SSMD: Semi-Supervised Medical Image Detection with Adaptive Consistency and Heterogeneous Perturbation

Semi-Supervised classification and segmentation methods have been widely investigated in medical image analysis. Both approaches can improve the performance of fully-supervised methods with additional unlabeled data. However, as a fundamental task, semi-supervised object detection has not gained enough attention in the field of medical image analysis. In this paper, we propose a novel Semi-Supervised Medical image Detector (SSMD). The motivation behind SSMD is to provide free yet effective supervision for unlabeled data, by regularizing the predictions at each position to be consistent. To achieve the above idea, we develop a novel adaptive consistency cost function to regularize different components in the predictions. Moreover, we introduce heterogeneous perturbation strategies that work in both feature space and image space, so that the proposed detector is promising to produce powerful image representations and robust predictions. Extensive experimental results show that the proposed SSMD achieves the state-of-the-art performance at a wide range of settings. We also demonstrate the strength of each proposed module with comprehensive ablation studies.

Hierarchical Deep Network with Uncertainty-aware Semi-supervised Learning for Vessel Segmentation

The analysis of organ vessels is essential for computer-aided diagnosis and surgical planning. But it is not a easy task since the fine-detailed connected regions of organ vessel bring a lot of ambiguity in vessel segmentation and sub-type recognition, especially for the low-contrast capillary regions. Furthermore, recent two-staged approaches would accumulate and even amplify these inaccuracies from the first-stage whole vessel segmentation into the second-stage sub-type vessel pixel-wise classification. Moreover, the scarcity of manual annotation in organ vessels poses another challenge. In this paper, to address the above issues, we propose a hierarchical deep network where an attention mechanism localizes the low-contrast capillary regions guided by the whole vessels, and enhance the spatial activation in those areas for the sub-type vessels. In addition, we propose an uncertainty-aware semi-supervised training framework to alleviate the annotation-hungry limitation of deep models. The proposed method achieves the state-of-the-art performance in the benchmarks of both retinal artery/vein segmentation in fundus images and liver portal/hepatic vessel segmentation in CT images.

Act Like a Radiologist: Towards Reliable Multi-view Correspondence Reasoning for Mammogram Mass Detection

Mammogram mass detection is crucial for diagnosing and preventing the breast cancers in clinical practice. The complementary effect of multi-view mammogram images provides valuable information about the breast anatomical prior structure and is of great significance in digital mammography interpretation. However, unlike radiologists who can utilize the natural reasoning ability to identify masses based on multiple mammographic views, how to endow the existing object detection models with the capability of multi-view reasoning is vital for decision-making in clinical diagnosis but remains the boundary to explore. In this paper, we propose an Anatomy-aware Graph convolutional Network (AGN), which is tailored for mammogram mass detection and endows existing detection methods with multi-view reasoning ability. The proposed AGN consists of three steps. Firstly, we introduce a Bipartite Graph convolutional Network (BGN) to model the intrinsic geometric and semantic relations of ipsilateral views. Secondly, considering that the visual asymmetry of bilateral views is widely adopted in clinical practice to assist the diagnosis of breast lesions, we propose an Inception Graph convolutional Network (IGN) to model the structural similarities of bilateral views. Finally, based on the constructed graphs, the multi-view information is propagated through nodes methodically, which equips the features learned from the examined view with multi-view reasoning ability. Experiments on two standard benchmarks reveal that AGN significantly exceeds the state-of-the-art performance. Visualization results show that AGN provides interpretable visual cues for clinical diagnosis.

