AlphaVC: High-Performance and Efficient Learned Video Compression

Recently, learned video compression has drawn lots of attention and show a rapid development trend with promising results. However, the previous works still suffer from some criticial issues and have a performance gap with traditional compression standards in terms of widely used PSNR metric. In this paper, we propose several techniques to effectively improve the performance. First, to address the problem of accumulative error, we introduce a conditional-I-frame as the first frame in the GoP, which stabilizes the reconstructed quality and saves the bit-rate. Second, to efficiently improve the accuracy of inter prediction without increasing the complexity of decoder, we propose a pixel-to-feature motion prediction method at encoder side that helps us to obtain high-quality motion information. Third, we propose a probability-based entropy skipping method, which not only brings performance gain, but also greatly reduces the runtime of entropy coding. With these powerful techniques, this paper proposes AlphaVC, a high-performance and efficient learned video compression scheme. To the best of our knowledge, AlphaVC is the first E2E AI codec that exceeds the latest compression standard VVC on all common test datasets for both PSNR (-28.2% BD-rate saving) and MSSSIM (-52.2% BD-rate saving), and has very fast encoding (0.001x VVC) and decoding (1.69x VVC) speeds.

Fine-Tuning BERT for Automatic ADME Semantic Labeling in FDA Drug Labeling to Enhance Product-Specific Guidance Assessment

Product-specific guidances (PSGs) recommended by the United States Food and Drug Administration (FDA) are instrumental to promote and guide generic drug product development. To assess a PSG, the FDA assessor needs to take extensive time and effort to manually retrieve supportive drug information of absorption, distribution, metabolism, and excretion (ADME) from the reference listed drug labeling. In this work, we leveraged the state-of-the-art pre-trained language models to automatically label the ADME paragraphs in the pharmacokinetics section from the FDA-approved drug labeling to facilitate PSG assessment. We applied a transfer learning approach by fine-tuning the pre-trained Bidirectional Encoder Representations from Transformers (BERT) model to develop a novel application of ADME semantic labeling, which can automatically retrieve ADME paragraphs from drug labeling instead of manual work. We demonstrated that fine-tuning the pre-trained BERT model can outperform the conventional machine learning techniques, achieving up to 11.6% absolute F1 improvement. To our knowledge, we were the first to successfully apply BERT to solve the ADME semantic labeling task. We further assessed the relative contribution of pre-training and fine-tuning to the overall performance of the BERT model in the ADME semantic labeling task using a series of analysis methods such as attention similarity and layer-based ablations. Our analysis revealed that the information learned via fine-tuning is focused on task-specific knowledge in the top layers of the BERT, whereas the benefit from the pre-trained BERT model is from the bottom layers.

Two-Stage Fine-Tuning: A Novel Strategy for Learning Class-Imbalanced Data

Classification on long-tailed distributed data is a challenging problem, which suffers from serious class-imbalance and hence poor performance on tail classes with only a few samples. Owing to this paucity of samples, learning on the tail classes is especially challenging for the fine-tuning when transferring a pretrained model to a downstream task. In this work, we present a simple modification of standard fine-tuning to cope with these challenges. Specifically, we propose a two-stage fine-tuning: we first fine-tune the final layer of the pretrained model with class-balanced reweighting loss, and then we perform the standard fine-tuning. Our modification has several benefits: (1) it leverages pretrained representations by only fine-tuning a small portion of the model parameters while keeping the rest untouched; (2) it allows the model to learn an initial representation of the specific task; and importantly (3) it protects the learning of tail classes from being at a disadvantage during the model updating. We conduct extensive experiments on synthetic datasets of both two-class and multi-class tasks of text classification as well as a real-world application to ADME (i.e., absorption, distribution, metabolism, and excretion) semantic labeling. The experimental results show that the proposed two-stage fine-tuning outperforms both fine-tuning with conventional loss and fine-tuning with a reweighting loss on the above datasets.

