Neural Ordinary Differential Equation based Sequential Image Registration for Dynamic Characterization

Deformable image registration (DIR) is crucial in medical image analysis, enabling the exploration of biological dynamics such as organ motions and longitudinal changes in imaging. Leveraging Neural Ordinary Differential Equations (ODE) for registration, this extension work discusses how this framework can aid in the characterization of sequential biological processes. Utilizing the Neural ODE's ability to model state derivatives with neural networks, our Neural Ordinary Differential Equation Optimization-based (NODEO) framework considers voxels as particles within a dynamic system, defining deformation fields through the integration of neural differential equations. This method learns dynamics directly from data, bypassing the need for physical priors, making it exceptionally suitable for medical scenarios where such priors are unavailable or inapplicable. Consequently, the framework can discern underlying dynamics and use sequence data to regularize the transformation trajectory. We evaluated our framework on two clinical datasets: one for cardiac motion tracking and another for longitudinal brain MRI analysis. Demonstrating its efficacy in both 2D and 3D imaging scenarios, our framework offers flexibility and model agnosticism, capable of managing image sequences and facilitating label propagation throughout these sequences. This study provides a comprehensive understanding of how the Neural ODE-based framework uniquely benefits the image registration challenge.

DD-RobustBench: An Adversarial Robustness Benchmark for Dataset Distillation

Dataset distillation is an advanced technique aimed at compressing datasets into significantly smaller counterparts, while preserving formidable training performance. Significant efforts have been devoted to promote evaluation accuracy under limited compression ratio while overlooked the robustness of distilled dataset. In this work, we introduce a comprehensive benchmark that, to the best of our knowledge, is the most extensive to date for evaluating the adversarial robustness of distilled datasets in a unified way. Our benchmark significantly expands upon prior efforts by incorporating a wider range of dataset distillation methods, including the latest advancements such as TESLA and SRe2L, a diverse array of adversarial attack methods, and evaluations across a broader and more extensive collection of datasets such as ImageNet-1K. Moreover, we assessed the robustness of these distilled datasets against representative adversarial attack algorithms like PGD and AutoAttack, while exploring their resilience from a frequency perspective. We also discovered that incorporating distilled data into the training batches of the original dataset can yield to improvement of robustness.

A Concept-based Interpretable Model for the Diagnosis of Choroid Neoplasias using Multimodal Data

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such technologies is hindered by the scarcity of data on rare conditions and the demand for models that are both interpretable and trustworthy in a clinical context. Interpretable AI, with its capacity for human-readable outputs, can facilitate validation by clinicians and contribute to medical education. In the current work, we focus on choroid neoplasias, the most prevalent form of eye cancer in adults, albeit rare with 5.1 per million. We built the so-far largest dataset consisting of 750 patients, incorporating three distinct imaging modalities collected from 2004 to 2022. Our work introduces a concept-based interpretable model that distinguishes between three types of choroidal tumors, integrating insights from domain experts via radiological reports. Remarkably, this model not only achieves an F1 score of 0.91, rivaling that of black-box models, but also boosts the diagnostic accuracy of junior doctors by 42%. This study highlights the significant potential of interpretable machine learning in improving the diagnosis of rare diseases, laying a groundwork for future breakthroughs in medical AI that could tackle a wider array of complex health scenarios.

An objective comparison of methods for augmented reality in laparoscopic liver resection by preoperative-to-intraoperative image fusion

Augmented reality for laparoscopic liver resection is a visualisation mode that allows a surgeon to localise tumours and vessels embedded within the liver by projecting them on top of a laparoscopic image. Preoperative 3D models extracted from CT or MRI data are registered to the intraoperative laparoscopic images during this process. In terms of 3D-2D fusion, most of the algorithms make use of anatomical landmarks to guide registration. These landmarks include the liver's inferior ridge, the falciform ligament, and the occluding contours. They are usually marked by hand in both the laparoscopic image and the 3D model, which is time-consuming and may contain errors if done by a non-experienced user. Therefore, there is a need to automate this process so that augmented reality can be used effectively in the operating room. We present the Preoperative-to-Intraoperative Laparoscopic Fusion Challenge (P2ILF), held during the Medical Imaging and Computer Assisted Interventions (MICCAI 2022) conference, which investigates the possibilities of detecting these landmarks automatically and using them in registration. The challenge was divided into two tasks: 1) A 2D and 3D landmark detection task and 2) a 3D-2D registration task. The teams were provided with training data consisting of 167 laparoscopic images and 9 preoperative 3D models from 9 patients, with the corresponding 2D and 3D landmark annotations. A total of 6 teams from 4 countries participated, whose proposed methods were evaluated on 16 images and two preoperative 3D models from two patients. All the teams proposed deep learning-based methods for the 2D and 3D landmark segmentation tasks and differentiable rendering-based methods for the registration task. Based on the experimental outcomes, we propose three key hypotheses that determine current limitations and future directions for research in this domain.

