A Vision-language Framework for Comparative Reasoning in Radiology

Medical imaging artificial intelligence has achieved strong performance in isolated image interpretation, but remains poorly aligned with radiological practice, where diagnosis and follow-up rely on comparison across prior studies and analogous reference cases. Here we formulate radiological comparison as an entity-aware cross-image reasoning problem and introduce a framework that supports both reference-case retrieval and temporal comparative interpretation. We construct MedReCo-DB, a large-scale comparative imaging resource derived from routine image-report pairs, comprising more than 690,000 images from over 160,000 patients across eight institutions, four countries and seven imaging modalities. Reports are decomposed into anatomical structures, abnormal findings and pathological conditions to provide supervision for entity-conditioned retrieval and comparative visual question answering. Using this resource, we develop MedReCo, an entity-aware visual encoder for controllable retrieval of clinically analogous cases, and MedReCo-VLM, a vision--language extension for generative interpretation of interval change. Across internal, external and cross-center evaluations, MedReCo achieved the highest Recall@1 in all 12 internal retrieval settings and improved external retrieval by a mean of 6.0 percentage points. In clinically confusable differential groups, it consistently outperformed the strongest baselines. MedReCo-VLM achieved the best performance across all comparative generation evaluations and improved longitudinal follow-up accuracy by 14.5-46.5 percentage points on chest radiographs and 13.0-27.9 percentage points on CT. These findings suggest that entity-aware comparative reasoning can be learned from routine clinical data at scale and may provide a more clinically aligned foundation for medical imaging AI.

Evaluating Large Language Models in Dynamic Clinical Decision-Making with Standardized Patient Cases

Large language models (LLMs) are increasingly proposed as clinical agents, yet static, single-turn benchmarks cannot capture how a model dynamically delivers care across an encounter: gathering information, planning treatment, and adapting longitudinal management across successive patient states. Medical education has long addressed an analogous challenge through standardized patients (SPs): trained actors who consistently portray clinical cases, enabling realistic practice and objective, scripted assessment. Here we introduce MedSP1000, an SP-derived interactive benchmark for clinical-agent evaluation, including 1,638 SP cases with 24,602 trajectory-level peer-reviewed rubrics. MedSP1000 converts peer-reviewed SP teaching cases into executable scenarios with defined SP case scripts, clinical environment contexts, and human-validated structured rubric. In each simulation evaluation run, a clinical agent interacts in closed loop with a patient agent and an environment controller, and its behaviour is scored throughout the encounter against expert criteria specified in the original materials. Applying MedSP1000 to a range of general-purpose and medically specialized LLMs, we find that performance on static benchmarks does not reliably translate to such educational scenarios. The best-performing model, GPT-5.5, completes only 60.4% of expert-defined rubric items, whereas the strongest medically specialized model reaches 40.0%; increasing test-time compute produces no measurable gain. These results suggest that current LLMs, including agentic systems tuned for medicine, are not yet reliable enough to be safely integrated into actual clinical practice. More broadly, MedSP1000 shows how process-level, SP-style evaluation can reveal clinically relevant failure modes that single-turn benchmarks miss.

GMOS: Grounding Moving Object Segmentation in 3D Space and Time

Moving Object Segmentation (MOS) aims to discover, segment, and track objects that move independently of the camera. Current MOS methods, however, exhibit two fundamental limitations: they rely on pre-computed 2D auxiliary modalities such as optical flow or point trajectories that lack 3D geometric information, and they treat motion as a sequence-level attribute, overlooking the instantaneous motion state of each object. We address both by grounding MOS in 3D space and time, and propose GMOS, a framework that operates directly on RGB video to produce 3D-aware, temporally fine-grained segmentation of multiple moving objects, alongside a foreground--background variant GMOS-S for faster deployment. To support training and evaluation in this regime, we curate GMOS-2K, a dataset of 2,210 real-world videos with per-object temporal motion annotations drawn from five established Video Object Segmentation (VOS) benchmarks, and formalise MOS-I ("I" for instantaneous), a temporally fine-grained evaluation protocol with three complementary metrics. GMOS achieves state-of-the-art results across MOS, MOS-I, and Unsupervised VOS benchmarks, while running significantly faster than prior multi-object MOS methods and supporting online inference for streaming deployment.

