PSO-XAI: A PSO-Enhanced Explainable AI Framework for Reliable Breast Cancer Detection

Breast cancer is considered the most critical and frequently diagnosed cancer in women worldwide, leading to an increase in cancer-related mortality. Early and accurate detection is crucial as it can help mitigate possible threats while improving survival rates. In terms of prediction, conventional diagnostic methods are often limited by variability, cost, and, most importantly, risk of misdiagnosis. To address these challenges, machine learning (ML) has emerged as a powerful tool for computer-aided diagnosis, with feature selection playing a vital role in improving model performance and interpretability. This research study proposes an integrated framework that incorporates customized Particle Swarm Optimization (PSO) for feature selection. This framework has been evaluated on a comprehensive set of 29 different models, spanning classical classifiers, ensemble techniques, neural networks, probabilistic algorithms, and instance-based algorithms. To ensure interpretability and clinical relevance, the study uses cross-validation in conjunction with explainable AI methods. Experimental evaluation showed that the proposed approach achieved a superior score of 99.1\% across all performance metrics, including accuracy and precision, while effectively reducing dimensionality and providing transparent, model-agnostic explanations. The results highlight the potential of combining swarm intelligence with explainable ML for robust, trustworthy, and clinically meaningful breast cancer diagnosis.

Dynamic Weight Adjustment for Knowledge Distillation: Leveraging Vision Transformer for High-Accuracy Lung Cancer Detection and Real-Time Deployment

This paper presents the FuzzyDistillViT-MobileNet model, a novel approach for lung cancer (LC) classification, leveraging dynamic fuzzy logic-driven knowledge distillation (KD) to address uncertainty and complexity in disease diagnosis. Unlike traditional models that rely on static KD with fixed weights, our method dynamically adjusts the distillation weight using fuzzy logic, enabling the student model to focus on high-confidence regions while reducing attention to ambiguous areas. This dynamic adjustment improves the model ability to handle varying uncertainty levels across different regions of LC images. We employ the Vision Transformer (ViT-B32) as the instructor model, which effectively transfers knowledge to the student model, MobileNet, enhancing the student generalization capabilities. The training process is further optimized using a dynamic wait adjustment mechanism that adapts the training procedure for improved convergence and performance. To enhance image quality, we introduce pixel-level image fusion improvement techniques such as Gamma correction and Histogram Equalization. The processed images (Pix1 and Pix2) are fused using a wavelet-based fusion method to improve image resolution and feature preservation. This fusion method uses the wavedec2 function to standardize images to a 224x224 resolution, decompose them into multi-scale frequency components, and recursively average coefficients at each level for better feature representation. To address computational efficiency, Genetic Algorithm (GA) is used to select the most suitable pre-trained student model from a pool of 12 candidates, balancing model performance with computational cost. The model is evaluated on two datasets, including LC25000 histopathological images (99.16% accuracy) and IQOTH/NCCD CT-scan images (99.54% accuracy), demonstrating robustness across different imaging domains.

A Density-Informed Multimodal Artificial Intelligence Framework for Improving Breast Cancer Detection Across All Breast Densities

Mammography, the current standard for breast cancer screening, has reduced sensitivity in women with dense breast tissue, contributing to missed or delayed diagnoses. Thermalytix, an AI-based thermal imaging modality, captures functional vascular and metabolic cues that may complement mammographic structural data. This study investigates whether a breast density-informed multi-modal AI framework can improve cancer detection by dynamically selecting the appropriate imaging modality based on breast tissue composition. A total of 324 women underwent both mammography and thermal imaging. Mammography images were analyzed using a multi-view deep learning model, while Thermalytix assessed thermal images through vascular and thermal radiomics. The proposed framework utilized Mammography AI for fatty breasts and Thermalytix AI for dense breasts, optimizing predictions based on tissue type. This multi-modal AI framework achieved a sensitivity of 94.55% (95% CI: 88.54-100) and specificity of 79.93% (95% CI: 75.14-84.71), outperforming standalone mammography AI (sensitivity 81.82%, specificity 86.25%) and Thermalytix AI (sensitivity 92.73%, specificity 75.46%). Importantly, the sensitivity of Mammography dropped significantly in dense breasts (67.86%) versus fatty breasts (96.30%), whereas Thermalytix AI maintained high and consistent sensitivity in both (92.59% and 92.86%, respectively). This demonstrates that a density-informed multi-modal AI framework can overcome key limitations of unimodal screening and deliver high performance across diverse breast compositions. The proposed framework is interpretable, low-cost, and easily deployable, offering a practical path to improving breast cancer screening outcomes in both high-resource and resource-limited settings.

