DistDD: Distributed Data Distillation Aggregation through Gradient Matching

In this paper, we introduce DistDD, a novel approach within the federated learning framework that reduces the need for repetitive communication by distilling data directly on clients' devices. Unlike traditional federated learning that requires iterative model updates across nodes, DistDD facilitates a one-time distillation process that extracts a global distilled dataset, maintaining the privacy standards of federated learning while significantly cutting down communication costs. By leveraging the DistDD's distilled dataset, the developers of the FL can achieve just-in-time parameter tuning and neural architecture search over FL without repeating the whole FL process multiple times. We provide a detailed convergence proof of the DistDD algorithm, reinforcing its mathematical stability and reliability for practical applications. Our experiments demonstrate the effectiveness and robustness of DistDD, particularly in non-i.i.d. and mislabeled data scenarios, showcasing its potential to handle complex real-world data challenges distinctively from conventional federated learning methods. We also evaluate DistDD's application in the use case and prove its effectiveness and communication-savings in the NAS use case.

Simple Unsupervised Knowledge Distillation With Space Similarity

As per recent studies, Self-supervised learning (SSL) does not readily extend to smaller architectures. One direction to mitigate this shortcoming while simultaneously training a smaller network without labels is to adopt unsupervised knowledge distillation (UKD). Existing UKD approaches handcraft preservation worthy inter/intra sample relationships between the teacher and its student. However, this may overlook/ignore other key relationships present in the mapping of a teacher. In this paper, instead of heuristically constructing preservation worthy relationships between samples, we directly motivate the student to model the teacher's embedding manifold. If the mapped manifold is similar, all inter/intra sample relationships are indirectly conserved. We first demonstrate that prior methods cannot preserve teacher's latent manifold due to their sole reliance on $L_2$ normalised embedding features. Subsequently, we propose a simple objective to capture the lost information due to normalisation. Our proposed loss component, termed \textbf{space similarity}, motivates each dimension of a student's feature space to be similar to the corresponding dimension of its teacher. We perform extensive experiments demonstrating strong performance of our proposed approach on various benchmarks.

DS-ViT: Dual-Stream Vision Transformer for Cross-Task Distillation in Alzheimer's Early Diagnosis

In the field of Alzheimer's disease diagnosis, segmentation and classification tasks are inherently interconnected. Sharing knowledge between models for these tasks can significantly improve training efficiency, particularly when training data is scarce. However, traditional knowledge distillation techniques often struggle to bridge the gap between segmentation and classification due to the distinct nature of tasks and different model architectures. To address this challenge, we propose a dual-stream pipeline that facilitates cross-task and cross-architecture knowledge sharing. Our approach introduces a dual-stream embedding module that unifies feature representations from segmentation and classification models, enabling dimensional integration of these features to guide the classification model. We validated our method on multiple 3D datasets for Alzheimer's disease diagnosis, demonstrating significant improvements in classification performance, especially on small datasets. Furthermore, we extended our pipeline with a residual temporal attention mechanism for early diagnosis, utilizing images taken before the atrophy of patients' brain mass. This advancement shows promise in enabling diagnosis approximately six months earlier in mild and asymptomatic stages, offering critical time for intervention.

A Quantitative Approach for Evaluating Disease Focus and Interpretability of Deep Learning Models for Alzheimer's Disease Classification

Deep learning (DL) models have shown significant potential in Alzheimer's Disease (AD) classification. However, understanding and interpreting these models remains challenging, which hinders the adoption of these models in clinical practice. Techniques such as saliency maps have been proven effective in providing visual and empirical clues about how these models work, but there still remains a gap in understanding which specific brain regions DL models focus on and whether these brain regions are pathologically associated with AD. To bridge such gap, in this study, we developed a quantitative disease-focusing strategy to first enhance the interpretability of DL models using saliency maps and brain segmentations; then we propose a disease-focus (DF) score that quantifies how much a DL model focuses on brain areas relevant to AD pathology based on clinically known MRI-based pathological regions of AD. Using this strategy, we compared several state-of-the-art DL models, including a baseline 3D ResNet model, a pretrained MedicalNet model, and a MedicalNet with data augmentation to classify patients with AD vs. cognitive normal patients using MRI data; then we evaluated these models in terms of their abilities to focus on disease-relevant regions. Our results show interesting disease-focusing patterns with different models, particularly characteristic patterns with the pretrained models and data augmentation, and also provide insight into their classification performance. These results suggest that the approach we developed for quantitatively assessing the abilities of DL models to focus on disease-relevant regions may help improve interpretability of these models for AD classification and facilitate their adoption for AD diagnosis in clinical practice. The code is publicly available at https://github.com/Liang-lt/ADNI.

Towards Reliable Advertising Image Generation Using Human Feedback

In the e-commerce realm, compelling advertising images are pivotal for attracting customer attention. While generative models automate image generation, they often produce substandard images that may mislead customers and require significant labor costs to inspect. This paper delves into increasing the rate of available generated images. We first introduce a multi-modal Reliable Feedback Network (RFNet) to automatically inspect the generated images. Combining the RFNet into a recurrent process, Recurrent Generation, results in a higher number of available advertising images. To further enhance production efficiency, we fine-tune diffusion models with an innovative Consistent Condition regularization utilizing the feedback from RFNet (RFFT). This results in a remarkable increase in the available rate of generated images, reducing the number of attempts in Recurrent Generation, and providing a highly efficient production process without sacrificing visual appeal. We also construct a Reliable Feedback 1 Million (RF1M) dataset which comprises over one million generated advertising images annotated by human, which helps to train RFNet to accurately assess the availability of generated images and faithfully reflect the human feedback. Generally speaking, our approach offers a reliable solution for advertising image generation.

