Generative Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challenges

Generative modeling has emerged as a promising direction in computational pathology, offering capabilities such as data-efficient learning, synthetic data augmentation, and multimodal representation across diverse diagnostic tasks. This review provides a comprehensive synthesis of recent progress in the field, organized into four key domains: image generation, text generation, multimodal image-text generation, and other generative applications, including spatial simulation and molecular inference. By analyzing over 150 representative studies, we trace the evolution of generative architectures from early generative adversarial networks to recent advances in diffusion models and foundation models with generative capabilities. We further examine the datasets and evaluation protocols commonly used in this domain and highlight ongoing limitations, including challenges in generating high-fidelity whole slide images, clinical interpretability, and concerns related to the ethical and legal implications of synthetic data. The review concludes with a discussion of open challenges and prospective research directions, with an emphasis on developing unified, multimodal, and clinically deployable generative systems. This work aims to provide a foundational reference for researchers and practitioners developing and applying generative models in computational pathology.

Can Language Models Understand Social Behavior in Clinical Conversations?

Effective communication between providers and their patients influences health and care outcomes. The effectiveness of such conversations has been linked not only to the exchange of clinical information, but also to a range of interpersonal behaviors; commonly referred to as social signals, which are often conveyed through non-verbal cues and shape the quality of the patient-provider relationship. Recent advances in large language models (LLMs) have demonstrated an increasing ability to infer emotional and social behaviors even when analyzing only textual information. As automation increases also in clinical settings, such as for transcription of patient-provider conversations, there is growing potential for LLMs to automatically analyze and extract social behaviors from these interactions. To explore the foundational capabilities of LLMs in tracking social signals in clinical dialogue, we designed task-specific prompts and evaluated model performance across multiple architectures and prompting styles using a highly imbalanced, annotated dataset spanning 20 distinct social signals such as provider dominance, patient warmth, etc. We present the first system capable of tracking all these 20 coded signals, and uncover patterns in LLM behavior. Further analysis of model configurations and clinical context provides insights for enhancing LLM performance on social signal processing tasks in healthcare settings.

PhenoAssistant: A Conversational Multi-Agent AI System for Automated Plant Phenotyping

Plant phenotyping increasingly relies on (semi-)automated image-based analysis workflows to improve its accuracy and scalability. However, many existing solutions remain overly complex, difficult to reimplement and maintain, and pose high barriers for users without substantial computational expertise. To address these challenges, we introduce PhenoAssistant: a pioneering AI-driven system that streamlines plant phenotyping via intuitive natural language interaction. PhenoAssistant leverages a large language model to orchestrate a curated toolkit supporting tasks including automated phenotype extraction, data visualisation and automated model training. We validate PhenoAssistant through several representative case studies and a set of evaluation tasks. By significantly lowering technical hurdles, PhenoAssistant underscores the promise of AI-driven methodologies to democratising AI adoption in plant biology.

ZipR1: Reinforcing Token Sparsity in MLLMs

Sparse attention mechanisms aim to reduce computational overhead by selectively processing a subset of salient tokens while preserving model performance. Despite the effectiveness of such designs, how to actively encourage token sparsity of well-posed MLLMs remains under-explored, which fundamentally limits the achievable acceleration effect during inference. In this paper, we propose a simple RL-based post-training method named \textbf{ZipR1} that treats the token reduction ratio as the efficiency reward and answer accuracy as the performance reward. In this way, our method can jointly alleviate the computation and memory bottlenecks via directly optimizing the inference-consistent efficiency-performance tradeoff. Experimental results demonstrate that ZipR1 can reduce the token ratio of Qwen2/2.5-VL from 80\% to 25\% with a minimal accuracy reduction on 13 image and video benchmarks.

DianJin-R1: Evaluating and Enhancing Financial Reasoning in Large Language Models

Effective reasoning remains a core challenge for large language models (LLMs) in the financial domain, where tasks often require domain-specific knowledge, precise numerical calculations, and strict adherence to compliance rules. We propose DianJin-R1, a reasoning-enhanced framework designed to address these challenges through reasoning-augmented supervision and reinforcement learning. Central to our approach is DianJin-R1-Data, a high-quality dataset constructed from CFLUE, FinQA, and a proprietary compliance corpus (Chinese Compliance Check, CCC), combining diverse financial reasoning scenarios with verified annotations. Our models, DianJin-R1-7B and DianJin-R1-32B, are fine-tuned from Qwen2.5-7B-Instruct and Qwen2.5-32B-Instruct using a structured format that generates both reasoning steps and final answers. To further refine reasoning quality, we apply Group Relative Policy Optimization (GRPO), a reinforcement learning method that incorporates dual reward signals: one encouraging structured outputs and another rewarding answer correctness. We evaluate our models on five benchmarks: three financial datasets (CFLUE, FinQA, and CCC) and two general reasoning benchmarks (MATH-500 and GPQA-Diamond). Experimental results show that DianJin-R1 models consistently outperform their non-reasoning counterparts, especially on complex financial tasks. Moreover, on the real-world CCC dataset, our single-call reasoning models match or even surpass the performance of multi-agent systems that require significantly more computational cost. These findings demonstrate the effectiveness of DianJin-R1 in enhancing financial reasoning through structured supervision and reward-aligned learning, offering a scalable and practical solution for real-world applications.

