LUMINA: Foundation Models for Topology Transferable ACOPF

Foundation models in general promise to accelerate scientific computation by learning reusable representations across problem instances, yet constrained scientific systems, where predictions must satisfy physical laws and safety limits, pose unique challenges that stress conventional training paradigms. We derive design principles for constrained scientific foundation models through systematic investigation of AC optimal power flow (ACOPF), a representative optimization problem in power grid operations where power balance equations and operational constraints are non-negotiable. Through controlled experiments spanning architectures, training objectives, and system diversity, we extract three empirically grounded principles governing scientific foundation model design. These principles characterize three design trade-offs: learning physics-invariant representations while respecting system-specific constraints, optimizing accuracy while ensuring constraint satisfaction, and ensuring reliability in high-impact operating regimes. We present the LUMINA framework, including data processing and training pipelines to support reproducible research on physics-informed, feasibility-aware foundation models across scientific applications.

PrivMedChat: End-to-End Differentially Private RLHF for Medical Dialogue Systems

Large language models are increasingly used for patient-facing medical assistance and clinical decision support, but adapting them to clinical dialogue often requires supervision derived from doctor-patient conversations that may contain sensitive information. Conventional supervised fine-tuning and reinforcement learning from human feedback (RLHF) can amplify memorization risks, enabling empirical membership inference and extraction of rare training-set content. We present PrivMedChat, an end-to-end framework for differentially private RLHF (DP-RLHF) for medical dialogue. Our design enforces differential privacy at every training stage that directly accesses dialogue-derived supervision: (i) Differential Private Stochastic Gradient Descent (DP-SGD) for medical SFT and (ii) DP-SGD for reward model learning from preference pairs. To limit additional privacy expenditure during alignment, we apply DP-SGD to the PPO actor and critic when operating on dialogue-derived prompts, while the reward model remains fixed after DP training. We also introduce an annotation-free preference construction strategy that pairs physician responses with filtered non-expert generations to produce scalable preference data without clinician labeling. Experiments on medical dialogue benchmarks show that PrivMedChat at $\varepsilon=7$ achieves the highest ROUGE-L of 0.156 among all DP models, reduces clinical hallucinations to 1.4% and harmful advice to 0.4%, and obtains the highest overall score of 2.86 in a 3-model LLM-jury evaluation, while producing membership-inference signals that are near chance (AUC 0.510-0.555). We open-source our code at https://github.com/sudip-bhujel/privmedchat.

Embedding interpretable $\ell_1$-regression into neural networks for uncovering temporal structure in cell imaging

While artificial neural networks excel in unsupervised learning of non-sparse structure, classical statistical regression techniques offer better interpretability, in particular when sparseness is enforced by $\ell_1$ regularization, enabling identification of which factors drive observed dynamics. We investigate how these two types of approaches can be optimally combined, exemplarily considering two-photon calcium imaging data where sparse autoregressive dynamics are to be extracted. We propose embedding a vector autoregressive (VAR) model as an interpretable regression technique into a convolutional autoencoder, which provides dimension reduction for tractable temporal modeling. A skip connection separately addresses non-sparse static spatial information, selectively channeling sparse structure into the $\ell_1$-regularized VAR. $\ell_1$-estimation of regression parameters is enabled by differentiating through the piecewise linear solution path. This is contrasted with approaches where the autoencoder does not adapt to the VAR model. Having an embedded statistical model also enables a testing approach for comparing temporal sequences from the same observational unit. Additionally, contribution maps visualize which spatial regions drive the learned dynamics.

