Phenome-Wide Multi-Omics Integration Uncovers Distinct Archetypes of Human Aging

Aging is a highly complex and heterogeneous process that progresses at different rates across individuals, making biological age (BA) a more accurate indicator of physiological decline than chronological age. While previous studies have built aging clocks using single-omics data, they often fail to capture the full molecular complexity of human aging. In this work, we leveraged the Human Phenotype Project, a large-scale cohort of 12,000 adults aged 30--70 years, with extensive longitudinal profiling that includes clinical, behavioral, environmental, and multi-omics datasets -- spanning transcriptomics, lipidomics, metabolomics, and the microbiome. By employing advanced machine learning frameworks capable of modeling nonlinear biological dynamics, we developed and rigorously validated a multi-omics aging clock that robustly predicts diverse health outcomes and future disease risk. Unsupervised clustering of the integrated molecular profiles from multi-omics uncovered distinct biological subtypes of aging, revealing striking heterogeneity in aging trajectories and pinpointing pathway-specific alterations associated with different aging patterns. These findings demonstrate the power of multi-omics integration to decode the molecular landscape of aging and lay the groundwork for personalized healthspan monitoring and precision strategies to prevent age-related diseases.

Contrastive Retrieval Heads Improve Attention-Based Re-Ranking

The strong zero-shot and long-context capabilities of recent Large Language Models (LLMs) have paved the way for highly effective re-ranking systems. Attention-based re-rankers leverage attention weights from transformer heads to produce relevance scores, but not all heads are created equally: many contribute noise and redundancy, thus limiting performance. To address this, we introduce CoRe heads, a small set of retrieval heads identified via a contrastive scoring metric that explicitly rewards high attention heads that correlate with relevant documents, while downplaying nodes with higher attention that correlate with irrelevant documents. This relative ranking criterion isolates the most discriminative heads for re-ranking and yields a state-of-the-art list-wise re-ranker. Extensive experiments with three LLMs show that aggregated signals from CoRe heads, constituting less than 1% of all heads, substantially improve re-ranking accuracy over strong baselines. We further find that CoRe heads are concentrated in middle layers, and pruning the computation of final 50% of model layers preserves accuracy while significantly reducing inference time and memory usage.

Towards Robust Visual Continual Learning with Multi-Prototype Supervision

Language-guided supervision, which utilizes a frozen semantic target from a Pretrained Language Model (PLM), has emerged as a promising paradigm for visual Continual Learning (CL). However, relying on a single target introduces two critical limitations: 1) semantic ambiguity, where a polysemous category name results in conflicting visual representations, and 2) intra-class visual diversity, where a single prototype fails to capture the rich variety of visual appearances within a class. To this end, we propose MuproCL, a novel framework that replaces the single target with multiple, context-aware prototypes. Specifically, we employ a lightweight LLM agent to perform category disambiguation and visual-modal expansion to generate a robust set of semantic prototypes. A LogSumExp aggregation mechanism allows the vision model to adaptively align with the most relevant prototype for a given image. Extensive experiments across various CL baselines demonstrate that MuproCL consistently enhances performance and robustness, establishing a more effective path for language-guided continual learning.

Deep Reactive Policy: Learning Reactive Manipulator Motion Planning for Dynamic Environments

Generating collision-free motion in dynamic, partially observable environments is a fundamental challenge for robotic manipulators. Classical motion planners can compute globally optimal trajectories but require full environment knowledge and are typically too slow for dynamic scenes. Neural motion policies offer a promising alternative by operating in closed-loop directly on raw sensory inputs but often struggle to generalize in complex or dynamic settings. We propose Deep Reactive Policy (DRP), a visuo-motor neural motion policy designed for reactive motion generation in diverse dynamic environments, operating directly on point cloud sensory input. At its core is IMPACT, a transformer-based neural motion policy pretrained on 10 million generated expert trajectories across diverse simulation scenarios. We further improve IMPACT's static obstacle avoidance through iterative student-teacher finetuning. We additionally enhance the policy's dynamic obstacle avoidance at inference time using DCP-RMP, a locally reactive goal-proposal module. We evaluate DRP on challenging tasks featuring cluttered scenes, dynamic moving obstacles, and goal obstructions. DRP achieves strong generalization, outperforming prior classical and neural methods in success rate across both simulated and real-world settings. Video results and code available at https://deep-reactive-policy.com

How Effectively Can Large Language Models Connect SNP Variants and ECG Phenotypes for Cardiovascular Risk Prediction?