Robust Analysis of Multi-Task Learning on a Complex Vision System

Multi-task learning (MTL) has been widely studied in the past decade. In particular, dozens of optimization algorithms have been proposed for different settings. While each of them claimed improvement when applied to certain models on certain datasets, there is still lack of deep understanding on the performance in complex real-worlds scenarios. We identify the gaps between research and application and make the following 4 contributions. (1) We comprehensively evaluate a large set of existing MTL optimization algorithms on the MetaGraspNet dataset designed for robotic grasping task, which is complex and has high real-world application values, and conclude the best-performing methods. (2) We empirically compare the method performance when applied on feature-level gradients versus parameter-level gradients over a large set of MTL optimization algorithms, and conclude that this feature-level gradients surrogate is reasonable when there are method-specific theoretical guarantee but not generalizable to all methods. (3) We provide insights on the problem of task interference and show that the existing perspectives of gradient angles and relative gradient norms do not precisely reflect the challenges of MTL, as the rankings of the methods based on these two indicators do not align well with those based on the test-set performance. (4) We provide a novel view of the task interference problem from the perspective of the latent space induced by the feature extractor and provide training monitoring results based on feature disentanglement.

A Statistical Framework for Measuring AI Reliance

Humans frequently make decisions with the aid of artificially intelligent (AI) systems. A common pattern is for the AI to recommend an action to the human who retains control over the final decision. Researchers have identified ensuring that a human has appropriate reliance on an AI as a critical component of achieving complementary performance. We argue that the current definition of appropriate reliance used in such research lacks formal statistical grounding and can lead to contradictions. We propose a formal definition of reliance, based on statistical decision theory, which separates the concepts of reliance as the probability the decision-maker follows the AI's prediction from challenges a human may face in differentiating the signals and forming accurate beliefs about the situation. Our definition gives rise to a framework that can be used to guide the design and interpretation of studies on human-AI complementarity and reliance. Using recent AI-advised decision making studies from literature, we demonstrate how our framework can be used to separate the loss due to mis-reliance from the loss due to not accurately differentiating the signals. We evaluate these losses by comparing to a baseline and a benchmark for complementary performance defined by the expected payoff achieved by a rational agent facing the same decision task as the behavioral agents.

Non-uniform Array and Frequency Spacing for Regularization-free Gridless DOA

Gridless direction-of-arrival (DOA) estimation with multiple frequencies can be applied in acoustics source localization problems. We formulate this as an atomic norm minimization (ANM) problem and derive an equivalent regularization-free semi-definite program (SDP) thereby avoiding regularization bias. The DOA is retrieved using a Vandermonde decomposition on the Toeplitz matrix obtained from the solution of the SDP. We also propose a fast SDP program to deal with non-uniform array and frequency spacing. For non-uniform spacings, the Toeplitz structure will not exist, but the DOA is retrieved via irregular Vandermonde decomposition (IVD), and we theoretically guarantee the existence of the IVD. We extend ANM to the multiple measurement vector (MMV) cases and derive its equivalent regularization-free SDP. Using multiple frequencies and the MMV model, we can resolve more sources than the number of physical sensors for a uniform linear array. Numerical results demonstrate that the regularization-free framework is robust to noise and aliasing, and it overcomes the regularization bias.

Generating and Reweighting Dense Contrastive Patterns for Unsupervised Anomaly Detection

Recent unsupervised anomaly detection methods often rely on feature extractors pretrained with auxiliary datasets or on well-crafted anomaly-simulated samples. However, this might limit their adaptability to an increasing set of anomaly detection tasks due to the priors in the selection of auxiliary datasets or the strategy of anomaly simulation. To tackle this challenge, we first introduce a prior-less anomaly generation paradigm and subsequently develop an innovative unsupervised anomaly detection framework named GRAD, grounded in this paradigm. GRAD comprises three essential components: (1) a diffusion model (PatchDiff) to generate contrastive patterns by preserving the local structures while disregarding the global structures present in normal images, (2) a self-supervised reweighting mechanism to handle the challenge of long-tailed and unlabeled contrastive patterns generated by PatchDiff, and (3) a lightweight patch-level detector to efficiently distinguish the normal patterns and reweighted contrastive patterns. The generation results of PatchDiff effectively expose various types of anomaly patterns, e.g. structural and logical anomaly patterns. In addition, extensive experiments on both MVTec AD and MVTec LOCO datasets also support the aforementioned observation and demonstrate that GRAD achieves competitive anomaly detection accuracy and superior inference speed.

Towards Establishing Dense Correspondence on Multiview Coronary Angiography: From Point-to-Point to Curve-to-Curve Query Matching

Coronary angiography is the gold standard imaging technique for studying and diagnosing coronary artery disease. However, the resulting 2D X-ray projections lose 3D information and exhibit visual ambiguities. In this work, we aim to establish dense correspondence in multi-view angiography, serving as a fundamental basis for various clinical applications and downstream tasks. To overcome the challenge of unavailable annotated data, we designed a data simulation pipeline using 3D Coronary Computed Tomography Angiography (CCTA). We formulated the problem of dense correspondence estimation as a query matching task over all points of interest in the given views. We established point-to-point query matching and advanced it to curve-to-curve correspondence, significantly reducing errors by minimizing ambiguity and improving topological awareness. The method was evaluated on a set of 1260 image pairs from different views across 8 clinically relevant angulation groups, demonstrating compelling results and indicating the feasibility of establishing dense correspondence in multi-view angiography.