A Clinical-grade Universal Foundation Model for Intraoperative Pathology

Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant strides, the lack of large-scale, prospective validation has impeded its routine adoption in surgical workflows. Here, we introduce CRISP, a clinical-grade foundation model developed on over 100,000 frozen sections from eight medical centers, specifically designed to provide Clinical-grade Robust Intraoperative Support for Pathology (CRISP). CRISP was comprehensively evaluated on more than 15,000 intraoperative slides across nearly 100 retrospective diagnostic tasks, including benign-malignant discrimination, key intraoperative decision-making, and pan-cancer detection, etc. The model demonstrated robust generalization across diverse institutions, tumor types, and anatomical sites-including previously unseen sites and rare cancers. In a prospective cohort of over 2,000 patients, CRISP sustained high diagnostic accuracy under real-world conditions, directly informing surgical decisions in 92.6% of cases. Human-AI collaboration further reduced diagnostic workload by 35%, avoided 105 ancillary tests and enhanced detection of micrometastases with 87.5% accuracy. Together, these findings position CRISP as a clinical-grade paradigm for AI-driven intraoperative pathology, bridging computational advances with surgical precision and accelerating the translation of artificial intelligence into routine clinical practice.

Transformer Classification of Breast Lesions: The BreastDCEDL_AMBL Benchmark Dataset and 0.92 AUC Baseline

The error is caused by special characters that arXiv's system doesn't recognize. Here's the cleaned version with all problematic characters replaced: Breast magnetic resonance imaging is a critical tool for cancer detection and treatment planning, but its clinical utility is hindered by poor specificity, leading to high false-positive rates and unnecessary biopsies. This study introduces a transformer-based framework for automated classification of breast lesions in dynamic contrast-enhanced MRI, addressing the challenge of distinguishing benign from malignant findings. We implemented a SegFormer architecture that achieved an AUC of 0.92 for lesion-level classification, with 100% sensitivity and 67% specificity at the patient level - potentially eliminating one-third of unnecessary biopsies without missing malignancies. The model quantifies malignant pixel distribution via semantic segmentation, producing interpretable spatial predictions that support clinical decision-making. To establish reproducible benchmarks, we curated BreastDCEDL_AMBL by transforming The Cancer Imaging Archive's AMBL collection into a standardized deep learning dataset with 88 patients and 133 annotated lesions (89 benign, 44 malignant). This resource addresses a key infrastructure gap, as existing public datasets lack benign lesion annotations, limiting benign-malignant classification research. Training incorporated an expanded cohort of over 1,200 patients through integration with BreastDCEDL datasets, validating transfer learning approaches despite primary tumor-only annotations. Public release of the dataset, models, and evaluation protocols provides the first standardized benchmark for DCE-MRI lesion classification, enabling methodological advancement toward clinical deployment.

Prostate Capsule Segmentation from Micro-Ultrasound Images using Adaptive Focal Loss

Micro-ultrasound (micro-US) is a promising imaging technique for cancer detection and computer-assisted visualization. This study investigates prostate capsule segmentation using deep learning techniques from micro-US images, addressing the challenges posed by the ambiguous boundaries of the prostate capsule. Existing methods often struggle in such cases, motivating the development of a tailored approach. This study introduces an adaptive focal loss function that dynamically emphasizes both hard and easy regions, taking into account their respective difficulty levels and annotation variability. The proposed methodology has two primary strategies: integrating a standard focal loss function as a baseline to design an adaptive focal loss function for proper prostate capsule segmentation. The focal loss baseline provides a robust foundation, incorporating class balancing and focusing on examples that are difficult to classify. The adaptive focal loss offers additional flexibility, addressing the fuzzy region of the prostate capsule and annotation variability by dilating the hard regions identified through discrepancies between expert and non-expert annotations. The proposed method dynamically adjusts the segmentation model's weights better to identify the fuzzy regions of the prostate capsule. The proposed adaptive focal loss function demonstrates superior performance, achieving a mean dice coefficient (DSC) of 0.940 and a mean Hausdorff distance (HD) of 1.949 mm in the testing dataset. These results highlight the effectiveness of integrating advanced loss functions and adaptive techniques into deep learning models. This enhances the accuracy of prostate capsule segmentation in micro-US images, offering the potential to improve clinical decision-making in prostate cancer diagnosis and treatment planning.