Quantitative Evaluation of the Saliency Map for Alzheimer's Disease Classifier with Anatomical Segmentation

Saliency maps have been widely used to interpret deep learning classifiers for Alzheimer's disease (AD). However, since AD is heterogeneous and has multiple subtypes, the pathological mechanism of AD remains not fully understood and may vary from patient to patient. Due to the lack of such understanding, it is difficult to comprehensively and effectively assess the saliency map of AD classifier. In this paper, we utilize the anatomical segmentation to allocate saliency values into different brain regions. By plotting the distributions of saliency maps corresponding to AD and NC (Normal Control), we can gain a comprehensive view of the model's decisions process. In order to leverage the fact that the brain volume shrinkage happens in AD patients during disease progression, we define a new evaluation metric, brain volume change score (VCS), by computing the average Pearson correlation of the brain volume changes and the saliency values of a model in different brain regions for each patient. Thus, the VCS metric can help us gain some knowledge of how saliency maps resulting from different models relate to the changes of the volumes across different regions in the whole brain. We trained candidate models on the ADNI dataset and tested on three different datasets. Our results indicate: (i) models with higher VCSs tend to demonstrate saliency maps with more details relevant to the AD pathology, (ii) using gradient-based adversarial training strategies such as FGSM and stochastic masking can improve the VCSs of the models.

JailbreakZoo: Survey, Landscapes, and Horizons in Jailbreaking Large Language and Vision-Language Models

The rapid evolution of artificial intelligence (AI) through developments in Large Language Models (LLMs) and Vision-Language Models (VLMs) has brought significant advancements across various technological domains. While these models enhance capabilities in natural language processing and visual interactive tasks, their growing adoption raises critical concerns regarding security and ethical alignment. This survey provides an extensive review of the emerging field of jailbreaking--deliberately circumventing the ethical and operational boundaries of LLMs and VLMs--and the consequent development of defense mechanisms. Our study categorizes jailbreaks into seven distinct types and elaborates on defense strategies that address these vulnerabilities. Through this comprehensive examination, we identify research gaps and propose directions for future studies to enhance the security frameworks of LLMs and VLMs. Our findings underscore the necessity for a unified perspective that integrates both jailbreak strategies and defensive solutions to foster a robust, secure, and reliable environment for the next generation of language models. More details can be found on our website: \url{https://chonghan-chen.com/llm-jailbreak-zoo-survey/}.

GenoTEX: A Benchmark for Evaluating LLM-Based Exploration of Gene Expression Data in Alignment with Bioinformaticians

Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their scalability. Large Language Model (LLM)-based agents have shown promise in automating these tasks due to their increasing problem-solving abilities. To support the evaluation and development of such methods, we introduce GenoTEX, a benchmark dataset for the automatic exploration of gene expression data, involving the tasks of dataset selection, preprocessing, and statistical analysis. GenoTEX provides annotated code and results for solving a wide range of gene identification problems, in a full analysis pipeline that follows the standard of computational genomics. These annotations are curated by human bioinformaticians who carefully analyze the datasets to ensure accuracy and reliability. To provide baselines for these tasks, we present GenoAgents, a team of LLM-based agents designed with context-aware planning, iterative correction, and domain expert consultation to collaboratively explore gene datasets. Our experiments with GenoAgents demonstrate the potential of LLM-based approaches in genomics data analysis, while error analysis highlights the challenges and areas for future improvement. We propose GenoTEX as a promising resource for benchmarking and enhancing AI-driven methods for genomics data analysis. We make our benchmark publicly available at \url{https://github.com/Liu-Hy/GenoTex}.

Deconstructing The Ethics of Large Language Models from Long-standing Issues to New-emerging Dilemmas

Large Language Models (LLMs) have achieved unparalleled success across diverse language modeling tasks in recent years. However, this progress has also intensified ethical concerns, impacting the deployment of LLMs in everyday contexts. This paper provides a comprehensive survey of ethical challenges associated with LLMs, from longstanding issues such as copyright infringement, systematic bias, and data privacy, to emerging problems like truthfulness and social norms. We critically analyze existing research aimed at understanding, examining, and mitigating these ethical risks. Our survey underscores integrating ethical standards and societal values into the development of LLMs, thereby guiding the development of responsible and ethically aligned language models.

From Tissue Plane to Organ World: A Benchmark Dataset for Multimodal Biomedical Image Registration using Deep Co-Attention Networks

Correlating neuropathology with neuroimaging findings provides a multiscale view of pathologic changes in the human organ spanning the meso- to micro-scales, and is an emerging methodology expected to shed light on numerous disease states. To gain the most information from this multimodal, multiscale approach, it is desirable to identify precisely where a histologic tissue section was taken from within the organ in order to correlate with the tissue features in exactly the same organ region. Histology-to-organ registration poses an extra challenge, as any given histologic section can capture only a small portion of a human organ. Making use of the capabilities of state-of-the-art deep learning models, we unlock the potential to address and solve such intricate challenges. Therefore, we create the ATOM benchmark dataset, sourced from diverse institutions, with the primary objective of transforming this challenge into a machine learning problem and delivering outstanding outcomes that enlighten the biomedical community. The performance of our RegisMCAN model demonstrates the potential of deep learning to accurately predict where a subregion extracted from an organ image was obtained from within the overall 3D volume. The code and dataset can be found at: https://github.com/haizailache999/Image-Registration/tree/main