DD-VNB: A Depth-based Dual-Loop Framework for Real-time Visually Navigated Bronchoscopy

Real-time 6 DOF localization of bronchoscopes is crucial for enhancing intervention quality. However, current vision-based technologies struggle to balance between generalization to unseen data and computational speed. In this study, we propose a Depth-based Dual-Loop framework for real-time Visually Navigated Bronchoscopy (DD-VNB) that can generalize across patient cases without the need of re-training. The DD-VNB framework integrates two key modules: depth estimation and dual-loop localization. To address the domain gap among patients, we propose a knowledge-embedded depth estimation network that maps endoscope frames to depth, ensuring generalization by eliminating patient-specific textures. The network embeds view synthesis knowledge into a cycle adversarial architecture for scale-constrained monocular depth estimation. For real-time performance, our localization module embeds a fast ego-motion estimation network into the loop of depth registration. The ego-motion inference network estimates the pose change of the bronchoscope in high frequency while depth registration against the pre-operative 3D model provides absolute pose periodically. Specifically, the relative pose changes are fed into the registration process as the initial guess to boost its accuracy and speed. Experiments on phantom and in-vivo data from patients demonstrate the effectiveness of our framework: 1) monocular depth estimation outperforms SOTA, 2) localization achieves an accuracy of Absolute Tracking Error (ATE) of 4.7 $\pm$ 3.17 mm in phantom and 6.49 $\pm$ 3.88 mm in patient data, 3) with a frame-rate approaching video capture speed, 4) without the necessity of case-wise network retraining. The framework's superior speed and accuracy demonstrate its promising clinical potential for real-time bronchoscopic navigation.

BronchoCopilot: Towards Autonomous Robotic Bronchoscopy via Multimodal Reinforcement Learning

Bronchoscopy plays a significant role in the early diagnosis and treatment of lung diseases. This process demands physicians to maneuver the flexible endoscope for reaching distal lesions, particularly requiring substantial expertise when examining the airways of the upper lung lobe. With the development of artificial intelligence and robotics, reinforcement learning (RL) method has been applied to the manipulation of interventional surgical robots. However, unlike human physicians who utilize multimodal information, most of the current RL methods rely on a single modality, limiting their performance. In this paper, we propose BronchoCopilot, a multimodal RL agent designed to acquire manipulation skills for autonomous bronchoscopy. BronchoCopilot specifically integrates images from the bronchoscope camera and estimated robot poses, aiming for a higher success rate within challenging airway environment. We employ auxiliary reconstruction tasks to compress multimodal data and utilize attention mechanisms to achieve an efficient latent representation of this data, serving as input for the RL module. This framework adopts a stepwise training and fine-tuning approach to mitigate the challenges of training difficulty. Our evaluation in the realistic simulation environment reveals that BronchoCopilot, by effectively harnessing multimodal information, attains a success rate of approximately 90\% in fifth generation airways with consistent movements. Additionally, it demonstrates a robust capacity to adapt to diverse cases.

Design and Visual Servoing Control of a Hybrid Dual-Segment Flexible Neurosurgical Robot for Intraventricular Biopsy

Traditional rigid endoscopes have challenges in flexibly treating tumors located deep in the brain, and low operability and fixed viewing angles limit its development. This study introduces a novel dual-segment flexible robotic endoscope MicroNeuro, designed to perform biopsies with dexterous surgical manipulation deep in the brain. Taking into account the uncertainty of the control model, an image-based visual servoing with online robot Jacobian estimation has been implemented to enhance motion accuracy. Furthermore, the application of model predictive control with constraints significantly bolsters the flexible robot's ability to adaptively track mobile objects and resist external interference. Experimental results underscore that the proposed control system enhances motion stability and precision. Phantom testing substantiates its considerable potential for deployment in neurosurgery.

Mudjacking: Patching Backdoor Vulnerabilities in Foundation Models

Foundation model has become the backbone of the AI ecosystem. In particular, a foundation model can be used as a general-purpose feature extractor to build various downstream classifiers. However, foundation models are vulnerable to backdoor attacks and a backdoored foundation model is a single-point-of-failure of the AI ecosystem, e.g., multiple downstream classifiers inherit the backdoor vulnerabilities simultaneously. In this work, we propose Mudjacking, the first method to patch foundation models to remove backdoors. Specifically, given a misclassified trigger-embedded input detected after a backdoored foundation model is deployed, Mudjacking adjusts the parameters of the foundation model to remove the backdoor. We formulate patching a foundation model as an optimization problem and propose a gradient descent based method to solve it. We evaluate Mudjacking on both vision and language foundation models, eleven benchmark datasets, five existing backdoor attacks, and thirteen adaptive backdoor attacks. Our results show that Mudjacking can remove backdoor from a foundation model while maintaining its utility.

