Domain Knowledge is Power: Leveraging Physiological Priors for Self Supervised Representation Learning in Electrocardiography

Objective: Electrocardiograms (ECGs) play a crucial role in diagnosing heart conditions; however, the effectiveness of artificial intelligence (AI)-based ECG analysis is often hindered by the limited availability of labeled data. Self-supervised learning (SSL) can address this by leveraging large-scale unlabeled data. We introduce PhysioCLR (Physiology-aware Contrastive Learning Representation for ECG), a physiology-aware contrastive learning framework that incorporates domain-specific priors to enhance the generalizability and clinical relevance of ECG-based arrhythmia classification. Methods: During pretraining, PhysioCLR learns to bring together embeddings of samples that share similar clinically relevant features while pushing apart those that are dissimilar. Unlike existing methods, our method integrates ECG physiological similarity cues into contrastive learning, promoting the learning of clinically meaningful representations. Additionally, we introduce ECG- specific augmentations that preserve the ECG category post augmentation and propose a hybrid loss function to further refine the quality of learned representations. Results: We evaluate PhysioCLR on two public ECG datasets, Chapman and Georgia, for multilabel ECG diagnoses, as well as a private ICU dataset labeled for binary classification. Across the Chapman, Georgia, and private cohorts, PhysioCLR boosts the mean AUROC by 12% relative to the strongest baseline, underscoring its robust cross-dataset generalization. Conclusion: By embedding physiological knowledge into contrastive learning, PhysioCLR enables the model to learn clinically meaningful and transferable ECG eatures. Significance: PhysioCLR demonstrates the potential of physiology-informed SSL to offer a promising path toward more effective and label-efficient ECG diagnostics.

Speaker Recognition with Random Digit Strings Using Uncertainty Normalized HMM-based i-vectors

In this paper, we combine Hidden Markov Models (HMMs) with i-vector extractors to address the problem of text-dependent speaker recognition with random digit strings. We employ digit-specific HMMs to segment the utterances into digits, to perform frame alignment to HMM states and to extract Baum-Welch statistics. By making use of the natural partition of input features into digits, we train digit-specific i-vector extractors on top of each HMM and we extract well-localized i-vectors, each modelling merely the phonetic content corresponding to a single digit. We then examine ways to perform channel and uncertainty compensation, and we propose a novel method for using the uncertainty in the i-vector estimates. The experiments on RSR2015 part III show that the proposed method attains 1.52\% and 1.77\% Equal Error Rate (EER) for male and female respectively, outperforming state-of-the-art methods such as x-vectors, trained on vast amounts of data. Furthermore, these results are attained by a single system trained entirely on RSR2015, and by a simple score-normalized cosine distance. Moreover, we show that the omission of channel compensation yields only a minor degradation in performance, meaning that the system attains state-of-the-art results even without recordings from multiple handsets per speaker for training or enrolment. Similar conclusions are drawn from our experiments on the RedDots corpus, where the same method is evaluated on phrases. Finally, we report results with bottleneck features and show that further improvement is attained when fusing them with spectral features.