Analyzing 16,193 LLM Papers for Fun and Profits

Large Language Models (LLMs) are reshaping the landscape of computer science research, driving significant shifts in research priorities across diverse conferences and fields. This study provides a comprehensive analysis of the publication trend of LLM-related papers in 77 top-tier computer science conferences over the past six years (2019-2024). We approach this analysis from four distinct perspectives: (1) We investigate how LLM research is driving topic shifts within major conferences. (2) We adopt a topic modeling approach to identify various areas of LLM-related topic growth and reveal the topics of concern at different conferences. (3) We explore distinct contribution patterns of academic and industrial institutions. (4) We study the influence of national origins on LLM development trajectories. Synthesizing the findings from these diverse analytical angles, we derive ten key insights that illuminate the dynamics and evolution of the LLM research ecosystem.

Learning from Elders: Making an LLM-powered Chatbot for Retirement Communities more Accessible through User-centered Design

Low technology and eHealth literacy among older adults in retirement communities hinder engagement with digital tools. To address this, we designed an LLM-powered chatbot prototype using a human-centered approach for a local retirement community. Through interviews and persona development, we prioritized accessibility and dual functionality: simplifying internal information retrieval and improving technology and eHealth literacy. A pilot trial with residents demonstrated high satisfaction and ease of use, but also identified areas for further improvement. Based on the feedback, we refined the chatbot using GPT-3.5 Turbo and Streamlit. The chatbot employs tailored prompt engineering to deliver concise responses. Accessible features like adjustable font size, interface theme and personalized follow-up responses were implemented. Future steps include enabling voice-to-text function and longitudinal intervention studies. Together, our results highlight the potential of LLM-driven chatbots to empower older adults through accessible, personalized interactions, bridging literacy gaps in retirement communities.

Training-free Dense-Aligned Diffusion Guidance for Modular Conditional Image Synthesis

Conditional image synthesis is a crucial task with broad applications, such as artistic creation and virtual reality. However, current generative methods are often task-oriented with a narrow scope, handling a restricted condition with constrained applicability. In this paper, we propose a novel approach that treats conditional image synthesis as the modular combination of diverse fundamental condition units. Specifically, we divide conditions into three primary units: text, layout, and drag. To enable effective control over these conditions, we design a dedicated alignment module for each. For the text condition, we introduce a Dense Concept Alignment (DCA) module, which achieves dense visual-text alignment by drawing on diverse textual concepts. For the layout condition, we propose a Dense Geometry Alignment (DGA) module to enforce comprehensive geometric constraints that preserve the spatial configuration. For the drag condition, we introduce a Dense Motion Alignment (DMA) module to apply multi-level motion regularization, ensuring that each pixel follows its desired trajectory without visual artifacts. By flexibly inserting and combining these alignment modules, our framework enhances the model's adaptability to diverse conditional generation tasks and greatly expands its application range. Extensive experiments demonstrate the superior performance of our framework across a variety of conditions, including textual description, segmentation mask (bounding box), drag manipulation, and their combinations. Code is available at https://github.com/ZixuanWang0525/DADG.

Detecting PTSD in Clinical Interviews: A Comparative Analysis of NLP Methods and Large Language Models

Post-Traumatic Stress Disorder (PTSD) remains underdiagnosed in clinical settings, presenting opportunities for automated detection to identify patients. This study evaluates natural language processing approaches for detecting PTSD from clinical interview transcripts. We compared general and mental health-specific transformer models (BERT/RoBERTa), embedding-based methods (SentenceBERT/LLaMA), and large language model prompting strategies (zero-shot/few-shot/chain-of-thought) using the DAIC-WOZ dataset. Domain-specific models significantly outperformed general models (Mental-RoBERTa F1=0.643 vs. RoBERTa-base 0.485). LLaMA embeddings with neural networks achieved the highest performance (F1=0.700). Zero-shot prompting using DSM-5 criteria yielded competitive results without training data (F1=0.657). Performance varied significantly across symptom severity and comorbidity status, with higher accuracy for severe PTSD cases and patients with comorbid depression. Our findings highlight the potential of domain-adapted embeddings and LLMs for scalable screening while underscoring the need for improved detection of nuanced presentations and offering insights for developing clinically viable AI tools for PTSD assessment.

Exploring the Hidden Reasoning Process of Large Language Models by Misleading Them

Large language models (LLMs) and Vision language models (VLMs) have been able to perform various forms of reasoning tasks in a wide range of scenarios, but are they truly engaging in task abstraction and rule-based reasoning beyond mere memorization and pattern matching? To answer this question, we propose a novel experimental approach, Misleading Fine-Tuning (MisFT), to examine whether LLMs/VLMs perform abstract reasoning by altering their original understanding of fundamental rules. In particular, by constructing a dataset with math expressions that contradict correct operation principles, we fine-tune the model to learn those contradictory rules and assess its generalization ability on different test domains. Through a series of experiments, we find that current LLMs/VLMs are capable of effectively applying contradictory rules to solve practical math word problems and math expressions represented by images, implying the presence of an internal mechanism that abstracts before reasoning.