Count Anything at Any Granularity

Open-world object counting remains brittle: despite rapid advances in vision-language models (VLMs), reliably counting the objects a user intends is far from solved. We argue that a central reason is that counting granularity is left implicit; users may refer to a specific identity, an attribute, an instance type, a category, or an abstract concept, yet most methods treat "what to count" as a single, category-level matching problem. In this work, we redefine open-world counting as multi-grained counting, where visual exemplars specify target appearance and fine-grained text, with optional negative prompts, specifies the intended semantic granularity across five explicit levels. Making granularity explicit, however, exposes a critical data bottleneck: existing counting datasets lack the multi-category scenes, controlled distractors, and instance-level annotations needed to verify fine-grained prompt semantics. To address this, we propose the first fully automatic data-scaling pipeline that integrates controllable 3D synthesis with consistent image editing and VLM-based filtering, and use it to construct KubriCount, the largest and most comprehensively annotated counting dataset to date, supporting both training and multi-grained evaluation. Systematic benchmarking reveals that both multimodal large language models and specialist counting models exhibit severe prompt-following failures under fine-grained distinctions. Motivated by these findings, we train HieraCount, a multi-grained counting model that jointly leverages text and visual exemplars as complementary target specifications. HieraCount substantially improves multi-grained counting accuracy and generalizes robustly to challenging real-world scenarios. The project page is available here: https://verg-avesta.github.io/KubriCount/.

POINTS-Seeker: Towards Training a Multimodal Agentic Search Model from Scratch

While Large Multimodal Models (LMMs) demonstrate impressive visual perception, they remain epistemically constrained by their static parametric knowledge. To transcend these boundaries, multimodal search models have been adopted to actively interact with the external environment for evidence retrieval. Diverging from prevailing paradigms that merely retrofit general LMMs with search tools as modular extensions, we explore the potential of building a multimodal agentic search model from scratch. Specifically, we make the following contributions: (i) we introduce Agentic Seeding, a dedicated phase designed to weave the foundational precursors necessary for eliciting agentic behaviors; (ii) we uncover a performance bottleneck in long-horizon interactions, where the increasing volume of interaction history overwhelms the model's ability to locate ground-truth evidence. To mitigate this, we propose V-Fold, an adaptive history-aware compression scheme that preserves recent dialogue turns in high fidelity while folding historical context into the visual space via rendering; and (iii) we develop POINTS-Seeker-8B, a state-of-the-art multimodal agentic search model that consistently outperforms existing models across six diverse benchmarks, effectively resolving the challenges of long-horizon, knowledge-intensive visual reasoning.

A Sanity Check on Composed Image Retrieval

Composed Image Retrieval (CIR) aims to retrieve a target image based on a query composed of a reference image, and a relative caption that specifies the desired modification. Despite the rapid development of CIR models, their performance is not well characterized by existing benchmarks, which inherently contain indeterminate queries degrading the evaluation (i.e., multiple candidate images, rather than solely the target image, meet the query criteria), and have not considered their effectiveness in the context of the multi-round system. Motivated by this, we consider improving the evaluation procedure from two aspects: 1) we introduce FISD, a Fully-Informed Semantically-Diverse benchmark, which employs generative models to precisely control the variables of reference-target image pairs, enabling a more accurate evaluation of CIR methods across six dimensions, without query ambiguity; 2) we propose an automatic multi-round agentic evaluation framework to probe the potential of the existing models in the interactive scenarios. By observing how models adapt and refine their choices over successive rounds of queries, this framework provides a more realistic appraisal of their efficacy in practical applications. Extensive experiments and comparisons prove the value of our novel evaluation on typical CIR methods.