Efficient Point Cloud Processing with High-Dimensional Positional Encoding and Non-Local MLPs

Multi-Layer Perceptron (MLP) models are the foundation of contemporary point cloud processing. However, their complex network architectures obscure the source of their strength and limit the application of these models. In this article, we develop a two-stage abstraction and refinement (ABS-REF) view for modular feature extraction in point cloud processing. This view elucidates that whereas the early models focused on ABS stages, the more recent techniques devise sophisticated REF stages to attain performance advantages. Then, we propose a High-dimensional Positional Encoding (HPE) module to explicitly utilize intrinsic positional information, extending the ``positional encoding'' concept from Transformer literature. HPE can be readily deployed in MLP-based architectures and is compatible with transformer-based methods. Within our ABS-REF view, we rethink local aggregation in MLP-based methods and propose replacing time-consuming local MLP operations, which are used to capture local relationships among neighbors. Instead, we use non-local MLPs for efficient non-local information updates, combined with the proposed HPE for effective local information representation. We leverage our modules to develop HPENets, a suite of MLP networks that follow the ABS-REF paradigm, incorporating a scalable HPE-based REF stage. Extensive experiments on seven public datasets across four different tasks show that HPENets deliver a strong balance between efficiency and effectiveness. Notably, HPENet surpasses PointNeXt, a strong MLP-based counterpart, by 1.1% mAcc, 4.0% mIoU, 1.8% mIoU, and 0.2% Cls. mIoU, with only 50.0%, 21.5%, 23.1%, 44.4% of FLOPs on ScanObjectNN, S3DIS, ScanNet, and ShapeNetPart, respectively. Source code is available at https://github.com/zouyanmei/HPENet_v2.git.

Spatial Autoregressive Modeling of DINOv3 Embeddings for Unsupervised Anomaly Detection

DINO models provide rich patch-level representations that have recently enabled strong performance in unsupervised anomaly detection (UAD). Most existing methods extract patch embeddings from ``normal'' images and model them independently, ignoring spatial and neighborhood relationships between patches. This implicitly assumes that self-attention and positional encodings sufficiently encode contextual information within each patch embedding. In addition, the normative distribution is often modeled as memory banks or prototype-based representations, which require storing large numbers of features and performing costly comparisons at inference time, leading to substantial memory and computational overhead. In this work, we address both limitations by proposing a simple and efficient framework that explicitly models spatial and contextual dependencies between patch embeddings using a 2D autoregressive (AR) model. Instead of storing embeddings or clustering prototypes, our approach learns a compact parametric model of the normative distribution via an AR convolutional neural network (CNN). At test time, anomaly detection reduces to a single forward pass through the network and enables fast and memory-efficient inference. We evaluate our method on the BMAD benchmark, which comprises three medical imaging datasets, and compare it against existing work including recent DINO-based methods. Experimental results demonstrate that explicitly modeling spatial dependencies achieves competitive anomaly detection performance while substantially reducing inference time and memory requirements. Code is available at the project page: https://eerdil.github.io/spatial-ar-dinov3-uad/.

Augmenting representations with scientific papers

Astronomers have acquired vast repositories of multimodal data, including images, spectra, and time series, complemented by decades of literature that analyzes astrophysical sources. Still, these data sources are rarely systematically integrated. This work introduces a contrastive learning framework designed to align X-ray spectra with domain knowledge extracted from scientific literature, facilitating the development of shared multimodal representations. Establishing this connection is inherently complex, as scientific texts encompass a broader and more diverse physical context than spectra. We propose a contrastive pipeline that achieves a 20% Recall@1% when retrieving texts from spectra, proving that a meaningful alignment between these modalities is not only possible but capable of accelerating the interpretation of rare or poorly understood sources. Furthermore, the resulting shared latent space effectively encodes physically significant information. By fusing spectral and textual data, we improve the estimation of 20 physical variables by 16-18% over unimodal spectral baselines. Our results indicate that a Mixture of Experts (MoE) strategy, which leverages both unimodal and shared representations, yields superior performance. Finally, outlier analysis within the multimodal latent space identifies high-priority targets for follow-up investigation, including a candidate pulsating ULX (PULX) and a gravitational lens system. Importantly, this framework can be extended to other scientific domains where aligning observational data with existing literature is possible.

