Noise-Driven AI Sensors: Secure Healthcare Monitoring with PUFs

Wearable and implantable healthcare sensors are pivotal for real-time patient monitoring but face critical challenges in power efficiency, data security, and signal noise. This paper introduces a novel platform that leverages hardware noise as a dual-purpose resource to enhance machine learning (ML) robustness and secure data via Physical Unclonable Functions (PUFs). By integrating noise-driven signal processing, PUFbased authentication, and ML-based anomaly detection, our system achieves secure, low-power monitoring for devices like ECG wearables. Simulations demonstrate that noise improves ML accuracy by 8% (92% for detecting premature ventricular contractions (PVCs) and atrial fibrillation (AF)), while PUFs provide 98% uniqueness for tamper-resistant security, all within a 50 uW power budget. This unified approach not only addresses power, security, and noise challenges but also enables scalable, intelligent sensing for telemedicine and IoT applications.

DeepBoost-AF: A Novel Unsupervised Feature Learning and Gradient Boosting Fusion for Robust Atrial Fibrillation Detection in Raw ECG Signals

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with elevated health risks, where timely detection is pivotal for mitigating stroke-related morbidity. This study introduces an innovative hybrid methodology integrating unsupervised deep learning and gradient boosting models to improve AF detection. A 19-layer deep convolutional autoencoder (DCAE) is coupled with three boosting classifiers-AdaBoost, XGBoost, and LightGBM (LGBM)-to harness their complementary advantages while addressing individual limitations. The proposed framework uniquely combines DCAE with gradient boosting, enabling end-to-end AF identification devoid of manual feature extraction. The DCAE-LGBM model attains an F1-score of 95.20%, sensitivity of 99.99%, and inference latency of four seconds, outperforming existing methods and aligning with clinical deployment requirements. The DCAE integration significantly enhances boosting models, positioning this hybrid system as a reliable tool for automated AF detection in clinical settings.

Uncertainty quantification with approximate variational learning for wearable photoplethysmography prediction tasks

Photoplethysmography (PPG) signals encode information about relative changes in blood volume that can be used to assess various aspects of cardiac health non-invasively, e.g.\ to detect atrial fibrillation (AF) or predict blood pressure (BP). Deep networks are well-equipped to handle the large quantities of data acquired from wearable measurement devices. However, they lack interpretability and are prone to overfitting, leaving considerable risk for poor performance on unseen data and misdiagnosis. Here, we describe the use of two scalable uncertainty quantification techniques: Monte Carlo Dropout and the recently proposed Improved Variational Online Newton. These techniques are used to assess the trustworthiness of models trained to perform AF classification and BP regression from raw PPG time series. We find that the choice of hyperparameters has a considerable effect on the predictive performance of the models and on the quality and composition of predicted uncertainties. E.g. the stochasticity of the model parameter sampling determines the proportion of the total uncertainty that is aleatoric, and has varying effects on predictive performance and calibration quality dependent on the chosen uncertainty quantification technique and the chosen expression of uncertainty. We find significant discrepancy in the quality of uncertainties over the predicted classes, emphasising the need for a thorough evaluation protocol that assesses local and adaptive calibration. This work suggests that the choice of hyperparameters must be carefully tuned to balance predictive performance and calibration quality, and that the optimal parameterisation may vary depending on the chosen expression of uncertainty.

GPT-PPG: A GPT-based Foundation Model for Photoplethysmography Signals

This study introduces a novel application of a Generative Pre-trained Transformer (GPT) model tailored for photoplethysmography (PPG) signals, serving as a foundation model for various downstream tasks. Adapting the standard GPT architecture to suit the continuous characteristics of PPG signals, our approach demonstrates promising results. Our models are pre-trained on our extensive dataset that contains more than 200 million 30s PPG samples. We explored different supervised fine-tuning techniques to adapt our model to downstream tasks, resulting in performance comparable to or surpassing current state-of-the-art (SOTA) methods in tasks like atrial fibrillation detection. A standout feature of our GPT model is its inherent capability to perform generative tasks such as signal denoising effectively, without the need for further fine-tuning. This success is attributed to the generative nature of the GPT framework.