POINTS-Long: Adaptive Dual-Mode Visual Reasoning in MLLMs

Multimodal Large Language Models (MLLMs) have recently demonstrated remarkable capabilities in cross-modal understanding and generation. However, the rapid growth of visual token sequences--especially in long-video and streaming scenarios--poses a major challenge to their scalability and real-world deployment. Thus, we introduce POINTS-Long, a native dual-mode MLLM featuring dynamic visual token scaling inspired by the human visual system. The model supports two complementary perception modes: focus mode and standby mode, enabling users to dynamically trade off efficiency and accuracy during inference. On fine-grained visual tasks, the focus mode retains the optimal performance, while on long-form general visual understanding, the standby mode retains 97.7-99.7% of the original accuracy using only 1/40-1/10th of the visual tokens. Moreover, POINTS-Long natively supports streaming visual understanding via a dynamically detachable KV-cache design, allowing efficient maintenance of ultra-long visual memory. Our work provides new insights into the design of future MLLMs and lays the foundation for adaptive and efficient long-form visual understanding.

GenTac: Generative Modeling and Forecasting of Soccer Tactics

Modeling open-play soccer tactics is a formidable challenge due to the stochastic, multi-agent nature of the game. Existing computational approaches typically produce single, deterministic trajectory forecasts or focus on highly structured set-pieces, fundamentally failing to capture the inherent variance and branching possibilities of real-world match evolution. Here, we introduce GenTac, a diffusion-based generative framework that conceptualizes soccer tactics as a stochastic process over continuous multi-player trajectories and discrete semantic events. By learning the underlying distribution of player movements from historical tracking data, GenTac samples diverse, plausible, long-horizon future trajectories. The framework supports rich contextual conditioning, including opponent behavior, specific team or league playing styles, and strategic objectives, while grounding continuous spatial dynamics into a 15-class tactical event space. Extensive evaluations on our proposed benchmark, TacBench, demonstrate four key capabilities: (1) GenTac achieves high geometric accuracy while strictly preserving the collective structural consistency of the team; (2) it accurately simulates stylistic nuances, distinguishing between specific teams (e.g., Auckland FC) and leagues (e.g., A-League versus German leagues); (3) it enables controllable counterfactual simulations, demonstrably altering spatial control and expected threat metrics based on offensive or defensive guidance; and (4) it reliably anticipates future tactical outcomes directly from generated rollouts. Finally, we demonstrate that GenTac can be successfully trained to generalize to other dynamic team sports, including basketball, American football, and ice hockey.

Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overfitting and opacity. We bridge this gap with a pretraining-finetuning framework to predict outcomes directly from resting-state fMRI. Critically, a generative virtual brain foundation model, pretrained on a collective dataset (2707 subjects, 5621 sessions) to capture universal disorder patterns, was finetuned on PD cohorts receiving TI (n=51) or DBS (n=55) to yield individualized virtual brains with high fidelity to empirical functional connectivity (r=0.935). By constructing counterfactual estimations between pathological and healthy neural states within these personalized models, we predicted clinical responses (TI: AUPR=0.853; DBS: AUPR=0.915), substantially outperforming baselines. External and prospective validations (n=14, n=11) highlight the feasibility of clinical translation. Moreover, our framework provides state-dependent regional patterns linked to response, offering hypothesis-generating mechanistic insights.

Real-World Point Tracking with Verifier-Guided Pseudo-Labeling

Models for long-term point tracking are typically trained on large synthetic datasets. The performance of these models degrades in real-world videos due to different characteristics and the absence of dense ground-truth annotations. Self-training on unlabeled videos has been explored as a practical solution, but the quality of pseudo-labels strongly depends on the reliability of teacher models, which vary across frames and scenes. In this paper, we address the problem of real-world fine-tuning and introduce verifier, a meta-model that learns to assess the reliability of tracker predictions and guide pseudo-label generation. Given candidate trajectories from multiple pretrained trackers, the verifier evaluates them per frame and selects the most trustworthy predictions, resulting in high-quality pseudo-label trajectories. When applied for fine-tuning, verifier-guided pseudo-labeling substantially improves the quality of supervision and enables data-efficient adaptation to unlabeled videos. Extensive experiments on four real-world benchmarks demonstrate that our approach achieves state-of-the-art results while requiring less data than prior self-training methods. Project page: https://kuis-ai.github.io/track_on_r