DynaPPI: A Large-scale Dynamic Protein Dataset for AI-driven Advances in Protein Interactomics

Diffusion models have been widely explored in protein backbone generation due to their powerful generation capabilities.However, in today's AI-driven biological research, predicting the structure of unknown multi-chain protein aggregates (called "complexes" in biology) remains an unsolved challenge.This is because existing static or dynamic protein datasets focus solely on static snapshots or single-entity trajectories, neglecting the dynamic process of multiple monomers forming complexes.To alleviate this dilemma, we present DynaPPI, a dynamic protein dataset comprising molecular dynamics (MD) trajectories of protein complex formation from dissociated chains to the bound state, as a pivotal resource to bridge the gap between static structural biology and the inherently temporal nature of dynamic molecular interactions.Benefiting from this dataset, diffusion models can explicitly learn the dynamic binding trajectories of known complexes and accurately predict the structures of unknown complexes based on their diverse generative properties, thereby further catalyzing AI-driven structural biology and protein interactomics.

Deterministic DTFT Interpolation for Joint Frequency and Chirp-Rate Estimation: Cell-Uniform Efficiency and Threshold Analysis

Joint estimation of the frequency and chirp rate of a noisy chirp signal arises in radar, sonar, and burst satellite communications. Conventional estimators combine a coarse grid search with fine interpolation; accuracy degrades at the edges of the residual cell (the edge effect) and below the breakdown SNR (the threshold effect). This paper presents a deterministic two-stage estimator that controls both failure modes uniformly over the entire residual cell. The estimator combines a time-centered, zero-padded dechirp-FFT acquisition bank with alternating selectable-$p$ amplitude-interpolation refinements on fractional-bin DTFT samples; in the centered frame, the frequency-chirp-rate cross-term of the Fisher information vanishes. The paper derives a mean-squared-error and threshold characterization across the full SNR range, in closed form except for one calibrated scalar (an effective cell count), to our knowledge the first for the joint problem: the breakdown threshold is governed by the cell count, and its cell-position dependence is dominated by the straddle loss of the coarse FFT, which the padding bounds at 0.4 dB. An asymptotic uniformity analysis over the whole cell, including the corners, gives closed-form fixed-point variance ratios of $1.003$ and $0.998$, analytically free of the residual. A closed-form bias analysis under unmodeled jerk shows the centered chirp-rate estimate is first-order immune. Monte Carlo experiments at $N=256$ (validated at $N=32$-$512$) measure frequency- and chirp-rate-axis efficiencies with median $1.03$ and worst case $1.07$ over $144$ cell positions at $-5$ dB. Threshold predictions hold within $1.0$ dB on four held-out configurations. The dechirp-FFT bank is fully parallel, and each of the four refinement iterations evaluates three DTFT samples per axis; under fixed operating conditions, per-estimate latency is constant at $O(N\log N)$ cost.

SciIR: A Large-scale Training Dataset and Benchmark for Scientific Image Reasoning Generation

While Text-to-Image (T2I) models have shown remarkable success in generating photorealistic visual content, they still struggle with the rigorous semantic alignment and logical reasoning required for scientific imagery. Inspired by Peirce's Semiotic Triad, we introduce Scientific Image Reasoning (SciIR), a comprehensive resource for training and evaluation of scientific image generation. We formalize scientific reasoning into three core dimensions: Entity Structure (Icon), Scientific Process (Index), and Scientific Law (Symbol). Specifically, to overcome the scarcity of training data in scientific image generation, we elaborately create SciIR-82k, a large-scale dataset containing over 80,000 high-quality scientific image-text pairs from cutting-edge publications. The dataset is hierarchically organized according to the semiotic dimensions and incorporates a Scientific Reasoning Chain-of-Thought (Sci-RCoT) to explicitly model underlying visual logic. For evaluation, we propose SciIR-Bench, which aligns with these three semiotic levels and employs an Atomic Checklist to convert the outcome-oriented scientific accuracy into process-oriented, verifiable, fine-grained questions. Our extensive experiments reveal significant deficiencies in current models' scientific reasoning capabilities. Furthermore, by fine-tuning on the SciIR-82k dataset, we developed the Qwen-Image-SciIR model, which achieves a substantial improvement on the SciIR-Bench, increasing the final score from 35\% to 43\%, laying a solid foundation for future advances in scientific image generation.

