From Sentences to Sequences: Rethinking Languages in Biological System

The paradigm of large language models in natural language processing (NLP) has also shown promise in modeling biological languages, including proteins, RNA, and DNA. Both the auto-regressive generation paradigm and evaluation metrics have been transferred from NLP to biological sequence modeling. However, the intrinsic structural correlations in natural and biological languages differ fundamentally. Therefore, we revisit the notion of language in biological systems to better understand how NLP successes can be effectively translated to biological domains. By treating the 3D structure of biomolecules as the semantic content of a sentence and accounting for the strong correlations between residues or bases, we highlight the importance of structural evaluation and demonstrate the applicability of the auto-regressive paradigm in biological language modeling. Code can be found at \href{https://github.com/zjuKeLiu/RiFold}{github.com/zjuKeLiu/RiFold}

SheetMind: An End-to-End LLM-Powered Multi-Agent Framework for Spreadsheet Automation

We present SheetMind, a modular multi-agent framework powered by large language models (LLMs) for spreadsheet automation via natural language instructions. The system comprises three specialized agents: a Manager Agent that decomposes complex user instructions into subtasks; an Action Agent that translates these into structured commands using a Backus Naur Form (BNF) grammar; and a Reflection Agent that validates alignment between generated actions and the user's original intent. Integrated into Google Sheets via a Workspace extension, SheetMind supports real-time interaction without requiring scripting or formula knowledge. Experiments on benchmark datasets demonstrate an 80 percent success rate on single step tasks and approximately 70 percent on multi step instructions, outperforming ablated and baseline variants. Our results highlight the effectiveness of multi agent decomposition and grammar based execution for bridging natural language and spreadsheet functionalities.

AI PsyRoom: Artificial Intelligence Platform for Segmented Yearning and Reactive Outcome Optimization Method

Psychological counseling faces huge challenges due to the growing demand for mental health services and the shortage of trained professionals. Large language models (LLMs) have shown potential to assist psychological counseling, especially in empathy and emotional support. However, existing models lack a deep understanding of emotions and are unable to generate personalized treatment plans based on fine-grained emotions. To address these shortcomings, we present AI PsyRoom, a multi-agent simulation framework designed to enhance psychological counseling by generating empathetic and emotionally nuanced conversations. By leveraging fine-grained emotion classification and a multi-agent framework, we construct a multi-agent PsyRoom A for dialogue reconstruction, generating a high-quality dialogue dataset EmoPsy, which contains 35 sub-emotions, 423 specific emotion scenarios, and 12,350 dialogues. We also propose PsyRoom B for generating personalized treatment plans. Quantitative evaluations demonstrate that AI PsyRoom significantly outperforms state-of-the-art methods, achieving 18% improvement in problem orientation, 23% in expression, 24% in Empathy, and 16% in interactive communication quality. The datasets and models are publicly available, providing a foundation for advancing AI-assisted psychological counseling research.

ImputeINR: Time Series Imputation via Implicit Neural Representations for Disease Diagnosis with Missing Data

Healthcare data frequently contain a substantial proportion of missing values, necessitating effective time series imputation to support downstream disease diagnosis tasks. However, existing imputation methods focus on discrete data points and are unable to effectively model sparse data, resulting in particularly poor performance for imputing substantial missing values. In this paper, we propose a novel approach, ImputeINR, for time series imputation by employing implicit neural representations (INR) to learn continuous functions for time series. ImputeINR leverages the merits of INR in that the continuous functions are not coupled to sampling frequency and have infinite sampling frequency, allowing ImputeINR to generate fine-grained imputations even on extremely sparse observed values. Extensive experiments conducted on eight datasets with five ratios of masked values show the superior imputation performance of ImputeINR, especially for high missing ratios in time series data. Furthermore, we validate that applying ImputeINR to impute missing values in healthcare data enhances the performance of downstream disease diagnosis tasks. Codes are available.

Uncertainty-Aware Multi-Expert Knowledge Distillation for Imbalanced Disease Grading

Automatic disease image grading is a significant application of artificial intelligence for healthcare, enabling faster and more accurate patient assessments. However, domain shifts, which are exacerbated by data imbalance, introduce bias into the model, posing deployment difficulties in clinical applications. To address the problem, we propose a novel \textbf{U}ncertainty-aware \textbf{M}ulti-experts \textbf{K}nowledge \textbf{D}istillation (UMKD) framework to transfer knowledge from multiple expert models to a single student model. Specifically, to extract discriminative features, UMKD decouples task-agnostic and task-specific features with shallow and compact feature alignment in the feature space. At the output space, an uncertainty-aware decoupled distillation (UDD) mechanism dynamically adjusts knowledge transfer weights based on expert model uncertainties, ensuring robust and reliable distillation. Additionally, UMKD also tackles the problems of model architecture heterogeneity and distribution discrepancies between source and target domains, which are inadequately tackled by previous KD approaches. Extensive experiments on histology prostate grading (\textit{SICAPv2}) and fundus image grading (\textit{APTOS}) demonstrate that UMKD achieves a new state-of-the-art in both source-imbalanced and target-imbalanced scenarios, offering a robust and practical solution for real-world disease image grading.

