A Deep Learning Method for Beat-Level Risk Analysis and Interpretation of Atrial Fibrillation Patients during Sinus Rhythm

Atrial Fibrillation (AF) is a common cardiac arrhythmia. Many AF patients experience complications such as stroke and other cardiovascular issues. Early detection of AF is crucial. Existing algorithms can only distinguish ``AF rhythm in AF patients'' from ``sinus rhythm in normal individuals'' . However, AF patients do not always exhibit AF rhythm, posing a challenge for diagnosis when the AF rhythm is absent. To address this, this paper proposes a novel artificial intelligence (AI) algorithm to distinguish ``sinus rhythm in AF patients'' and ``sinus rhythm in normal individuals'' in beat-level. We introduce beat-level risk interpreters, trend risk interpreters, addressing the interpretability issues of deep learning models and the difficulty in explaining AF risk trends. Additionally, the beat-level information fusion decision is presented to enhance model accuracy. The experimental results demonstrate that the average AUC for single beats used as testing data from CPSC 2021 dataset is 0.7314. By employing 150 beats for information fusion decision algorithm, the average AUC can reach 0.7591. Compared to previous segment-level algorithms, we utilized beats as input, reducing data dimensionality and making the model more lightweight, facilitating deployment on portable medical devices. Furthermore, we draw new and interesting findings through average beat analysis and subgroup analysis, considering varying risk levels.

Conditional Diffusion Feature Refinement for Continuous Sign Language Recognition

In this work, we are dedicated to leveraging the denoising diffusion models' success and formulating feature refinement as the autoencoder-formed diffusion process. The state-of-the-art CSLR framework consists of a spatial module, a visual module, a sequence module, and a sequence learning function. However, this framework has faced sequence module overfitting caused by the objective function and small-scale available benchmarks, resulting in insufficient model training. To overcome the overfitting problem, some CSLR studies enforce the sequence module to learn more visual temporal information or be guided by more informative supervision to refine its representations. In this work, we propose a novel autoencoder-formed conditional diffusion feature refinement~(ACDR) to refine the sequence representations to equip desired properties by learning the encoding-decoding optimization process in an end-to-end way. Specifically, for the ACDR, a noising Encoder is proposed to progressively add noise equipped with semantic conditions to the sequence representations. And a denoising Decoder is proposed to progressively denoise the noisy sequence representations with semantic conditions. Therefore, the sequence representations can be imbued with the semantics of provided semantic conditions. Further, a semantic constraint is employed to prevent the denoised sequence representations from semantic corruption. Extensive experiments are conducted to validate the effectiveness of our ACDR, benefiting state-of-the-art methods and achieving a notable gain on three benchmarks.

Learning Optimal Treatment Strategies for Sepsis Using Offline Reinforcement Learning in Continuous Space

Sepsis is a leading cause of death in the ICU. It is a disease requiring complex interventions in a short period of time, but its optimal treatment strategy remains uncertain. Evidence suggests that the practices of currently used treatment strategies are problematic and may cause harm to patients. To address this decision problem, we propose a new medical decision model based on historical data to help clinicians recommend the best reference option for real-time treatment. Our model combines offline reinforcement learning with deep reinforcement learning to address the problem that traditional reinforcement learning in healthcare cannot interact with the environment, enabling our model to make decisions in a continuous state-action space. We demonstrate that, on average, the treatments recommended by the model are more valuable and reliable than those recommended by clinicians. In a large validation dataset, we found that patients whose actual doses from clinicians matched the AI's decisions had the lowest mortality rates. Our model provides personalized, clinically interpretable treatment decisions for sepsis that can improve patient care.

Infrared Small Target Detection Using Multi-patch Attention Network

Infrared small target detection plays an important role in the infrared search and tracking applications. In recent years, deep learning techniques were introduced to this task and achieved noteworthy effects. Following general object segmentation methods, existing deep learning methods usually processed the image from the global view. However, the imaging locality of small targets and extreme class-imbalance between the target and background pixels were not well-considered by these deep learning methods, which causes the low-efficiency on training and high-dependence on numerous data. A multi-patch attention network (MANet) is proposed in this paper to detect small targets by jointly considering the global and local properties of infrared small target images. From the global view, a supervised attention module trained by the small target spread map is proposed to suppress most background pixels irrelevant with small target features. From the local view, local patches are split from global features and share the same convolution weights with each other in a patch net. By synthesizing the global and local properties, the data-driven framework proposed in this paper has fused multi-scale features for small target detection. Extensive synthetic and real data experiments show that the proposed method achieves the state-of-the-art performance compared with existing both conventional and deep learning methods.

Opportunities and Challenges in Deep Learning Methods on Electrocardiogram Data: A Systematic Review

Objective: To conduct a systematic review of deep learning methods on Electrocardiogram (ECG) data from the perspective of model architecture and their application task. Methods: First, we extensively searched papers deploying deep learning (deep neural network networks) on ECG data that published between January 1st 2010 and September 30th 2019 from Google Scholar, PubMed and DBLP. Then we analyze them in three aspects including task, model and data. Finally, we conclude unresolved challenges and problems that existing models can not handle well. Results: The total number of papers is 124, among them 97 papers are published after in recent two years. Almost all kinds of common deep learning architectures have been used in ECG analytics tasks like disease detection/classification, annotation/localization, sleep staging, biometric human identification, denoising and so on. Conclusion: The number of works about deep learning on ECG data is growing explosively in recent years. Indeed, these works have achieve a far more better performance in terms of accuracy. However, there are some new challenges and problems like interpretability, scalability, efficiency, which need to be addressed and paid more attention. Moreover, it is also worth to investigate by discovering new interesting applications from both the dataset view and the method view. Significance: This paper summarizes existing deep learning methods on modeling ECG data from multiple views, while also point out existing challenges and problems, while can become potential research direction in the future.