Leveraging Self-Supervised Learning Methods for Remote Screening of Subjects with Paroxysmal Atrial Fibrillation

The integration of Artificial Intelligence (AI) into clinical research has great potential to reveal patterns that are difficult for humans to detect, creating impactful connections between inputs and clinical outcomes. However, these methods often require large amounts of labeled data, which can be difficult to obtain in healthcare due to strict privacy laws and the need for experts to annotate data. This requirement creates a bottleneck when investigating unexplored clinical questions. This study explores the application of Self-Supervised Learning (SSL) as a way to obtain preliminary results from clinical studies with limited sized cohorts. To assess our approach, we focus on an underexplored clinical task: screening subjects for Paroxysmal Atrial Fibrillation (P-AF) using remote monitoring, single-lead ECG signals captured during normal sinus rhythm. We evaluate state-of-the-art SSL methods alongside supervised learning approaches, where SSL outperforms supervised learning in this task of interest. More importantly, it prevents misleading conclusions that may arise from poor performance in the latter paradigm when dealing with limited cohort settings.

A Review on Multisensor Data Fusion for Wearable Health Monitoring

The growing demand for accurate, continuous, and non-invasive health monitoring has propelled multi-sensor data fusion to the forefront of healthcare technology. This review aims to provide an overview of the development of fusion frameworks in the literature and common terminology used in fusion literature. The review introduces the fusion classification standards and methods that are most relevant from an algorithm development perspective. Applications of the reviewed fusion frameworks in fields such as defense, autonomous driving, robotics, and image fusion are also discussed to provide contextual information on the various fusion methodologies that have been developed in this field. This review provides a comprehensive analysis of multi-sensor data fusion methods applied to health monitoring systems, focusing on key algorithms, applications, challenges, and future directions. We examine commonly used fusion techniques, including Kalman filters, Bayesian networks, and machine learning models. By integrating data from various sources, these fusion approaches enhance the reliability, accuracy, and resilience of health monitoring systems. However, challenges such as data quality and differences in acquisition systems exist, calling for intelligent fusion algorithms in recent years. The review finally converges on applications of fusion algorithms in biomedical inference tasks like heartbeat detection, respiration rate estimation, sleep apnea detection, arrhythmia detection, and atrial fibrillation detection.

Compact Neural Network Algorithm for Electrocardiogram Classification

In this paper, we present a high-performance, compact electrocardiogram (ECG)-based system for automatic classification of arrhythmias, integrating machine learning approaches to achieve robust cardiac diagnostics. Our method combines a compact artificial neural network with feature enhancement techniques, including mathematical transformations, signal analysis and data extraction algorithms, to capture both morphological and time-frequency features from ECG signals. A novel aspect of this work is the addition of 17 newly engineered features, which complement the algorithm's capability to extract significant data and physiological patterns from the ECG signal. This combination enables the classifier to detect multiple arrhythmia types, such as atrial fibrillation, sinus tachycardia, ventricular flutter, and other common arrhythmic disorders. The system achieves an accuracy of 97.36% on the MIT-BIH arrhythmia database, using a lower complexity compared to state-of-the-art models. This compact tool shows potential for clinical deployment, as well as adaptation for portable devices in long-term cardiac health monitoring applications.

