SDR-Former: A Siamese Dual-Resolution Transformer for Liver Lesion Classification Using 3D Multi-Phase Imaging

Automated classification of liver lesions in multi-phase CT and MR scans is of clinical significance but challenging. This study proposes a novel Siamese Dual-Resolution Transformer (SDR-Former) framework, specifically designed for liver lesion classification in 3D multi-phase CT and MR imaging with varying phase counts. The proposed SDR-Former utilizes a streamlined Siamese Neural Network (SNN) to process multi-phase imaging inputs, possessing robust feature representations while maintaining computational efficiency. The weight-sharing feature of the SNN is further enriched by a hybrid Dual-Resolution Transformer (DR-Former), comprising a 3D Convolutional Neural Network (CNN) and a tailored 3D Transformer for processing high- and low-resolution images, respectively. This hybrid sub-architecture excels in capturing detailed local features and understanding global contextual information, thereby, boosting the SNN's feature extraction capabilities. Additionally, a novel Adaptive Phase Selection Module (APSM) is introduced, promoting phase-specific intercommunication and dynamically adjusting each phase's influence on the diagnostic outcome. The proposed SDR-Former framework has been validated through comprehensive experiments on two clinical datasets: a three-phase CT dataset and an eight-phase MR dataset. The experimental results affirm the efficacy of the proposed framework. To support the scientific community, we are releasing our extensive multi-phase MR dataset for liver lesion analysis to the public. This pioneering dataset, being the first publicly available multi-phase MR dataset in this field, also underpins the MICCAI LLD-MMRI Challenge. The dataset is accessible at:https://bit.ly/3IyYlgN.

TransXNet: Learning Both Global and Local Dynamics with a Dual Dynamic Token Mixer for Visual Recognition

Recent studies have integrated convolution into transformers to introduce inductive bias and improve generalization performance. However, the static nature of conventional convolution prevents it from dynamically adapting to input variations, resulting in a representation discrepancy between convolution and self-attention as self-attention calculates attention matrices dynamically. Furthermore, when stacking token mixers that consist of convolution and self-attention to form a deep network, the static nature of convolution hinders the fusion of features previously generated by self-attention into convolution kernels. These two limitations result in a sub-optimal representation capacity of the constructed networks. To find a solution, we propose a lightweight Dual Dynamic Token Mixer (D-Mixer) that aggregates global information and local details in an input-dependent way. D-Mixer works by applying an efficient global attention module and an input-dependent depthwise convolution separately on evenly split feature segments, endowing the network with strong inductive bias and an enlarged effective receptive field. We use D-Mixer as the basic building block to design TransXNet, a novel hybrid CNN-Transformer vision backbone network that delivers compelling performance. In the ImageNet-1K image classification task, TransXNet-T surpasses Swin-T by 0.3\% in top-1 accuracy while requiring less than half of the computational cost. Furthermore, TransXNet-S and TransXNet-B exhibit excellent model scalability, achieving top-1 accuracy of 83.8\% and 84.6\% respectively, with reasonable computational costs. Additionally, our proposed network architecture demonstrates strong generalization capabilities in various dense prediction tasks, outperforming other state-of-the-art networks while having lower computational costs.