MolSculpt: Sculpting 3D Molecular Geometries from Chemical Syntax

Generating precise 3D molecular geometries is crucial for drug discovery and material science. While prior efforts leverage 1D representations like SELFIES to ensure molecular validity, they fail to fully exploit the rich chemical knowledge entangled within 1D models, leading to a disconnect between 1D syntactic generation and 3D geometric realization. To bridge this gap, we propose MolSculpt, a novel framework that "sculpts" 3D molecular geometries from chemical syntax. MolSculpt is built upon a frozen 1D molecular foundation model and a 3D molecular diffusion model. We introduce a set of learnable queries to extract inherent chemical knowledge from the foundation model, and a trainable projector then injects this cross-modal information into the conditioning space of the diffusion model to guide the 3D geometry generation. In this way, our model deeply integrates 1D latent chemical knowledge into the 3D generation process through end-to-end optimization. Experiments demonstrate that MolSculpt achieves state-of-the-art (SOTA) performance in \textit{de novo} 3D molecule generation and conditional 3D molecule generation, showing superior 3D fidelity and stability on both the GEOM-DRUGS and QM9 datasets. Code is available at https://github.com/SakuraTroyChen/MolSculpt.

MoCoRP: Modeling Consistent Relations between Persona and Response for Persona-based Dialogue

As dialogue systems become increasingly important across various domains, a key challenge in persona-based dialogue is generating engaging and context-specific interactions while ensuring the model acts with a coherent personality. However, existing persona-based dialogue datasets lack explicit relations between persona sentences and responses, which makes it difficult for models to effectively capture persona information. To address these issues, we propose MoCoRP (Modeling Consistent Relations between Persona and Response), a framework that incorporates explicit relations into language models. MoCoRP leverages an NLI expert to explicitly extract the NLI relations between persona sentences and responses, enabling the model to effectively incorporate appropriate persona information from the context into its responses. We applied this framework to pre-trained models like BART and further extended it to modern large language models (LLMs) through alignment tuning. Experimental results on the public datasets ConvAI2 and MPChat demonstrate that MoCoRP outperforms existing baselines, achieving superior persona consistency and engaging, context-aware dialogue generation. Furthermore, our model not only excels in quantitative metrics but also shows significant improvements in qualitative aspects. These results highlight the effectiveness of explicitly modeling persona-response relations in persona-based dialogue. The source codes of MoCoRP are available at https://github.com/DMCB-GIST/MoCoRP.

Graph Laplacian Transformer with Progressive Sampling for Prostate Cancer Grading

Prostate cancer grading from whole-slide images (WSIs) remains a challenging task due to the large-scale nature of WSIs, the presence of heterogeneous tissue structures, and difficulty of selecting diagnostically relevant regions. Existing approaches often rely on random or static patch selection, leading to the inclusion of redundant or non-informative regions that degrade performance. To address this, we propose a Graph Laplacian Attention-Based Transformer (GLAT) integrated with an Iterative Refinement Module (IRM) to enhance both feature learning and spatial consistency. The IRM iteratively refines patch selection by leveraging a pretrained ResNet50 for local feature extraction and a foundation model in no-gradient mode for importance scoring, ensuring only the most relevant tissue regions are preserved. The GLAT models tissue-level connectivity by constructing a graph where patches serve as nodes, ensuring spatial consistency through graph Laplacian constraints and refining feature representations via a learnable filtering mechanism that enhances discriminative histological structures. Additionally, a convex aggregation mechanism dynamically adjusts patch importance to generate a robust WSI-level representation. Extensive experiments on five public and one private dataset demonstrate that our model outperforms state-of-the-art methods, achieving higher performance and spatial consistency while maintaining computational efficiency.

chatter: a Python library for applying information theory and AI/ML models to animal communication

The study of animal communication often involves categorizing units into types (e.g. syllables in songbirds, or notes in humpback whales). While this approach is useful in many cases, it necessarily flattens the complexity and nuance present in real communication systems. chatter is a new Python library for analyzing animal communication in continuous latent space using information theory and modern machine learning techniques. It is taxonomically agnostic, and has been tested with the vocalizations of birds, bats, whales, and primates. By leveraging a variety of different architectures, including variational autoencoders and vision transformers, chatter represents vocal sequences as trajectories in high-dimensional latent space, bypassing the need for manual or automatic categorization of units. The library provides an end-to-end workflow -- from preprocessing and segmentation to model training and feature extraction -- that enables researchers to quantify the complexity, predictability, similarity, and novelty of vocal sequences.