A Dynamic Fuzzy Rule and Attribute Management Framework for Fuzzy Inference Systems in High-Dimensional Data

This paper presents an Adaptive Dynamic Attribute and Rule (ADAR) framework designed to address the challenges posed by high-dimensional data in neuro-fuzzy inference systems. By integrating dual weighting mechanisms-assigning adaptive importance to both attributes and rules-together with automated growth and pruning strategies, ADAR adaptively streamlines complex fuzzy models without sacrificing performance or interpretability. Experimental evaluations on four diverse datasets - Auto MPG (7 variables), Beijing PM2.5 (10 variables), Boston Housing (13 variables), and Appliances Energy Consumption (27 variables) show that ADAR-based models achieve consistently lower Root Mean Square Error (RMSE) compared to state-of-the-art baselines. On the Beijing PM2.5 dataset, for instance, ADAR-SOFENN attained an RMSE of 56.87 with nine rules, surpassing traditional ANFIS [12] and SOFENN [16] models. Similarly, on the high-dimensional Appliances Energy dataset, ADAR-ANFIS reached an RMSE of 83.25 with nine rules, outperforming established fuzzy logic approaches and interpretability-focused methods such as APLR. Ablation studies further reveal that combining rule-level and attribute-level weight assignment significantly reduces model overlap while preserving essential features, thereby enhancing explainability. These results highlight ADAR's effectiveness in dynamically balancing rule complexity and feature importance, paving the way for scalable, high-accuracy, and transparent neuro-fuzzy systems applicable to a range of real-world scenarios.

Matrix Factorization with Dynamic Multi-view Clustering for Recommender System

Matrix factorization (MF), a cornerstone of recommender systems, decomposes user-item interaction matrices into latent representations. Traditional MF approaches, however, employ a two-stage, non-end-to-end paradigm, sequentially performing recommendation and clustering, resulting in prohibitive computational costs for large-scale applications like e-commerce and IoT, where billions of users interact with trillions of items. To address this, we propose Matrix Factorization with Dynamic Multi-view Clustering (MFDMC), a unified framework that balances efficient end-to-end training with comprehensive utilization of web-scale data and enhances interpretability. MFDMC leverages dynamic multi-view clustering to learn user and item representations, adaptively pruning poorly formed clusters. Each entity's representation is modeled as a weighted projection of robust clusters, capturing its diverse roles across views. This design maximizes representation space utilization, improves interpretability, and ensures resilience for downstream tasks. Extensive experiments demonstrate MFDMC's superior performance in recommender systems and other representation learning domains, such as computer vision, highlighting its scalability and versatility.

Learning Implicit Social Navigation Behavior using Deep Inverse Reinforcement Learning

This paper reports on learning a reward map for social navigation in dynamic environments where the robot can reason about its path at any time, given agents' trajectories and scene geometry. Humans navigating in dense and dynamic indoor environments often work with several implied social rules. A rule-based approach fails to model all possible interactions between humans, robots, and scenes. We propose a novel Smooth Maximum Entropy Deep Inverse Reinforcement Learning (S-MEDIRL) algorithm that can extrapolate beyond expert demos to better encode scene navigability from few-shot demonstrations. The agent learns to predict the cost maps reasoning on trajectory data and scene geometry. The agent samples a trajectory that is then executed using a local crowd navigation controller. We present results in a photo-realistic simulation environment, with a robot and a human navigating a narrow crossing scenario. The robot implicitly learns to exhibit social behaviors such as yielding to oncoming traffic and avoiding deadlocks. We compare the proposed approach to the popular model-based crowd navigation algorithm ORCA and a rule-based agent that exhibits yielding.

Automatically Planning Optimal Parallel Strategy for Large Language Models

The number of parameters in large-scale language models based on transformers is gradually increasing, and the scale of computing clusters is also growing. The technology of quickly mobilizing large amounts of computing resources for parallel computing is becoming increasingly important. In this paper, we propose an automatic parallel algorithm that automatically plans the parallel strategy with maximum throughput based on model and hardware information. By decoupling the training time into computation, communication, and overlap, we established a training duration simulation model. Based on this simulation model, we prune the parallel solution space to shorten the search time required. The multi-node experiment results show that the algorithm can estimate the parallel training duration in real time with an average accuracy of 96%. In our test, the recommendation strategy provided by the algorithm is always globally optimal.

Less is More: Towards Green Code Large Language Models via Unified Structural Pruning

The extensive application of Large Language Models (LLMs) in generative coding tasks has raised concerns due to their high computational demands and energy consumption. Unlike previous structural pruning methods designed for classification models that deal with lowdimensional classification logits, generative Code LLMs produce high-dimensional token logit sequences, making traditional pruning objectives inherently limited. Moreover, existing single component pruning approaches further constrain the effectiveness when applied to generative Code LLMs. In response, we propose Flab-Pruner, an innovative unified structural pruning method that combines vocabulary, layer, and Feed-Forward Network (FFN) pruning. This approach effectively reduces model parameters while maintaining performance. Additionally, we introduce a customized code instruction data strategy for coding tasks to enhance the performance recovery efficiency of the pruned model. Through extensive evaluations on three state-of-the-art Code LLMs across multiple generative coding tasks, the results demonstrate that Flab-Pruner retains 97% of the original performance after pruning 22% of the parameters and achieves the same or even better performance after post-training. The pruned models exhibit significant improvements in storage, GPU usage, computational efficiency, and environmental impact, while maintaining well robustness. Our research provides a sustainable solution for green software engineering and promotes the efficient deployment of LLMs in real-world generative coding intelligence applications.