Geometrically Constrained Outlier Synthesis

Deep neural networks for image classification often exhibit overconfidence on out-of-distribution (OOD) samples. To address this, we introduce Geometrically Constrained Outlier Synthesis (GCOS), a training-time regularization framework aimed at improving OOD robustness during inference. GCOS addresses a limitation of prior synthesis methods by generating virtual outliers in the hidden feature space that respect the learned manifold structure of in-distribution (ID) data. The synthesis proceeds in two stages: (i) a dominant-variance subspace extracted from the training features identifies geometrically informed, off-manifold directions; (ii) a conformally-inspired shell, defined by the empirical quantiles of a nonconformity score from a calibration set, adaptively controls the synthesis magnitude to produce boundary samples. The shell ensures that generated outliers are neither trivially detectable nor indistinguishable from in-distribution data, facilitating smoother learning of robust features. This is combined with a contrastive regularization objective that promotes separability of ID and OOD samples in a chosen score space, such as Mahalanobis or energy-based. Experiments demonstrate that GCOS outperforms state-of-the-art methods using standard energy-based inference on near-OOD benchmarks, defined as tasks where outliers share the same semantic domain as in-distribution data. As an exploratory extension, the framework naturally transitions to conformal OOD inference, which translates uncertainty scores into statistically valid p-values and enables thresholds with formal error guarantees, providing a pathway toward more predictable and reliable OOD detection.

A Hypertoroidal Covering for Perfect Color Equivariance

When the color distribution of input images changes at inference, the performance of conventional neural network architectures drops considerably. A few researchers have begun to incorporate prior knowledge of color geometry in neural network design. These color equivariant architectures have modeled hue variation with 2D rotations, and saturation and luminance transformations as 1D translations. While this approach improves neural network robustness to color variations in a number of contexts, we find that approximating saturation and luminance (interval valued quantities) as 1D translations introduces appreciable artifacts. In this paper, we introduce a color equivariant architecture that is truly equivariant. Instead of approximating the interval with the real line, we lift values on the interval to values on the circle (a double-cover) and build equivariant representations there. Our approach resolves the approximation artifacts of previous methods, improves interpretability and generalizability, and achieves better predictive performance than conventional and equivariant baselines on tasks such as fine-grained classification and medical imaging tasks. Going beyond the context of color, we show that our proposed lifting can also extend to geometric transformations such as scale.

Harmonic Beltrami Signature Network: a Shape Prior Module in Deep Learning Framework

This paper presents the Harmonic Beltrami Signature Network (HBSN), a novel deep learning architecture for computing the Harmonic Beltrami Signature (HBS) from binary-like images. HBS is a shape representation that provides a one-to-one correspondence with 2D simply connected shapes, with invariance to translation, scaling, and rotation. By exploiting the function approximation capacity of neural networks, HBSN enables efficient extraction and utilization of shape prior information. The proposed network architecture incorporates a pre-Spatial Transformer Network (pre-STN) for shape normalization, a UNet-based backbone for HBS prediction, and a post-STN for angle regularization. Experiments show that HBSN accurately computes HBS representations, even for complex shapes. Furthermore, we demonstrate how HBSN can be directly incorporated into existing deep learning segmentation models, improving their performance through the use of shape priors. The results confirm the utility of HBSN as a general-purpose module for embedding geometric shape information into computer vision pipelines.

Decoupling Vision and Language: Codebook Anchored Visual Adaptation

Large Vision-Language Models (LVLMs) use their vision encoders to translate images into representations for downstream reasoning, but the encoders often underperform in domain-specific visual tasks such as medical image diagnosis or fine-grained classification, where representation errors can cascade through the language model, leading to incorrect responses. Existing adaptation methods modify the continuous feature interface between encoder and language model through projector tuning or other parameter-efficient updates, which still couples the two components and requires re-alignment whenever the encoder changes. We introduce CRAFT (Codebook RegulAted Fine-Tuning), a lightweight method that fine-tunes the encoder using a discrete codebook that anchors visual representations to a stable token space, achieving domain adaptation without modifying other parts of the model. This decoupled design allows the adapted encoder to seamlessly boost the performance of LVLMs with different language architectures, as long as they share the same codebook. Empirically, CRAFT achieves an average gain of 13.51% across 10 domain-specific benchmarks such as VQARAD and PlantVillage, while preserving the LLM's linguistic capabilities and outperforming peer methods that operate on continuous tokens.

Diffusion Probe: Generated Image Result Prediction Using CNN Probes

Text-to-image (T2I) diffusion models lack an efficient mechanism for early quality assessment, leading to costly trial-and-error in multi-generation scenarios such as prompt iteration, agent-based generation, and flow-grpo. We reveal a strong correlation between early diffusion cross-attention distributions and final image quality. Based on this finding, we introduce Diffusion Probe, a framework that leverages internal cross-attention maps as predictive signals. We design a lightweight predictor that maps statistical properties of early-stage cross-attention extracted from initial denoising steps to the final image's overall quality. This enables accurate forecasting of image quality across diverse evaluation metrics long before full synthesis is complete. We validate Diffusion Probe across a wide range of settings. On multiple T2I models, across early denoising windows, resolutions, and quality metrics, it achieves strong correlation (PCC > 0.7) and high classification performance (AUC-ROC > 0.9). Its reliability translates into practical gains. By enabling early quality-aware decisions in workflows such as prompt optimization, seed selection, and accelerated RL training, the probe supports more targeted sampling and avoids computation on low-potential generations. This reduces computational overhead while improving final output quality.Diffusion Probe is model-agnostic, efficient, and broadly applicable, offering a practical solution for improving T2I generation efficiency through early quality prediction.