A Structure-Aware Relation Network for Thoracic Diseases Detection and Segmentation

Instance level detection and segmentation of thoracic diseases or abnormalities are crucial for automatic diagnosis in chest X-ray images. Leveraging on constant structure and disease relations extracted from domain knowledge, we propose a structure-aware relation network (SAR-Net) extending Mask R-CNN. The SAR-Net consists of three relation modules: 1. the anatomical structure relation module encoding spatial relations between diseases and anatomical parts. 2. the contextual relation module aggregating clues based on query-key pair of disease RoI and lung fields. 3. the disease relation module propagating co-occurrence and causal relations into disease proposals. Towards making a practical system, we also provide ChestX-Det, a chest X-Ray dataset with instance-level annotations (boxes and masks). ChestX-Det is a subset of the public dataset NIH ChestX-ray14. It contains ~3500 images of 13 common disease categories labeled by three board-certified radiologists. We evaluate our SAR-Net on it and another dataset DR-Private. Experimental results show that it can enhance the strong baseline of Mask R-CNN with significant improvements. The ChestX-Det is released at https://github.com/Deepwise-AILab/ChestX-Det-Dataset.

Cross-Domain Adaptive Clustering for Semi-Supervised Domain Adaptation

In semi-supervised domain adaptation, a few labeled samples per class in the target domain guide features of the remaining target samples to aggregate around them. However, the trained model cannot produce a highly discriminative feature representation for the target domain because the training data is dominated by labeled samples from the source domain. This could lead to disconnection between the labeled and unlabeled target samples as well as misalignment between unlabeled target samples and the source domain. In this paper, we propose a novel approach called Cross-domain Adaptive Clustering to address this problem. To achieve both inter-domain and intra-domain adaptation, we first introduce an adversarial adaptive clustering loss to group features of unlabeled target data into clusters and perform cluster-wise feature alignment across the source and target domains. We further apply pseudo labeling to unlabeled samples in the target domain and retain pseudo-labels with high confidence. Pseudo labeling expands the number of ``labeled" samples in each class in the target domain, and thus produces a more robust and powerful cluster core for each class to facilitate adversarial learning. Extensive experiments on benchmark datasets, including DomainNet, Office-Home and Office, demonstrate that our proposed approach achieves the state-of-the-art performance in semi-supervised domain adaptation.

Generalized Organ Segmentation by Imitating One-shot Reasoning using Anatomical Correlation

Learning by imitation is one of the most significant abilities of human beings and plays a vital role in human's computational neural system. In medical image analysis, given several exemplars (anchors), experienced radiologist has the ability to delineate unfamiliar organs by imitating the reasoning process learned from existing types of organs. Inspired by this observation, we propose OrganNet which learns a generalized organ concept from a set of annotated organ classes and then transfer this concept to unseen classes. In this paper, we show that such process can be integrated into the one-shot segmentation task which is a very challenging but meaningful topic. We propose pyramid reasoning modules (PRMs) to model the anatomical correlation between anchor and target volumes. In practice, the proposed module first computes a correlation matrix between target and anchor computerized tomography (CT) volumes. Then, this matrix is used to transform the feature representations of both anchor volume and its segmentation mask. Finally, OrganNet learns to fuse the representations from various inputs and predicts segmentation results for target volume. Extensive experiments show that OrganNet can effectively resist the wide variations in organ morphology and produce state-of-the-art results in one-shot segmentation task. Moreover, even when compared with fully-supervised segmentation models, OrganNet is still able to produce satisfying segmentation results.

I3Net: Implicit Instance-Invariant Network for Adapting One-Stage Object Detectors

Recent works on two-stage cross-domain detection have widely explored the local feature patterns to achieve more accurate adaptation results. These methods heavily rely on the region proposal mechanisms and ROI-based instance-level features to design fine-grained feature alignment modules with respect to the foreground objects. However, for one-stage detectors, it is hard or even impossible to obtain explicit instance-level features in the detection pipelines. Motivated by this, we propose an Implicit Instance-Invariant Network (I3Net), which is tailored for adapting one-stage detectors and implicitly learns instance-invariant features via exploiting the natural characteristics of deep features in different layers. Specifically, we facilitate the adaptation from three aspects: (1) Dynamic and Class-Balanced Reweighting (DCBR) strategy, which considers the coexistence of intra-domain and intra-class variations to assign larger weights to those sample-scarce categories and easy-to-adapt samples; (2) Category-aware Object Pattern Matching (COPM) module, which boosts the cross-domain foreground objects matching guided by the categorical information and suppresses the uninformative background features; (3) Regularized Joint Category Alignment (RJCA) module, which jointly enforces the category alignment at different domain-specific layers with a consistency regularization. Experiments reveal that I3Net exceeds the state-of-the-art performance on benchmark datasets.

