DeepFAN, a transformer-based deep learning model for human-artificial intelligence collaborative assessment of incidental pulmonary nodules in CT scans: a multi-reader, multi-case trial

The widespread adoption of CT has notably increased the number of detected lung nodules. However, current deep learning methods for classifying benign and malignant nodules often fail to comprehensively integrate global and local features, and most of them have not been validated through clinical trials. To address this, we developed DeepFAN, a transformer-based model trained on over 10K pathology-confirmed nodules and further conducted a multi-reader, multi-case clinical trial to evaluate its efficacy in assisting junior radiologists. DeepFAN achieved diagnostic area under the curve (AUC) of 0.939 (95% CI 0.930-0.948) on an internal test set and 0.954 (95% CI 0.934-0.973) on the clinical trial dataset involving 400 cases across three independent medical institutions. Explainability analysis indicated higher contributions from global than local features. Twelve readers' average performance significantly improved by 10.9% (95% CI 8.3%-13.5%) in AUC, 10.0% (95% CI 8.9%-11.1%) in accuracy, 7.6% (95% CI 6.1%-9.2%) in sensitivity, and 12.6% (95% CI 10.9%-14.3%) in specificity (P<0.001 for all). Nodule-level inter-reader diagnostic consistency improved from fair to moderate (overall k: 0.313 vs. 0.421; P=0.019). In conclusion, DeepFAN effectively assisted junior radiologists and may help homogenize diagnostic quality and reduce unnecessary follow-up of indeterminate pulmonary nodules. Chinese Clinical Trial Registry: ChiCTR2400084624.

CGSA: Class-Guided Slot-Aware Adaptation for Source-Free Object Detection

Source-Free Domain Adaptive Object Detection (SF-DAOD) aims to adapt a detector trained on a labeled source domain to an unlabeled target domain without retaining any source data. Despite recent progress, most popular approaches focus on tuning pseudo-label thresholds or refining the teacher-student framework, while overlooking object-level structural cues within cross-domain data. In this work, we present CGSA, the first framework that brings Object-Centric Learning (OCL) into SF-DAOD by integrating slot-aware adaptation into the DETR-based detector. Specifically, our approach integrates a Hierarchical Slot Awareness (HSA) module into the detector to progressively disentangle images into slot representations that act as visual priors. These slots are then guided toward class semantics via a Class-Guided Slot Contrast (CGSC) module, maintaining semantic consistency and prompting domain-invariant adaptation. Extensive experiments on multiple cross-domain datasets demonstrate that our approach outperforms previous SF-DAOD methods, with theoretical derivations and experimental analysis further demonstrating the effectiveness of the proposed components and the framework, thereby indicating the promise of object-centric design in privacy-sensitive adaptation scenarios. Code is released at https://github.com/Michael-McQueen/CGSA.

Vision Transformers Need More Than Registers

Vision Transformers (ViTs), when pre-trained on large-scale data, provide general-purpose representations for diverse downstream tasks. However, artifacts in ViTs are widely observed across different supervision paradigms and downstream tasks. Through systematic analysis of artifacts in ViTs, we find that their fundamental mechanisms have yet to be sufficiently elucidated. In this paper, through systematic analysis, we conclude that these artifacts originate from a lazy aggregation behavior: ViT uses semantically irrelevant background patches as shortcuts to represent global semantics, driven by global attention and Coarse-grained semantic supervision. Our solution selectively integrates patch features into the CLS token, reducing the influence of background-dominated shortcuts and consistently improving performance across 12 benchmarks under label-, text-, and self-supervision. We hope this work offers a new perspective on ViT behavior.