GENAI WORKBENCH: AI-Assisted Analysis and Synthesis of Engineering Systems from Multimodal Engineering Data

Modern engineering design platforms excel at discipline-specific tasks such as CAD, CAM, and CAE, but often lack native systems engineering frameworks. This creates a disconnect where system-level requirements and architectures are managed separately from detailed component design, hindering holistic development and increasing integration risks. To address this, we present the conceptual framework for the GenAI Workbench, a Model-Based Systems Engineering (MBSE) environment that integrates systems engineering principles into the designer's workflow. Built on an open-source PLM platform, it establishes a unified digital thread by linking semantic data from documents, physical B-rep geometry, and relational system graphs. The workbench facilitates an AI-assisted workflow where a designer can ingest source documents, from which the system automatically extracts requirements and uses vision-language models to generate an initial system architecture, such as a Design Structure Matrix (DSM). This paper presents the conceptual architecture, proposed methodology, and anticipated impact of this work-in-progress framework, which aims to foster a more integrated, data-driven, and informed engineering design methodology.

Extracting Training Dialogue Data from Large Language Model based Task Bots

Large Language Models (LLMs) have been widely adopted to enhance Task-Oriented Dialogue Systems (TODS) by modeling complex language patterns and delivering contextually appropriate responses. However, this integration introduces significant privacy risks, as LLMs, functioning as soft knowledge bases that compress extensive training data into rich knowledge representations, can inadvertently memorize training dialogue data containing not only identifiable information such as phone numbers but also entire dialogue-level events like complete travel schedules. Despite the critical nature of this privacy concern, how LLM memorization is inherited in developing task bots remains unexplored. In this work, we address this gap through a systematic quantitative study that involves evaluating existing training data extraction attacks, analyzing key characteristics of task-oriented dialogue modeling that render existing methods ineffective, and proposing novel attack techniques tailored for LLM-based TODS that enhance both response sampling and membership inference. Experimental results demonstrate the effectiveness of our proposed data extraction attack. Our method can extract thousands of training labels of dialogue states with best-case precision exceeding 70%. Furthermore, we provide an in-depth analysis of training data memorization in LLM-based TODS by identifying and quantifying key influencing factors and discussing targeted mitigation strategies.

Adaptive Memory Admission Control for LLM Agents

LLM-based agents increasingly rely on long-term memory to support multi-session reasoning and interaction, yet current systems provide little control over what information is retained. In practice, agents either accumulate large volumes of conversational content, including hallucinated or obsolete facts, or depend on opaque, fully LLM-driven memory policies that are costly and difficult to audit. As a result, memory admission remains a poorly specified and weakly controlled component in agent architectures. To address this gap, we propose Adaptive Memory Admission Control (A-MAC), a framework that treats memory admission as a structured decision problem. A-MAC decomposes memory value into five complementary and interpretable factors: future utility, factual confidence, semantic novelty, temporal recency, and content type prior. The framework combines lightweight rule-based feature extraction with a single LLM-assisted utility assessment, and learns domain-adaptive admission policies through cross-validated optimization. This design enables transparent and efficient control over long-term memory. Experiments on the LoCoMo benchmark show that A-MAC achieves a superior precision-recall tradeoff, improving F1 to 0.583 while reducing latency by 31% compared to state-of-the-art LLM-native memory systems. Ablation results identify content type prior as the most influential factor for reliable memory admission. These findings demonstrate that explicit and interpretable admission control is a critical design principle for scalable and reliable memory in LLM-based agents.

A Browser-based Open Source Assistant for Multimodal Content Verification

Disinformation and false content produced by generative AI pose a significant challenge for journalists and fact-checkers who must rapidly verify digital media information. While there is an abundance of NLP models for detecting credibility signals such as persuasion techniques, subjectivity, or machine-generated text, such methods often remain inaccessible to non-expert users and are not integrated into their daily workflows as a unified framework. This paper demonstrates the VERIFICATION ASSISTANT, a browser-based tool designed to bridge this gap. The VERIFICATION ASSISTANT, a core component of the widely adopted VERIFICATION PLUGIN (140,000+ users), allows users to submit URLs or media files to a unified interface. It automatically extracts content and routes it to a suite of backend NLP classifiers, delivering actionable credibility signals, estimating AI-generated content, and providing other verification guidance in a clear, easy-to-digest format. This paper showcases the tool architecture, its integration of multiple NLP services, and its real-world application to detecting disinformation.