QKVQA: Question-Focused Filtering for Knowledge-based VQA

Knowledge-based Visual Question Answering (KB-VQA) aims to answer questions by integrating images with external knowledge. Effective knowledge filtering is crucial for improving accuracy. Typical filtering methods use similarity metrics to locate relevant article sections from one article, leading to information selection errors at the article and intra-article levels. Although recent explorations of Multimodal Large Language Model (MLLM)-based filtering methods demonstrate superior semantic understanding and cross-article filtering capabilities, their high computational cost limits practical application. To address these issues, this paper proposes a question-focused filtering method. This approach can perform question-focused, cross-article filtering, efficiently obtaining high-quality filtered knowledge while keeping computational costs comparable to typical methods. Specifically, we design a trainable Question-Focused Filter (QFF) and a Chunk-based Dynamic Multi-Article Selection (CDA) module, which collectively alleviate information selection errors at both the article and intra-article levels. Experiments show that our method outperforms current state-of-the-art models by 4.9% on E-VQA and 3.8% on InfoSeek, validating its effectiveness. The code is publicly available at: https://github.com/leaffeall/QKVQA.

I2E: From Image Pixels to Actionable Interactive Environments for Text-Guided Image Editing

Existing text-guided image editing methods primarily rely on end-to-end pixel-level inpainting paradigm. Despite its success in simple scenarios, this paradigm still significantly struggles with compositional editing tasks that require precise local control and complex multi-object spatial reasoning. This paradigm is severely limited by 1) the implicit coupling of planning and execution, 2) the lack of object-level control granularity, and 3) the reliance on unstructured, pixel-centric modeling. To address these limitations, we propose I2E, a novel "Decompose-then-Action" paradigm that revisits image editing as an actionable interaction process within a structured environment. I2E utilizes a Decomposer to transform unstructured images into discrete, manipulable object layers and then introduces a physics-aware Vision-Language-Action Agent to parse complex instructions into a series of atomic actions via Chain-of-Thought reasoning. Further, we also construct I2E-Bench, a benchmark designed for multi-instance spatial reasoning and high-precision editing. Experimental results on I2E-Bench and multiple public benchmarks demonstrate that I2E significantly outperforms state-of-the-art methods in handling complex compositional instructions, maintaining physical plausibility, and ensuring multi-turn editing stability.

SCIR: A Self-Correcting Iterative Refinement Framework for Enhanced Information Extraction Based on Schema

Although Large language Model (LLM)-powered information extraction (IE) systems have shown impressive capabilities, current fine-tuning paradigms face two major limitations: high training costs and difficulties in aligning with LLM preferences. To address these issues, we propose a novel universal IE paradigm, the Self-Correcting Iterative Refinement (SCIR) framework, along with a Multi-task Bilingual (Chinese-English) Self-Correcting (MBSC) dataset containing over 100,000 entries. The SCIR framework achieves plug-and-play compatibility with existing LLMs and IE systems through its Dual-Path Self-Correcting module and feedback-driven optimization, thereby significantly reducing training costs. Concurrently, the MBSC dataset tackles the challenge of preference alignment by indirectly distilling GPT-4's capabilities into IE result detection models. Experimental results demonstrate that SCIR outperforms state-of-the-art IE methods across three key tasks: named entity recognition, relation extraction, and event extraction, achieving a 5.27 percent average improvement in span-based Micro-F1 while reducing training costs by 87 percent compared to baseline approaches. These advancements not only enhance the flexibility and accuracy of IE systems but also pave the way for lightweight and efficient IE paradigms.

Flow Diverse and Efficient: Learning Momentum Flow Matching via Stochastic Velocity Field Sampling