Parameters as Experts: Adapting Vision Models with Dynamic Parameter Routing

Adapting pre-trained vision models using parameter-efficient fine-tuning (PEFT) remains challenging, as it aims to achieve performance comparable to full fine-tuning using a minimal number of trainable parameters. When applied to complex dense prediction tasks, existing methods exhibit limitations, including input-agnostic modeling and redundant cross-layer representations. To this end, we propose AdaRoute, a new adapter-style method featuring a simple mixture-of-experts (MoE) architecture. Specifically, we introduce shared expert centers, where each expert is a trainable parameter matrix. During a feedforward pass, each AdaRoute module in the network dynamically generates weight matrices tailored for the current module via a simple dynamic parameter routing mechanism, which selectively aggregates parameter matrices in the corresponding expert center. Dynamic weight matrices in AdaRoute modules facilitate low-rank adaptation in an input-dependent manner, thus generating more customized and powerful feature representations. Moreover, since AdaRoute modules across multiple network layers share the same expert center, they improve feature diversity by promoting implicit cross-layer feature interaction. Extensive experiments demonstrate the superiority of AdaRoute on diverse vision tasks, including semantic segmentation, object detection and instance segmentation, and panoptic segmentation. Code will be available at: https://bit.ly/3NZcr0H.

Scaling Continual Learning with Bi-Level Routing Mixture-of-Experts

Continual learning, especially class-incremental learning (CIL), on the basis of a pre-trained model (PTM) has garnered substantial research interest in recent years. However, how to effectively learn both discriminative and comprehensive feature representations while maintaining stability and plasticity over very long task sequences remains an open problem. We propose CaRE, a scalable {C}ontinual Le{a}rner with efficient Bi-Level {R}outing Mixture-of-{E}xperts (BR-MoE). The core idea of BR-MoE is a bi-level routing mechanism: a router selection stage that dynamically activates relevant task-specific routers, followed by an expert routing phase that dynamically activates and aggregates experts, aiming to inject discriminative and comprehensive representations into every intermediate network layer. On the other hand, we introduce a challenging evaluation protocol for comprehensively assessing CIL methods across very long task sequences spanning hundreds of tasks. Extensive experiments show that CaRE demonstrates leading performance across a variety of datasets and task settings, including commonly used CIL datasets with classical CIL settings (e.g., 5-20 tasks). To the best of our knowledge, CaRE is the first continual learner that scales to very long task sequences (ranging from 100 to over 300 non-overlapping tasks), while outperforming all baselines by a large margin on such task sequences. Code will be publicly released at https://github.com/LMMMEng/CaRE.git.

LDRNet: Large Deformation Registration Model for Chest CT Registration

Most of the deep learning based medical image registration algorithms focus on brain image registration tasks.Compared with brain registration, the chest CT registration has larger deformation, more complex background and region over-lap. In this paper, we propose a fast unsupervised deep learning method, LDRNet, for large deformation image registration of chest CT images. We first predict a coarse resolution registration field, then refine it from coarse to fine. We propose two innovative technical components: 1) a refine block that is used to refine the registration field in different resolutions, 2) a rigid block that is used to learn transformation matrix from high-level features. We train and evaluate our model on the private dataset and public dataset SegTHOR. We compare our performance with state-of-the-art traditional registration methods as well as deep learning registration models VoxelMorph, RCN, and LapIRN. The results demonstrate that our model achieves state-of-the-art performance for large deformation images registration and is much faster.

A2Mamba: Attention-augmented State Space Models for Visual Recognition

Transformers and Mamba, initially invented for natural language processing, have inspired backbone architectures for visual recognition. Recent studies integrated Local Attention Transformers with Mamba to capture both local details and global contexts. Despite competitive performance, these methods are limited to simple stacking of Transformer and Mamba layers without any interaction mechanism between them. Thus, deep integration between Transformer and Mamba layers remains an open problem. We address this problem by proposing A2Mamba, a powerful Transformer-Mamba hybrid network architecture, featuring a new token mixer termed Multi-scale Attention-augmented State Space Model (MASS), where multi-scale attention maps are integrated into an attention-augmented SSM (A2SSM). A key step of A2SSM performs a variant of cross-attention by spatially aggregating the SSM's hidden states using the multi-scale attention maps, which enhances spatial dependencies pertaining to a two-dimensional space while improving the dynamic modeling capabilities of SSMs. Our A2Mamba outperforms all previous ConvNet-, Transformer-, and Mamba-based architectures in visual recognition tasks. For instance, A2Mamba-L achieves an impressive 86.1% top-1 accuracy on ImageNet-1K. In semantic segmentation, A2Mamba-B exceeds CAFormer-S36 by 2.5% in mIoU, while exhibiting higher efficiency. In object detection and instance segmentation with Cascade Mask R-CNN, A2Mamba-S surpasses MambaVision-B by 1.2%/0.9% in AP^b/AP^m, while having 40% less parameters. Code is publicly available at https://github.com/LMMMEng/A2Mamba.