Atrial Fibrillation Detection System via Acoustic Sensing for Mobile Phones

Atrial fibrillation (AF) is characterized by irregular electrical impulses originating in the atria, which can lead to severe complications and even death. Due to the intermittent nature of the AF, early and timely monitoring of AF is critical for patients to prevent further exacerbation of the condition. Although ambulatory ECG Holter monitors provide accurate monitoring, the high cost of these devices hinders their wider adoption. Current mobile-based AF detection systems offer a portable solution, however, these systems have various applicability issues such as being easily affected by environmental factors and requiring significant user effort. To overcome the above limitations, we present MobileAF, a novel smartphone-based AF detection system using speakers and microphones. In order to capture minute cardiac activities, we propose a multi-channel pulse wave probing method. In addition, we enhance the signal quality by introducing a three-stage pulse wave purification pipeline. What's more, a ResNet-based network model is built to implement accurate and reliable AF detection. We collect data from 23 participants utilizing our data collection application on the smartphone. Extensive experimental results demonstrate the superior performance of our system, with 97.9% accuracy, 96.8% precision, 97.2% recall, 98.3% specificity, and 97.0% F1 score.

Electrocardiogram (ECG) Based Cardiac Arrhythmia Detection and Classification using Machine Learning Algorithms

The rapid advancements in Artificial Intelligence, specifically Machine Learning (ML) and Deep Learning (DL), have opened new prospects in medical sciences for improved diagnosis, prognosis, and treatment of severe health conditions. This paper focuses on the development of an ML model with high predictive accuracy to classify arrhythmic electrocardiogram (ECG) signals. The ECG signals datasets utilized in this study were sourced from the PhysioNet and MIT-BIH databases. The research commenced with binary classification, where an optimized Bidirectional Long Short-Term Memory (Bi-LSTM) model yielded excellent results in differentiating normal and atrial fibrillation signals. A pivotal aspect of this research was a survey among medical professionals, which not only validated the practicality of AI-based ECG classifiers but also identified areas for improvement, including accuracy and the inclusion of more arrhythmia types. These insights drove the development of an advanced Convolutional Neural Network (CNN) system capable of classifying five different types of ECG signals with better accuracy and precision. The CNN model's robust performance was ensured through rigorous stratified 5-fold cross validation. A web portal was also developed to demonstrate real-world utility, offering access to the trained model for real-time classification. This study highlights the potential applications of such models in remote health monitoring, predictive healthcare, assistive diagnostic tools, and simulated environments for educational training and interdisciplinary collaboration between data scientists and medical personnel.

A Novel Generative Multi-Task Representation Learning Approach for Predicting Postoperative Complications in Cardiac Surgery Patients

Early detection of surgical complications allows for timely therapy and proactive risk mitigation. Machine learning (ML) can be leveraged to identify and predict patient risks for postoperative complications. We developed and validated the effectiveness of predicting postoperative complications using a novel surgical Variational Autoencoder (surgVAE) that uncovers intrinsic patterns via cross-task and cross-cohort presentation learning. This retrospective cohort study used data from the electronic health records of adult surgical patients over four years (2018 - 2021). Six key postoperative complications for cardiac surgery were assessed: acute kidney injury, atrial fibrillation, cardiac arrest, deep vein thrombosis or pulmonary embolism, blood transfusion, and other intraoperative cardiac events. We compared prediction performances of surgVAE against widely-used ML models and advanced representation learning and generative models under 5-fold cross-validation. 89,246 surgeries (49% male, median (IQR) age: 57 (45-69)) were included, with 6,502 in the targeted cardiac surgery cohort (61% male, median (IQR) age: 60 (53-70)). surgVAE demonstrated superior performance over existing ML solutions across all postoperative complications of cardiac surgery patients, achieving macro-averaged AUPRC of 0.409 and macro-averaged AUROC of 0.831, which were 3.4% and 3.7% higher, respectively, than the best alternative method (by AUPRC scores). Model interpretation using Integrated Gradients highlighted key risk factors based on preoperative variable importance. surgVAE showed excellent discriminatory performance for predicting postoperative complications and addressing the challenges of data complexity, small cohort sizes, and low-frequency positive events. surgVAE enables data-driven predictions of patient risks and prognosis while enhancing the interpretability of patient risk profiles.