A Novel Recurrent Neural Network Framework for Prediction and Treatment of Oncogenic Mutation Progression

Despite significant medical advancements, cancer remains the second leading cause of death, with over 600,000 deaths per year in the US. One emerging field, pathway analysis, is promising but still relies on manually derived wet lab data, which is time-consuming to acquire. This work proposes an efficient, effective end-to-end framework for Artificial Intelligence (AI) based pathway analysis that predicts both cancer severity and mutation progression, thus recommending possible treatments. The proposed technique involves a novel combination of time-series machine learning models and pathway analysis. First, mutation sequences were isolated from The Cancer Genome Atlas (TCGA) Database. Then, a novel preprocessing algorithm was used to filter key mutations by mutation frequency. This data was fed into a Recurrent Neural Network (RNN) that predicted cancer severity. Then, the model probabilistically used the RNN predictions, information from the preprocessing algorithm, and multiple drug-target databases to predict future mutations and recommend possible treatments. This framework achieved robust results and Receiver Operating Characteristic (ROC) curves (a key statistical metric) with accuracies greater than 60%, similar to existing cancer diagnostics. In addition, preprocessing played an instrumental role in isolating important mutations, demonstrating that each cancer stage studied may contain on the order of a few-hundred key driver mutations, consistent with current research. Heatmaps based on predicted gene frequency were also generated, highlighting key mutations in each cancer. Overall, this work is the first to propose an efficient, cost-effective end-to-end framework for projecting cancer progression and providing possible treatments without relying on expensive, time-consuming wet lab work.

A Learnable Fully Interacted Two-Tower Model for Pre-Ranking System

Pre-ranking plays a crucial role in large-scale recommender systems by significantly improving the efficiency and scalability within the constraints of providing high-quality candidate sets in real time. The two-tower model is widely used in pre-ranking systems due to a good balance between efficiency and effectiveness with decoupled architecture, which independently processes user and item inputs before calculating their interaction (e.g. dot product or similarity measure). However, this independence also leads to the lack of information interaction between the two towers, resulting in less effectiveness. In this paper, a novel architecture named learnable Fully Interacted Two-tower Model (FIT) is proposed, which enables rich information interactions while ensuring inference efficiency. FIT mainly consists of two parts: Meta Query Module (MQM) and Lightweight Similarity Scorer (LSS). Specifically, MQM introduces a learnable item meta matrix to achieve expressive early interaction between user and item features. Moreover, LSS is designed to further obtain effective late interaction between the user and item towers. Finally, experimental results on several public datasets show that our proposed FIT significantly outperforms the state-of-the-art baseline pre-ranking models.

LLM-as-a-Judge: Rapid Evaluation of Legal Document Recommendation for Retrieval-Augmented Generation

The evaluation bottleneck in recommendation systems has become particularly acute with the rise of Generative AI, where traditional metrics fall short of capturing nuanced quality dimensions that matter in specialized domains like legal research. Can we trust Large Language Models to serve as reliable judges of their own kind? This paper investigates LLM-as-a-Judge as a principled approach to evaluating Retrieval-Augmented Generation systems in legal contexts, where the stakes of recommendation quality are exceptionally high. We tackle two fundamental questions that determine practical viability: which inter-rater reliability metrics best capture the alignment between LLM and human assessments, and how do we conduct statistically sound comparisons between competing systems? Through systematic experimentation, we discover that traditional agreement metrics like Krippendorff's alpha can be misleading in the skewed distributions typical of AI system evaluations. Instead, Gwet's AC2 and rank correlation coefficients emerge as more robust indicators for judge selection, while the Wilcoxon Signed-Rank Test with Benjamini-Hochberg corrections provides the statistical rigor needed for reliable system comparisons. Our findings suggest a path toward scalable, cost-effective evaluation that maintains the precision demanded by legal applications, transforming what was once a human-intensive bottleneck into an automated, yet statistically principled, evaluation framework.

