Density-based Isometric Mapping

The isometric mapping method employs the shortest path algorithm to estimate the Euclidean distance between points on High dimensional (HD) manifolds. This may not be sufficient for weakly uniformed HD data as it could lead to overestimating distances between far neighboring points, resulting in inconsistencies between the intrinsic (local) and extrinsic (global) distances during the projection. To address this issue, we modify the shortest path algorithm by adding a novel constraint inspired by the Parzen-Rosenblatt (PR) window, which helps to maintain the uniformity of the constructed shortest-path graph in Isomap. Multiple imaging datasets overall of 72,236 cases, 70,000 MINST data, 1596 from multiple Chest-XRay pneumonia datasets, and three NSCLC CT/PET datasets with a total of 640 lung cancer patients, were used to benchmark and validate PR-Isomap. 431 imaging biomarkers were extracted from each modality. Our results indicate that PR-Isomap projects HD attributes into a lower-dimensional (LD) space while preserving information, visualized by the MNIST dataset indicating the maintaining local and global distances. PR-Isomap achieved the highest comparative accuracies of 80.9% (STD:5.8) for pneumonia and 78.5% (STD:4.4), 88.4% (STD:1.4), and 61.4% (STD:11.4) for three NSCLC datasets, with a confidence interval of 95% for outcome prediction. Similarly, the multivariate Cox model showed higher overall survival, measured with c-statistics and log-likelihood test, of PR-Isomap compared to other dimensionality reduction methods. Kaplan Meier survival curve also signifies the notable ability of PR-Isomap to distinguish between high-risk and low-risk patients using multimodal imaging biomarkers preserving HD imaging characteristics for precision medicine.

AI-Enabled Lung Cancer Prognosis

Lung cancer is the primary cause of cancer-related mortality, claiming approximately 1.79 million lives globally in 2020, with an estimated 2.21 million new cases diagnosed within the same period. Among these, Non-Small Cell Lung Cancer (NSCLC) is the predominant subtype, characterized by a notably bleak prognosis and low overall survival rate of approximately 25% over five years across all disease stages. However, survival outcomes vary considerably based on the stage at diagnosis and the therapeutic interventions administered. Recent advancements in artificial intelligence (AI) have revolutionized the landscape of lung cancer prognosis. AI-driven methodologies, including machine learning and deep learning algorithms, have shown promise in enhancing survival prediction accuracy by efficiently analyzing complex multi-omics data and integrating diverse clinical variables. By leveraging AI techniques, clinicians can harness comprehensive prognostic insights to tailor personalized treatment strategies, ultimately improving patient outcomes in NSCLC. Overviewing AI-driven data processing can significantly help bolster the understanding and provide better directions for using such systems.

Compliant actuators that mimic biological muscle performance with applications in a highly biomimetic robotic arm

This paper endeavours to bridge the existing gap in muscular actuator design for ligament-skeletal-inspired robots, thereby fostering the evolution of these robotic systems. We introduce two novel compliant actuators, namely the Internal Torsion Spring Compliant Actuator (ICA) and the External Spring Compliant Actuator (ECA), and present a comparative analysis against the previously conceived Magnet Integrated Soft Actuator (MISA) through computational and experimental results. These actuators, employing a motor-tendon system, emulate biological muscle-like forms, enhancing artificial muscle technology. A robotic arm application inspired by the skeletal ligament system is presented. Experiments demonstrate satisfactory power in tasks like lifting dumbbells (peak power: 36W), playing table tennis (end-effector speed: 3.2 m/s), and door opening, without compromising biomimetic aesthetics. Compared to other linear stiffness serial elastic actuators (SEAs), ECA and ICA exhibit high power-to-volume (361 x 10^3 W/m) and power-to-mass (111.6 W/kg) ratios respectively, endorsing the biomimetic design's promise in robotic development.