Precise Liver Tumor Segmentation in CT Using a Hybrid Deep Learning-Radiomics Framework

Accurate three-dimensional delineation of liver tumors on contrast-enhanced CT is a prerequisite for treatment planning, navigation and response assessment, yet manual contouring is slow, observer-dependent and difficult to standardise across centres. Automatic segmentation is complicated by low lesion-parenchyma contrast, blurred or incomplete boundaries, heterogeneous enhancement patterns, and confounding structures such as vessels and adjacent organs. We propose a hybrid framework that couples an attention-enhanced cascaded U-Net with handcrafted radiomics and voxel-wise 3D CNN refinement for joint liver and liver-tumor segmentation. First, a 2.5D two-stage network with a densely connected encoder, sub-pixel convolution decoders and multi-scale attention gates produces initial liver and tumor probability maps from short stacks of axial slices. Inter-slice temporal consistency is then enforced by a simple three-slice refinement rule along the cranio-caudal direction, which restores thin and tiny lesions while suppressing isolated noise. Next, 728 radiomic descriptors spanning intensity, texture, shape, boundary and wavelet feature groups are extracted from candidate lesions and reduced to 20 stable, highly informative features via multi-strategy feature selection; a random forest classifier uses these features to reject false-positive regions. Finally, a compact 3D patch-based CNN derived from AlexNet operates in a narrow band around the tumor boundary to perform voxel-level relabelling and contour smoothing.

mmWEAVER: Environment-Specific mmWave Signal Synthesis from a Photo and Activity Description

Realistic signal generation and dataset augmentation are essential for advancing mmWave radar applications such as activity recognition and pose estimation, which rely heavily on diverse, and environment-specific signal datasets. However, mmWave signals are inherently complex, sparse, and high-dimensional, making physical simulation computationally expensive. This paper presents mmWeaver, a novel framework that synthesizes realistic, environment-specific complex mmWave signals by modeling them as continuous functions using Implicit Neural Representations (INRs), achieving up to 49-fold compression. mmWeaver incorporates hypernetworks that dynamically generate INR parameters based on environmental context (extracted from RGB-D images) and human motion features (derived from text-to-pose generation via MotionGPT), enabling efficient and adaptive signal synthesis. By conditioning on these semantic and geometric priors, mmWeaver generates diverse I/Q signals at multiple resolutions, preserving phase information critical for downstream tasks such as point cloud estimation and activity classification. Extensive experiments show that mmWeaver achieves a complex SSIM of 0.88 and a PSNR of 35 dB, outperforming existing methods in signal realism while improving activity recognition accuracy by up to 7% and reducing human pose estimation error by up to 15%, all while operating 6-35 times faster than simulation-based approaches.

Exploring Protein Language Model Architecture-Induced Biases for Antibody Comprehension

Recent advances in protein language models (PLMs) have demonstrated remarkable capabilities in understanding protein sequences. However, the extent to which different model architectures capture antibody-specific biological properties remains unexplored. In this work, we systematically investigate how architectural choices in PLMs influence their ability to comprehend antibody sequence characteristics and functions. We evaluate three state-of-the-art PLMs-AntiBERTa, BioBERT, and ESM2--against a general-purpose language model (GPT-2) baseline on antibody target specificity prediction tasks. Our results demonstrate that while all PLMs achieve high classification accuracy, they exhibit distinct biases in capturing biological features such as V gene usage, somatic hypermutation patterns, and isotype information. Through attention attribution analysis, we show that antibody-specific models like AntiBERTa naturally learn to focus on complementarity-determining regions (CDRs), while general protein models benefit significantly from explicit CDR-focused training strategies. These findings provide insights into the relationship between model architecture and biological feature extraction, offering valuable guidance for future PLM development in computational antibody design.