Positive-Negative Equal Contrastive Loss for Semantic Segmentation

The contextual information is critical for various computer vision tasks, previous works commonly design plug-and-play modules and structural losses to effectively extract and aggregate the global context. These methods utilize fine-label to optimize the model but ignore that fine-trained features are also precious training resources, which can introduce preferable distribution to hard pixels (i.e., misclassified pixels). Inspired by contrastive learning in unsupervised paradigm, we apply the contrastive loss in a supervised manner and re-design the loss function to cast off the stereotype of unsupervised learning (e.g., imbalance of positives and negatives, confusion of anchors computing). To this end, we propose Positive-Negative Equal contrastive loss (PNE loss), which increases the latent impact of positive embedding on the anchor and treats the positive as well as negative sample pairs equally. The PNE loss can be directly plugged right into existing semantic segmentation frameworks and leads to excellent performance with neglectable extra computational costs. We utilize a number of classic segmentation methods (e.g., DeepLabV3, OCRNet, UperNet) and backbone (e.g., ResNet, HRNet, Swin Transformer) to conduct comprehensive experiments and achieve state-of-the-art performance on two benchmark datasets (e.g., Cityscapes and COCO-Stuff). Our code will be publicly available soon.

Reading and Writing: Discriminative and Generative Modeling for Self-Supervised Text Recognition

Existing text recognition methods usually need large-scale training data. Most of them rely on synthetic training data due to the lack of annotated real images. However, there is a domain gap between the synthetic data and real data, which limits the performance of the text recognition models. Recent self-supervised text recognition methods attempted to utilize unlabeled real images by introducing contrastive learning, which mainly learns the discrimination of the text images. Inspired by the observation that humans learn to recognize the texts through both reading and writing, we propose to learn discrimination and generation by integrating contrastive learning and masked image modeling in our self-supervised method. The contrastive learning branch is adopted to learn the discrimination of text images, which imitates the reading behavior of humans. Meanwhile, masked image modeling is firstly introduced for text recognition to learn the context generation of the text images, which is similar to the writing behavior. The experimental results show that our method outperforms previous self-supervised text recognition methods by 10.2%-20.2% on irregular scene text recognition datasets. Moreover, our proposed text recognizer exceeds previous state-of-the-art text recognition methods by averagely 5.3% on 11 benchmarks, with similar model size. We also demonstrate that our pre-trained model can be easily applied to other text-related tasks with obvious performance gain.

Taxonomy and evolution predicting using deep learning in images

Molecular and morphological characters, as important parts of biological taxonomy, are contradictory but need to be integrated. Organism's image recognition and bioinformatics are emerging and hot problems nowadays but with a gap between them. In this work, a multi-branching recognition framework mediated by genetic information bridges this barrier, which establishes the link between macro-morphology and micro-molecular information of mushrooms. The novel multi-perspective structure is proposed to fuse the feature images from three branching models, which significantly improves the accuracy of recognition by about 10% and up to more than 90%. Further, genetic information is implemented to the mushroom image recognition task by using genetic distance embeddings as the representation space for predicting image distance and species identification. Semantic overfitting of traditional classification tasks and the granularity of fine-grained image recognition are also discussed in depth for the first time. The generalizability of the model was investigated in fine-grained scenarios using zero-shot learning tasks, which could predict the taxonomic and evolutionary information of unseen samples. We presented the first method to map images to DNA, namely used an encoder mapping image to genetic distances, and then decoded DNA through a pre-trained decoder, where the total test accuracy on 37 species for DNA prediction is 87.45%. This study creates a novel recognition framework by systematically studying the mushroom image recognition problem, bridging the gap between macroscopic biological information and microscopic molecular information, which will provide a new reference for intelligent biometrics in the future.

Med-DANet: Dynamic Architecture Network for Efficient Medical Volumetric Segmentation

For 3D medical image (e.g. CT and MRI) segmentation, the difficulty of segmenting each slice in a clinical case varies greatly. Previous research on volumetric medical image segmentation in a slice-by-slice manner conventionally use the identical 2D deep neural network to segment all the slices of the same case, ignoring the data heterogeneity among image slices. In this paper, we focus on multi-modal 3D MRI brain tumor segmentation and propose a dynamic architecture network named Med-DANet based on adaptive model selection to achieve effective accuracy and efficiency trade-off. For each slice of the input 3D MRI volume, our proposed method learns a slice-specific decision by the Decision Network to dynamically select a suitable model from the predefined Model Bank for the subsequent 2D segmentation task. Extensive experimental results on both BraTS 2019 and 2020 datasets show that our proposed method achieves comparable or better results than previous state-of-the-art methods for 3D MRI brain tumor segmentation with much less model complexity. Compared with the state-of-the-art 3D method TransBTS, the proposed framework improves the model efficiency by up to 3.5x without sacrificing the accuracy. Our code will be publicly available soon.