Enhancing the Performance of a Biomimetic Robotic Elbow-and-Forearm System Through Bionics-Inspired Optimization

This paper delineates the formulation and verification of an innovative robotic forearm and elbow design, mirroring the intricate biomechanics of human skeletal and ligament systems. Conventional robotic models often undervalue the substantial function of soft tissues, leading to a compromise between compactness, safety, stability, and range of motion. In contrast, this study proposes a holistic replication of biological joints, encompassing bones, cartilage, ligaments, and tendons, culminating in a biomimetic robot. The research underscores the compact and stable structure of the human forearm, attributable to a tri-bone framework and diverse soft tissues. The methodology involves exhaustive examinations of human anatomy, succeeded by a theoretical exploration of the contribution of soft tissues to the stability of the prototype. The evaluation results unveil remarkable parallels between the range of motion of the robotic joints and their human counterparts. The robotic elbow emulates 98.8% of the biological elbow's range of motion, with high torque capacities of 11.25 Nm (extension) and 24 Nm (flexion). Similarly, the robotic forearm achieves 58.6% of the human forearm's rotational range, generating substantial output torques of 14 Nm (pronation) and 7.8 Nm (supination). Moreover, the prototype exhibits significant load-bearing abilities, resisting a 5kg dumbbell load without substantial displacement. It demonstrates a payload capacity exceeding 4kg and rapid action capabilities, such as lifting a 2kg dumbbell at a speed of 0.74Hz and striking a ping-pong ball at an end-effector speed of 3.2 m/s. This research underscores that a detailed anatomical study can address existing robotic design obstacles, optimize performance and anthropomorphic resemblance, and reaffirm traditional anatomical principles.

Development and Characteristics of a Highly Biomimetic Robotic Shoulder Through Bionics-Inspired Optimization

This paper critically analyzes conventional and biomimetic robotic arms, underscoring the trade-offs between size, motion range, and load capacity in current biomimetic models. By delving into the human shoulder's mechanical intelligence, particularly the glenohumeral joint's intricate features such as its unique ball-and-socket structure and self-locking mechanism, we pinpoint innovations that bolster both stability and mobility while maintaining compactness. To substantiate these insights, we present a groundbreaking biomimetic robotic glenohumeral joint that authentically mirrors human musculoskeletal elements, from ligaments to tendons, integrating the biological joint's mechanical intelligence. Our exhaustive simulations and tests reveal enhanced flexibility and load capacity for the robotic joint. The advanced robotic arm demonstrates notable capabilities, including a significant range of motions and a 4 kg payload capacity, even exerting over 1.5 Nm torque. This study not only confirms the human shoulder joint's mechanical innovations but also introduces a pioneering design for a next-generation biomimetic robotic arm, setting a new benchmark in robotic technology.

XPrompt: Exploring the Extreme of Prompt Tuning

Prompt tuning learns soft prompts to condition frozen Pre-trained Language Models (PLMs) for performing downstream tasks in a parameter-efficient manner. While prompt tuning has gradually reached the performance level of fine-tuning as the model scale increases, there is still a large performance gap between prompt tuning and fine-tuning for models of moderate and small scales (typically less than 11B parameters). In this paper, we empirically show that the trained prompt tokens can have a negative impact on a downstream task and thus degrade its performance. To bridge the gap, we propose a novel Prompt tuning model with an eXtremely small scale (XPrompt) under the regime of lottery tickets hypothesis. Specifically, XPrompt eliminates the negative prompt tokens at different granularity levels through a hierarchical structured pruning, yielding a more parameter-efficient prompt yet with a competitive performance. Comprehensive experiments are carried out on SuperGLUE tasks, and the extensive results indicate that XPrompt is able to close the performance gap at smaller model scales.

Structural Bias for Aspect Sentiment Triplet Extraction

Structural bias has recently been exploited for aspect sentiment triplet extraction (ASTE) and led to improved performance. On the other hand, it is recognized that explicitly incorporating structural bias would have a negative impact on efficiency, whereas pretrained language models (PLMs) can already capture implicit structures. Thus, a natural question arises: Is structural bias still a necessity in the context of PLMs? To answer the question, we propose to address the efficiency issues by using an adapter to integrate structural bias in the PLM and using a cheap-to-compute relative position structure in place of the syntactic dependency structure. Benchmarking evaluation is conducted on the SemEval datasets. The results show that our proposed structural adapter is beneficial to PLMs and achieves state-of-the-art performance over a range of strong baselines, yet with a light parameter demand and low latency. Meanwhile, we give rise to the concern that the current evaluation default with data of small scale is under-confident. Consequently, we release a large-scale dataset for ASTE. The results on the new dataset hint that the structural adapter is confidently effective and efficient to a large scale. Overall, we draw the conclusion that structural bias shall still be a necessity even with PLMs.

