Design as Desired: Utilizing Visual Question Answering for Multimodal Pre-training

Multimodal pre-training demonstrates its potential in the medical domain, which learns medical visual representations from paired medical reports. However, many pre-training tasks require extra annotations from clinicians, and most of them fail to explicitly guide the model to learn the desired features of different pathologies. To the best of our knowledge, we are the first to utilize Visual Question Answering (VQA) for multimodal pre-training to guide the framework focusing on targeted pathological features. In this work, we leverage descriptions in medical reports to design multi-granular question-answer pairs associated with different diseases, which assist the framework in pre-training without requiring extra annotations from experts. We also propose a novel pre-training framework with a quasi-textual feature transformer, a module designed to transform visual features into a quasi-textual space closer to the textual domain via a contrastive learning strategy. This narrows the vision-language gap and facilitates modality alignment. Our framework is applied to four downstream tasks: report generation, classification, segmentation, and detection across five datasets. Extensive experiments demonstrate the superiority of our framework compared to other state-of-the-art methods. Our code will be released upon acceptance.

Rethinking Self-training for Semi-supervised Landmark Detection: A Selection-free Approach

Self-training is a simple yet effective method for semi-supervised learning, during which pseudo-label selection plays an important role for handling confirmation bias. Despite its popularity, applying self-training to landmark detection faces three problems: 1) The selected confident pseudo-labels often contain data bias, which may hurt model performance; 2) It is not easy to decide a proper threshold for sample selection as the localization task can be sensitive to noisy pseudo-labels; 3) coordinate regression does not output confidence, making selection-based self-training infeasible. To address the above issues, we propose Self-Training for Landmark Detection (STLD), a method that does not require explicit pseudo-label selection. Instead, STLD constructs a task curriculum to deal with confirmation bias, which progressively transitions from more confident to less confident tasks over the rounds of self-training. Pseudo pretraining and shrink regression are two essential components for such a curriculum, where the former is the first task of the curriculum for providing a better model initialization and the latter is further added in the later rounds to directly leverage the pseudo-labels in a coarse-to-fine manner. Experiments on three facial and one medical landmark detection benchmark show that STLD outperforms the existing methods consistently in both semi- and omni-supervised settings.

GUARD: Role-playing to Generate Natural-language Jailbreakings to Test Guideline Adherence of Large Language Models

The discovery of "jailbreaks" to bypass safety filters of Large Language Models (LLMs) and harmful responses have encouraged the community to implement safety measures. One major safety measure is to proactively test the LLMs with jailbreaks prior to the release. Therefore, such testing will require a method that can generate jailbreaks massively and efficiently. In this paper, we follow a novel yet intuitive strategy to generate jailbreaks in the style of the human generation. We propose a role-playing system that assigns four different roles to the user LLMs to collaborate on new jailbreaks. Furthermore, we collect existing jailbreaks and split them into different independent characteristics using clustering frequency and semantic patterns sentence by sentence. We organize these characteristics into a knowledge graph, making them more accessible and easier to retrieve. Our system of different roles will leverage this knowledge graph to generate new jailbreaks, which have proved effective in inducing LLMs to generate unethical or guideline-violating responses. In addition, we also pioneer a setting in our system that will automatically follow the government-issued guidelines to generate jailbreaks to test whether LLMs follow the guidelines accordingly. We refer to our system as GUARD (Guideline Upholding through Adaptive Role-play Diagnostics). We have empirically validated the effectiveness of GUARD on three cutting-edge open-sourced LLMs (Vicuna-13B, LongChat-7B, and Llama-2-7B), as well as a widely-utilized commercial LLM (ChatGPT). Moreover, our work extends to the realm of vision language models (MiniGPT-v2 and Gemini Vision Pro), showcasing GUARD's versatility and contributing valuable insights for the development of safer, more reliable LLM-based applications across diverse modalities.

Unsupervised Domain Adaptation for Anatomical Landmark Detection

Recently, anatomical landmark detection has achieved great progresses on single-domain data, which usually assumes training and test sets are from the same domain. However, such an assumption is not always true in practice, which can cause significant performance drop due to domain shift. To tackle this problem, we propose a novel framework for anatomical landmark detection under the setting of unsupervised domain adaptation (UDA), which aims to transfer the knowledge from labeled source domain to unlabeled target domain. The framework leverages self-training and domain adversarial learning to address the domain gap during adaptation. Specifically, a self-training strategy is proposed to select reliable landmark-level pseudo-labels of target domain data with dynamic thresholds, which makes the adaptation more effective. Furthermore, a domain adversarial learning module is designed to handle the unaligned data distributions of two domains by learning domain-invariant features via adversarial training. Our experiments on cephalometric and lung landmark detection show the effectiveness of the method, which reduces the domain gap by a large margin and outperforms other UDA methods consistently. The code is available at https://github.com/jhb86253817/UDA_Med_Landmark.