Cardiovascular disease (CVD) prediction remains a tremendous challenge due to its multifactorial etiology and global burden of morbidity and mortality. Despite the growing availability of genomic and electrophysiological data, extracting biologically meaningful insights from such high-dimensional, noisy, and sparsely annotated datasets remains a non-trivial task. Recently, LLMs has been applied effectively to predict structural variations in biological sequences. In this work, we explore the potential of fine-tuned LLMs to predict cardiac diseases and SNPs potentially leading to CVD risk using genetic markers derived from high-throughput genomic profiling. We investigate the effect of genetic patterns associated with cardiac conditions and evaluate how LLMs can learn latent biological relationships from structured and semi-structured genomic data obtained by mapping genetic aspects that are inherited from the family tree. By framing the problem as a Chain of Thought (CoT) reasoning task, the models are prompted to generate disease labels and articulate informed clinical deductions across diverse patient profiles and phenotypes. The findings highlight the promise of LLMs in contributing to early detection, risk assessment, and ultimately, the advancement of personalized medicine in cardiac care.

SAM-aware Test-time Adaptation for Universal Medical Image Segmentation

Universal medical image segmentation using the Segment Anything Model (SAM) remains challenging due to its limited adaptability to medical domains. Existing adaptations, such as MedSAM, enhance SAM's performance in medical imaging but at the cost of reduced generalization to unseen data. Therefore, in this paper, we propose SAM-aware Test-Time Adaptation (SAM-TTA), a fundamentally different pipeline that preserves the generalization of SAM while improving its segmentation performance in medical imaging via a test-time framework. SAM-TTA tackles two key challenges: (1) input-level discrepancies caused by differences in image acquisition between natural and medical images and (2) semantic-level discrepancies due to fundamental differences in object definition between natural and medical domains (e.g., clear boundaries vs. ambiguous structures). Specifically, our SAM-TTA framework comprises (1) Self-adaptive Bezier Curve-based Transformation (SBCT), which adaptively converts single-channel medical images into three-channel SAM-compatible inputs while maintaining structural integrity, to mitigate the input gap between medical and natural images, and (2) Dual-scale Uncertainty-driven Mean Teacher adaptation (DUMT), which employs consistency learning to align SAM's internal representations to medical semantics, enabling efficient adaptation without auxiliary supervision or expensive retraining. Extensive experiments on five public datasets demonstrate that our SAM-TTA outperforms existing TTA approaches and even surpasses fully fine-tuned models such as MedSAM in certain scenarios, establishing a new paradigm for universal medical image segmentation. Code can be found at https://github.com/JianghaoWu/SAM-TTA.

Towards Dynamic 3D Reconstruction of Hand-Instrument Interaction in Ophthalmic Surgery

Accurate 3D reconstruction of hands and instruments is critical for vision-based analysis of ophthalmic microsurgery, yet progress has been hampered by the lack of realistic, large-scale datasets and reliable annotation tools. In this work, we introduce OphNet-3D, the first extensive RGB-D dynamic 3D reconstruction dataset for ophthalmic surgery, comprising 41 sequences from 40 surgeons and totaling 7.1 million frames, with fine-grained annotations of 12 surgical phases, 10 instrument categories, dense MANO hand meshes, and full 6-DoF instrument poses. To scalably produce high-fidelity labels, we design a multi-stage automatic annotation pipeline that integrates multi-view data observation, data-driven motion prior with cross-view geometric consistency and biomechanical constraints, along with a combination of collision-aware interaction constraints for instrument interactions. Building upon OphNet-3D, we establish two challenging benchmarks-bimanual hand pose estimation and hand-instrument interaction reconstruction-and propose two dedicated architectures: H-Net for dual-hand mesh recovery and OH-Net for joint reconstruction of two-hand-two-instrument interactions. These models leverage a novel spatial reasoning module with weak-perspective camera modeling and collision-aware center-based representation. Both architectures outperform existing methods by substantial margins, achieving improvements of over 2mm in Mean Per Joint Position Error (MPJPE) and up to 23% in ADD-S metrics for hand and instrument reconstruction, respectively.