Tell2Adapt: A Unified Framework for Source Free Unsupervised Domain Adaptation via Vision Foundation Model

Source Free Unsupervised Domain Adaptation (SFUDA) is critical for deploying deep learning models across diverse clinical settings. However, existing methods are typically designed for low-gap, specific domain shifts and cannot generalize into a unified, multi-modalities, and multi-target framework, which presents a major barrier to real-world application. To overcome this issue, we introduce Tell2Adapt, a novel SFUDA framework that harnesses the vast, generalizable knowledge of the Vision Foundation Model (VFM). Our approach ensures high-fidelity VFM prompts through Context-Aware Prompts Regularization (CAPR), which robustly translates varied text prompts into canonical instructions. This enables the generation of high-quality pseudo-labels for efficiently adapting the lightweight student model to target domain. To guarantee clinical reliability, the framework incorporates Visual Plausibility Refinement (VPR), which leverages the VFM's anatomical knowledge to re-ground the adapted model's predictions in target image's low-level visual features, effectively removing noise and false positives. We conduct one of the most extensive SFUDA evaluations to date, validating our framework across 10 domain adaptation directions and 22 anatomical targets, including brain, cardiac, polyp, and abdominal targets. Our results demonstrate that Tell2Adapt consistently outperforms existing approaches, achieving SOTA for a unified SFUDA framework in medical image segmentation. Code are avaliable at https://github.com/derekshiii/Tell2Adapt.

Unpaired Image-to-Image Translation via a Self-Supervised Semantic Bridge

Adversarial diffusion and diffusion-inversion methods have advanced unpaired image-to-image translation, but each faces key limitations. Adversarial approaches require target-domain adversarial loss during training, which can limit generalization to unseen data, while diffusion-inversion methods often produce low-fidelity translations due to imperfect inversion into noise-latent representations. In this work, we propose the Self-Supervised Semantic Bridge (SSB), a versatile framework that integrates external semantic priors into diffusion bridge models to enable spatially faithful translation without cross-domain supervision. Our key idea is to leverage self-supervised visual encoders to learn representations that are invariant to appearance changes but capture geometric structure, forming a shared latent space that conditions the diffusion bridges. Extensive experiments show that SSB outperforms strong prior methods for challenging medical image synthesis in both in-domain and out-of-domain settings, and extends easily to high-quality text-guided editing.

Pushing the Limits of Inverse Lithography with Generative Reinforcement Learning

Inverse lithography (ILT) is critical for modern semiconductor manufacturing but suffers from highly non-convex objectives that often trap optimization in poor local minima. Generative AI has been explored to warm-start ILT, yet most approaches train deterministic image-to-image translators to mimic sub-optimal datasets, providing limited guidance for escaping non-convex traps during refinement. We reformulate mask synthesis as conditional sampling: a generator learns a distribution over masks conditioned on the design and proposes multiple candidates. The generator is first pretrained with WGAN plus a reconstruction loss, then fine-tuned using Group Relative Policy Optimization (GRPO) with an ILT-guided imitation loss. At inference, we sample a small batch of masks, run fast batched ILT refinement, evaluate lithography metrics (e.g., EPE, process window), and select the best candidate. On \texttt{LithoBench} dataset, the proposed hybrid framework reduces EPE violations under a 3\,nm tolerance and roughly doubles throughput versus a strong numerical ILT baseline, while improving final mask quality. We also present over 20\% EPE improvement on \texttt{ICCAD13} contest cases with 3$\times$ speedup over the SOTA numerical ILT solver. By learning to propose ILT-friendly initializations, our approach mitigates non-convexity and advances beyond what traditional solvers or GenAI can achieve.

Bridging Day and Night: Target-Class Hallucination Suppression in Unpaired Image Translation

Day-to-night unpaired image translation is important to downstream tasks but remains challenging due to large appearance shifts and the lack of direct pixel-level supervision. Existing methods often introduce semantic hallucinations, where objects from target classes such as traffic signs and vehicles, as well as man-made light effects, are incorrectly synthesized. These hallucinations significantly degrade downstream performance. We propose a novel framework that detects and suppresses hallucinations of target-class features during unpaired translation. To detect hallucination, we design a dual-head discriminator that additionally performs semantic segmentation to identify hallucinated content in background regions. To suppress these hallucinations, we introduce class-specific prototypes, constructed by aggregating features of annotated target-domain objects, which act as semantic anchors for each class. Built upon a Schrodinger Bridge-based translation model, our framework performs iterative refinement, where detected hallucination features are explicitly pushed away from class prototypes in feature space, thus preserving object semantics across the translation trajectory.Experiments show that our method outperforms existing approaches both qualitatively and quantitatively. On the BDD100K dataset, it improves mAP by 15.5% for day-to-night domain adaptation, with a notable 31.7% gain for classes such as traffic lights that are prone to hallucinations.

BRIGHT: A Collaborative Generalist-Specialist Foundation Model for Breast Pathology

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.