Visual Hallucinations of Multi-modal Large Language Models

Visual hallucination (VH) means that a multi-modal LLM (MLLM) imagines incorrect details about an image in visual question answering. Existing studies find VH instances only in existing image datasets, which results in biased understanding of MLLMs' performance under VH due to limited diversity of such VH instances. In this work, we propose a tool called VHTest to generate a diverse set of VH instances. Specifically, VHTest finds some initial VH instances in existing image datasets (e.g., COCO), generates a text description for each VH mode, and uses a text-to-image generative model (e.g., DALL-E-3) to generate VH images based on the text descriptions. We collect a benchmark dataset with 1,200 VH instances in 8 VH modes using VHTest. We find that existing MLLMs such as GPT-4V, LLaVA-1.5, and MiniGPT-v2 hallucinate for a large fraction of the instances in our benchmark. Moreover, we find that fine-tuning an MLLM using our benchmark dataset reduces its likelihood to hallucinate without sacrificing its performance on other benchmarks. Our benchmarks are publicly available: https://github.com/wenhuang2000/VHTest.

ChemReasoner: Heuristic Search over a Large Language Model's Knowledge Space using Quantum-Chemical Feedback

The discovery of new catalysts is essential for the design of new and more efficient chemical processes in order to transition to a sustainable future. We introduce an AI-guided computational screening framework unifying linguistic reasoning with quantum-chemistry based feedback from 3D atomistic representations. Our approach formulates catalyst discovery as an uncertain environment where an agent actively searches for highly effective catalysts via the iterative combination of large language model (LLM)-derived hypotheses and atomistic graph neural network (GNN)-derived feedback. Identified catalysts in intermediate search steps undergo structural evaluation based on spatial orientation, reaction pathways, and stability. Scoring functions based on adsorption energies and barriers steer the exploration in the LLM's knowledge space toward energetically favorable, high-efficiency catalysts. We introduce planning methods that automatically guide the exploration without human input, providing competitive performance against expert-enumerated chemical descriptor-based implementations. By integrating language-guided reasoning with computational chemistry feedback, our work pioneers AI-accelerated, trustworthy catalyst discovery.

BronchoTrack: Airway Lumen Tracking for Branch-Level Bronchoscopic Localization

Localizing the bronchoscope in real time is essential for ensuring intervention quality. However, most existing methods struggle to balance between speed and generalization. To address these challenges, we present BronchoTrack, an innovative real-time framework for accurate branch-level localization, encompassing lumen detection, tracking, and airway association.To achieve real-time performance, we employ a benchmark lightweight detector for efficient lumen detection. We are the first to introduce multi-object tracking to bronchoscopic localization, mitigating temporal confusion in lumen identification caused by rapid bronchoscope movement and complex airway structures. To ensure generalization across patient cases, we propose a training-free detection-airway association method based on a semantic airway graph that encodes the hierarchy of bronchial tree structures.Experiments on nine patient datasets demonstrate BronchoTrack's localization accuracy of 85.64 \%, while accessing up to the 4th generation of airways.Furthermore, we tested BronchoTrack in an in-vivo animal study using a porcine model, where it successfully localized the bronchoscope into the 8th generation airway.Experimental evaluation underscores BronchoTrack's real-time performance in both satisfying accuracy and generalization, demonstrating its potential for clinical applications.

DaFoEs: Mixing Datasets towards the generalization of vision-state deep-learning Force Estimation in Minimally Invasive Robotic Surgery

Precisely determining the contact force during safe interaction in Minimally Invasive Robotic Surgery (MIRS) is still an open research challenge. Inspired by post-operative qualitative analysis from surgical videos, the use of cross-modality data driven deep neural network models has been one of the newest approaches to predict sensorless force trends. However, these methods required for large and variable datasets which are not currently available. In this paper, we present a new vision-haptic dataset (DaFoEs) with variable soft environments for the training of deep neural models. In order to reduce the bias from a single dataset, we present a pipeline to generalize different vision and state data inputs for mixed dataset training, using a previously validated dataset with different setup. Finally, we present a variable encoder-decoder architecture to predict the forces done by the laparoscopic tool using single input or sequence of inputs. For input sequence, we use a recurrent decoder, named with the prefix R, and a new temporal sampling to represent the acceleration of the tool. During our training, we demonstrate that single dataset training tends to overfit to the training data domain, but has difficulties on translating the results across new domains. However, dataset mixing presents a good translation with a mean relative estimated force error of 5% and 12% for the recurrent and non-recurrent models respectively. Our method, also marginally increase the effectiveness of transformers for force estimation up to a maximum of ~15%, as the volume of available data is increase by 150%. In conclusion, we demonstrate that mixing experimental set ups for vision-state force estimation in MIRS is a possible approach towards the general solution of the problem.