Lesion classification by model-based feature extraction: A differential affine invariant model of soft tissue elasticity

The elasticity of soft tissues has been widely considered as a characteristic property to differentiate between healthy and vicious tissues and, therefore, motivated several elasticity imaging modalities, such as Ultrasound Elastography, Magnetic Resonance Elastography, and Optical Coherence Elastography. This paper proposes an alternative approach of modeling the elasticity using Computed Tomography (CT) imaging modality for model-based feature extraction machine learning (ML) differentiation of lesions. The model describes a dynamic non-rigid (or elastic) deformation in differential manifold to mimic the soft tissues elasticity under wave fluctuation in vivo. Based on the model, three local deformation invariants are constructed by two tensors defined by the first and second order derivatives from the CT images and used to generate elastic feature maps after normalization via a novel signal suppression method. The model-based elastic image features are extracted from the feature maps and fed to machine learning to perform lesion classifications. Two pathologically proven image datasets of colon polyps (44 malignant and 43 benign) and lung nodules (46 malignant and 20 benign) were used to evaluate the proposed model-based lesion classification. The outcomes of this modeling approach reached the score of area under the curve of the receiver operating characteristics of 94.2 % for the polyps and 87.4 % for the nodules, resulting in an average gain of 5 % to 30 % over ten existing state-of-the-art lesion classification methods. The gains by modeling tissue elasticity for ML differentiation of lesions are striking, indicating the great potential of exploring the modeling strategy to other tissue properties for ML differentiation of lesions.

A Model Predictive Control Functional Continuous Time Bayesian Network for Self-Management of Multiple Chronic Conditions

Multiple chronic conditions (MCC) are one of the biggest challenges of modern times. The evolution of MCC follows a complex stochastic process that is influenced by a variety of risk factors, ranging from pre-existing conditions to modifiable lifestyle behavioral factors (e.g. diet, exercise habits, tobacco use, alcohol use, etc.) to non-modifiable socio-demographic factors (e.g., age, gender, education, marital status, etc.). People with MCC are at an increased risk of new chronic conditions and mortality. This paper proposes a model predictive control functional continuous time Bayesian network, an online recursive method to examine the impact of various lifestyle behavioral changes on the emergence trajectories of MCC and generate strategies to minimize the risk of progression of chronic conditions in individual patients. The proposed method is validated based on the Cameron county Hispanic cohort (CCHC) dataset, which has a total of 385 patients. The dataset examines the emergence of 5 chronic conditions (diabetes, obesity, cognitive impairment, hyperlipidemia, and hypertension) based on four modifiable risk factors representing lifestyle behaviors (diet, exercise habits, tobacco use, alcohol use) and four non-modifiable risk factors, including socio-demographic information (age, gender, education, marital status). The proposed method is tested under different scenarios (e.g., age group, the prior existence of MCC), demonstrating the effective intervention strategies for improving the lifestyle behavioral risk factors to offset MCC evolution.

MSTRIQ: No Reference Image Quality Assessment Based on Swin Transformer with Multi-Stage Fusion

Measuring the perceptual quality of images automatically is an essential task in the area of computer vision, as degradations on image quality can exist in many processes from image acquisition, transmission to enhancing. Many Image Quality Assessment(IQA) algorithms have been designed to tackle this problem. However, it still remains un settled due to the various types of image distortions and the lack of large-scale human-rated datasets. In this paper, we propose a novel algorithm based on the Swin Transformer [31] with fused features from multiple stages, which aggregates information from both local and global features to better predict the quality. To address the issues of small-scale datasets, relative rankings of images have been taken into account together with regression loss to simultaneously optimize the model. Furthermore, effective data augmentation strategies are also used to improve the performance. In comparisons with previous works, experiments are carried out on two standard IQA datasets and a challenge dataset. The results demonstrate the effectiveness of our work. The proposed method outperforms other methods on standard datasets and ranks 2nd in the no-reference track of NTIRE 2022 Perceptual Image Quality Assessment Challenge [53]. It verifies that our method is promising in solving diverse IQA problems and thus can be used to real-word applications.