TAGS: A Test-Time Generalist-Specialist Framework with Retrieval-Augmented Reasoning and Verification

Recent advances such as Chain-of-Thought prompting have significantly improved large language models (LLMs) in zero-shot medical reasoning. However, prompting-based methods often remain shallow and unstable, while fine-tuned medical LLMs suffer from poor generalization under distribution shifts and limited adaptability to unseen clinical scenarios. To address these limitations, we present TAGS, a test-time framework that combines a broadly capable generalist with a domain-specific specialist to offer complementary perspectives without any model fine-tuning or parameter updates. To support this generalist-specialist reasoning process, we introduce two auxiliary modules: a hierarchical retrieval mechanism that provides multi-scale exemplars by selecting examples based on both semantic and rationale-level similarity, and a reliability scorer that evaluates reasoning consistency to guide final answer aggregation. TAGS achieves strong performance across nine MedQA benchmarks, boosting GPT-4o accuracy by 13.8%, DeepSeek-R1 by 16.8%, and improving a vanilla 7B model from 14.1% to 23.9%. These results surpass several fine-tuned medical LLMs, without any parameter updates. The code will be available at https://github.com/JianghaoWu/TAGS.

Rhythm of Opinion: A Hawkes-Graph Framework for Dynamic Propagation Analysis

The rapid development of social media has significantly reshaped the dynamics of public opinion, resulting in complex interactions that traditional models fail to effectively capture. To address this challenge, we propose an innovative approach that integrates multi-dimensional Hawkes processes with Graph Neural Network, modeling opinion propagation dynamics among nodes in a social network while considering the intricate hierarchical relationships between comments. The extended multi-dimensional Hawkes process captures the hierarchical structure, multi-dimensional interactions, and mutual influences across different topics, forming a complex propagation network. Moreover, recognizing the lack of high-quality datasets capable of comprehensively capturing the evolution of public opinion dynamics, we introduce a new dataset, VISTA. It includes 159 trending topics, corresponding to 47,207 posts, 327,015 second-level comments, and 29,578 third-level comments, covering diverse domains such as politics, entertainment, sports, health, and medicine. The dataset is annotated with detailed sentiment labels across 11 categories and clearly defined hierarchical relationships. When combined with our method, it offers strong interpretability by linking sentiment propagation to the comment hierarchy and temporal evolution. Our approach provides a robust baseline for future research.

ScalingNoise: Scaling Inference-Time Search for Generating Infinite Videos

Video diffusion models (VDMs) facilitate the generation of high-quality videos, with current research predominantly concentrated on scaling efforts during training through improvements in data quality, computational resources, and model complexity. However, inference-time scaling has received less attention, with most approaches restricting models to a single generation attempt. Recent studies have uncovered the existence of "golden noises" that can enhance video quality during generation. Building on this, we find that guiding the scaling inference-time search of VDMs to identify better noise candidates not only evaluates the quality of the frames generated in the current step but also preserves the high-level object features by referencing the anchor frame from previous multi-chunks, thereby delivering long-term value. Our analysis reveals that diffusion models inherently possess flexible adjustments of computation by varying denoising steps, and even a one-step denoising approach, when guided by a reward signal, yields significant long-term benefits. Based on the observation, we proposeScalingNoise, a plug-and-play inference-time search strategy that identifies golden initial noises for the diffusion sampling process to improve global content consistency and visual diversity. Specifically, we perform one-step denoising to convert initial noises into a clip and subsequently evaluate its long-term value, leveraging a reward model anchored by previously generated content. Moreover, to preserve diversity, we sample candidates from a tilted noise distribution that up-weights promising noises. In this way, ScalingNoise significantly reduces noise-induced errors, ensuring more coherent and spatiotemporally consistent video generation. Extensive experiments on benchmark datasets demonstrate that the proposed ScalingNoise effectively improves long video generation.