Making Pre-trained Language Models Good Long-tailed Learners

Prompt-tuning has shown appealing performance in few-shot classification by virtue of its capability in effectively exploiting pre-trained knowledge. This motivates us to check the hypothesis that prompt-tuning is also a promising choice for long-tailed classification, since the tail classes are intuitively few-shot ones. To achieve this aim, we conduct empirical studies to examine the hypothesis. The results demonstrate that prompt-tuning exactly makes pre-trained language models at least good long-tailed learners. For intuitions on why prompt-tuning can achieve good performance in long-tailed classification, we carry out an in-depth analysis by progressively bridging the gap between prompt-tuning and commonly used fine-tuning. The summary is that the classifier structure and parameterization form the key to making good long-tailed learners, in comparison with the less important input structure. Finally, we verify the applicability of our finding to few-shot classification.

ASAP: A Chinese Review Dataset Towards Aspect Category Sentiment Analysis and Rating Prediction

Sentiment analysis has attracted increasing attention in e-commerce. The sentiment polarities underlying user reviews are of great value for business intelligence. Aspect category sentiment analysis (ACSA) and review rating prediction (RP) are two essential tasks to detect the fine-to-coarse sentiment polarities. %Considering the sentiment of the aspects(ACSA) and the overall review rating(RP) simultaneously has the potential to improve the overall performance. ACSA and RP are highly correlated and usually employed jointly in real-world e-commerce scenarios. While most public datasets are constructed for ACSA and RP separately, which may limit the further exploitation of both tasks. To address the problem and advance related researches, we present a large-scale Chinese restaurant review dataset \textbf{ASAP} including $46,730$ genuine reviews from a leading online-to-offline (O2O) e-commerce platform in China. Besides a $5$-star scale rating, each review is manually annotated according to its sentiment polarities towards $18$ pre-defined aspect categories. We hope the release of the dataset could shed some light on the fields of sentiment analysis. Moreover, we propose an intuitive yet effective joint model for ACSA and RP. Experimental results demonstrate that the joint model outperforms state-of-the-art baselines on both tasks.

Iterative Inversion of Deformation Vector Fields with Feedback Control

Purpose: Often, the inverse deformation vector field (DVF) is needed together with the corresponding forward DVF in 4D reconstruction and dose calculation, adaptive radiation therapy, and simultaneous deformable registration. This study aims at improving both accuracy and efficiency of iterative algorithms for DVF inversion, and advancing our understanding of divergence and latency conditions. Method: We introduce a framework of fixed-point iteration algorithms with active feedback control for DVF inversion. Based on rigorous convergence analysis, we design control mechanisms for modulating the inverse consistency (IC) residual of the current iterate, to be used as feedback into the next iterate. The control is designed adaptively to the input DVF with the objective to enlarge the convergence area and expedite convergence. Three particular settings of feedback control are introduced: constant value over the domain throughout the iteration; alternating values between iteration steps; and spatially variant values. We also introduce three spectral measures of the displacement Jacobian for characterizing a DVF. These measures reveal the critical role of what we term the non-translational displacement component (NTDC) of the DVF. We carry out inversion experiments with an analytical DVF pair, and with DVFs associated with thoracic CT images of 6 patients at end of expiration and end of inspiration. Results: NTDC-adaptive iterations are shown to attain a larger convergence region at a faster pace compared to previous non-adaptive DVF inversion iteration algorithms. By our numerical experiments, alternating control yields smaller IC residuals and inversion errors than constant control. Spatially variant control renders smaller residuals and errors by at least an order of magnitude, compared to other schemes, in no more than 10 steps. Inversion results also show remarkable quantitative agreement with analysis-based predictions. Conclusion: Our analysis captures properties of DVF data associated with clinical CT images, and provides new understanding of iterative DVF inversion algorithms with a simple residual feedback control. Adaptive control is necessary and highly effective in the presence of non-small NTDCs. The adaptive iterations or the spectral measures, or both, may potentially be incorporated into deformable image registration methods.