PromptMRG: Diagnosis-Driven Prompts for Medical Report Generation

Automatic medical report generation (MRG) is of great research value as it has the potential to relieve radiologists from the heavy burden of report writing. Despite recent advancements, accurate MRG remains challenging due to the need for precise clinical understanding and the identification of clinical findings. Moreover, the imbalanced distribution of diseases makes the challenge even more pronounced, as rare diseases are underrepresented in training data, making their diagnostic performance unreliable. To address these challenges, we propose diagnosis-driven prompts for medical report generation (PromptMRG), a novel framework that aims to improve the diagnostic accuracy of MRG with the guidance of diagnosis-aware prompts. Specifically, PromptMRG is based on encoder-decoder architecture with an extra disease classification branch. When generating reports, the diagnostic results from the classification branch are converted into token prompts to explicitly guide the generation process. To further improve the diagnostic accuracy, we design cross-modal feature enhancement, which retrieves similar reports from the database to assist the diagnosis of a query image by leveraging the knowledge from a pre-trained CLIP. Moreover, the disease imbalanced issue is addressed by applying an adaptive logit-adjusted loss to the classification branch based on the individual learning status of each disease, which overcomes the barrier of text decoder's inability to manipulate disease distributions. Experiments on two MRG benchmarks show the effectiveness of the proposed method, where it obtains state-of-the-art clinical efficacy performance on both datasets.

Towards Generalizable Diabetic Retinopathy Grading in Unseen Domains

Diabetic Retinopathy (DR) is a common complication of diabetes and a leading cause of blindness worldwide. Early and accurate grading of its severity is crucial for disease management. Although deep learning has shown great potential for automated DR grading, its real-world deployment is still challenging due to distribution shifts among source and target domains, known as the domain generalization problem. Existing works have mainly attributed the performance degradation to limited domain shifts caused by simple visual discrepancies, which cannot handle complex real-world scenarios. Instead, we present preliminary evidence suggesting the existence of three-fold generalization issues: visual and degradation style shifts, diagnostic pattern diversity, and data imbalance. To tackle these issues, we propose a novel unified framework named Generalizable Diabetic Retinopathy Grading Network (GDRNet). GDRNet consists of three vital components: fundus visual-artifact augmentation (FundusAug), dynamic hybrid-supervised loss (DahLoss), and domain-class-aware re-balancing (DCR). FundusAug generates realistic augmented images via visual transformation and image degradation, while DahLoss jointly leverages pixel-level consistency and image-level semantics to capture the diverse diagnostic patterns and build generalizable feature representations. Moreover, DCR mitigates the data imbalance from a domain-class view and avoids undesired over-emphasis on rare domain-class pairs. Finally, we design a publicly available benchmark for fair evaluations. Extensive comparison experiments against advanced methods and exhaustive ablation studies demonstrate the effectiveness and generalization ability of GDRNet.

CertPri: Certifiable Prioritization for Deep Neural Networks via Movement Cost in Feature Space

Deep neural networks (DNNs) have demonstrated their outperformance in various software systems, but also exhibit misbehavior and even result in irreversible disasters. Therefore, it is crucial to identify the misbehavior of DNN-based software and improve DNNs' quality. Test input prioritization is one of the most appealing ways to guarantee DNNs' quality, which prioritizes test inputs so that more bug-revealing inputs can be identified earlier with limited time and manual labeling efforts. However, the existing prioritization methods are still limited from three aspects: certifiability, effectiveness, and generalizability. To overcome the challenges, we propose CertPri, a test input prioritization technique designed based on a movement cost perspective of test inputs in DNNs' feature space. CertPri differs from previous works in three key aspects: (1) certifiable: it provides a formal robustness guarantee for the movement cost; (2) effective: it leverages formally guaranteed movement costs to identify malicious bug-revealing inputs; and (3) generic: it can be applied to various tasks, data, models, and scenarios. Extensive evaluations across 2 tasks (i.e., classification and regression), 6 data forms, 4 model structures, and 2 scenarios (i.e., white-box and black-box) demonstrate CertPri's superior performance. For instance, it significantly improves 53.97% prioritization effectiveness on average compared with baselines. Its robustness and generalizability are 1.41~2.00 times and 1.33~3.39 times that of baselines on average, respectively.

TraffNet: Learning Causality of Traffic Generation for Road Network Digital Twins

Road network digital twins (RNDTs) play a critical role in the development of next-generation intelligent transportation systems, enabling more precise traffic planning and control. To support just-in-time (JIT) decision making, RNDTs require a model that dynamically learns the traffic patterns from online sensor data and generates high-fidelity simulation results. Although current traffic prediction techniques based on graph neural networks have achieved state-of-the-art performance, these techniques only predict future traffic by mining correlations in historical traffic data, disregarding the causes of traffic generation, such as Origin-Destination (OD) demands and route selection. Therefore, their performance is unreliable for JIT decision making. To fill this gap, we introduce a novel deep learning framework called TraffNet that learns the causality of traffic volumes from vehicle trajectory data. First, we use a heterogeneous graph to represent the road network, allowing the model to incorporate causal features of traffic volumes. Next, inspired by the traffic domain knowledge, we propose a traffic causality learning method to learn an embedding vector that encodes OD demands and path-level dependencies for each road segment. Then, we model temporal dependencies to match the underlying process of traffic generation. Finally, the experiments verify the utility of TraffNet. The code of TraffNet is available at https://github.com/mayunyi-1999/TraffNet_code.git.