Knowledge Graph Tokenization for Behavior-Aware Generative Next POI Recommendation

Generative paradigm, especially powered by Large Language Models (LLMs), has emerged as a new solution to the next point-of-interest (POI) recommendation. Pioneering studies usually adopt a two-stage pipeline, starting with a tokenizer converting POIs into discrete identifiers that can be processed by LLMs, followed by POI behavior prediction tasks to instruction-tune LLM for next POI recommendation. Despite of remarkable progress, they still face two limitations: (1) existing tokenizers struggle to encode heterogeneous signals in the recommendation data, suffering from information loss issue, and (2) previous instruction-tuning tasks only focus on users' POI visit behavior while ignore other behavior types, resulting in insufficient understanding of mobility. To address these limitations, we propose KGTB (Knowledge Graph Tokenization for Behavior-aware generative next POI recommendation). Specifically, KGTB organizes the recommendation data in a knowledge graph (KG) format, of which the structure can seamlessly preserve the heterogeneous information. Then, a KG-based tokenizer is developed to quantize each node into an individual structural ID. This process is supervised by the KG's structure, thus reducing the loss of heterogeneous information. Using generated IDs, KGTB proposes multi-behavior learning that introduces multiple behavior-specific prediction tasks for LLM fine-tuning, e.g., POI, category, and region visit behaviors. Learning on these behavior tasks provides LLMs with comprehensive insights on the target POI visit behavior. Experiments on four real-world city datasets demonstrate the superior performance of KGTB.

Understanding Prompt Management in GitHub Repositories: A Call for Best Practices

The rapid adoption of foundation models (e.g., large language models) has given rise to promptware, i.e., software built using natural language prompts. Effective management of prompts, such as organization and quality assurance, is essential yet challenging. In this study, we perform an empirical analysis of 24,800 open-source prompts from 92 GitHub repositories to investigate prompt management practices and quality attributes. Our findings reveal critical challenges such as considerable inconsistencies in prompt formatting, substantial internal and external prompt duplication, and frequent readability and spelling issues. Based on these findings, we provide actionable recommendations for developers to enhance the usability and maintainability of open-source prompts within the rapidly evolving promptware ecosystem.

What News Recommendation Research Did (But Mostly Didn't) Teach Us About Building A News Recommender

One of the goals of recommender systems research is to provide insights and methods that can be used by practitioners to build real-world systems that deliver high-quality recommendations to actual people grounded in their genuine interests and needs. We report on our experience trying to apply the news recommendation literature to build POPROX, a live platform for news recommendation research, and reflect on the extent to which the current state of research supports system-building efforts. Our experience highlights several unexpected challenges encountered in building personalization features that are commonly found in products from news aggregators and publishers, and shows how those difficulties are connected to surprising gaps in the literature. Finally, we offer a set of lessons learned from building a live system with a persistent user base and highlight opportunities to make future news recommendation research more applicable and impactful in practice.

Incorporating AI Incident Reporting into Telecommunications Law and Policy: Insights from India

The integration of artificial intelligence (AI) into telecommunications infrastructure introduces novel risks, such as algorithmic bias and unpredictable system behavior, that fall outside the scope of traditional cybersecurity and data protection frameworks. This paper introduces a precise definition and a detailed typology of telecommunications AI incidents, establishing them as a distinct category of risk that extends beyond conventional cybersecurity and data protection breaches. It argues for their recognition as a distinct regulatory concern. Using India as a case study for jurisdictions that lack a horizontal AI law, the paper analyzes the country's key digital regulations. The analysis reveals that India's existing legal instruments, including the Telecommunications Act, 2023, the CERT-In Rules, and the Digital Personal Data Protection Act, 2023, focus on cybersecurity and data breaches, creating a significant regulatory gap for AI-specific operational incidents, such as performance degradation and algorithmic bias. The paper also examines structural barriers to disclosure and the limitations of existing AI incident repositories. Based on these findings, the paper proposes targeted policy recommendations centered on integrating AI incident reporting into India's existing telecom governance. Key proposals include mandating reporting for high-risk AI failures, designating an existing government body as a nodal agency to manage incident data, and developing standardized reporting frameworks. These recommendations aim to enhance regulatory clarity and strengthen long-term resilience, offering a pragmatic and replicable blueprint for other nations seeking to govern AI risks within their existing sectoral frameworks.