Rethinking Discrete Tokens: Treating Them as Conditions for Continuous Autoregressive Image Synthesis

Recent advances in large language models (LLMs) have spurred interests in encoding images as discrete tokens and leveraging autoregressive (AR) frameworks for visual generation. However, the quantization process in AR-based visual generation models inherently introduces information loss that degrades image fidelity. To mitigate this limitation, recent studies have explored to autoregressively predict continuous tokens. Unlike discrete tokens that reside in a structured and bounded space, continuous representations exist in an unbounded, high-dimensional space, making density estimation more challenging and increasing the risk of generating out-of-distribution artifacts. Based on the above findings, this work introduces DisCon (Discrete-Conditioned Continuous Autoregressive Model), a novel framework that reinterprets discrete tokens as conditional signals rather than generation targets. By modeling the conditional probability of continuous representations conditioned on discrete tokens, DisCon circumvents the optimization challenges of continuous token modeling while avoiding the information loss caused by quantization. DisCon achieves a gFID score of 1.38 on ImageNet 256$\times$256 generation, outperforming state-of-the-art autoregressive approaches by a clear margin.

Aerial Vision-and-Language Navigation with Grid-based View Selection and Map Construction

Aerial Vision-and-Language Navigation (Aerial VLN) aims to obtain an unmanned aerial vehicle agent to navigate aerial 3D environments following human instruction. Compared to ground-based VLN, aerial VLN requires the agent to decide the next action in both horizontal and vertical directions based on the first-person view observations. Previous methods struggle to perform well due to the longer navigation path, more complicated 3D scenes, and the neglect of the interplay between vertical and horizontal actions. In this paper, we propose a novel grid-based view selection framework that formulates aerial VLN action prediction as a grid-based view selection task, incorporating vertical action prediction in a manner that accounts for the coupling with horizontal actions, thereby enabling effective altitude adjustments. We further introduce a grid-based bird's eye view map for aerial space to fuse the visual information in the navigation history, provide contextual scene information, and mitigate the impact of obstacles. Finally, a cross-modal transformer is adopted to explicitly align the long navigation history with the instruction. We demonstrate the superiority of our method in extensive experiments.

OverLoCK: An Overview-first-Look-Closely-next ConvNet with Context-Mixing Dynamic Kernels

In the human vision system, top-down attention plays a crucial role in perception, wherein the brain initially performs an overall but rough scene analysis to extract salient cues (i.e., overview first), followed by a finer-grained examination to make more accurate judgments (i.e., look closely next). However, recent efforts in ConvNet designs primarily focused on increasing kernel size to obtain a larger receptive field without considering this crucial biomimetic mechanism to further improve performance. To this end, we propose a novel pure ConvNet vision backbone, termed OverLoCK, which is carefully devised from both the architecture and mixer perspectives. Specifically, we introduce a biomimetic Deep-stage Decomposition Strategy (DDS) that fuses semantically meaningful context representations into middle and deep layers by providing dynamic top-down context guidance at both feature and kernel weight levels. To fully unleash the power of top-down context guidance, we further propose a novel \textbf{Cont}ext-\textbf{Mix}ing Dynamic Convolution (ContMix) that effectively models long-range dependencies while preserving inherent local inductive biases even when the input resolution increases. These properties are absent in previous convolutions. With the support from both DDS and ContMix, our OverLoCK exhibits notable performance improvement over existing methods. For instance, OverLoCK-T achieves a Top-1 accuracy of 84.2\%, significantly surpassing ConvNeXt-B while only using around one-third of the FLOPs/parameters. On object detection with Cascade Mask R-CNN, our OverLoCK-S surpasses MogaNet-B by a significant 1\% in AP$^b$. On semantic segmentation with UperNet, our OverLoCK-T remarkably improves UniRepLKNet-T by 1.7\% in mIoU. Code is publicly available at https://github.com/LMMMEng/OverLoCK.