Recently, the rectified flow (RF) has emerged as the new state-of-the-art among flow-based diffusion models due to its high efficiency advantage in straight path sampling, especially with the amazing images generated by a series of RF models such as Flux 1.0 and SD 3.0. Although a straight-line connection between the noisy and natural data distributions is intuitive, fast, and easy to optimize, it still inevitably leads to: 1) Diversity concerns, which arise since straight-line paths only cover a fairly restricted sampling space. 2) Multi-scale noise modeling concerns, since the straight line flow only needs to optimize the constant velocity field $\bm v$ between the two distributions $\bm\pi_0$ and $\bm\pi_1$. In this work, we present Discretized-RF, a new family of rectified flow (also called momentum flow models since they refer to the previous velocity component and the random velocity component in each diffusion step), which discretizes the straight path into a series of variable velocity field sub-paths (namely ``momentum fields'') to expand the search space, especially when close to the distribution $p_\text{noise}$. Different from the previous case where noise is directly superimposed on $\bm x$, we introduce noise on the velocity $\bm v$ of the sub-path to change its direction in order to improve the diversity and multi-scale noise modeling abilities. Experimental results on several representative datasets demonstrate that learning momentum flow matching by sampling random velocity fields will produce trajectories that are both diverse and efficient, and can consistently generate high-quality and diverse results. Code is available at https://github.com/liuruixun/momentum-fm.

Context-Aware Autoregressive Models for Multi-Conditional Image Generation

Autoregressive transformers have recently shown impressive image generation quality and efficiency on par with state-of-the-art diffusion models. Unlike diffusion architectures, autoregressive models can naturally incorporate arbitrary modalities into a single, unified token sequence--offering a concise solution for multi-conditional image generation tasks. In this work, we propose $\textbf{ContextAR}$, a flexible and effective framework for multi-conditional image generation. ContextAR embeds diverse conditions (e.g., canny edges, depth maps, poses) directly into the token sequence, preserving modality-specific semantics. To maintain spatial alignment while enhancing discrimination among different condition types, we introduce hybrid positional encodings that fuse Rotary Position Embedding with Learnable Positional Embedding. We design Conditional Context-aware Attention to reduces computational complexity while preserving effective intra-condition perception. Without any fine-tuning, ContextAR supports arbitrary combinations of conditions during inference time. Experimental results demonstrate the powerful controllability and versatility of our approach, and show that the competitive perpormance than diffusion-based multi-conditional control approaches the existing autoregressive baseline across diverse multi-condition driven scenarios. Project page: $\href{https://context-ar.github.io/}{https://context-ar.github.io/.}$

CMAL: A Novel Cross-Modal Associative Learning Framework for Vision-Language Pre-Training

With the flourishing of social media platforms, vision-language pre-training (VLP) recently has received great attention and many remarkable progresses have been achieved. The success of VLP largely benefits from the information complementation and enhancement between different modalities. However, most of recent studies focus on cross-modal contrastive learning (CMCL) to promote image-text alignment by pulling embeddings of positive sample pairs together while pushing those of negative pairs apart, which ignores the natural asymmetry property between different modalities and requires large-scale image-text corpus to achieve arduous progress. To mitigate this predicament, we propose CMAL, a Cross-Modal Associative Learning framework with anchor points detection and cross-modal associative learning for VLP. Specifically, we first respectively embed visual objects and textual tokens into separate hypersphere spaces to learn intra-modal hidden features, and then design a cross-modal associative prompt layer to perform anchor point masking and swap feature filling for constructing a hybrid cross-modal associative prompt. Afterwards, we exploit a unified semantic encoder to learn their cross-modal interactive features for context adaptation. Finally, we design an associative mapping classification layer to learn potential associative mappings between modalities at anchor points, within which we develop a fresh self-supervised associative mapping classification task to boost CMAL's performance. Experimental results verify the effectiveness of CMAL, showing that it achieves competitive performance against previous CMCL-based methods on four common downstream vision-and-language tasks, with significantly fewer corpus. Especially, CMAL obtains new state-of-the-art results on SNLI-VE and REC (testA).

Efficient Diffusion Models: A Comprehensive Survey from Principles to Practices

As one of the most popular and sought-after generative models in the recent years, diffusion models have sparked the interests of many researchers and steadily shown excellent advantage in various generative tasks such as image synthesis, video generation, molecule design, 3D scene rendering and multimodal generation, relying on their dense theoretical principles and reliable application practices. The remarkable success of these recent efforts on diffusion models comes largely from progressive design principles and efficient architecture, training, inference, and deployment methodologies. However, there has not been a comprehensive and in-depth review to summarize these principles and practices to help the rapid understanding and application of diffusion models. In this survey, we provide a new efficiency-oriented perspective on these existing efforts, which mainly focuses on the profound principles and efficient practices in architecture designs, model training, fast inference and reliable deployment, to guide further theoretical research, algorithm migration and model application for new scenarios in a reader-friendly way. \url{https://github.com/ponyzym/Efficient-DMs-Survey}