MetaLLMix : An XAI Aided LLM-Meta-learning Based Approach for Hyper-parameters Optimization

Effective model and hyperparameter selection remains a major challenge in deep learning, often requiring extensive expertise and computation. While AutoML and large language models (LLMs) promise automation, current LLM-based approaches rely on trial and error and expensive APIs, which provide limited interpretability and generalizability. We propose MetaLLMiX, a zero-shot hyperparameter optimization framework combining meta-learning, explainable AI, and efficient LLM reasoning. By leveraging historical experiment outcomes with SHAP explanations, MetaLLMiX recommends optimal hyperparameters and pretrained models without additional trials. We further employ an LLM-as-judge evaluation to control output format, accuracy, and completeness. Experiments on eight medical imaging datasets using nine open-source lightweight LLMs show that MetaLLMiX achieves competitive or superior performance to traditional HPO methods while drastically reducing computational cost. Our local deployment outperforms prior API-based approaches, achieving optimal results on 5 of 8 tasks, response time reductions of 99.6-99.9%, and the fastest training times on 6 datasets (2.4-15.7x faster), maintaining accuracy within 1-5% of best-performing baselines.

Constructing a Question-Answering Simulator through the Distillation of LLMs

The question-answering (QA) simulator is a model that mimics real student learning behaviors and predicts their correctness of their responses to questions. QA simulators enable educational recommender systems (ERS) to collect large amounts of training data without interacting with real students, thereby preventing harmful recommendations made by an undertrained ERS from undermining actual student learning. Given the QA history, there are two categories of solutions to predict the correctness, conducting the simulation: (1) LLM-free methods, which apply a traditional sequential model to transfer the QA history into a vector representation first, and make predictions based on the representation; (2) LLM-based methods, which leverage the domain knowledge and reasoning capability of LLM to enhence the prediction. LLM-free methods offer fast inference but generally yield suboptimal performance. In contrast, most LLM-based methods achieve better results, but at the cost of slower inference speed and higher GPU memory consumption. In this paper, we propose a method named LLM Distillation based Simulator (LDSim), which distills domain knowledge and reasoning capability from an LLM to better assist prediction, thereby improving simulation performance. Extensive experiments demonstrate that our LDSim achieves strong results on both the simulation task and the knowledge tracing (KT) task. Our code is publicly available at https://anonymous.4open.science/r/LDSim-05A9.

CESRec: Constructing Pseudo Interactions for Sequential Recommendation via Conversational Feedback

Sequential Recommendation Systems (SRS) have become essential in many real-world applications. However, existing SRS methods often rely on collaborative filtering signals and fail to capture real-time user preferences, while Conversational Recommendation Systems (CRS) excel at eliciting immediate interests through natural language interactions but neglect historical behavior. To bridge this gap, we propose CESRec, a novel framework that integrates the long-term preference modeling of SRS with the real-time preference elicitation of CRS. We introduce semantic-based pseudo interaction construction, which dynamically updates users'historical interaction sequences by analyzing conversational feedback, generating a pseudo-interaction sequence that seamlessly combines long-term and real-time preferences. Additionally, we reduce the impact of outliers in historical items that deviate from users'core preferences by proposing dual alignment outlier items masking, which identifies and masks such items using semantic-collaborative aligned representations. Extensive experiments demonstrate that CESRec achieves state-of-the-art performance by boosting strong SRS models, validating its effectiveness in integrating conversational feedback into SRS.