Coarse-to-Fine Domain Adaptive Semantic Segmentation with Photometric Alignment and Category-Center Regularization

Unsupervised domain adaptation (UDA) in semantic segmentation is a fundamental yet promising task relieving the need for laborious annotation works. However, the domain shifts/discrepancies problem in this task compromise the final segmentation performance. Based on our observation, the main causes of the domain shifts are differences in imaging conditions, called image-level domain shifts, and differences in object category configurations called category-level domain shifts. In this paper, we propose a novel UDA pipeline that unifies image-level alignment and category-level feature distribution regularization in a coarse-to-fine manner. Specifically, on the coarse side, we propose a photometric alignment module that aligns an image in the source domain with a reference image from the target domain using a set of image-level operators; on the fine side, we propose a category-oriented triplet loss that imposes a soft constraint to regularize category centers in the source domain and a self-supervised consistency regularization method in the target domain. Experimental results show that our proposed pipeline improves the generalization capability of the final segmentation model and significantly outperforms all previous state-of-the-arts.

Scene-Intuitive Agent for Remote Embodied Visual Grounding

Humans learn from life events to form intuitions towards the understanding of visual environments and languages. Envision that you are instructed by a high-level instruction, "Go to the bathroom in the master bedroom and replace the blue towel on the left wall", what would you possibly do to carry out the task? Intuitively, we comprehend the semantics of the instruction to form an overview of where a bathroom is and what a blue towel is in mind; then, we navigate to the target location by consistently matching the bathroom appearance in mind with the current scene. In this paper, we present an agent that mimics such human behaviors. Specifically, we focus on the Remote Embodied Visual Referring Expression in Real Indoor Environments task, called REVERIE, where an agent is asked to correctly localize a remote target object specified by a concise high-level natural language instruction, and propose a two-stage training pipeline. In the first stage, we pretrain the agent with two cross-modal alignment sub-tasks, namely the Scene Grounding task and the Object Grounding task. The agent learns where to stop in the Scene Grounding task and what to attend to in the Object Grounding task respectively. Then, to generate action sequences, we propose a memory-augmented attentive action decoder to smoothly fuse the pre-trained vision and language representations with the agent's past memory experiences. Without bells and whistles, experimental results show that our method outperforms previous state-of-the-art(SOTA) significantly, demonstrating the effectiveness of our method.

Refer-it-in-RGBD: A Bottom-up Approach for 3D Visual Grounding in RGBD Images

Grounding referring expressions in RGBD image has been an emerging field. We present a novel task of 3D visual grounding in single-view RGBD image where the referred objects are often only partially scanned due to occlusion. In contrast to previous works that directly generate object proposals for grounding in the 3D scenes, we propose a bottom-up approach to gradually aggregate context-aware information, effectively addressing the challenge posed by the partial geometry. Our approach first fuses the language and the visual features at the bottom level to generate a heatmap that coarsely localizes the relevant regions in the RGBD image. Then our approach conducts an adaptive feature learning based on the heatmap and performs the object-level matching with another visio-linguistic fusion to finally ground the referred object. We evaluate the proposed method by comparing to the state-of-the-art methods on both the RGBD images extracted from the ScanRefer dataset and our newly collected SUNRefer dataset. Experiments show that our method outperforms the previous methods by a large margin (by 11.2% and 15.6% Acc@0.5) on both datasets.