Breast Cancer Detection in Thermographic Images via Diffusion-Based Augmentation and Nonlinear Feature Fusion

Data scarcity hinders deep learning for medical imaging. We propose a framework for breast cancer classification in thermograms that addresses this using a Diffusion Probabilistic Model (DPM) for data augmentation. Our DPM-based augmentation is shown to be superior to both traditional methods and a ProGAN baseline. The framework fuses deep features from a pre-trained ResNet-50 with handcrafted nonlinear features (e.g., Fractal Dimension) derived from U-Net segmented tumors. An XGBoost classifier trained on these fused features achieves 98.0\% accuracy and 98.1\% sensitivity. Ablation studies and statistical tests confirm that both the DPM augmentation and the nonlinear feature fusion are critical, statistically significant components of this success. This work validates the synergy between advanced generative models and interpretable features for creating highly accurate medical diagnostic tools.

Interpretable Deep Transfer Learning for Breast Ultrasound Cancer Detection: A Multi-Dataset Study

Breast cancer remains a leading cause of cancer-related mortality among women worldwide. Ultrasound imaging, widely used due to its safety and cost-effectiveness, plays a key role in early detection, especially in patients with dense breast tissue. This paper presents a comprehensive study on the application of machine learning and deep learning techniques for breast cancer classification using ultrasound images. Using datasets such as BUSI, BUS-BRA, and BrEaST-Lesions USG, we evaluate classical machine learning models (SVM, KNN) and deep convolutional neural networks (ResNet-18, EfficientNet-B0, GoogLeNet). Experimental results show that ResNet-18 achieves the highest accuracy (99.7%) and perfect sensitivity for malignant lesions. Classical ML models, though outperformed by CNNs, achieve competitive performance when enhanced with deep feature extraction. Grad-CAM visualizations further improve model transparency by highlighting diagnostically relevant image regions. These findings support the integration of AI-based diagnostic tools into clinical workflows and demonstrate the feasibility of deploying high-performing, interpretable systems for ultrasound-based breast cancer detection.

OCELOT 2023: Cell Detection from Cell-Tissue Interaction Challenge

Pathologists routinely alternate between different magnifications when examining Whole-Slide Images, allowing them to evaluate both broad tissue morphology and intricate cellular details to form comprehensive diagnoses. However, existing deep learning-based cell detection models struggle to replicate these behaviors and learn the interdependent semantics between structures at different magnifications. A key barrier in the field is the lack of datasets with multi-scale overlapping cell and tissue annotations. The OCELOT 2023 challenge was initiated to gather insights from the community to validate the hypothesis that understanding cell and tissue (cell-tissue) interactions is crucial for achieving human-level performance, and to accelerate the research in this field. The challenge dataset includes overlapping cell detection and tissue segmentation annotations from six organs, comprising 673 pairs sourced from 306 The Cancer Genome Atlas (TCGA) Whole-Slide Images with hematoxylin and eosin staining, divided into training, validation, and test subsets. Participants presented models that significantly enhanced the understanding of cell-tissue relationships. Top entries achieved up to a 7.99 increase in F1-score on the test set compared to the baseline cell-only model that did not incorporate cell-tissue relationships. This is a substantial improvement in performance over traditional cell-only detection methods, demonstrating the need for incorporating multi-scale semantics into the models. This paper provides a comparative analysis of the methods used by participants, highlighting innovative strategies implemented in the OCELOT 2023 challenge.

Deep Learning Framework for Early Detection of Pancreatic Cancer Using Multi-Modal Medical Imaging Analysis

Pacreatic ductal adenocarcinoma (PDAC) remains one of the most lethal forms of cancer, with a five-year survival rate below 10% primarily due to late detection. This research develops and validates a deep learning framework for early PDAC detection through analysis of dual-modality imaging: autofluorescence and second harmonic generation (SHG). We analyzed 40 unique patient samples to create a specialized neural network capable of distinguishing between normal, fibrotic, and cancerous tissue. Our methodology evaluated six distinct deep learning architectures, comparing traditional Convolutional Neural Networks (CNNs) with modern Vision Transformers (ViTs). Through systematic experimentation, we identified and overcome significant challenges in medical image analysis, including limited dataset size and class imbalance. The final optimized framework, based on a modified ResNet architecture with frozen pre-trained layers and class-weighted training, achieved over 90% accuracy in cancer detection. This represents a significant improvement over current manual analysis methods an demonstrates potential for clinical deployment. This work establishes a robust pipeline for automated PDAC detection that can augment pathologists' capabilities while providing a foundation for future expansion to other cancer types. The developed methodology also offers valuable insights for applying deep learning to limited-size medical imaging datasets, a common challenge in clinical applications.