Mapping AI Risk Mitigations: Evidence Scan and Preliminary AI Risk Mitigation Taxonomy

Organizations and governments that develop, deploy, use, and govern AI must coordinate on effective risk mitigation. However, the landscape of AI risk mitigation frameworks is fragmented, uses inconsistent terminology, and has gaps in coverage. This paper introduces a preliminary AI Risk Mitigation Taxonomy to organize AI risk mitigations and provide a common frame of reference. The Taxonomy was developed through a rapid evidence scan of 13 AI risk mitigation frameworks published between 2023-2025, which were extracted into a living database of 831 AI risk mitigations. The mitigations were iteratively clustered & coded to create the Taxonomy. The preliminary AI Risk Mitigation Taxonomy organizes mitigations into four categories and 23 subcategories: (1) Governance & Oversight: Formal organizational structures and policy frameworks that establish human oversight mechanisms and decision protocols; (2) Technical & Security: Technical, physical, and engineering safeguards that secure AI systems and constrain model behaviors; (3) Operational Process: processes and management frameworks governing AI system deployment, usage, monitoring, incident handling, and validation; and (4) Transparency & Accountability: formal disclosure practices and verification mechanisms that communicate AI system information and enable external scrutiny. The rapid evidence scan and taxonomy construction also revealed several cases where terms like 'risk management' and 'red teaming' are used widely but refer to different responsible actors, actions, and mechanisms of action to reduce risk. This Taxonomy and associated mitigation database, while preliminary, offers a starting point for collation and synthesis of AI risk mitigations. It also offers an accessible, structured way for different actors in the AI ecosystem to discuss and coordinate action to reduce risks from AI.

Enhancing Small Object Detection with YOLO: A Novel Framework for Improved Accuracy and Efficiency

This paper investigates and develops methods for detecting small objects in large-scale aerial images. Current approaches for detecting small objects in aerial images often involve image cropping and modifications to detector network architectures. Techniques such as sliding window cropping and architectural enhancements, including higher-resolution feature maps and attention mechanisms, are commonly employed. Given the growing importance of aerial imagery in various critical and industrial applications, the need for robust frameworks for small object detection becomes imperative. To address this need, we adopted the base SW-YOLO approach to enhance speed and accuracy in small object detection by refining cropping dimensions and overlap in sliding window usage and subsequently enhanced it through architectural modifications. we propose a novel model by modifying the base model architecture, including advanced feature extraction modules in the neck for feature map enhancement, integrating CBAM in the backbone to preserve spatial and channel information, and introducing a new head to boost small object detection accuracy. Finally, we compared our method with SAHI, one of the most powerful frameworks for processing large-scale images, and CZDet, which is also based on image cropping, achieving significant improvements in accuracy. The proposed model achieves significant accuracy gains on the VisDrone2019 dataset, outperforming baseline YOLOv5L detection by a substantial margin. Specifically, the final proposed model elevates the mAP .5.5 accuracy on the VisDrone2019 dataset from the base accuracy of 35.5 achieved by the YOLOv5L detector to 61.2. Notably, the accuracy of CZDet, which is another classic method applied to this dataset, is 58.36. This research demonstrates a significant improvement, achieving an increase in accuracy from 35.5 to 61.2.

Detection of Digital Facial Retouching utilizing Face Beauty Information

Facial retouching to beautify images is widely spread in social media, advertisements, and it is even applied in professional photo studios to let individuals appear younger, remove wrinkles and skin impurities. Generally speaking, this is done to enhance beauty. This is not a problem itself, but when retouched images are used as biometric samples and enrolled in a biometric system, it is one. Since previous work has proven facial retouching to be a challenge for face recognition systems,the detection of facial retouching becomes increasingly necessary. This work proposes to study and analyze changes in beauty assessment algorithms of retouched images, assesses different feature extraction methods based on artificial intelligence in order to improve retouching detection, and evaluates whether face beauty can be exploited to enhance the detection rate. In a scenario where the attacking retouching algorithm is unknown, this work achieved 1.1% D-EER on single image detection.