Voxel2Hemodynamics: An End-to-end Deep Learning Method for Predicting Coronary Artery Hemodynamics

Local hemodynamic forces play an important role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) have been widely performed to simulate hemodynamics non-invasively from coronary computed tomography angiography (CCTA) images. However, accurate computational analysis is still limited by the complex construction of patient-specific modeling and time-consuming computation. In this work, we proposed an end-to-end deep learning framework, which could predict the coronary artery hemodynamics from CCTA images. The model was trained on the hemodynamic data obtained from 3D simulations of synthetic and real datasets. Extensive experiments demonstrated that the predicted hemdynamic distributions by our method agreed well with the CFD-derived results. Quantitatively, the proposed method has the capability of predicting the fractional flow reserve with an average error of 0.5\% and 2.5\% for the synthetic dataset and real dataset, respectively. Particularly, our method achieved much better accuracy for the real dataset compared to PointNet++ with the point cloud input. This study demonstrates the feasibility and great potential of our end-to-end deep learning method as a fast and accurate approach for hemodynamic analysis.

Segmentation and Vascular Vectorization for Coronary Artery by Geometry-based Cascaded Neural Network

Segmentation of the coronary artery is an important task for the quantitative analysis of coronary computed tomography angiography (CCTA) images and is being stimulated by the field of deep learning. However, the complex structures with tiny and narrow branches of the coronary artery bring it a great challenge. Coupled with the medical image limitations of low resolution and poor contrast, fragmentations of segmented vessels frequently occur in the prediction. Therefore, a geometry-based cascaded segmentation method is proposed for the coronary artery, which has the following innovations: 1) Integrating geometric deformation networks, we design a cascaded network for segmenting the coronary artery and vectorizing results. The generated meshes of the coronary artery are continuous and accurate for twisted and sophisticated coronary artery structures, without fragmentations. 2) Different from mesh annotations generated by the traditional marching cube method from voxel-based labels, a finer vectorized mesh of the coronary artery is reconstructed with the regularized morphology. The novel mesh annotation benefits the geometry-based segmentation network, avoiding bifurcation adhesion and point cloud dispersion in intricate branches. 3) A dataset named CCA-200 is collected, consisting of 200 CCTA images with coronary artery disease. The ground truths of 200 cases are coronary internal diameter annotations by professional radiologists. Extensive experiments verify our method on our collected dataset CCA-200 and public ASOCA dataset, with a Dice of 0.778 on CCA-200 and 0.895 on ASOCA, showing superior results. Especially, our geometry-based model generates an accurate, intact and smooth coronary artery, devoid of any fragmentations of segmented vessels.

Synergistic Redundancy: Towards Verifiable Safety for Autonomous Vehicles

As Autonomous Vehicle (AV) development has progressed, concerns regarding the safety of passengers and agents in their environment have risen. Each real world traffic collision involving autonomously controlled vehicles has compounded this concern. Open source autonomous driving implementations show a software architecture with complex interdependent tasks, heavily reliant on machine learning and Deep Neural Networks (DNN), which are vulnerable to non deterministic faults and corner cases. These complex subsystems work together to fulfill the mission of the AV while also maintaining safety. Although significant improvements are being made towards increasing the empirical reliability and confidence in these systems, the inherent limitations of DNN verification create an, as yet, insurmountable challenge in providing deterministic safety guarantees in AV. We propose Synergistic Redundancy (SR), a safety architecture for complex cyber physical systems, like AV. SR provides verifiable safety guarantees against specific faults by decoupling the mission and safety tasks of the system. Simultaneous to independently fulfilling their primary roles, the partially functionally redundant mission and safety tasks are able to aid each other, synergistically improving the combined system. The synergistic safety layer uses only verifiable and logically analyzable software to fulfill its tasks. Close coordination with the mission layer allows easier and early detection of safety critical faults in the system. SR simplifies the mission layer's optimization goals and improves its design. SR provides safe deployment of high performance, although inherently unverifiable, machine learning software. In this work, we first present the design and features of the SR architecture and then evaluate the efficacy of the solution, focusing on the crucial problem of obstacle existence detection faults in AV.

Verifiable Obstacle Detection

Perception of obstacles remains a critical safety concern for autonomous vehicles. Real-world collisions have shown that the autonomy faults leading to fatal collisions originate from obstacle existence detection. Open source autonomous driving implementations show a perception pipeline with complex interdependent Deep Neural Networks. These networks are not fully verifiable, making them unsuitable for safety-critical tasks. In this work, we present a safety verification of an existing LiDAR based classical obstacle detection algorithm. We establish strict bounds on the capabilities of this obstacle detection algorithm. Given safety standards, such bounds allow for determining LiDAR sensor properties that would reliably satisfy the standards. Such analysis has as yet been unattainable for neural network based perception systems. We provide a rigorous analysis of the obstacle detection system with empirical results based on real-world sensor data.

LiDAR Cluster First and Camera Inference Later: A New Perspective Towards Autonomous Driving

Object detection in state-of-the-art Autonomous Vehicles (AV) framework relies heavily on deep neural networks. Typically, these networks perform object detection uniformly on the entire camera LiDAR frames. However, this uniformity jeopardizes the safety of the AV by giving the same priority to all objects in the scenes regardless of their risk of collision to the AV. In this paper, we present a new end-to-end pipeline for AV that introduces the concept of LiDAR cluster first and camera inference later to detect and classify objects. The benefits of our proposed framework are twofold. First, our pipeline prioritizes detecting objects that pose a higher risk of collision to the AV, giving more time for the AV to react to unsafe conditions. Second, it also provides, on average, faster inference speeds compared to popular deep neural network pipelines. We design our framework using the real-world datasets, the Waymo Open Dataset, solving challenges arising from the limitations of LiDAR sensors and object detection algorithms. We show that our novel object detection pipeline prioritizes the detection of higher risk objects while simultaneously achieving comparable accuracy and a 25% higher average speed compared to camera inference only.