolution inputs that produce tens of thousands of visual tokens. We observe that this cost is largely wasteful -- across document and GUI benchmarks, only 22--71\% of image patches are pixel-unique, the rest being exact duplicates of another patch in the same image. We propose \textbf{PixelPrune}, which exploits this pixel-level redundancy through predictive-coding-based compression, pruning redundant patches \emph{before} the Vision Transformer (ViT) encoder. Because it operates in pixel space prior to any neural computation, PixelPrune accelerates both the ViT encoder and the downstream LLM, covering the full inference pipeline. The method is training-free, requires no learnable parameters, and supports pixel-lossless compression ($τ{=}0$) as well as controlled lossy compression ($τ{>}0$). Experiments across three model scales and document and GUI benchmarks show that PixelPrune maintains competitive task accuracy while delivering up to 4.2$\times$ inference speedup and 1.9$\times$ training acceleration. Code is available at https://github.com/OPPO-Mente-Lab/PixelPrune.