Conditional Score-Based Diffusion Model for Cortical Thickness Trajectory Prediction

Alzheimer's Disease (AD) is a neurodegenerative condition characterized by diverse progression rates among individuals, with changes in cortical thickness (CTh) closely linked to its progression. Accurately forecasting CTh trajectories can significantly enhance early diagnosis and intervention strategies, providing timely care. However, the longitudinal data essential for these studies often suffer from temporal sparsity and incompleteness, presenting substantial challenges in modeling the disease's progression accurately. Existing methods are limited, focusing primarily on datasets without missing entries or requiring predefined assumptions about CTh progression. To overcome these obstacles, we propose a conditional score-based diffusion model specifically designed to generate CTh trajectories with the given baseline information, such as age, sex, and initial diagnosis. Our conditional diffusion model utilizes all available data during the training phase to make predictions based solely on baseline information during inference without needing prior history about CTh progression. The prediction accuracy of the proposed CTh prediction pipeline using a conditional score-based model was compared for sub-groups consisting of cognitively normal, mild cognitive impairment, and AD subjects. The Bland-Altman analysis shows our diffusion-based prediction model has a near-zero bias with narrow 95% confidential interval compared to the ground-truth CTh in 6-36 months. In addition, our conditional diffusion model has a stochastic generative nature, therefore, we demonstrated an uncertainty analysis of patient-specific CTh prediction through multiple realizations.

Exploring Energy-based Language Models with Different Architectures and Training Methods for Speech Recognition

Energy-based language models (ELMs) parameterize an unnormalized distribution for natural sentences and are radically different from popular autoregressive language models (ALMs). As an important application, ELMs have been successfully used as a means for calculating sentence scores in speech recognition, but they all use less-modern CNN or LSTM networks. The recent progress in Transformer networks and large pretrained models such as BERT and GPT2 opens new possibility to further advancing ELMs. In this paper, we explore different architectures of energy functions and different training methods to investigate the capabilities of ELMs in rescoring for speech recognition, all using large pretrained models as backbones.

Determination of building flood risk maps from LiDAR mobile mapping data

With increasing urbanization, flooding is a major challenge for many cities today. Based on forecast precipitation, topography, and pipe networks, flood simulations can provide early warnings for areas and buildings at risk of flooding. Basement windows, doors, and underground garage entrances are common places where floodwater can flow into a building. Some buildings have been prepared or designed considering the threat of flooding, but others have not. Therefore, knowing the heights of these facade openings helps to identify places that are more susceptible to water ingress. However, such data is not yet readily available in most cities. Traditional surveying of the desired targets may be used, but this is a very time-consuming and laborious process. This research presents a new process for the extraction of windows and doors from LiDAR mobile mapping data. Deep learning object detection models are trained to identify these objects. Usually, this requires to provide large amounts of manual annotations. In this paper, we mitigate this problem by leveraging a rule-based method. In a first step, the rule-based method is used to generate pseudo-labels. A semi-supervised learning strategy is then applied with three different levels of supervision. The results show that using only automatically generated pseudo-labels, the learning-based model outperforms the rule-based approach by 14.6% in terms of F1-score. After five hours of human supervision, it is possible to improve the model by another 6.2%. By comparing the detected facade openings' heights with the predicted water levels from a flood simulation model, a map can be produced which assigns per-building flood risk levels. This information can be combined with flood forecasting to provide a more targeted disaster prevention guide for the city's infrastructure and residential buildings.